PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31932327-8 2020 Both glycine lipid classes were shown to promote TLR2-dependent TNF-alpha release from bone marrow macrophages and both were shown to activate human embryonic kidney (HEK) cells through TLR2 and TLR6, but not TLR1. Glycine 5-12 tumor necrosis factor Homo sapiens 64-73 33049473-7 2021 Molecular docking analysis revealed that the Al12N12/Gly (-11.7 kcal/mol) and the Al12ON11/Gly (-9.2 kcal/mol) complexes have a good binding affinity with protein tumor necrosis factor alpha (TNF-alpha). Glycine 53-56 tumor necrosis factor Homo sapiens 163-190 33049473-7 2021 Molecular docking analysis revealed that the Al12N12/Gly (-11.7 kcal/mol) and the Al12ON11/Gly (-9.2 kcal/mol) complexes have a good binding affinity with protein tumor necrosis factor alpha (TNF-alpha). Glycine 53-56 tumor necrosis factor Homo sapiens 192-201 33049473-7 2021 Molecular docking analysis revealed that the Al12N12/Gly (-11.7 kcal/mol) and the Al12ON11/Gly (-9.2 kcal/mol) complexes have a good binding affinity with protein tumor necrosis factor alpha (TNF-alpha). Glycine 91-94 tumor necrosis factor Homo sapiens 163-190 33049473-7 2021 Molecular docking analysis revealed that the Al12N12/Gly (-11.7 kcal/mol) and the Al12ON11/Gly (-9.2 kcal/mol) complexes have a good binding affinity with protein tumor necrosis factor alpha (TNF-alpha). Glycine 91-94 tumor necrosis factor Homo sapiens 192-201 33049473-9 2021 These results suggest that the Al12N12/Gly complex in comparison with the Al16N16/Gly, Al12ON11/Gly, and the Al12CN11/Gly complexes could be efficient inhibitors of TNF-alpha. Glycine 39-42 tumor necrosis factor Homo sapiens 165-174 33049473-9 2021 These results suggest that the Al12N12/Gly complex in comparison with the Al16N16/Gly, Al12ON11/Gly, and the Al12CN11/Gly complexes could be efficient inhibitors of TNF-alpha. Glycine 82-85 tumor necrosis factor Homo sapiens 165-174 33049473-9 2021 These results suggest that the Al12N12/Gly complex in comparison with the Al16N16/Gly, Al12ON11/Gly, and the Al12CN11/Gly complexes could be efficient inhibitors of TNF-alpha. Glycine 82-85 tumor necrosis factor Homo sapiens 165-174 33049473-9 2021 These results suggest that the Al12N12/Gly complex in comparison with the Al16N16/Gly, Al12ON11/Gly, and the Al12CN11/Gly complexes could be efficient inhibitors of TNF-alpha. Glycine 82-85 tumor necrosis factor Homo sapiens 165-174 29802438-3 2018 Mechanistic studies were able to identify several "new targets", such as the inhibition of spinal glycine transporters or of inflammatory signaling as induced by tumor necrosis factor alpha. Glycine 98-105 tumor necrosis factor Homo sapiens 162-189 29550635-0 2018 Participation of the IKK-alpha/beta complex in the inhibition of the TNF-alpha/NF-kappaB pathway by glycine: Possible involvement of a membrane receptor specific to adipocytes. Glycine 100-107 tumor necrosis factor Homo sapiens 69-78 29550635-1 2018 Glycine modulates inflammatory processes mediated by macrophages and adipocytes through decreasing the secretion of TNF-alpha, IL-6, and leptin, while increasing adiponectin. Glycine 0-7 tumor necrosis factor Homo sapiens 116-125 29550635-3 2018 However, glycine upstream mainly influences the IkappaB kinase (IKK) complex, a multi-protein kinase complex considered a critical point in regulation of the NF-kappaB pathway; whether that is responsible for the TNF-alpha-induced phosphorylation of IkB has not been explored. Glycine 9-16 tumor necrosis factor Homo sapiens 213-222 29550635-5 2018 In this research, participation of the IKK-alpha/beta complex in the inhibition of the TNF-alpha/NF-kappaB pathway by glycine was evaluated and associated with the synthesis and secretion of inflammatory cytokines in 3T3-L1 adipocytes. Glycine 118-125 tumor necrosis factor Homo sapiens 87-96 29550635-7 2018 Glycine decreased the IKK-alpha/beta complex and the phosphorylation of NF-kappaB, diminishing the expression and secretion of IL-6 and TNF-alpha, but increasing that of adiponectin. Glycine 0-7 tumor necrosis factor Homo sapiens 136-145 29550635-10 2018 In conclusion, the reduction of TNF-alpha and IL-6 and suppression of the TNF-alpha/NF-kappaB pathway by glycine may be explained in part by inhibition of the IKK-alpha/beta complex, with a possible participation of GlyR in 3T3-L1 adipocytes. Glycine 105-112 tumor necrosis factor Homo sapiens 74-83 29246256-13 2017 TNF-alpha in serum and IL-6 and G-CSF in sputum tended to decline at the end of the