PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28861168-6 2017 We also demonstrated that niclosamide specifically suppresses the levels of p-LRP6, Dvl2, and beta-catenin, but not p-STAT3, in Y79 cells. Niclosamide 26-37 LDL receptor related protein 6 Homo sapiens 78-82 22195040-0 2011 Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/beta-catenin pathway. Niclosamide 0-11 LDL receptor related protein 6 Homo sapiens 70-74 24552774-5 2014 Niclosamide has been shown to inhibit the Wnt/beta-catenin signaling pathway by causing degradation of LRP6. Niclosamide 0-11 LDL receptor related protein 6 Homo sapiens 103-107 24552774-11 2014 Niclosamide treatment produced reduced levels of LRP6 and beta-catenin, which is a downstream Wnt/beta-catenin signaling protein. Niclosamide 0-11 LDL receptor related protein 6 Homo sapiens 49-53 22195040-4 2011 We found that niclosamide was able to suppress LRP6 expression and phosphorylation, block Wnt3A-induced beta-catenin accumulation, and inhibit Wnt/beta-catenin signaling in HEK293 cells. Niclosamide 14-25 LDL receptor related protein 6 Homo sapiens 47-51 22195040-5 2011 Furthermore, the inhibitory effects of niclosamide on LRP6 expression/phosphorylation and Wnt/beta-catenin signaling were conformed in human prostate PC-3 and DU145 and breast MDA-MB-231 and T-47D cancer cells. Niclosamide 39-50 LDL receptor related protein 6 Homo sapiens 54-58 22195040-6 2011 Moreover, we showed that the mechanism by which niclosamide suppressed LRP6 resulted from increased degradation as evident by a shorter half-life. Niclosamide 48-59 LDL receptor related protein 6 Homo sapiens 71-75 22195040-9 2011 Our data indicate that niclosamide is a unique small molecule Wnt/beta-catenin signaling inhibitor targeting the Wnt co-receptor LRP6 on the cell surface, and that niclosamide has a potential to be developed a novel chemopreventive or therapeutic agent for human prostate and breast cancer. Niclosamide 23-34 LDL receptor related protein 6 Homo sapiens 129-133