PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30618614-3	2018	TDP-43 is an RNA binding protein with glycine-rich domains that binds to more than 6,000 RNAs in the human brain.	Glycine	38-45	TAR DNA binding protein	Homo sapiens	0-6	
25090004-0	2014	The influence of pathological mutations and proline substitutions in TDP-43 glycine-rich peptides on its amyloid properties and cellular toxicity.	Glycine	76-83	TAR DNA binding protein	Homo sapiens	69-75	
27518042-4	2016	The co-repression occurs through binding of TDP-43 to mRNA(s) at specific UG/GU sequences and recruitment of the inhibitory CYFIP1-FMRP complex by its glycine-rich domain.	Glycine	151-158	TAR DNA binding protein	Homo sapiens	44-50	
25090004-2	2014	Later on, numerous ALS-related mutations were found in either the glycine or glutamine/asparagine-rich region on the TDP-43 C-terminus, which hinted on the importance of mutations on the disease pathogenesis.	Glycine	66-73	TAR DNA binding protein	Homo sapiens	117-123	
22563080-6	2012	For TDP-43, both the RRM1 and the C-terminal glycine-rich domain are required for SG localization.	Glycine	45-52	TAR DNA binding protein	Homo sapiens	4-10	
23372158-2	2013	The pathogenic forms of TDP-43 are processed C-terminal fragments containing a truncated RNA-recognition motif (RRM2) and a glycine-rich region.	Glycine	124-131	TAR DNA binding protein	Homo sapiens	24-30	
23372158-4	2013	Here, using size-exclusion chromatography, pulldown assays, and small angle x-ray scattering, we show that the C-terminal-deleted TDP-43 without the glycine-rich tail is sufficient to form a head-to-head homodimer primarily via its N-terminal domain.	Glycine	149-156	TAR DNA binding protein	Homo sapiens	130-136	
22424122-5	2012	Results showed that a novel heterozygous in-frame insertion/deletion (indel), c.1158_1159delAT; c.1158_1159insCACCAACC, was identified in a highly conserved region encoding the glycine-rich area of TDP-43 in a patient with FAV.	Glycine	177-184	TAR DNA binding protein	Homo sapiens	198-204	
24651281-3	2014	The majority of these mutations are found in the glycine-rich domain, including the variant M337V, which is one of the most common mutations in TDP-43.	Glycine	49-56	TAR DNA binding protein	Homo sapiens	144-150	
22563080-7	2012	ALS-associated point mutations located in the glycine-rich domain of TDP-43 do not affect SG recruitment.	Glycine	46-53	TAR DNA binding protein	Homo sapiens	69-75	
18396105-9	2008	INTERPRETATION: The Gly290Ala and Gly298Ser mutations are located in the glycine-rich domain of TDP-43, which regulates gene expression and mediates protein-protein interactions such as those with heterogeneous ribonucleoproteins.	Glycine	73-80	TAR DNA binding protein	Homo sapiens	96-102	
19285963-3	2009	Interestingly, 18 of them were located in the C-terminal glycine-rich region of TDP-43.	Glycine	57-64	TAR DNA binding protein	Homo sapiens	80-86	
22539580-8	2012	The type of mutation influenced survival (p < 0.0001), and the G298S1, lying in the TARDBP super rich glycine-residue domain, was associated with the worst survival (27 months).	Glycine	102-109	TAR DNA binding protein	Homo sapiens	84-90	
21173160-5	2011	We quantify the association of TDP-43 with stress granules over time and show that stress granule association and size are dependent on the glycine-rich region of TDP-43, which harbors the majority of pathogenic mutations.	Glycine	140-147	TAR DNA binding protein	Homo sapiens	31-37	
21173160-5	2011	We quantify the association of TDP-43 with stress granules over time and show that stress granule association and size are dependent on the glycine-rich region of TDP-43, which harbors the majority of pathogenic mutations.	Glycine	140-147	TAR DNA binding protein	Homo sapiens	163-169	
19864664-5	2009	A novel familial ALS mutation in TDP-43 was identified that substitutes a highly conserved residue (G294V) and is predicted to disrupt the glycine rich domain in the C terminus, a region that plays a role in RNA binding and is required for the exon skipping activity of TDP-43.	Glycine	139-146	TAR DNA binding protein	Homo sapiens	33-39	
19864664-5	2009	A novel familial ALS mutation in TDP-43 was identified that substitutes a highly conserved residue (G294V) and is predicted to disrupt the glycine rich domain in the C terminus, a region that plays a role in RNA binding and is required for the exon skipping activity of TDP-43.	Glycine	139-146	TAR DNA binding protein	Homo sapiens	270-276	
19808791-0	2009	Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis.	Glycine	25-32	TAR DNA binding protein	Homo sapiens	13-19	
19808791-4	2009	TDP-43 possesses two RNA binding domains (RBD) and a glycine-rich C terminus classifying it with other heterogeneous nuclear ribonucleoproteins known as 2XRBD-Gly proteins.	Glycine	53-60	TAR DNA binding protein	Homo sapiens	0-6	
