PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11882509-2	2002	Herein, we show that multiple receptor agonists, including 17alpha-estradiol and estriol as well as the antagonist ICI-182780, stimulate proteasome-dependent proteolysis of ERalpha in a process that requires ligand binding to the receptor.	Estriol	81-88	estrogen receptor 1	Homo sapiens	173-180	
11178903-6	2001	The affinity of the estradiol or estriol bound ERalpha/SRC-1 complexes was found to be significantly higher than that observed in the presence of estrone.	Estriol	33-40	estrogen receptor 1	Homo sapiens	47-54	
2011412-1	1991	The equilibrium binding kinetics of the interaction between the estrogen receptor and natural estrogens (estradiol, estriol and estrone), non-steroidal estrogen agonists (11 beta-chloromethyl-estradiol-17 beta, diethyl-stilbestrol, hexestrol) and non-steroidal antiestrogens (clomiphene, tamoxifen) have been characterized.	Estriol	116-123	estrogen receptor 1	Homo sapiens	64-81	
7629815-3	1995	Four new classes of 11 beta-substituted estradiol and estriol derivatives (cyanoalkyl, ethynyl, propynyl, and iodovinyl) have been synthesized, and their binding affinity for the estrogen receptor has been evaluated.	Estriol	54-61	estrogen receptor 1	Homo sapiens	179-196	
8366504-1	1993	Partial agonists such as estriol and estrone have been reported to diminish or even eliminate the upward convexity of the Scatchard plot of the binding of labeled estradiol to estrogen receptor.	Estriol	25-32	estrogen receptor 1	Homo sapiens	176-193	
3943090-5	1986	The estrogen receptor shows binding selectivity for estrogens and antiestrogens, and its affinity for ligands follows the order diethylstilbestrol (190%) greater than estradiol (100%) greater than estriol (13%) greater than tamoxifen (3%), as expected for estrogen receptor.	Estriol	197-204	estrogen receptor 1	Homo sapiens	4-21	
34611658-7	2021	The unique results indicated that estrogen hormones (ER), e.g., estrone and estriol, 1) interacting with ESR1/2 receptors, 2) can inhibit SARS-CoV-2 caused inflammation and immune response signaling in host cells; and 3) estrogen hormone is associated with the distinct fatality rates between male and female COVID-19 patients.	Estriol	76-83	estrogen receptor 1	Homo sapiens	105-111	
870192-9	1977	We conclude that estriol can bind to estrogen receptor and stimulate human breast cancer in tissue culture.	Estriol	17-24	estrogen receptor 1	Homo sapiens	37-54	
29929224-6	2018	Chemical analysis of active fractions by LC-MS/MS and LC-HRMS/MS found female reproductive hormones (estrone (E1), estradiol (E2), estriol (E3)) as cause of ERalpha activity while male reproductive hormones (testosterone, dihydrotestosterone (DHT)) and gestagens (progesterone and medroxyprogesterone) were active in the AR bioassay.	Estriol	131-138	estrogen receptor 1	Homo sapiens	157-164	
18544561-1	2008	Reports of the ability of estrogenic agents such as 17beta-estradiol (E2), estriol (E3) and bisphenol A (BPA) to induce micronuclei (MN) in MCF-7 breast cancer cells have prompted us to investigate whether these effects are linked to activation of the estrogen receptor (ER) alpha.	Estriol	75-82	estrogen receptor 1	Homo sapiens	252-280	
30415118-3	2019	An optimized MIP prepared with methacrylic acid as an additional functional monomer and estriol (E3), an analogue of 17beta-estradiol (E2), exhibited highly selective adsorption for ER-active compounds such as E2 and E3, with significant suppression of non-specific hydrophobic adsorption.	Estriol	88-95	estrogen receptor 1	Homo sapiens	182-184	
20138962-0	2010	Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells.	Estriol	0-7	estrogen receptor 1	Homo sapiens	38-55	
19668239-10	2009	In conclusion, estriol acting through ERalpha to reduce MMP-9 from immune cells is one mechanism potentially underlying the estriol-mediated reduction in enhancing lesions in MS and inflammatory lesions in EAE.	Estriol	15-22	estrogen receptor 1	Homo sapiens	38-45	
21479371-6	2008	During pregnancy, however, there is a preponderance of activation of ERbeta over ERalpha conferred by various pregnancy estrogens such as estriol and other D-ring derivatives of 17beta-estradiol (E2).	Estriol	138-145	estrogen receptor 1	Homo sapiens	81-88	
16728493-3	2006	For instance, several of the D-ring metabolites, such as 16 alpha-hydroxyestradiol (estriol), 16 beta-hydroxyestradiol-17 alpha, and 16-ketoestrone, had distinct preferential binding affinity for human ER beta over ER alpha (difference up to 18-fold).	Estriol	57-82	estrogen receptor 1	Homo sapiens	215-223	
16728493-3	2006	For instance, several of the D-ring metabolites, such as 16 alpha-hydroxyestradiol (estriol), 16 beta-hydroxyestradiol-17 alpha, and 16-ketoestrone, had distinct preferential binding affinity for human ER beta over ER alpha (difference up to 18-fold).	Estriol	84-91	estrogen receptor 1	Homo sapiens	215-223	
16728493-4	2006	Notably, although E2 has nearly the highest and equal binding affinity for ER alpha and ER beta, E1 and 2-hydroxyestrone (two quantitatively predominant endogenous estrogens in nonpregnant woman) have preferential binding affinity for ER alpha over ER beta, whereas 16 alpha-hydroxyestradiol (estriol) and other D-ring metabolites (quantitatively predominant endogenous estrogens formed during pregnancy) have preferential binding affinity for ER beta over ER alpha.	Estriol	293-300	estrogen receptor 1	Homo sapiens	75-83