PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29753073-6 2018 Glycine transporter-1 inhibitor blocked the antioxidative effect of glycine by reducing the intracellular GSH content, and glycine receptor inhibitor reversed the glycine antioxidative effect by blocking p22phox. Glycine 68-75 solute carrier family 6 member 9 Rattus norvegicus 0-21 8183239-8 1994 When expressed in COS-7 cells, both the human GlyT-1b and GlyT-1c display a time- and dose-dependent uptake of glycine, which is abolished when either Na+ or Cl- is substituted with other ions. Glycine 111-118 solute carrier family 6 member 9 Rattus norvegicus 46-53 8183239-9 1994 For both GlyT-1b and GlyT-1c the affinities for glycine are similar, with Km values of 70-90 microM, and this uptake is inhibited by sarcosine with similar potencies. Glycine 48-55 solute carrier family 6 member 9 Rattus norvegicus 9-16 33351169-4 2021 Glycine transporter 1 (GlyT-1) inhibitors, which raise extracellular glycine levels, have repeatedly been shown to decrease ethanol intake in the rat. Glycine 69-76 solute carrier family 6 member 9 Rattus norvegicus 0-21 33351169-4 2021 Glycine transporter 1 (GlyT-1) inhibitors, which raise extracellular glycine levels, have repeatedly been shown to decrease ethanol intake in the rat. Glycine 69-76 solute carrier family 6 member 9 Rattus norvegicus 23-29 10367958-2 1999 In all species, all glycine-containing amacrine cells expressed immunoreactivity for glyt-1, though the intensity of immunoreactivity for glyt-1 did not appear to directly correlate with the intensity of immunoreactivity for glycine in individual cells. Glycine 20-27 solute carrier family 6 member 9 Rattus norvegicus 85-91 10367958-3 1999 A small subpopulation of glycine-immunoreactive displaced amacrine cells or ganglion cells also expressed glyt-1 in retinae from macaques, cats, chickens, and rats but not in retinae from rabbits. Glycine 25-32 solute carrier family 6 member 9 Rattus norvegicus 106-112 10367958-5 1999 In monkeys, cats, and rats, populations of cells which we interpret as being glycine-containing interplexiform cells expressed glyt-1: these cells lacked a content of glutamate, suggesting they are not bipolar cells. Glycine 77-84 solute carrier family 6 member 9 Rattus norvegicus 127-133 1353889-2 1992 mRNA synthesized from this clone (designated GLYT1) directs the expression of sodium- and chloride-dependent, high-affinity uptake of [3H]glycine by Xenopus oocytes. Glycine 138-145 solute carrier family 6 member 9 Rattus norvegicus 45-50 1353889-4 1992 In situ hybridization reveals that GLYT1 is prominently expressed in the cervical spinal cord and brainstem, two regions of the central nervous system where glycine is a putative neurotransmitter. Glycine 157-164 solute carrier family 6 member 9 Rattus norvegicus 35-40 29753073-7 2018 Collectively, our findings reveal a mechanism by which glycine protects diabetic beta-cells against damage caused by oxidative stress by increasing glycine transporter-1-mediated synthesis of GSH and by reducing glycine receptor-mediated ROS production. Glycine 55-62 solute carrier family 6 member 9 Rattus norvegicus 148-169 27403535-1 2016 Glycine is a key rate-limiting component of heme biosynthesis in erythropoietic cells, where the high intracellular glycine demand is primarily supplied by the glycine transporter 1 (GlyT1). Glycine 0-7 solute carrier family 6 member 9 Rattus norvegicus 160-181 27874011-4 2016 Considering the clinical safety and efficacy of GlyT1 inhibitors in raising glycine levels in clinical trials for schizophrenia, we propose that GlyT1 inhibitors have the potential to be repurposed as a treatment of both obesity and diabetes. Glycine 76-83 solute carrier family 6 member 9 Rattus norvegicus 48-53 27874011-4 2016 Considering the clinical safety and efficacy of GlyT1 inhibitors in raising glycine levels in clinical trials for schizophrenia, we propose that GlyT1 inhibitors have the potential to be repurposed as a treatment of both obesity and diabetes. Glycine 76-83 solute carrier family 6 member 9 Rattus norvegicus 145-150 29886732-4 2018 In vivo inhibition of GlyT1 was demonstrated for select compounds within this series by measuring the