PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18482992-0	2008	Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway.	sphingosine 1-phosphate	27-50	phosphatase and tensin homolog	Homo sapiens	154-158	
24098536-0	2013	Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling.	sphingosine 1-phosphate	56-79	phosphatase and tensin homolog	Homo sapiens	43-47	
24098536-5	2013	We found that acid ceramidase promotes a reduction in nuclear PTEN that is dependent upon sphingosine 1-phosphate-mediated activation of Akt.	sphingosine 1-phosphate	90-113	phosphatase and tensin homolog	Homo sapiens	62-66	
24098536-6	2013	We were further able to show that sphingosine 1-phosphate promotes formation of a complex between Crm1 and PTEN, and that leptomycin B prevents acid ceramidase and sphingosine 1-phosphate mediated loss of nuclear PTEN, suggesting an active exportin-mediated event.	sphingosine 1-phosphate	34-57	phosphatase and tensin homolog	Homo sapiens	107-111	
24098536-6	2013	We were further able to show that sphingosine 1-phosphate promotes formation of a complex between Crm1 and PTEN, and that leptomycin B prevents acid ceramidase and sphingosine 1-phosphate mediated loss of nuclear PTEN, suggesting an active exportin-mediated event.	sphingosine 1-phosphate	164-187	phosphatase and tensin homolog	Homo sapiens	213-217	
24098536-9	2013	These findings suggest that acid ceramidase, through sphingosine 1-phosphate, promotes nuclear export of PTEN as a means of promoting tumor formation, cell proliferation, and resistance to therapy.	sphingosine 1-phosphate	53-76	phosphatase and tensin homolog	Homo sapiens	105-109