PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32440368-3 2019 Serum histidine is also inversely correlated with proinflammatory cytokines (e.g., TNF, IFN-y), which have been linked to MS fatigue. Histidine 6-15 tumor necrosis factor Homo sapiens 83-86 32440368-9 2019 Gene expression of TNF correlated with histidine only in people with normal fatigue (r = .51, p = .034), while no other cytokines related to histidine levels. Histidine 39-48 tumor necrosis factor Homo sapiens 19-22 24699213-4 2014 We found that systemic administration of cyclo(His-Pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFalpha expression thereby counteracting LPS-induced gliosis. Histidine 47-50 tumor necrosis factor Homo sapiens 167-175 24123819-1 2013 Human microbiome-derived strains of Lactobacillus reuteri potently suppress proinflammatory cytokines like human tumor necrosis factor (TNF) by converting the amino acid l-histidine to the biogenic amine histamine. Histidine 170-181 tumor necrosis factor Homo sapiens 113-134 24488273-3 2014 Histamine suppresses tumor necrosis factor (TNF) production by human myeloid cells and is a product of L-histidine decarboxylation, which is a proton-facilitated reaction. Histidine 103-114 tumor necrosis factor Homo sapiens 21-42 24123819-1 2013 Human microbiome-derived strains of Lactobacillus reuteri potently suppress proinflammatory cytokines like human tumor necrosis factor (TNF) by converting the amino acid l-histidine to the biogenic amine histamine. Histidine 170-181 tumor necrosis factor Homo sapiens 136-139 22530913-6 2012 Docking study revealed the important amino acid residues (His 15, Tyr 59, Tyr 151, Gly 121 and Gly 122) in the active site of TNFalpha that are involved in binding of the active ligand. Histidine 58-61 tumor necrosis factor Homo sapiens 126-134 21893202-6 2011 Analysis of mixed TNF trimers, prepared from tag-free TNF doped with various amounts of histidine-tagged TNF, revealed an increased retention of the trimeric protein on immobilized metal-ion affinity chromatography (IMAC) columns. Histidine 88-97 tumor necrosis factor Homo sapiens 18-21 22236003-6 2012 Cysteine, histidine and glycine significantly reduced NF-kappaB activation and inhibitor kappaBalpha (IkappaBalpha) degradation in HCAECs stimulated with TNF-alpha. Histidine 10-19 tumor necrosis factor Homo sapiens 154-163 21785859-5 2011 RESULTS: Cysteine, histidine and glycine significantly reduced the activation of NF-kappaB in THP-1 cells stimulated with TNF-alpha. Histidine 19-28 tumor necrosis factor Homo sapiens 122-131 21893202-7 2011 When 20% of histidine-tagged TNF was added, more than 50% of the protein was retained on the IMAC column. Histidine 12-21 tumor necrosis factor Homo sapiens 29-32 21893202-9 2011 Various histidine-tags were fused to the N-terminus of full-length TNF-alpha and to the truncated form (dN6) of TNF-alpha. Histidine 8-17 tumor necrosis factor Homo sapiens 67-76 21893202-9 2011 Various histidine-tags were fused to the N-terminus of full-length TNF-alpha and to the truncated form (dN6) of TNF-alpha. Histidine 8-17 tumor necrosis factor Homo sapiens 112-121 18826058-5 2008 Using human tumor necrosis factor alpha as a model protein, we describe here the steps involved in the removal of a His-tag using TAGZyme. Histidine 116-119 tumor necrosis factor Homo sapiens 12-39 20368109-9 2010 Western blot showed recombinant protein can specificly reacted with anti-human HMGB1 polyclonal antibody and anti-His-Tag polyclonal antibody.The purpose protein was found more than 90% after purified, and can effectively inhibit the production of BAFF, IFN-gamma and TNF-alpha in monocyte which were induced by IC. Histidine 114-117 tumor necrosis factor Homo sapiens 268-277 16256128-6 2006 Analysis of mixed TNF trimers, prepared from tag-free TNF doped with various amounts of histidine-tagged TNF, revealed an increased retention of the trimeric protein on immobilized metal-ion affinity chromatography (IMAC) columns. Histidine 88-97 tumor necrosis factor Homo sapiens 18-21 16256128-7 2006 When 20% of histidine-tagged TNF was added, more than 50% of the protein was retained on the IMAC