elevation of glycine in the cerebrospinal fluid (CSF) of rats after a single oral dose of 10 mg/kg. Glycine 115-122 solute carrier family 6 member 9 Rattus norvegicus 22-27 27403535-1 2016 Glycine is a key rate-limiting component of heme biosynthesis in erythropoietic cells, where the high intracellular glycine demand is primarily supplied by the glycine transporter 1 (GlyT1). Glycine 0-7 solute carrier family 6 member 9 Rattus norvegicus 183-188 27403535-1 2016 Glycine is a key rate-limiting component of heme biosynthesis in erythropoietic cells, where the high intracellular glycine demand is primarily supplied by the glycine transporter 1 (GlyT1). Glycine 116-123 solute carrier family 6 member 9 Rattus norvegicus 160-181 27403535-1 2016 Glycine is a key rate-limiting component of heme biosynthesis in erythropoietic cells, where the high intracellular glycine demand is primarily supplied by the glycine transporter 1 (GlyT1). Glycine 116-123 solute carrier family 6 member 9 Rattus norvegicus 183-188 26843416-3 2016 The aim of this study is to investigate the effects of a selective GlyT-1 inhibitor that can increase endogenous glycine concentration on the micturition reflex in urethane-anesthetized rats. Glycine 113-120 solute carrier family 6 member 9 Rattus norvegicus 67-73 26364050-13 2016 The possibility to inhibit glycine transporter type-1 mediated glycine efflux by drugs more potently than glycine uptake might offer some therapeutic potential for the treatment of various neurodegenerative disorders of the retina. Glycine 63-70 solute carrier family 6 member 9 Rattus norvegicus 27-53 26364050-0 2016 Some Operational Characteristics of Glycine Release in Rat Retina: The Role of Reverse Mode Operation of Glycine Transporter Type-1 (GlyT-1) in Ischemic Conditions. Glycine 36-43 solute carrier family 6 member 9 Rattus norvegicus 105-131 26364050-0 2016 Some Operational Characteristics of Glycine Release in Rat Retina: The Role of Reverse Mode Operation of Glycine Transporter Type-1 (GlyT-1) in Ischemic Conditions. Glycine 36-43 solute carrier family 6 member 9 Rattus norvegicus 133-139 23529192-1 2014 GlyT1 and GlyT2 are the transporters responsible for glycine uptake from the synaptic cleft. Glycine 53-60 solute carrier family 6 member 9 Rattus norvegicus 0-5 25869273-2 2015 OBJECTIVES: We investigated the efficacy of a glycine transporter 1 (GlyT1) inhibitor that potentiates NMDA receptor function by increasing synaptic glycine levels in animal models for cognitive dysfunction and negative symptoms, both of which are poorly managed by current antipsychotics. Glycine 46-53 solute carrier family 6 member 9 Rattus norvegicus 69-74 26101830-11 2015 The co-expression of GlyT1 and NMDA receptors in DRG suggests that GlyT1 regulates glycine concentration at the glycine binding site of the NMDA receptor. Glycine 83-90 solute carrier family 6 member 9 Rattus norvegicus 67-72 26101830-11 2015 The co-expression of GlyT1 and NMDA receptors in DRG suggests that GlyT1 regulates glycine concentration at the glycine binding site of the NMDA receptor. Glycine 112-119 solute carrier family 6 member 9 Rattus norvegicus 21-26 26101830-11 2015 The co-expression of GlyT1 and NMDA receptors in DRG suggests that GlyT1 regulates glycine concentration at the glycine binding site of the NMDA receptor. Glycine 112-119 solute carrier family 6 member 9 Rattus norvegicus 67-72 25300471-8 2015 The present results show that the stimulation of the NMDA receptor through the glycine site on the receptor either directly with D-serine or by blocking glycine transporter-1 attenuates the immobility elicited by the subchronic administration of MK-801 and may be potentially useful for the treatment of negative symptoms of schizophrenia. Glycine 79-86 solute carrier family 6 member 9 Rattus norvegicus 153-174 24147951-1 2014 CONTEXT: Selective inhibitors of glycine transporter type 1 (GlyT1) increase synaptic glycine concentrations and are being developed to treat cognitive and negative symptoms of schizophrenia. Glycine 33-40 solute carrier family 6 member 9 Rattus norvegicus 61-66 25057202-5 2014 Blockade of GlyT1 also caused a profound increase in the baseline current induced by exogenous glycine. Glycine 