glycine period (p = 0.061, p = 0.068 and p = 0.04, respectively, vs placebo). Glycine 84-91 tumor necrosis factor Homo sapiens 0-9 30647695-9 2017 On the other hand, Se and GLY reduced hydrogen peroxide-mediated production of TNF-alpha, IL-1, IL-6 and expression of iNOS and NF-kappaB. Glycine 26-29 tumor necrosis factor Homo sapiens 79-88 27055186-7 2016 The free cysteine and glycine treatment reduced TNF-alpha in sow-fed animals (P < 0.05). Glycine 22-29 tumor necrosis factor Homo sapiens 48-57 25721693-7 2016 GLY decreased the secretion of TNF-alpha from the oral cancer CAL 27 cells. Glycine 0-3 tumor necrosis factor Homo sapiens 31-40 25721693-8 2016 Furthermore, 2000 mug/mL of GLY significantly suppressed TNF-alpha mRNA expression of CAL 27 cells in a time-dependent manner. Glycine 28-31 tumor necrosis factor Homo sapiens 57-66 25721693-11 2016 We suggest that GLY might promote the cure of oral cancer through decreasing the level of TNF-alpha cytokine, and these actions were mediated partially through the NF-kappaB, AKT, and ERK-dependent pathways in vitro. Glycine 16-19 tumor necrosis factor Homo sapiens 90-99 27225947-9 2016 Furthermore, glycine resulted in decreased plasma tumor necrosis factor-alpha (TNF-alpha) concentration and muscle TNF-alpha mRNA abundance. Glycine 13-20 tumor necrosis factor Homo sapiens 50-77 27225947-9 2016 Furthermore, glycine resulted in decreased plasma tumor necrosis factor-alpha (TNF-alpha) concentration and muscle TNF-alpha mRNA abundance. Glycine 13-20 tumor necrosis factor Homo sapiens 79-88 27225947-9 2016 Furthermore, glycine resulted in decreased plasma tumor necrosis factor-alpha (TNF-alpha) concentration and muscle TNF-alpha mRNA abundance. Glycine 13-20 tumor necrosis factor Homo sapiens 115-124 21785859-5 2011 RESULTS: Cysteine, histidine and glycine significantly reduced the activation of NF-kappaB in THP-1 cells stimulated with TNF-alpha. Glycine 33-40 tumor necrosis factor Homo sapiens 122-131 22236003-6 2012 Cysteine, histidine and glycine significantly reduced NF-kappaB activation and inhibitor kappaBalpha (IkappaBalpha) degradation in HCAECs stimulated with TNF-alpha. Glycine 24-31 tumor necrosis factor Homo sapiens 154-163 26716989-9 2015 In particular, the abundance of glycine, citrulline, arachidonic acid, and saturated fatty acids in TNF-alpha-stimulated FLS was restored to the control level after treatment with curcumin, suggesting that the effect of curcumin on preventing joint inflammation may be elucidated with the levels of these metabolites. Glycine 32-39 tumor necrosis factor Homo sapiens 100-109 22530913-6 2012 Docking study revealed the important amino acid residues (His 15, Tyr 59, Tyr 151, Gly 121 and Gly 122) in the active site of TNFalpha that are involved in binding of the active ligand. Glycine 83-86 tumor necrosis factor Homo sapiens 126-134 22530913-6 2012 Docking study revealed the important amino acid residues (His 15, Tyr 59, Tyr 151, Gly 121 and Gly 122) in the active site of TNFalpha that are involved in binding of the active ligand. Glycine 95-98 tumor necrosis factor Homo sapiens 126-134 17049125-8 2006 However, glycine, which led to improved survival rate and liver function, significantly alleviated liver parenchyma cell damage by downregulating IRAK-4, TNF-alpha expression and NF-kappaB transcriptional activity compared with the control group. Glycine 9-16 tumor necrosis factor Homo sapiens 154-163 20939853-8 2011 Preoperative glycine injection significantly reduced the induction of interleukin-6 (IL-6), tumor necrosis factor-alpha, inducible nitric oxide synthase and intercellular adhesion molecule-1 mRNAs, which was associated with the attenuation in postoperative leukocyte recruitment. Glycine 13-20 tumor necrosis factor Homo sapiens 92-119 20623529-6 2010 In contrast, 2-aminoisobutyric acid, a substrate of neutral amino acid transporters (NAATs), inhibits the glycine-mediated enhancement of myelin phagocytosis as well as of NO and TNF-alpha production. Glycine 106-113 tumor necrosis factor Homo sapiens 179-188 19365107-10 2009 Upon tumor necrosis factor-alpha stimulation, IL-6 and IL-8 mRNA and protein levels in A549-PLA2G2D-Ser cells were elevated compared with those of A549-PLA2G2D-Gly cells. Glycine 160-163 tumor necrosis factor Homo sapiens 5-32 18852529-2 2008 In vitro, glycine reduces tumor necrosis factor (TNF)-alpha secretion and increases interleukin-10 secretion in human monocytes stimulated with lipopolysaccharide. Glycine 10-17 tumor necrosis factor