column. Histidine 12-21 tumor necrosis factor Homo sapiens 29-32 16256128-9 2006 Various histidine-tags were fused to the N-terminus of full-length TNF-alpha and to the truncated form (dN6) of TNF-alpha. Histidine 8-17 tumor necrosis factor Homo sapiens 67-76 16256128-9 2006 Various histidine-tags were fused to the N-terminus of full-length TNF-alpha and to the truncated form (dN6) of TNF-alpha. Histidine 8-17 tumor necrosis factor Homo sapiens 112-121 16287242-4 2005 The TNF mutants were modified at the N-terminus by PCR cloning by introducing a His-Tag for purification and a free cysteine group for reaction with the particle-attached maleimide group. Histidine 80-83 tumor necrosis factor Homo sapiens 4-7 11097743-5 2000 Co-transfection of the p53 His(273)expression construct with a luciferase gene controlled by the p21(WAF1)promoter showed that the p53 His(273)was inactive, although TNF-alpha increased the transcriptional rate of p21(WAF1)in these cells. Histidine 27-30 tumor necrosis factor Homo sapiens 166-175 16107255-0 2005 Histidine inhibits oxidative stress- and TNF-alpha-induced interleukin-8 secretion in intestinal epithelial cells. Histidine 0-9 tumor necrosis factor Homo sapiens 41-50 16107255-2 2005 We found that histidine, one of the conditionally essential amino acids, significantly inhibited both hydrogen peroxide- and TNF-alpha-induced IL-8 secretion and mRNA expression in Caco-2 cells and HT-29 cells. Histidine 14-23 tumor necrosis factor Homo sapiens 125-134 16107255-4 2005 TNF-alpha increased the transcriptional activity of the IL-8 promoter which was significantly inhibited by treating Caco-2 cells with histidine. Histidine 134-143 tumor necrosis factor Homo sapiens 0-9 16107255-5 2005 Histidine also abolished the NF-kappaB-dependent activation of the IL-8 promoter induced by TNF-alpha. Histidine 0-9 tumor necrosis factor Homo sapiens 92-101 16107255-6 2005 These results indicate that histidine inhibited the hydrogen peroxide- and TNF-alpha-induced IL-8 secretion at the transcriptional level in intestinal epithelial cells, suggesting that histidine has the potential to attenuate intestinal inflammation. Histidine 28-37 tumor necrosis factor Homo sapiens 75-84 16107255-6 2005 These results indicate that histidine inhibited the hydrogen peroxide- and TNF-alpha-induced IL-8 secretion at the transcriptional level in intestinal epithelial cells, suggesting that histidine has the potential to attenuate intestinal inflammation. Histidine 185-194 tumor necrosis factor Homo sapiens 75-84 16004422-6 2005 Oriented coupling of the Fab fragments on chelate-epoxy cellulose via a C-terminal histidine tag, however, increased the adsorption capacity to 178.3 +/- 8.6 pg TNF/mg adsorbent wet weight. Histidine 83-92 tumor necrosis factor Homo sapiens 161-164 11097743-5 2000 Co-transfection of the p53 His(273)expression construct with a luciferase gene controlled by the p21(WAF1)promoter showed that the p53 His(273)was inactive, although TNF-alpha increased the transcriptional rate of p21(WAF1)in these cells. Histidine 135-138 tumor necrosis factor Homo sapiens 166-175 2018798-5 1991 TNF-M1 and TNF-M4 have deletions of His-73 and Gln-102, respectively. Histidine 36-39 tumor necrosis factor Homo sapiens 0-3 2018798-5 1991 TNF-M1 and TNF-M4 have deletions of His-73 and Gln-102, respectively. Histidine 36-39 tumor necrosis factor Homo sapiens 11-14 34410849-7 2021 Interestingly, both HI and MI upregulated gene sets involved in inflammation (IL6-JAK-STAT3 signaling, allograft rejection, TNFA signaling via NFKB, and inflammatory response; FDR q-value<0.25). Histidine 20-22 tumor necrosis factor Homo sapiens 124-128 2546145-2 1989 TNF contains three histidine residues, located at positions 15, 73 and 78. Histidine 19-28 tumor necrosis factor Homo sapiens 0-3 2546145-3 1989 The histidine-specific reagent diethylpyrocarbonate (DEP) was used to chemically modify TNF. Histidine 4-13 tumor necrosis factor Homo sapiens 88-91 2546145-10 1989 The data show that the histidine residue at position 15 is an amino acid that is required for the cytotoxic activity of TNF. Histidine 23-32 tumor necrosis factor Homo sapiens 120-123