95-102 solute carrier family 6 member 9 Rattus norvegicus 12-17 24598217-2 2014 The synaptic glycine concentration is controlled by the two glycine transporters (GlyT) 1 and 2. Glycine 13-20 solute carrier family 6 member 9 Rattus norvegicus 60-95 26200505-1 2015 Glycine transporters (GlyT), GlyT1 and GlyT2, are responsible for the termination of glycine-mediated synaptic activity through removal of neurotransmitter from synaptic cleft. Glycine 85-92 solute carrier family 6 member 9 Rattus norvegicus 29-34 26302655-4 2015 Using two different rodent models of temporal lobe epilepsy (TLE)--the intrahippocampal kainic acid model of TLE in mice, and the rat model of tetanic stimulation-induced TLE--we first demonstrated robust overexpression of GlyT1 in the hippocampal formation, suggesting dysfunctional glycine signaling in epilepsy. Glycine 284-291 solute carrier family 6 member 9 Rattus norvegicus 223-228 26101830-2 2015 The glycine concentration in the synaptic cleft is controlled by the glycine transporters GlyT1 and GlyT2. Glycine 4-11 solute carrier family 6 member 9 Rattus norvegicus 90-95 26101830-11 2015 The co-expression of GlyT1 and NMDA receptors in DRG suggests that GlyT1 regulates glycine concentration at the glycine binding site of the NMDA receptor. Glycine 83-90 solute carrier family 6 member 9 Rattus norvegicus 21-26 25578890-6 2015 The pyridazine-containing GlyT-1 inhibitors with in vitro GlyT-1 inhibitory potency also enhanced extracellular glycine concentrations in conscious rat striatum as was measured by microdialysis technique. Glycine 112-119 solute carrier family 6 member 9 Rattus norvegicus 26-32 25578890-6 2015 The pyridazine-containing GlyT-1 inhibitors with in vitro GlyT-1 inhibitory potency also enhanced extracellular glycine concentrations in conscious rat striatum as was measured by microdialysis technique. Glycine 112-119 solute carrier family 6 member 9 Rattus norvegicus 58-64 24797328-6 2014 Hippocampal levels of glycine were decreased in sarcosine-treated animals, which was associated with a reduction of [(3)H] glycine uptake and a decrease in glycine transporter expression (GlyT-1 and GlyT-2). Glycine 22-29 solute carrier family 6 member 9 Rattus norvegicus 188-194 23529192-6 2014 The functional characterization of GlyT1 and GlyT2 in cultured astrocytes performed by [(3)H]glycine uptake experiments revealed that both transporters take up glycine in a concentration-dependent way, but with a very distinct affinity. Glycine 93-100 solute carrier family 6 member 9 Rattus norvegicus 35-40 23529192-6 2014 The functional characterization of GlyT1 and GlyT2 in cultured astrocytes performed by [(3)H]glycine uptake experiments revealed that both transporters take up glycine in a concentration-dependent way, but with a very distinct affinity. Glycine 160-167 solute carrier family 6 member 9 Rattus norvegicus 35-40 21955180-2 2012 Glycine availability is also crucial for regulating alcohol consumption and the glycine transporter 1 (GlyT-1) inhibitor Org25935 robustly decreases alcohol intake in rats. Glycine 0-7 solute carrier family 6 member 9 Rattus norvegicus 103-109 22341128-1 2012 BACKGROUND: Glycine is a major inhibitory neurotransmitter in the spinal cord, the concentration of which is regulated by two types of glycine transporters (GlyTs): GlyT1 and GlyT2. Glycine 12-19 solute carrier family 6 member 9 Rattus norvegicus 165-170 24121745-9 2013 In order to demonstrate the feasibility of the LC-MS/MS method, we measured glycine levels in striatal in vivo microdialysates and CSF of rats after administration of the commercially available glycine transporter 1 (GlyT1) inhibitor LY 2365109 (10mg/kg, p.o.). Glycine 76-83 solute carrier family 6 member 9 Rattus norvegicus 217-222 21731704-1 2011 Glycine transporter-1 (GlyT-1) in glial cells regulates extracellular levels of glycine, which acts as an obligatory co-agonist at the N-methyl-D-aspartate (NMDA) receptors in the brain. Glycine 80-87 solute carrier family 6 member 9 Rattus norvegicus 0-21 21530555-2 2011 The concentration of glycine is controlled, among other factors, by the glycine transporter 1 (GlyT1). Glycine 21-28 solute carrier family 6 member 9 Rattus norvegicus 72-93 