PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21566011-2	2011	We have shown before that ABCC2, ABCC3, and ABCG2 together influence the pharmacokinetics of the anticancer and antirheumatic drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX) after intravenous MTX administration.	7-hydroxymethotrexate	175-196	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	33-38	
19996279-0	2009	Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo.	7-hydroxymethotrexate	135-156	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	14-19	
19996279-0	2009	Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo.	7-hydroxymethotrexate	135-156	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	21-25	
19996279-7	2009	Furthermore, the urinary and fecal excretion of the nephrotoxic metabolite 7OH-MTX were increased 27- and 7-fold, respectively, in Abcc2;Abcc3;Abcg2-/- mice.	7-hydroxymethotrexate	75-82	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	137-142	
19996279-8	2009	Thus, Abcc2, Abcc3, and Abcg2 together mediate the rapid elimination of MTX and 7OH-MTX after i.v.	7-hydroxymethotrexate	80-87	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	13-18	
19088030-0	2008	Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate.	7-hydroxymethotrexate	113-134	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	27-32	
19088030-0	2008	Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate.	7-hydroxymethotrexate	113-134	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	34-38	
19088030-9	2008	The plasma AUCi.v.s of 7OH-MTX were 6.0-fold and 4.3-fold increased in Abcc2(-/-) and Abcc2;Abcc3(-/-) mice, respectively, leading to increased urinary excretion.	7-hydroxymethotrexate	23-30	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	92-97	
19088030-11	2008	7OH-MTX accumulated substantially in the liver of Abcc2(-/-) and especially Abcc2;Abcc3(-/-) mice.	7-hydroxymethotrexate	0-7	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	82-87	
19088030-13	2008	When Abcc2 is absent, Abcc3 transports MTX and 7OH-MTX back from the liver into the circulation, leading to increased plasma levels and urinary excretion.	7-hydroxymethotrexate	47-54	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	22-27