PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33476693-9	2021	Indeed, our data indicated that niclosamide hindered RSV infection via proapoptotic activity by a reduction of AKT prosurvival protein, activation of cleaved caspase-3 and PARP (poly ADP-ribose polymerase), and an early apoptosis induction.	Niclosamide	32-43	AKT serine/threonine kinase 1	Homo sapiens	111-114	
29358661-7	2018	Treatment of WT- and T315I-BCR-ABL-expressing CML cells by niclosamide diminished such an enrichment of Sp1, and decreased WT- and T315I-BCR-ABL transcription and its downstream signaling molecules such as STAT5 and Akt.	Niclosamide	59-70	AKT serine/threonine kinase 1	Homo sapiens	216-219	
28877265-5	2017	In addition, niclosamide treatment led to down-regulation of Wnt/beta-catenin, PI3K/AKT, MAPK/ERK, and STAT3 pro-survival signal transduction pathways to further reduce U-87 MG cell viability.	Niclosamide	13-24	AKT serine/threonine kinase 1	Homo sapiens	84-87	
26810188-9	2016	Mechanistically, niclosamide treatment in combination with or without cisplatin significantly inhibited Akt, ERK, and Src signaling pathways.	Niclosamide	17-28	AKT serine/threonine kinase 1	Homo sapiens	104-107	
26792726-5	2016	Our in vitro study showed that receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast differentiation was inhibited by niclosamide, due to inhibition of serine-threonine protein kinase (Akt) phosphorylation, inhibitor of nuclear factor-kappaB (IkappaB), and STAT3 serine(727).	Niclosamide	142-153	AKT serine/threonine kinase 1	Homo sapiens	209-212	
26703449-7	2016	Additionally, niclosamide inhibited the phosphorylation of Akt.	Niclosamide	14-25	AKT serine/threonine kinase 1	Homo sapiens	59-62	
26703449-8	2016	Collectively, our results reveal that niclosamide inhibits cell proliferation and induces mitochondrial apoptosis of RAFLSs, which is associated with the modulation of Akt signaling pathways.	Niclosamide	38-49	AKT serine/threonine kinase 1	Homo sapiens	168-171	
32132037-7	2020	AMPK/AKT/mTOR pathway were involved in niclosamide-induced cell death and autophagy in response to ATP depletion.	Niclosamide	39-50	AKT serine/threonine kinase 1	Homo sapiens	5-8	
27449264-9	2016	Treatment with PI3K inhibitor ZSTK474 or STAT3 inhibitor niclosamide reversed the effects of WSTF overexpression by inhibiting cell proliferation, migration and invasion, with decreased level of p-Akt, p-STAT3 and IL-6.	Niclosamide	57-68	AKT serine/threonine kinase 1	Homo sapiens	197-200