21530555-2 2011 The concentration of glycine is controlled, among other factors, by the glycine transporter 1 (GlyT1). Glycine 21-28 solute carrier family 6 member 9 Rattus norvegicus 95-100 21348870-4 2011 The NMDA/glycine-induced release in 1.2 mM Mg(2+) strictly depended on glycine uptake through the glycine transporter type 1 (GlyT1), because the GlyT1 blocker N-[3-(4"-fluorophenyl)-3-(4"-phenylphenoxy)propyl])sarcosine hydrochloride, but not the GlyT2 blocker Org 25534, prevented it. Glycine 9-16 solute carrier family 6 member 9 Rattus norvegicus 98-124 21348870-4 2011 The NMDA/glycine-induced release in 1.2 mM Mg(2+) strictly depended on glycine uptake through the glycine transporter type 1 (GlyT1), because the GlyT1 blocker N-[3-(4"-fluorophenyl)-3-(4"-phenylphenoxy)propyl])sarcosine hydrochloride, but not the GlyT2 blocker Org 25534, prevented it. Glycine 9-16 solute carrier family 6 member 9 Rattus norvegicus 126-131 21348870-4 2011 The NMDA/glycine-induced release in 1.2 mM Mg(2+) strictly depended on glycine uptake through the glycine transporter type 1 (GlyT1), because the GlyT1 blocker N-[3-(4"-fluorophenyl)-3-(4"-phenylphenoxy)propyl])sarcosine hydrochloride, but not the GlyT2 blocker Org 25534, prevented it. Glycine 9-16 solute carrier family 6 member 9 Rattus norvegicus 146-151 21348870-4 2011 The NMDA/glycine-induced release in 1.2 mM Mg(2+) strictly depended on glycine uptake through the glycine transporter type 1 (GlyT1), because the GlyT1 blocker N-[3-(4"-fluorophenyl)-3-(4"-phenylphenoxy)propyl])sarcosine hydrochloride, but not the GlyT2 blocker Org 25534, prevented it. Glycine 71-78 solute carrier family 6 member 9 Rattus norvegicus 98-124 21348870-4 2011 The NMDA/glycine-induced release in 1.2 mM Mg(2+) strictly depended on glycine uptake through the glycine transporter type 1 (GlyT1), because the GlyT1 blocker N-[3-(4"-fluorophenyl)-3-(4"-phenylphenoxy)propyl])sarcosine hydrochloride, but not the GlyT2 blocker Org 25534, prevented it. Glycine 71-78 solute carrier family 6 member 9 Rattus norvegicus 126-131 21348870-4 2011 The NMDA/glycine-induced release in 1.2 mM Mg(2+) strictly depended on glycine uptake through the glycine transporter type 1 (GlyT1), because the GlyT1 blocker N-[3-(4"-fluorophenyl)-3-(4"-phenylphenoxy)propyl])sarcosine hydrochloride, but not the GlyT2 blocker Org 25534, prevented it. Glycine 71-78 solute carrier family 6 member 9 Rattus norvegicus 146-151 22542656-2 2012 Inhibition of glycine transporter-1 (GlyT1) is expected to increase glycine, a co-agonist of the NMDA receptor and, consequently, to facilitate NMDA receptor function. Glycine 14-21 solute carrier family 6 member 9 Rattus norvegicus 37-42 22133759-6 2012 METHODS: The effects of lidocaine and its metabolites monoethylglycinexylidide (MEGX), glycinexylidide, and N-ethylglycine on GlyT1 function were investigated in uptake experiments with [14C]-labeled glycine in primary rat astrocytes. Glycine 63-70 solute carrier family 6 member 9 Rattus norvegicus 126-131 21920385-6 2011 D-serine modestly decreased levels of glycine, which were enhanced by administration of glycine itself and of the glycine transporter-1 inhibitor, sarcosine. Glycine 38-45 solute carrier family 6 member 9 Rattus norvegicus 114-135 21348870-5 2011 Accordingly, [(3)H]glycine was taken up during superfusion, while lowering the external concentration of Na(+), the monovalent cation co-transported with glycine by GlyT1, abrogated the NMDA-induced effect. Glycine 19-26 solute carrier family 6 member 9 Rattus norvegicus 165-170 21348870-7 2011 It is proposed that GlyT1s coexist with NMDA autoreceptors on rat hippocampal glutamatergic terminals and that glycine taken up by GlyT1 may permit physiological activation of NMDA pre-synaptic autoreceptors. Glycine 111-118 solute carrier family 6 member 9 Rattus norvegicus 131-136 21245148-2 2011 The mainly glial GLYT1 is the key regulator of the glycine levels in glycinergic and glutamatergic pathways, whereas the neuronal GLYT2 is involved in the recycling of synaptic glycine from the inhibitory synaptic cleft. Glycine 51-58 solute carrier family 6 member 9 Rattus norvegicus 17-22 21245148-2 2011 The mainly glial GLYT1 is the key regulator of