PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34901149-1 2021 The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 34901149-1 2021 The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins. Histidine 83-92 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 31538680-1 2020 Genetic analysis has strongly implicated human FHIT (Fragile Histidine Triad) as a tumor suppressor gene, being mutated in a large proportion of early-stage cancers. Histidine 61-70 fragile histidine triad diadenosine triphosphatase Homo sapiens 47-51 35254116-1 2022 BACKGROUND: Fragile histidine triad (FHIT) is a strong tumor suppressor gene, and cells deficient in FHIT are prone to acquiring cancer-promoting mutations. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 37-41 35254116-1 2022 BACKGROUND: Fragile histidine triad (FHIT) is a strong tumor suppressor gene, and cells deficient in FHIT are prone to acquiring cancer-promoting mutations. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 101-105 35522782-1 2022 The tumor suppressor protein fragile histidine triad (Fhit) is known to be associated with genomic instability and apoptosis. Histidine 37-46 fragile histidine triad diadenosine triphosphatase Homo sapiens 54-58 34092254-3 2021 The tumor suppressor gene, Fragile Histidine Triad Diadenosine Triphosphatase (FHIT), is frequently lost in cancer through epigenetic modifications and/or deletion. Histidine 35-44 fragile histidine triad diadenosine triphosphatase Homo sapiens 79-83 32474857-1 2020 In order to demonstrate the relationship between methylation of fragile histidine triad (FHIT) and T-cadherin/H-cadherin (CDH13) genes and liver cancer, the methylation status of FHIT and CDH13 was detected in healthy individuals and in Mongolian and Han patients with liver cancer. Histidine 72-81 fragile histidine triad diadenosine triphosphatase Homo sapiens 89-93 32474857-1 2020 In order to demonstrate the relationship between methylation of fragile histidine triad (FHIT) and T-cadherin/H-cadherin (CDH13) genes and liver cancer, the methylation status of FHIT and CDH13 was detected in healthy individuals and in Mongolian and Han patients with liver cancer. Histidine 72-81 fragile histidine triad diadenosine triphosphatase Homo sapiens 179-183 32661472-1 2020 Endometrial carcinoma is the most common malignant tumors of the reproductive system, and fragile histidine triad (FHIT) plays an important role in multiple tumors. Histidine 98-107 fragile histidine triad diadenosine triphosphatase Homo sapiens 115-119 32237123-2 2020 With the aim of refining the target population for anti-HER2 therapies in NSCLC, we investigated the relationships between HER2 and the tumour suppressor fragile histidine triad (FHIT) in lung tumour cells. Histidine 162-171 fragile histidine triad diadenosine triphosphatase Homo sapiens 179-183 30655841-1 2019 Effects of interventional embolotherapy on the expression of fragile histidine triad (FHIT) and p16 in hepatocellular carcinoma (HCC) patients were investigated. Histidine 69-78 fragile histidine triad diadenosine triphosphatase Homo sapiens 86-90 30242938-4 2019 Notably, the fragile locus, FRA3B, lies within the fragile histidine triad (FHIT) gene, and consequently deletions within FHIT are common in cancer. Histidine 59-68 fragile histidine triad diadenosine triphosphatase Homo sapiens 28-33 30242938-4 2019 Notably, the fragile locus, FRA3B, lies within the fragile histidine triad (FHIT) gene, and consequently deletions within FHIT are common in cancer. Histidine 59-68 fragile histidine triad diadenosine triphosphatase Homo sapiens 76-80 30242938-4 2019 Notably, the fragile locus, FRA3B, lies within the fragile histidine triad (FHIT) gene, and consequently deletions within FHIT are common in cancer. Histidine 59-68 fragile histidine triad diadenosine triphosphatase Homo sapiens 122-126 30941950-1 2019 PURPOSE: The study aimed to investigate the expression level of fragile histidine triad (FHIT) in breast cancer and analyze its prognostic value. Histidine 72-81 fragile histidine triad diadenosine triphosphatase Homo sapiens 89-93 30248342-10 2018 Heterozygous loss of the tumor-suppressor fragile histidine triad (FHIT) gene also was observed, although protein expression was preserved. Histidine 50-59 fragile histidine triad diadenosine triphosphatase Homo sapiens 67-71 29282095-3 2017 Fhit belongs to the histidine triad family of enzymes that catalyze the degradation of nucleoside 5",5"-triphosphates, including the m7GpppN "caps" that are generated when mRNAs undergo 3"-5" decay. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 29960902-7 2018 RESULTS: The real-time RT-PCR and DNA sequencing data for the identified genes indicated that the N-terminal domain-interacting receptor 1 (Nir1) gene was suppressed whereas Nir2 and fragile histidine triad (FHIT) genes were upregulated followed by the overexpression of TGIF2LX gene. Histidine 191-200 fragile histidine triad diadenosine triphosphatase Homo sapiens 208-212 29434897-2 2018 Fragile histidine triad (FHIT) is a tumor suppressor gene that is frequently silenced in cervical cancer (CC) and preneoplastic lesions. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 29860820-1 2018 Objective: To explore the relationship between abnormal expression of fragile histidine triad (FHIT) gene and methyl-CpG-binding protein 2 (MeCP2) as well as their interaction on cervical cancerization. Histidine 78-87 fragile histidine triad diadenosine triphosphatase Homo sapiens 95-99 25422218-1 2014 Fragile histidine triad (FHIT) is a suppressor gene related to cervical cancer through CpG island hypermethylation. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 28414756-0 2017 Reduction in the copy number and expression level of the recurrent human papillomavirus integration gene fragile histidine triad (FHIT) predicts the transition of cervical lesions. Histidine 113-122 fragile histidine triad diadenosine triphosphatase Homo sapiens 130-134 25975556-1 2015 OBJECTIVE: To explore the interaction between folate deficiency and aberrant expression related to fragile histidine triad (FHIT) gene in the progression of cervical cancerization. Histidine 107-116 fragile histidine triad diadenosine triphosphatase Homo sapiens 124-128 25735361-1 2015 BACKGROUND: Fragile histidine triad (FHIT) gene is a tumor suppressor gene which involved in breast cancer pathogenesis. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 37-41 24729090-1 2014 Our current meta-analysis is aimed to investigate the relationships between fragile histidine triad (FHIT) protein expression and prognosis in gastric cancer patients. Histidine 84-93 fragile histidine triad diadenosine triphosphatase Homo sapiens 101-105 24396396-1 2014 The aim of this study was to investigate the methylation status of fragile histidine triad (FHIT) and the effects of FHIT on cell growth and cyclin D1 expression in hepatoma cells. Histidine 75-84 fragile histidine triad diadenosine triphosphatase Homo sapiens 92-96 24935385-3 2014 Therefore, the aim of this study was to evaluate the association between gene hypermethylation and expression of fragile histidine triad (FHIT), glutathione S-transferase P1 (GSTP1) and p16 genes and various clinicopathologic characteristics in primary non-small cell lung carcinomas (NSCLC). Histidine 121-130 fragile histidine triad diadenosine triphosphatase Homo sapiens 138-142 28404875-1 2017 Inactivation of the fragile histidine triad (Fhit) gene has been reported in the majority of human cancers, particularly in lung cancer. Histidine 28-37 fragile histidine triad diadenosine triphosphatase Homo sapiens 45-49 28164627-1 2016 BACKGROUND: Fragile histidine triad (FHIT), fibronectin (FN), and phosphatase and tensin homology deleted on chromosome ten (PTEN) are widely reported as having abnormal expression in malignant tumors. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 37-41 27346116-1 2016 OBJECTIVE: To investigate the association between fragile histidine triad (FHIT) gene methylation, abnormal protein expression and HPV16 infection as well as their interactions in cervical carcinogenesis. Histidine 58-67 fragile histidine triad diadenosine triphosphatase Homo sapiens 75-79 25711523-1 2015 The tumor-suppressor protein fragile histidine triad (Fhit) exerts its functions in the cytoplasm, although some reports suggest that it may also act in the nucleus. Histidine 37-46 fragile histidine triad diadenosine triphosphatase Homo sapiens 54-58 26171037-1 2015 High-risk human papillomavirus (HPV)16/18 infection in the development of lung cancer has previously been identified, and fragile histidine triad (FHIT) loss and p53 mutation are frequently observed in the disease. Histidine 130-139 fragile histidine triad diadenosine triphosphatase Homo sapiens 147-151 26137124-1 2015 The fragile histidine triad (FHIT) gene is known to be a tumor suppressor gene and the abnormal methylation of FHIT has been identified in leukemia and several solid tumors. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 26137124-1 2015 The fragile histidine triad (FHIT) gene is known to be a tumor suppressor gene and the abnormal methylation of FHIT has been identified in leukemia and several solid tumors. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 111-115 24998847-1 2015 Fragile histidine triad (FHIT) loss by the two-hit mechanism of loss of heterozygosity and promoter hypermethylation commonly occurrs in non-small cell lung cancer (NSCLC) and may confer cisplatin resistance in NSCLC cells. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 25460508-3 2015 Using a methylation microarray, we identified promoter hypermethylation of FHIT (fragile histidine triad) in radioresistant OML1-R cells, established from hypo-fractionated irradiation of parental OML1 radiosensitive oral cancer cells. Histidine 89-98 fragile histidine triad diadenosine triphosphatase Homo sapiens 75-79 25221773-1 2014 BACKGROUND: Fragile histidine triad (FHIT) is considered as a member of the histidine triad (HIT) nucleotide-binding protein superfamily regarded as a putative tumor suppressor executing crucial role in inhibiting p53 degradation by MDM2. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 37-41 25221773-1 2014 BACKGROUND: Fragile histidine triad (FHIT) is considered as a member of the histidine triad (HIT) nucleotide-binding protein superfamily regarded as a putative tumor suppressor executing crucial role in inhibiting p53 degradation by MDM2. Histidine 76-85 fragile histidine triad diadenosine triphosphatase Homo sapiens 37-41 24464917-1 2014 UNLABELLED: In many cancers, including lung carcinomas, Fragile histidine triad (Fhit) is frequently decreased or lost. Histidine 64-73 fragile histidine triad diadenosine triphosphatase Homo sapiens 81-85 25059370-1 2014 OBJECTIVE: To explore the effect of folate on cell proliferation and apoptosis as well as on DNA methylation, expression of mRNA and protein of fragile histidine triad (FHIT)gene in cervical cancer cells. Histidine 152-161 fragile histidine triad diadenosine triphosphatase Homo sapiens 169-173 24757411-0 2014 Fragile histidine triad (FHIT) suppresses proliferation and promotes apoptosis in cholangiocarcinoma cells by blocking PI3K-Akt pathway. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 24757411-1 2014 Fragile histidine triad (FHIT) is a tumor suppressor protein that regulates cancer cell proliferation and apoptosis. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 25486479-1 2014 Fragile histidine triad (FHIT) gene deletions are among the earliest and most frequent events in carcinogenesis, particularly in carcinogen-exposed tissues. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 24984545-1 2014 PURPOSE: To explore the significance of combined detection of p53 genes and fragile histidine triad (FHIT) genes in cervical carcinoma. Histidine 84-93 fragile histidine triad diadenosine triphosphatase Homo sapiens 101-105 23969757-2 2013 The fragile histidine triad (FHIT) gene is a putative tumor suppressor gene in breast and other types of cancer, and loss of Fhit expression has been observed in breast cancer. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 23969757-2 2013 The fragile histidine triad (FHIT) gene is a putative tumor suppressor gene in breast and other types of cancer, and loss of Fhit expression has been observed in breast cancer. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 125-129 23797051-3 2013 Here, we attempt to corroborate and provide further insight pertinent to the fragile histidine triad (FHIT) gene in microsatellite instable (MSI), microsatellite stable (MSS), and CpG island methylator phenotype (CIMP) CRC subtypes. Histidine 85-94 fragile histidine triad diadenosine triphosphatase Homo sapiens 102-106 21962529-6 2013 Simultaneously, the allelic deletion status of fragile histidine triad (FHIT) gene was studied by FISH in cRCC and major epithelial carcinoma (MEC) tumors. Histidine 55-64 fragile histidine triad diadenosine triphosphatase Homo sapiens 72-76 23709347-1 2013 The purpose of this study was to investigate the diagnostic value of the deletion of fragile histidine triad (FHIT) and p16INK4a (p16) mRNA in biopsies obtained by bronchoscopy. Histidine 93-102 fragile histidine triad diadenosine triphosphatase Homo sapiens 110-114 23947369-2 2013 The Fhit protein is a member of the ubiquitous histidine triad proteins which hydrolyze dinucleoside polyphosphates such as Ap3A. Histidine 47-56 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 23102829-1 2013 The fragile histidine triad protein, Fhit, has a number of reported tumor suppressive functions which include signaling of apoptosis in cancer cells in vitro and in vivo, modulation of the DNA damage response, down-regulation of target oncogene expression, suppression of tumor growth in vivo, and suppression of cancer cell invasion and metastasis. