PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18829842-3	2008	Intriguingly, GPCR ligands such as thrombin, sphingosine-1-phosphate, and lysophosphatidic acid, which signal through G(12/13) and activate RhoA, have recently been shown to induce the expression of the extracellular matrix protein Cyr61 (i.e., CCN1).	sphingosine 1-phosphate	45-68	coagulation factor II, thrombin	Homo sapiens	35-43	
29131082-2	2018	We previously described that aspirin has effects beyond inhibition of platelet aggregation, as it inhibited thrombin-mediated release of sphingosine-1-phosphate (S1P) from human platelets.	sphingosine 1-phosphate	137-160	coagulation factor II, thrombin	Homo sapiens	108-116	
15626732-2	2005	Pro-inflammatory signaling by the blood coagulation protease thrombin through protease activated receptor-1 (PAR1) can disrupt endothelial barrier integrity, whereas the bioactive lipid sphingosine 1-phosphate (S1P) recently has been demonstrated to have potent barrier protective effects.	sphingosine 1-phosphate	211-214	coagulation factor II, thrombin	Homo sapiens	61-69	
10213177-1	1999	Thrombin activation of human platelets causes release of sphingosine-1-phosphate from platelets and an increase in sphingosine levels.	sphingosine 1-phosphate	57-80	coagulation factor II, thrombin	Homo sapiens	0-8	
34413778-1	2021	Aims: To explore the role of the Sphingosine 1-Phosphate (S1P)/Receptor2 (S1PR2) pathway in thrombin-induced hyperpermeability (TIP) and to test whether bivalirudin can reverse TIP via the S1P-S1PRs pathway.	sphingosine 1-phosphate	33-56	coagulation factor II, thrombin	Homo sapiens	92-100	
12730100-0	2003	Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells.	sphingosine 1-phosphate	22-45	coagulation factor II, thrombin	Homo sapiens	49-57	
9692614-2	1998	During activation of human platelets by thrombin, sphingosine-1-phosphate is released from platelets and can potentiate their aggregation.	sphingosine 1-phosphate	50-73	coagulation factor II, thrombin	Homo sapiens	40-48	
29131082-2	2018	We previously described that aspirin has effects beyond inhibition of platelet aggregation, as it inhibited thrombin-mediated release of sphingosine-1-phosphate (S1P) from human platelets.	sphingosine 1-phosphate	162-165	coagulation factor II, thrombin	Homo sapiens	108-116	
24990321-0	2014	Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes.	sphingosine 1-phosphate	0-23	coagulation factor II, thrombin	Homo sapiens	32-40