the glycine levels in glycinergic and glutamatergic pathways, whereas the neuronal GLYT2 is involved in the recycling of synaptic glycine from the inhibitory synaptic cleft. Glycine 69-76 solute carrier family 6 member 9 Rattus norvegicus 17-22 20725779-3 2010 N-methyl-D-aspartate (NMDA) receptor hypofunction in schizophrenia can be reversed by glycine transporter type-1 (GlyT-1) inhibitors, which regulate glycine concentrations at the vicinity of NMDA receptors. Glycine 86-93 solute carrier family 6 member 9 Rattus norvegicus 114-120 20558222-3 2010 [(14)C]Glycine uptake by TR-MUL5 cells was Na(+)- and Cl(-)-dependent, and a saturable process with Michaelis-Menten constants of 48.6 microM and 4.53 mM, and inhibited by glycine transporter 1 (GlyT1) and system A substrates. Glycine 7-14 solute carrier family 6 member 9 Rattus norvegicus 172-193 20558222-3 2010 [(14)C]Glycine uptake by TR-MUL5 cells was Na(+)- and Cl(-)-dependent, and a saturable process with Michaelis-Menten constants of 48.6 microM and 4.53 mM, and inhibited by glycine transporter 1 (GlyT1) and system A substrates. Glycine 7-14 solute carrier family 6 member 9 Rattus norvegicus 195-200 20558222-6 2010 These uptake studies suggest that GlyT1 and system A are involved in [(14)C]glycine uptake for the high- and low-affinity processes, respectively, in TR-MUL5 cells. Glycine 76-83 solute carrier family 6 member 9 Rattus norvegicus 34-39 20558222-11 2010 In conclusion, GlyT1 and CAT1 most likely mediate glycine and L-arginine uptake, respectively, by Muller cells and are expected to play an important role in supplying precursors for creatine biosynthesis in Muller cells. Glycine 50-57 solute carrier family 6 member 9 Rattus norvegicus 15-20 20691713-13 2010 Glycine produced concentration-dependent decreases in binding affinity of both radioligands without major changes in B(max) values, suggesting that both [(3)H]-SB-733993 and [(3)H]-GSK931145 bind to sites on GlyT-1 that are orthosteric to the site at which glycine itself binds. Glycine 0-7 solute carrier family 6 member 9 Rattus norvegicus 208-214 21731704-1 2011 Glycine transporter-1 (GlyT-1) in glial cells regulates extracellular levels of glycine, which acts as an obligatory co-agonist at the N-methyl-D-aspartate (NMDA) receptors in the brain. Glycine 80-87 solute carrier family 6 member 9 Rattus norvegicus 23-29 17919119-1 2008 The GLYT1 (glycine transporter-1) regulates both glycinergic and glutamatergic neurotransmission by controlling the reuptake of glycine at synapses. Glycine 11-18 solute carrier family 6 member 9 Rattus norvegicus 4-9 19875446-1 2009 Concentrations of extracellular glycine in the central nervous system are regulated by Na(+)/Cl(-)-dependent glycine transporters, GLYT1 and GLYT2. Glycine 32-39 solute carrier family 6 member 9 Rattus norvegicus 131-136 19666071-5 2009 These uptake studies suggest that GlyT1 and system A are involved in [(14)C]glycine uptake by TR-iBRB2 cells. Glycine 76-83 solute carrier family 6 member 9 Rattus norvegicus 34-39 19666071-8 2009 In conclusion, GlyT1 most likely mediates glycine transport at the inner BRB and is expected to play an important role in regulating the glycine concentration in the neural retina. Glycine 42-49 solute carrier family 6 member 9 Rattus norvegicus 15-20 19666071-8 2009 In conclusion, GlyT1 most likely mediates glycine transport at the inner BRB and is expected to play an important role in regulating the glycine concentration in the neural retina. Glycine 137-144 solute carrier family 6 member 9 Rattus norvegicus 15-20 18400471-3 2008 D-serine is primarily transported by Asc-1, and glycine by GlyT1 but maybe also by SNAT2. Glycine 48-55 solute carrier family 6 member 9 Rattus norvegicus 59-64 20303337-3 2010 In the present study we tested several glycine transporter 1 (GlyT1) inhibitors including NFPS, SSR 504734, Lu AA21279, Org 25935, SB-710622, GSK931145, as well as the glycine agonist d-serine, in the maximal electroshock threshold (MEST) test in the rat. Glycine 39-46 solute carrier family 6 member 9 Rattus norvegicus 62-67 20198471-3 2010 OBJECTIVES: In the present study, we investigated the effects of positive modulation of glycine sites on the NMDA receptor