PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21492934-0	2011	The induction of innate and adaptive immunity by biodegradable poly(gamma-glutamic acid) nanoparticles via a TLR4 and MyD88 signaling pathway.	poly(gamma-glutamic acid)	63-88	toll-like receptor 4	Mus musculus	109-113	
29875467-1	2018	Poly-gamma-glutamic acid (gamma-PGA), an extracellular biopolymer produced by Bacillus sp., is a non-canonical toll-like receptor 4 (TLR4) agonist.	poly(gamma-glutamic acid)	0-24	toll-like receptor 4	Mus musculus	133-137	
29875467-1	2018	Poly-gamma-glutamic acid (gamma-PGA), an extracellular biopolymer produced by Bacillus sp., is a non-canonical toll-like receptor 4 (TLR4) agonist.	poly(gamma-glutamic acid)	26-35	toll-like receptor 4	Mus musculus	133-137	
29875467-6	2018	gamma-PGA sensing by TLR4 required the two TLR4-associated accessory factors MD2 and CD14.	poly(gamma-glutamic acid)	0-9	toll-like receptor 4	Mus musculus	21-25	
29875467-6	2018	gamma-PGA sensing by TLR4 required the two TLR4-associated accessory factors MD2 and CD14.	poly(gamma-glutamic acid)	0-9	toll-like receptor 4	Mus musculus	43-47	
29875467-10	2018	Our results disclose a gamma-PGA-mediated non-conventional TLR4 signaling in the ileum, highlighting the potential use of gamma-PGA as a prophylactic antiviral agent against noroviruses.	poly(gamma-glutamic acid)	23-32	toll-like receptor 4	Mus musculus	59-63	
21672055-10	2011	These effects of gamma-PGA were dependent on TLR-4 and independent of TLR-2.	poly(gamma-glutamic acid)	17-26	toll-like receptor 4	Mus musculus	45-50	
21672055-13	2011	These anti-asthmatic effects of gamma-PGA were also abolished in TLR-4-defective mice.	poly(gamma-glutamic acid)	32-41	toll-like receptor 4	Mus musculus	65-70	
21672055-14	2011	CONCLUSIONS AND CLINICAL RELEVANCE: Our data indicate that gamma-PGA activates DCs to favour Th1 cell induction through a TLR-4-dependent pathway and alleviates pathologic symptoms in a Th2-biased asthmatic model.	poly(gamma-glutamic acid)	59-68	toll-like receptor 4	Mus musculus	122-127	
21672055-0	2011	Bacillus-derived poly-gamma-glutamic acid attenuates allergic airway inflammation through a Toll-like receptor-4-dependent pathway in a murine model of asthma.	poly(gamma-glutamic acid)	17-41	toll-like receptor 4	Mus musculus	92-112	
21492934-3	2011	We describe in this study that biodegradable nanoparticles (NPs) elaborated with poly(gamma-glutamic acid) (gamma-PGA) are able to induce potent innate and adaptive immune responses through Toll-like receptor 4 (TLR4) and MyD88 signaling pathways.	poly(gamma-glutamic acid)	81-106	toll-like receptor 4	Mus musculus	190-210	
21492934-3	2011	We describe in this study that biodegradable nanoparticles (NPs) elaborated with poly(gamma-glutamic acid) (gamma-PGA) are able to induce potent innate and adaptive immune responses through Toll-like receptor 4 (TLR4) and MyD88 signaling pathways.	poly(gamma-glutamic acid)	81-106	toll-like receptor 4	Mus musculus	212-216	
21492934-3	2011	We describe in this study that biodegradable nanoparticles (NPs) elaborated with poly(gamma-glutamic acid) (gamma-PGA) are able to induce potent innate and adaptive immune responses through Toll-like receptor 4 (TLR4) and MyD88 signaling pathways.	poly(gamma-glutamic acid)	108-117	toll-like receptor 4	Mus musculus	190-210	
21492934-3	2011	We describe in this study that biodegradable nanoparticles (NPs) elaborated with poly(gamma-glutamic acid) (gamma-PGA) are able to induce potent innate and adaptive immune responses through Toll-like receptor 4 (TLR4) and MyD88 signaling pathways.	poly(gamma-glutamic acid)	108-117	toll-like receptor 4	Mus musculus	212-216	
21492934-4	2011	The production of inflammatory cytokines from macrophages and the maturation of dendritic cells were impaired in MyD88-knockout and TLR4-deficient mice compared with their wild-types, when the cells were stimulated with gamma-PGA NPs.	poly(gamma-glutamic acid)	220-229	toll-like receptor 4	Mus musculus	132-136	
19294383-0	2009	Oral administration of poly-gamma-glutamate induces TLR4- and dendritic cell-dependent antitumor effect.	poly(gamma-glutamic acid)	23-43	toll-like receptor 4	Mus musculus	52-56	
19294383-2	2009	In the present study, we found that application of high molecular mass gamma-PGA induced secretion of tumor necrosis factor (TNF)-alpha from the bone-marrow-derived macrophages of wild type (C57BL/6 and C3H/HeN) and Toll-like receptor 2 knockout (TLR2(-/-)) mice, but not those of myeloid differentiation factor 88 knockout (MyD88(-/-)) and TLR4-defective mice (C3H/HeJ).	poly(gamma-glutamic acid)	71-80	toll-like receptor 4	Mus musculus	341-345	
19294383-6	2009	Downregulation of MyD88 and TLR4 expression using small interfering RNA (siRNA) significantly inhibited gamma-PGA-induced TNF-alpha secretion from the RAW264.7 cells.	poly(gamma-glutamic acid)	104-113	toll-like receptor 4	Mus musculus	28-32	
19294383-9	2009	These findings strongly suggest that the antitumor activity of gamma-PGA is mediated by TLR4.	poly(gamma-glutamic acid)	63-72	toll-like receptor 4	Mus musculus	88-92