PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29362667-4 2017 Typical morphology of apoptosis, cell cycle arrest in the G2/M phase, increased internucleosomal DNA fragmentation, loss of the mitochondrial transmembrane potential, and increased phosphatidylserine externalization and caspase-3 activation were observed in xylopine-treated HCT116 cells. xylopine 258-266 caspase 3 Homo sapiens 220-229 29362667-5 2017 Moreover, pretreatment with a caspase-3 inhibitor (Z-DEVD-FMK), but not with a p53 inhibitor (cyclic pifithrin-alpha), reduced xylopine-induced apoptosis, indicating induction of caspase-mediated apoptosis by the p53-independent pathway. xylopine 127-135 caspase 3 Homo sapiens 30-39