using an agonist of the glycine modulatory site, D: -serine, and a glycine transporter-1 inhibitor, (R)-(N-[3-(4"-fluorophenyl)-3-(4"-phenylphenoxy)propyl])sarcosine (NFPS). Glycine 88-95 solute carrier family 6 member 9 Rattus norvegicus 190-211 20198471-10 2010 CONCLUSIONS: The present results show that stimulation of the glycine modulatory sites on the NMDA receptor either directly with D: -serine or by blocking glycine transporter-1 enhances social memory and may be an effective approach for the treatment of the cognitive dysfunction observed in schizophrenic patients. Glycine 62-69 solute carrier family 6 member 9 Rattus norvegicus 155-176 19666071-4 2009 [(14)C]Glycine uptake by TR-iBRB2 cells was Na(+)- and Cl(-)-dependent, and concentration-dependent with Michaelis-Menten constants of 55.4 microM and 8.02 mM, and inhibited by glycine transporter 1 (GlyT1) and system A inhibitors. Glycine 7-14 solute carrier family 6 member 9 Rattus norvegicus 177-198 19666071-4 2009 [(14)C]Glycine uptake by TR-iBRB2 cells was Na(+)- and Cl(-)-dependent, and concentration-dependent with Michaelis-Menten constants of 55.4 microM and 8.02 mM, and inhibited by glycine transporter 1 (GlyT1) and system A inhibitors. Glycine 7-14 solute carrier family 6 member 9 Rattus norvegicus 200-205 18793697-2 2008 Since the concentration of glycine in the synaptic cleft is controlled by specialized proteins, the glycine transporters GlyT1 and GlyT2, manipulation of this system might have significant effects on nociception. Glycine 27-34 solute carrier family 6 member 9 Rattus norvegicus 121-126 18695510-2 2008 The effective synaptic concentrations of glycine are regulated by at least two transporters: glycine transporter 1 and glycine transporter 2. Glycine 41-48 solute carrier family 6 member 9 Rattus norvegicus 93-114 17980459-2 2008 Extracellular levels of glycine are primarily regulated by the plasma membrane glycine transporter 1. Glycine 24-31 solute carrier family 6 member 9 Rattus norvegicus 79-100 15956994-3 2005 Blocking the glycine transporter-1 (GlyT1) should, by increasing extracellular glycine levels, potentiate glutamatergic neurotransmission. Glycine 13-20 solute carrier family 6 member 9 Rattus norvegicus 36-41 17462677-0 2007 Glycine-induced long-term synaptic potentiation is mediated by the glycine transporter GLYT1. Glycine 0-7 solute carrier family 6 member 9 Rattus norvegicus 87-92 17462677-9 2007 In contrast, LTP-GLY is partially or totally blocked with the antagonists of glycine transporter GLYT1, sarcosine or ALX-5407, respectively. Glycine 17-20 solute carrier family 6 member 9 Rattus norvegicus 97-102 17462677-10 2007 These results indicate that LTP-GLY requires the activation of GLYT1, a glycine transporter co-localized and associated to NMDA receptors. Glycine 32-35 solute carrier family 6 member 9 Rattus norvegicus 63-68 17462677-11 2007 In addition, the fact that NMDA receptor inhibition increases LTP-GLY magnitude, opens the possibility that these receptors could have a negative control on GLYT1 activity. Glycine 66-69 solute carrier family 6 member 9 Rattus norvegicus 157-162 16271045-1 2005 Recent evidence indicates that the glycine transporter-1 (GLYT1) plays a role in regulation of NMDA receptor function through tight control of glycine concentration in its surrounding medium. Glycine 35-42 solute carrier family 6 member 9 Rattus norvegicus 58-63 16271045-8 2005 We hypothesize that PSD-95 might act as a scaffold for GLYT1 and NMDA receptors, allowing GLYT1 to regulate the concentrations of glycine in the micro-environment of NMDA receptors. Glycine 130-137 solute carrier family 6 member 9 Rattus norvegicus 55-60 16271045-8 2005 We hypothesize that PSD-95 might act as a scaffold for GLYT1 and NMDA receptors, allowing GLYT1 to regulate the concentrations of glycine in the micro-environment of NMDA receptors. Glycine 130-137 solute carrier family 6 member 9 Rattus norvegicus 90-95 17962467-10 2007 Although high levels of glycine labeling in the outer cortex correlated well with the expression of the glycine transporter GLYT1, the absence of GLYT1 in the core, despite an increase of glycine in this region, suggests an alternative glycine uptake system such