PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12686470-10 2003 Glycine-extended forms of gastrin-16 and gastrin-17 comprises 45% of the total gastrin immunoreactivity. Glycine 0-7 gastrin Rattus norvegicus 26-33 20641448-0 2004 [(99m)Tc(N)(NS-Cys-Gly-CCK-8)(PNP3)](+) [(99m)Tc-(N)(NS-Cys-Gly-CCK-8)(PNP3)](+) ((99m)Tc(N)(PNP3)-CCK-8) is a radiolabeled peptide developed for single-photon emission computed tomography (SPECT) imaging of tumors that express the gastrin/cholecystokinin-2 (CCK-2) receptor (1). Glycine 19-22 gastrin Rattus norvegicus 232-239 12379816-0 2002 Effects of amidated gastrin and glycine-extended gastrin on cell proliferation and crypt fission in parenterally and orally fed rats. Glycine 32-39 gastrin Rattus norvegicus 49-56 12388176-7 2002 Glycine-gastrin antibody, indomethacin and nitro-l-arginine methyl ester had no effect. Glycine 0-7 gastrin Rattus norvegicus 8-15 11860374-0 2002 Glycine-extended gastrin-17 stimulates acid secretion only via CCK-2 receptor-induced histamine release in the totally isolated vascularly perfused rat stomach. Glycine 0-7 gastrin Rattus norvegicus 17-24 11860374-3 2002 This study examines the effect of glycine-extended gastrin-17 (Gly-G-17), the main non-amidated gastrin precursor, on gastric acid secretion and histamine release in the totally isolated vascularly perfused rat stomach. Glycine 34-41 gastrin Rattus norvegicus 51-58 11860374-4 2002 Glycine-extended gastrin-17 at the concentrations from 0.52 to 520 nmol L(-1) was administered to the totally isolated vascularly perfused rat stomach. Glycine 0-7 gastrin Rattus norvegicus 17-24 11860374-8 2002 Glycine-extended gastrin-17 at lower concentrations from 0.52 to 5.2 nmol L(-1) did not stimulate gastric acid output or histamine release, whereas higher concentrations from 52 to 520 nmol L(-1) elicited a concentration-dependent increase in acid secretion and histamine release. Glycine 0-7 gastrin Rattus norvegicus 17-24 11860374-10 2002 Glycine-extended gastrin-17 at maximally effective concentration of 520 nmol L(-1) did not augment maximal gastrin stimulated acid secretion or histamine release. Glycine 0-7 gastrin Rattus norvegicus 17-24 11736730-2 2001 It raises in situ antibodies against two proliferative forms of gastrin: amidated and glycine-extended gastrin-17. Glycine 86-93 gastrin Rattus norvegicus 64-71 11736730-2 2001 It raises in situ antibodies against two proliferative forms of gastrin: amidated and glycine-extended gastrin-17. Glycine 86-93 gastrin Rattus norvegicus 103-110 11745407-0 2001 Short term infusion of glycine-extended gastrin(17) stimulates both proliferation and formation of aberrant crypt foci in rat colonic mucosa. Glycine 23-30 gastrin Rattus norvegicus 40-47 11745407-3 2001 The aim of our study was to determine whether continuous systemic infusion of glycine-extended gastrin(17) stimulated proliferation and accelerated carcinogenesis in the colorectal mucosa. Glycine 78-85 gastrin Rattus norvegicus 95-102 11745407-8 2001 We conclude that short term administration of glycine-extended gastrin(17) to mature rats not only has a proliferative effect upon colonic mucosa, but also increases the number of aberrant crypt foci formed in the colorectal mucosa after treatment with azoxymethane. Glycine 46-53 gastrin Rattus norvegicus 63-70 11745407-9 2001 Glycine-extended gastrin(17) could thus potentially act as a promoter of carcinogenesis. Glycine 0-7 gastrin Rattus norvegicus 17-24 9932724-4 1999 This study examines the effects on histamine release from the vascularly perfused rat stomach of amidated