19808791-7	2009	Currently, 29 different TARDBP missense mutations have been reported in 51 unrelated sporadic or familial ALS cases and two cases of ALS plus concomitant frontotemporal lobar degeneration with a remarkable concentration of mutations in the C-terminal glycine-rich domain of TDP-43.	Glycine	251-258	TAR DNA binding protein	Homo sapiens	24-30	
15826655-9	2005	TDP43 from C.elegans lacks the glycine-rich domain found at the carboxy terminus of the other two homologues.	Glycine	31-38	TAR DNA binding protein	Homo sapiens	0-5	
33151007-2	2021	Over sixty TDP-43 mutations have been identified in patients suffering from these two diseases, but most variations are located in the protein"s disordered C-terminal glycine-rich region.	Glycine	167-174	TAR DNA binding protein	Homo sapiens	11-17	
14667816-4	2004	With DNA transfection assay, we have established the importance of the glycine-rich domain for the exon-skipping activity of TDP-43.	Glycine	71-78	TAR DNA binding protein	Homo sapiens	125-131	
26222336-2	2015	The ALS-associated mutations in the glycine-rich C-terminal domain of TDP-43 established a causal link between TDP-43 and disease, and conferred both loss- and gain-of-function properties in neurons.	Glycine	36-43	TAR DNA binding protein	Homo sapiens	70-76	
26222336-2	2015	The ALS-associated mutations in the glycine-rich C-terminal domain of TDP-43 established a causal link between TDP-43 and disease, and conferred both loss- and gain-of-function properties in neurons.	Glycine	36-43	TAR DNA binding protein	Homo sapiens	111-117	
34537246-6	2021	LARKS have high glycine content, which enables kinks to form as exemplified by the known LARKS-rich amyloidogenic structures of TDP43, FUS, and hnRNPA2, three proteins that are known to participate in MLOs.	Glycine	16-23	TAR DNA binding protein	Homo sapiens	128-133	
34169068-4	2021	The effect of pathogenic TDP-43 mutations within glycine-rich regions (where the majority of ALS-causing TDP-43 mutations occur) on SG dynamics in motor neurons is poorly understood.	Glycine	49-56	TAR DNA binding protein	Homo sapiens	25-31	
34169068-4	2021	The effect of pathogenic TDP-43 mutations within glycine-rich regions (where the majority of ALS-causing TDP-43 mutations occur) on SG dynamics in motor neurons is poorly understood.	Glycine	49-56	TAR DNA binding protein	Homo sapiens	105-111	
32529876-0	2020	High glycine content in TDP-43: a potential culprit in limbic-predominant age-related TDP-43 encephalopathy.	Glycine	5-12	TAR DNA binding protein	Homo sapiens	24-30	
32337711-0	2020	Molecular dissection of ALS-linked TDP-43: involvement of the Gly-rich domain in interaction with G-quadruplex mRNA.	Glycine	62-65	TAR DNA binding protein	Homo sapiens	35-41	
32337711-3	2020	For the molecular dissection of the TDP-43 and G4-RNA interaction, we analyzed it here in vitro and in cultured cells using a set of ten mutant TDP-43 proteins from familial and sporadic ALS patients as well as using the TDP-43 C-terminal Gly-rich domain alone.	Glycine	239-242	TAR DNA binding protein	Homo sapiens	36-42	
32337711-4	2020	Our results altogether indicate the involvement of the Gly-rich region of TDP-43 in the initial recognition and binding of G4-RNA, which then induces tight binding of TDP-43 with target RNAs, supposedly in conjunction with its RNA recognition motifs (RRMs).	Glycine	55-58	TAR DNA binding protein	Homo sapiens	74-80	
32337711-4	2020	Our results altogether indicate the involvement of the Gly-rich region of TDP-43 in the initial recognition and binding of G4-RNA, which then induces tight binding of TDP-43 with target RNAs, supposedly in conjunction with its RNA recognition motifs (RRMs).	Glycine	55-58	TAR DNA binding protein	Homo sapiens	167-173	
32529876-2	2020	Interestingly, TDP-43 contains 6.0% valine and 13.3% glycine, and the buildup of this protein in the brains of patients with limbic-predominant age-related TDP-43 encephalopathy has dire consequences.	Glycine	53-60	TAR DNA binding protein	Homo sapiens	15-21	
32529876-2	2020	Interestingly, TDP-43 contains 6.0% valine and 13.3% glycine, and the buildup of this protein in the brains of patients with limbic-predominant age-related TDP-43 encephalopathy has dire consequences.	Glycine	53-60	TAR DNA binding protein	Homo sapiens	156-162	
31955980-6	2020	In line with reported pathogenic mutations in the glycine/phenylalanine (G/F) domain of DNAJB6, both the novel mutations showed reduced anti-aggregation capacity by filter trap assay and TDP-43 disaggregation assays.	Glycine	50-57	TAR DNA binding protein	Homo sapiens	187-193	
31165305-3	2019	To date, over 50 dominant mutations were found in TDP-43 in both familial and sporadic ALS patients, most of which were missense mutations in the C-terminal glycine-rich region.	Glycine	157-164	TAR DNA binding protein	Homo sapiens	50-56