as GLYT2 exists in the core. Glycine 104-111 solute carrier family 6 member 9 Rattus norvegicus 124-129 17962467-10 2007 Although high levels of glycine labeling in the outer cortex correlated well with the expression of the glycine transporter GLYT1, the absence of GLYT1 in the core, despite an increase of glycine in this region, suggests an alternative glycine uptake system such as GLYT2 exists in the core. Glycine 104-111 solute carrier family 6 member 9 Rattus norvegicus 124-129 16635486-15 2006 The molecular identification and localisation of GLYT1 and ASCT2 in the lens suggests that these transporters may be responsible for the uptake of the precursor amino acids, glycine and glutamine, which are involved in GSH synthesis. Glycine 174-181 solute carrier family 6 member 9 Rattus norvegicus 49-54 15175365-12 2004 We suggest that modulation of glycine concentration by GLYT1 is an important mechanism to regulate NMDAR-mediated synaptic transmission. Glycine 30-37 solute carrier family 6 member 9 Rattus norvegicus 55-60 15225720-1 2004 Elevation of glycine levels and activation of the NMDA receptor by inhibition of the glycine transporter 1 (GlyT-1) is a potential strategy for the treatment of schizophrenia. Glycine 13-20 solute carrier family 6 member 9 Rattus norvegicus 85-106 15225720-1 2004 Elevation of glycine levels and activation of the NMDA receptor by inhibition of the glycine transporter 1 (GlyT-1) is a potential strategy for the treatment of schizophrenia. Glycine 13-20 solute carrier family 6 member 9 Rattus norvegicus 108-114 15207356-7 2004 These data provide evidence that the observed increased in extracellular citrulline is a consequence of positive modulation of NMDA-R, secondary to increased extracellular glycine and support a protective role for GlyT-1 against fluctuations in extracellular glycine uptake at glutamatergic synapses in the dorsal spinal cord. Glycine 259-266 solute carrier family 6 member 9 Rattus norvegicus 214-220 12923815-3 2003 An increase in extracellular glycine concentration by treatment with a glycine transporter 1 (GlyT1)-selective inhibitor, NFPS ethyl ester, significantly decreased the cerebellar localization of [(11)C]L-703,717 in rats. Glycine 29-36 solute carrier family 6 member 9 Rattus norvegicus 71-92 12923815-3 2003 An increase in extracellular glycine concentration by treatment with a glycine transporter 1 (GlyT1)-selective inhibitor, NFPS ethyl ester, significantly decreased the cerebellar localization of [(11)C]L-703,717 in rats. Glycine 29-36 solute carrier family 6 member 9 Rattus norvegicus 94-99 15064326-0 2004 Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels. Glycine 146-153 solute carrier family 6 member 9 Rattus norvegicus 0-26 15064326-3 2004 Previous pharmacological studies suggest that the glycine transporter type 1 (GlyT1) maintains subsaturating concentrations of glycine at synaptic NMDARs. Glycine 50-57 solute carrier family 6 member 9 Rattus norvegicus 78-83 15064326-4 2004 Antagonists of GlyT1 increase levels of glycine in the synaptic cleft and, like direct glycine site agonists, can augment NMDAR currents and NMDAR-mediated functions such as LTP. Glycine 40-47 solute carrier family 6 member 9 Rattus norvegicus 15-20 15064326-4 2004 Antagonists of GlyT1 increase levels of glycine in the synaptic cleft and, like direct glycine site agonists, can augment NMDAR currents and NMDAR-mediated functions such as LTP. Glycine 87-94 solute carrier family 6 member 9 Rattus norvegicus 15-20 12941372-1 2003 In the central nervous system, re-uptake of the neurotransmitter glycine is mediated by two different glycine transporters, GlyT1 and GlyT2. Glycine 65-72 solute carrier family 6 member 9 Rattus norvegicus 124-129 12941372-2 2003 GlyT2 is found in brainstem and spinal cord, whereas GlyT1 is expressed in rat forebrain regions where it is responsible for most glycine transport activity. Glycine 130-137 solute carrier family 6 member 9 Rattus norvegicus 53-58 11445189-0 2001 Pharmacological assessment of the role of the glycine transporter GlyT-1 in mediating high-affinity glycine uptake by rat cerebral cortex and cerebellum synaptosomes. Glycine 46-53 solute carrier family 6 member 9 Rattus