gastrin-17, COOH-terminal glycine-extended gastrin-17, gastrin-17 extended at the COOH-terminal including the remaining progastrin sequence, and carboxy-terminal progastrin fragments (SAEDEN and GRRSAEDEN). Glycine 132-139 gastrin Rattus norvegicus 149-156 9416989-6 1997 Glycine-extended gastrin was without effect. Glycine 0-7 gastrin Rattus norvegicus 17-24 9506532-2 1998 The immunogen Gastrimmune is composed of the amino terminus of gastrin-17 linked to diphtheria toxoid and raises antibodies in situ which neutralise amidated and glycine-extended gastrin-17. Glycine 162-169 gastrin Rattus norvegicus 179-186 9396534-6 1997 RESULTS: The galactose absorption, glycine absorption, DNA content, and protein content were significantly increased by EGF (69%, 28%, 64%, and 55%, respectively) and gastrin (72%, 60%, 93%, and 48%, respectively) when compared with control. Glycine 35-42 gastrin Rattus norvegicus 167-174 9263920-10 1997 In contrast, cleavage of G34 (the thirty-four amino acid amidated gastrin) at Lys-74-75 to give G17 (the seventeen amino acid amidated gastrin), and of G34-Gly to G17-Gly (G34 and G17 with COOH-terminal glycine), was increased 3-fold after treatment with omeprazole for either 1 or 5 days. Glycine 156-159 gastrin Rattus norvegicus 66-73 9263920-10 1997 In contrast, cleavage of G34 (the thirty-four amino acid amidated gastrin) at Lys-74-75 to give G17 (the seventeen amino acid amidated gastrin), and of G34-Gly to G17-Gly (G34 and G17 with COOH-terminal glycine), was increased 3-fold after treatment with omeprazole for either 1 or 5 days. Glycine 203-210 gastrin Rattus norvegicus 66-73 9192308-9 1997 The dopamine precursor L-beta-3,4-dihydroxyphenylalanine (L-DOPA) inhibited cleavage of 35S-labelled thirty-four amino acid amidated gastrin, i.e. [35S]G34, and of [35S]G34 with COOH-terminal glycine, i.e. [35S]G34-Gly, at a pair of lysine residues, but did not influence cleavage of progastrin at pairs of arginine residues. Glycine 192-199 gastrin Rattus norvegicus 133-140 9192308-9 1997 The dopamine precursor L-beta-3,4-dihydroxyphenylalanine (L-DOPA) inhibited cleavage of 35S-labelled thirty-four amino acid amidated gastrin, i.e. [35S]G34, and of [35S]G34 with COOH-terminal glycine, i.e. [35S]G34-Gly, at a pair of lysine residues, but did not influence cleavage of progastrin at pairs of arginine residues. Glycine 215-218 gastrin Rattus norvegicus 133-140 9324163-5 1997 Glycine-extended gastrin had no effect at 100 nM and a small but significant effect at 1 microM. Glycine 0-7 gastrin Rattus norvegicus 17-24 9324163-6 1997 The CCK-B receptor antagonist L365,260 almost totally blocked MAPK activation in AR42J cells after stimulation with gastrin and glycine-extended gastrin and substantially reduced the activation of both kinases by CCK-8, while the CCK-A receptor antagonist L364,718 was much less effective. Glycine 128-135 gastrin Rattus norvegicus 145-152 8647628-1 1996 Glycine-extended gastrin (gastrin-Gly) stimulates proliferation of AR4-2J pancreatic tumor cell line through a specific receptor, different from the gastrin-cholecystokinin B receptor. Glycine 0-7 gastrin Rattus norvegicus 17-24 8647628-1 1996 Glycine-extended gastrin (gastrin-Gly) stimulates proliferation of AR4-2J pancreatic tumor cell line through a specific receptor, different from the gastrin-cholecystokinin B receptor. Glycine 0-7 gastrin Rattus norvegicus 26-33 8647628-1 1996 Glycine-extended gastrin (gastrin-Gly) stimulates proliferation of AR4-2J pancreatic tumor cell line through a specific receptor, different from the gastrin-cholecystokinin