Homo sapiens 26-59 10564180-0 1999 Production of superoxide and TNF-alpha from alveolar macrophages is blunted by glycine. Glycine 79-86 tumor necrosis factor Homo sapiens 29-38 11520168-4 2001 RESULTS: (1) IL-1- and TNF-stimulated release of aggrecan was associated with cleavage of aggrecan within the C-terminus at the ADAM-TS4 and ADAM-TS5-sensitive sites, Glu(1480)-Gly(1481), Glu(1667)-Gly(1668), and Glu(1871)-Leu(1872). Glycine 177-180 tumor necrosis factor Homo sapiens 23-26 11520168-4 2001 RESULTS: (1) IL-1- and TNF-stimulated release of aggrecan was associated with cleavage of aggrecan within the C-terminus at the ADAM-TS4 and ADAM-TS5-sensitive sites, Glu(1480)-Gly(1481), Glu(1667)-Gly(1668), and Glu(1871)-Leu(1872). Glycine 198-201 tumor necrosis factor Homo sapiens 23-26 11418128-3 2001 Inhibition of TNFalpha-induced degradation was achieved by insertion of octamers containing three alanines or valines, interspersed by no more then three consecutive glycines. Glycine 166-174 tumor necrosis factor Homo sapiens 14-22 11229371-5 2000 Peroxisome proliferators have been shown to activate Kupffer cells both in vitro and in vivo, and the use of Kupffer cell inhibitors such as methyl palmitate and dietary glycine have demonstrated that Kupffer cells are responsible for hepatocyte proliferation by mechanisms involve TNF-alpha. Glycine 170-177 tumor necrosis factor Homo sapiens 282-291 10564180-1 1999 Glycine blunts lipopolysaccharide (LPS)-induced increases in intracellular calcium concentration ([Ca(2+)](i)) and tumor necrosis factor-alpha (TNF-alpha) production by Kupffer cells through a glycine-gated chloride channel. Glycine 0-7 tumor necrosis factor Homo sapiens 115-142 10564180-1 1999 Glycine blunts lipopolysaccharide (LPS)-induced increases in intracellular calcium concentration ([Ca(2+)](i)) and tumor necrosis factor-alpha (TNF-alpha) production by Kupffer cells through a glycine-gated chloride channel. Glycine 0-7 tumor necrosis factor Homo sapiens 144-153 10564180-4 1999 The ability of glycine to prevent endotoxin [lipopolysaccharide (LPS)]-induced increases in [Ca(2+)](i) and subsequent production of superoxide and TNF-alpha in alveolar macrophages was examined. Glycine 15-22 tumor necrosis factor Homo sapiens 148-157 10564180-10 1999 Moreover, TNF-alpha production was also inhibited by glycine and also required nearly 10 microM glycine for half-inhibition. Glycine 53-60 tumor necrosis factor Homo sapiens 10-19 10564180-10 1999 Moreover, TNF-alpha production was also inhibited by glycine and also required nearly 10 microM glycine for half-inhibition. Glycine 96-103 tumor necrosis factor Homo sapiens 10-19 8590320-0 1995 Overcoming the metastasis-enhancing potential of human tumor necrosis factor alpha by introducing the cell-adhesive Arg-Gly-Asp sequence. Glycine 120-123 tumor necrosis factor Homo sapiens 55-82 9227496-7 1997 Moreover, tumor necrosis factor-alpha (TNF-alpha) production in cultured Kupffer cells due to LPS was decreased significantly by glycine. Glycine 129-136 tumor necrosis factor Homo sapiens 10-37 9227496-7 1997 Moreover, tumor necrosis factor-alpha (TNF-alpha) production in cultured Kupffer cells due to LPS was decreased significantly by glycine. Glycine 129-136 tumor necrosis factor Homo sapiens 39-48 8590320-1 1995 A mutein, F4168, of human tumor necrosis factor alpha (hTNF-alpha) containing the cell-adhesive Arg-Gly-Asp (RGD) sequence near the N terminus was constructed. Glycine 100-103 tumor necrosis factor Homo sapiens 26-53 8590320-1 1995 A mutein, F4168, of human tumor necrosis factor alpha (hTNF-alpha) containing the cell-adhesive Arg-Gly-Asp (RGD) sequence near the N terminus was constructed. Glycine 100-103 tumor necrosis factor Homo sapiens 55-65 34646012-5 2021 Here we show that the cytokine-binding segments of human ALK and LTK comprise a novel architectural chimera of a permuted TNF-like module that braces a glycine-rich subdomain featuring a hexagonal lattice of long polyglycine type II helices. Glycine 152-159 tumor necrosis factor Homo sapiens 122-125 18472928-0 1994 A novel Mutein of TNFalpha Containing the Arg-Gly-Asp Sequence Shows Reduced Toxicity in Intestine. Glycine 46-49 tumor necrosis factor Homo sapiens 18-26 18472928-6 1994 These results suggest that the Arg-Gly-Asp sequence introduced into the TNFalpha molecule abrogates the side effect of this cytokine such as tissue injury or shock, and that F4168 could be useful for systemic therapy. Glycine 35-38 tumor necrosis factor Homo sapiens 72-80