PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31914336-3 2020 Currently, several DAA options are available on the market.Areas covered: This review focuses on the pharmacokinetics, efficacy, tolerability and safety profile of DCV-TRIO, a twice-daily fixed-dose combination of daclatasvir, asunaprevir and beclabuvir approved in Japan for the treatment of genotype 1 HCV infection.Expert opinion: The DCV-TRIO combination achieved good response rates in genotype 1 patients (SVR12 >= 95% in naive subtype 1b), independently from IL28B genotype, cirrhotic status and prior interferon exposure. daa 19-22 trio Rho guanine nucleotide exchange factor Homo sapiens 168-172