B receptor. Glycine 0-7 gastrin Rattus norvegicus 26-33 8647628-7 1996 Gel chromatography revealed that the predominant molecular forms secreted were glycine-extended gastrin-34 and gastrin- 17. Glycine 79-86 gastrin Rattus norvegicus 96-103 8647628-8 1996 Furthermore, epidermal growth factor (EGF), a stimulator of gastrin gene transcription, modulates gastrin-Gly secretion by AR4-2J. Glycine 106-109 gastrin Rattus norvegicus 60-67 8647628-8 1996 Furthermore, epidermal growth factor (EGF), a stimulator of gastrin gene transcription, modulates gastrin-Gly secretion by AR4-2J. Glycine 106-109 gastrin Rattus norvegicus 98-105 8772521-0 1996 Glycine-extended gastrin potentiates gastrin-stimulated gastric acid secretion in rats. Glycine 0-7 gastrin Rattus norvegicus 17-24 8631028-0 1996 Gastrimmune raises antibodies that neutralize amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer. Glycine 59-66 gastrin Rattus norvegicus 76-83 8772521-0 1996 Glycine-extended gastrin potentiates gastrin-stimulated gastric acid secretion in rats. Glycine 0-7 gastrin Rattus norvegicus 37-44 8772521-1 1996 The purpose of this study was to examine whether an intermediate form of amidated gastrin, glycine-extended gastrin (Gly-G), can stimulate gastric acid secretion in conscious rats prepared with gastric fistulas. Glycine 117-120 gastrin Rattus norvegicus 82-89 8772521-1 1996 The purpose of this study was to examine whether an intermediate form of amidated gastrin, glycine-extended gastrin (Gly-G), can stimulate gastric acid secretion in conscious rats prepared with gastric fistulas. Glycine 117-120 gastrin Rattus norvegicus 108-115 8462797-7 1993 Glycine-extended gastrin and CCK were also present in the fetal colon, but towards adult life they decreased below 0.2 pmol/g. Glycine 0-7 gastrin Rattus norvegicus 17-24 2163679-1 1990 Various gastrin analogues and CCK-8 (Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2) are hydrolyzed in vitro by angiotensin-converting enzyme (ACE), the main and initial cleavage occurring at the Met-Asp (or Leu-Asp) bond, releasing the C-terminal dipeptide amide Asp-Phe-NH2. Glycine 55-58 gastrin Rattus norvegicus 8-15 2159243-1 1990 Formation of biologically active amidated gastrin from glycine-extended progastrin processing intermediates (G-Gly) is achieved via the action of peptidyl-glycyl alpha-amidating monooxygenase. Glycine 55-62 gastrin Rattus norvegicus 42-49 2343164-1 1990 The formation of biologically active gastrin from glycine-extended processing intermediates occurs via the action of a peptide alpha-amidating enzyme. Glycine 50-57 gastrin Rattus norvegicus 37-44 3202824-4 1988 In the third week of life the immediate precursor of amidated gastrin, glycine-extended gastrin, accumulated, and at weaning (day 21) the concentrations exceeded those of amidated gastrin. Glycine 71-78 gastrin Rattus norvegicus 62-69 3202824-4 1988 In the third week of life the immediate precursor of amidated gastrin, glycine-extended gastrin, accumulated, and at weaning (day 21) the concentrations exceeded those of amidated gastrin. Glycine 71-78 gastrin Rattus norvegicus 88-95 3202824-4 1988 In the third week of life the immediate precursor of amidated gastrin, glycine-extended gastrin, accumulated, and at weaning (day 21) the concentrations exceeded those of amidated gastrin. Glycine 71-78 gastrin Rattus norvegicus 88-95 3794976-8 1986 The response of mature jejunum and ileum following systemic gastrin infusion was a mild to moderate rise in galactose and glycine absorption, although statistical significance was