norvegicus 66-72 12574447-4 2003 Extracellular glycine near NMDA-R is regulated effectively by a glial glycine transporter (GlyT1). Glycine 14-21 solute carrier family 6 member 9 Rattus norvegicus 91-96 12574447-10 2003 These data suggest that direct GlyB site stimulation by D-serine, or blockade of GLYT1 to elevate endogenous glycine to act on unsaturated GlyB sites on NMDA-Rs, potentiated NMDA-R-mediated firing responses in rat PFC. Glycine 109-116 solute carrier family 6 member 9 Rattus norvegicus 81-86 12574447-11 2003 Hence, blockade of GlyT1 to elevate glycine near the NMDA-R may activate hypofunctional NMDA-R, which has been implicated to play a critical role in the pathophysiology of schizophrenia. Glycine 36-43 solute carrier family 6 member 9 Rattus norvegicus 19-24 12602503-5 2002 Expression of Glyt-1 mRNA, studied by reverse transcriptase-polymerase chain reaction, was significantly decreased in the brain at coma stages of encephalopathy (to approximately 50% of control) concomitant with a significant threefold increase of extracellular glycine, measured by in vivo cerebral microdialysis. Glycine 262-269 solute carrier family 6 member 9 Rattus norvegicus 14-20 12602503-6 2002 These findings suggest that loss of expression of the Glyt-1 transporter may cause an impairment of regulation of glycine concentration at synaptic level and contribute to an overactivation of the NMDA receptor in ALF. Glycine 114-121 solute carrier family 6 member 9 Rattus norvegicus 54-60 12091465-3 2002 Functional analysis of the GFP-GLYT1 and GFP-GLYT2 stable cell lines demonstrated that they exhibited high affinity for glycine and the characteristic properties of both glycine transporter subtypes. Glycine 120-127 solute carrier family 6 member 9 Rattus norvegicus 31-36 11445189-6 2001 Efflux of pre-loaded [3H]-glycine from GlyT-1c cells was increased by glycine or sarcosine, whereas NFPS had no effect on its own but blocked the effects of glycine or sarcosine. Glycine 26-33 solute carrier family 6 member 9 Rattus norvegicus 39-45 11445189-6 2001 Efflux of pre-loaded [3H]-glycine from GlyT-1c cells was increased by glycine or sarcosine, whereas NFPS had no effect on its own but blocked the effects of glycine or sarcosine. Glycine 70-77 solute carrier family 6 member 9 Rattus norvegicus 39-45 11445189-6 2001 Efflux of pre-loaded [3H]-glycine from GlyT-1c cells was increased by glycine or sarcosine, whereas NFPS had no effect on its own but blocked the effects of glycine or sarcosine. Glycine 70-77 solute carrier family 6 member 9 Rattus norvegicus 39-45 11445189-12 2001 Overall, our findings indicate that high-affinity glycine uptake in cerebral cortex occurs predominantly via GlyT-1. Glycine 50-57 solute carrier family 6 member 9 Rattus norvegicus 109-115 10750822-1 2000 Previous studies show that glycine transporter-1 (glyt-1) is a consistent membrane marker of adult retinal neurons that are likely to release glycine at their synaptic terminals (Pow, 1998; Vaney et al., 1998; Pow & Hendrickson, 1999). Glycine 27-34 solute carrier family 6 member 9 Rattus norvegicus 50-56 10750822-12 2000 This temporal pattern of labelling strongly indicates that bipolar cells label for glycine when gap junctions become functional between glycine/glyt-1 immunoreactive amacrine cells and cone bipolar cells. Glycine 83-90 solute carrier family 6 member 9 Rattus norvegicus 144-150 10910114-1 2000 Previous studies show that glycine transporter-1 (glyt-1) is a consistent membrane marker of adult retinal neurons that are likely to release glycine at their synaptic terminals (Pow, 1998; Vaney et al., 1998; Pow & Hendrickson, 1999). Glycine 27-34 solute carrier family 6 member 9 Rattus norvegicus 50-56 10910114-12 2000 This temporal pattern of labelling strongly indicates that bipolar cells label for glycine when gap junctions become functional between glycine/glyt-1 immunoreactive amacrine cells and cone bipolar cells. Glycine 83-90 solute carrier family 6 member 9 Rattus norvegicus 144-150 10722844-3 2000 Co-transfection of syntaxin 1A with GLYT1 or GLYT2 in COS cells resulted in approximately 40% inhibition in glycine transport. Glycine 108-115 solute carrier family 6 member 9 Rattus norvegicus 36-41