not achieved. Glycine 122-129 gastrin Rattus norvegicus 60-67 3337238-3 1988 Unlike gastrin, glycine-extended precursors of gastrin (G-Gly) increased abruptly in the first day of life but thereafter increased at a steady state. Glycine 16-23 gastrin Rattus norvegicus 47-54 3596169-1 1987 Recently, glycine-extended processing intermediates of progastrin were identified in porcine stomach using a radioimmunoassay with conventional polyclonal antisera developed against a synthetic peptide analogue for progastrin processing intermediates, gastrin 6-G(Tyr-Gly-Trp-Met-Asp-Phe-Gly). Glycine 10-17 gastrin Rattus norvegicus 58-65 3596169-2 1987 We developed monoclonal antibodies specific for glycine-extended processing intermediates of progastrin (gastrin G). Glycine 48-55 gastrin Rattus norvegicus 96-103 3596152-0 1987 Secretion and biosynthesis of COOH-terminal glycine extended progastrin (gastrin-G) in rat gastric antrum. Glycine 44-51 gastrin Rattus norvegicus 64-71 3596152-1 1987 The effects of serotonin (5-HT) on gastrin and COOH-terminal glycine extended progastrin (gastrin-G) secretion, biosynthesis of gastrin and gastrin-G, and the effects of gastrin-G on gastric acid secretion were examined in rats. Glycine 61-68 gastrin Rattus norvegicus 81-88 3596152-1 1987 The effects of serotonin (5-HT) on gastrin and COOH-terminal glycine extended progastrin (gastrin-G) secretion, biosynthesis of gastrin and gastrin-G, and the effects of gastrin-G on gastric acid secretion were examined in rats. Glycine 61-68 gastrin Rattus norvegicus 81-88 3596152-1 1987 The effects of serotonin (5-HT) on gastrin and COOH-terminal glycine extended progastrin (gastrin-G) secretion, biosynthesis of gastrin and gastrin-G, and the effects of gastrin-G on gastric acid secretion were examined in rats. Glycine 61-68 gastrin Rattus norvegicus 81-88 3596152-1 1987 The effects of serotonin (5-HT) on gastrin and COOH-terminal glycine extended progastrin (gastrin-G) secretion, biosynthesis of gastrin and gastrin-G, and the effects of gastrin-G on gastric acid secretion were examined in rats. Glycine 61-68 gastrin Rattus norvegicus 81-88 3794976-9 1986 However, following luminal gastrin infusion into mature small intestine segments, there was a 4.54 fold rise in galactose absorption (P less than .01) and a 4.79 fold rise in glycine absorption (P less than .01) when compared with controls. Glycine 175-182 gastrin Rattus norvegicus 27-34 889039-1 1977 Gastrin is released from isolated perfused rat antra in a regular fashion by a variety of stimuli, including acetylcholine, glycine, and calcium. Glycine 124-131 gastrin Rattus norvegicus 0-7 3736029-9 1986 Glycine absorption was 1.63 +/- 0.31 for the control group and 7.83 +/- 0.62 for the gastrin infused group. Glycine 0-7 gastrin Rattus norvegicus 85-92 3736029-10 1986 Thus, in this rat model, intraluminal gastrin infusion was capable of increasing carbohydrate (galactose) absorption 456% (P less than 0.01) and protein (glycine) absorption 480% (P less than 0.01). Glycine 154-161 gastrin Rattus norvegicus 38-45 4010269-12 1985 More importantly, to our knowledge, this is the first demonstration that exogenously administered gastrin can increase absorption of carbohydrate (galactose; P less than 0.01) and protein (glycine; P less than 0.05). Glycine 189-196 gastrin Rattus norvegicus 98-105 844795-2 1977 Furthermore, serum immunoreactive gastrin levels were higher in the absence than in the presence of the thyroid gland following the oral administration of glycine or rat chaw. Glycine 155-162 gastrin Rattus norvegicus 34-41