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 37-41 23443232-1 2012 AIM: To characterize aberrant crypt focus (ACF) in adjoining mucosa in sporadic colorectal carcinoma and to evaluate fragile histidine triad (Fhit) protein and Ki67. Histidine 125-134 fragile histidine triad diadenosine triphosphatase Homo sapiens 142-146 23534718-0 2013 Expression of fragile histidine triad (FHIT) and WW-domain oxidoreductase gene (WWOX) in nasopharyngeal carcinoma. Histidine 22-31 fragile histidine triad diadenosine triphosphatase Homo sapiens 39-43 23736021-2 2013 The aim of this study was to evaluate the diagnostic value of the fragile histidine triad (FHIT) and p16 mRNA loss and the K-ras gene mutation in distinguishing malignant from benign pleural effusion. Histidine 74-83 fragile histidine triad diadenosine triphosphatase Homo sapiens 91-95 23724516-0 2013 Loss of heterozygosity in the fragile histidine triad (FHIT) locus and expression analysis of FHIT protein in patients with breast disorders. Histidine 38-47 fragile histidine triad diadenosine triphosphatase Homo sapiens 55-59 23724516-1 2013 PURPOSE OF INVESTIGATION: The fragile histidine triad (FHIT) gene is a tumor suppressor frequently inactivated in various types of tumors. Histidine 38-47 fragile histidine triad diadenosine triphosphatase Homo sapiens 55-59 23724516-8 2013 The changes in the locus of the FHIT gene occur with greater frequency in the coded region of the gene, principally near exons 5 and 8, where the FRA3B site and the histidine triad respectively are found. Histidine 165-174 fragile histidine triad diadenosine triphosphatase Homo sapiens 32-36 22843886-2 2012 AIM: Our study aimed to characterise alterations in the immunohistochemical expression of the Fragile Histidine Traid (FHIT) and Cyclin-dependent Kinase Inhibitor 2A (CDKN2A) (p16(INK4a)) genes during tumour progression model from PSA to Ca-ex-PA in a cross sectional study. Histidine 102-111 fragile histidine triad diadenosine triphosphatase Homo sapiens 119-123 22932087-2 2012 Our study aimed to investigate the differential expression of Ki-67, galectin-3, fragile histidine triad (FHIT) gene, and parafibromin in PC, parathyroid adenoma (PA), parathyroid hyperplasia (PH), and normal parathyroid (NP) tissues; then to assess these expression values for use in differential diagnosis of malignant and benign parathyroid tumors. Histidine 89-98 fragile histidine triad diadenosine triphosphatase Homo sapiens 106-110 22315171-1 2012 BACKGROUND: The relationship between the expression of CD133 and fragile histidine triad (FHIT) or prognosis in Chinese colorectal adenocarcinoma is unknown and needs to be explored. Histidine 73-82 fragile histidine triad diadenosine triphosphatase Homo sapiens 90-94 22613411-1 2012 OBJECTIVES: The role and clinical significance of fragile histidine triad (FHIT) gene in the pathogenesis of bladder urothelial carcinoma (UC) and the potential of Fhit protein as a prognostic biomarker for UC were investigated. Histidine 58-67 fragile histidine triad diadenosine triphosphatase Homo sapiens 75-79 21679157-1 2012 Accumulating evidence has demonstrated that FHIT (fragile histidine triad) is a bona fide tumour suppressor gene in a large fraction of human tumours, including hepatocellular cancer. Histidine 58-67 fragile histidine triad diadenosine triphosphatase Homo sapiens 44-48 21830375-1 2011 BACKGROUND/AIMS: The fragile histidine triad (FHIT) gene is a candidate tumor suppressor gene. Histidine 29-38 fragile histidine triad diadenosine triphosphatase Homo sapiens 46-50 22085272-1 2011 The candidate tumor suppressor fragile histidine traid (FHIT) is frequently inactivated in small cell lung cancer (SCLC). Histidine 39-48 fragile histidine triad diadenosine triphosphatase Homo sapiens 56-60 21757356-1 2011 Fragile histidine triad (Fhit) protein encoded by tumour suppressor FHIT gene is a proapoptotic protein with diadenosine polyphosphate (Ap(n)A, n=2-6) hydrolase activity. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 21757356-1 2011 Fragile histidine triad (Fhit) protein encoded by tumour suppressor FHIT gene is a proapoptotic protein with diadenosine polyphosphate (Ap(n)A, n=2-6) hydrolase activity. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 68-72 21711110-3 2011 Fragile histidine triad (FHIT) gene deletion, methylation, and reduced Fhit protein expression occur in about 70% of human epithelial tumors and are clearly associated with tumor progression. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 20690795-0 2010 Restoration of fragile histidine triad (FHIT) expression inhibits cell growth and induces apoptosis in cutaneous T-cell lymphoma cell line. Histidine 23-32 fragile histidine triad diadenosine triphosphatase Homo sapiens 40-44 21870644-2 2011 The present study aimed to identify and analyze the role of homozygous deletion (HZD) and transcriptional alterations of fragile histidine triad (FHIT) gene in the development and progression of bilharzial bladder cancer in Egyptian patients. Histidine 129-138 fragile histidine triad diadenosine triphosphatase Homo sapiens 146-150 21241597-0 2010 [Expression of fragile histidine triad (FHIT) protein and Ki-67 in transformed epithelial cells induced by Yunnan tin mine dust]. Histidine 23-32 fragile histidine triad diadenosine triphosphatase Homo sapiens 40-44 21241597-1 2010 OBJECTIVE: To study the expression and significance of fragile histidine triad (FHIT) and Ki-67 in transformed epithelial cells induced by Yunnan tin mine dust. Histidine 63-72 fragile histidine triad diadenosine triphosphatase Homo sapiens 80-84 21743838-1 2011 The Fragile Histidine Triad gene or FHIT functions as tumor suppressor in many epithelial cell types. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 36-40 20690795-1 2010 To investigate the effects of fragile histidine triad (FHIT) restoration on cell proliferation and apoptosis in human cutaneous T-cell lymphoma cell line, Hut-78, in vitro and in nude mouse. Histidine 38-47 fragile histidine triad diadenosine triphosphatase Homo sapiens 55-59 19479888-1 2009 The fragile histidine triad gene (human FHIT, mouse Fhit) has been shown to act as a tumor suppressor gene. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 40-44 20878579-1 2010 OBJECTIVE: To investigate the effect of fragile histidine triad (FHIT) gene transfection on human colorectal cancer cell line SW480 through up-regulation of caspase-8 expression. Histidine 48-57 fragile histidine triad diadenosine triphosphatase Homo sapiens 65-69 20622329-1 2010 OBJECTIVE: To determine the role of fragile histidine triad (FHIT) and MDM2 in carcinogenesis of oral submucous fibrosis (OSF). Histidine 44-53 fragile histidine triad diadenosine triphosphatase Homo sapiens 61-65 19935706-1 2010 In many types of cancers, the fragile histidine triad (Fhit) gene is frequently targeted by genomic alterations leading to a decrease or loss of gene and protein expression. Histidine 38-47 fragile histidine triad diadenosine triphosphatase Homo sapiens 55-59 20689140-0 2010 Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma. Histidine 69-78 fragile histidine triad diadenosine triphosphatase Homo sapiens 86-90 20689140-1 2010 The fragile histidine triad (FHIT) gene encompasses the most common human fragile site, FRA3B at 3p14.2, a region that is involved in homozygous deletions in a variety of human tumors. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 20689140-1 2010 The fragile histidine triad (FHIT) gene encompasses the most common human fragile site, FRA3B at 3p14.2, a region that is involved in homozygous deletions in a variety of human tumors. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 88-93 20033706-1 2010 BACKGROUND: The human fragile histidine triad (FHIT) gene is a putative tumor suppressor gene, which is located at chromosome region 3p14.2. Histidine 30-39 fragile histidine triad diadenosine triphosphatase Homo sapiens 47-51 19730990-3 2010 Fragile Histidine Triad (FHIT) has been shown to play a pivotal role in carcinogenesis. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 19751438-1 2009 BACKGROUND: The expression of a fragile histidine triad (FHIT) protein is lost in stomach tumors. Histidine 40-49 fragile histidine triad diadenosine triphosphatase Homo sapiens 57-61 19418484-1 2009 Fragile histidine triad (FHIT) is a tumor suppressor gene whose allelic loss is associated to a number of human cancers. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 18247301-1 2008 OBJECTIVE: To study the methylation status of fragile histidine triad (FHIT) gene promoter in patients with myelodysplastic syndrome (MDS) and its clinical relevance. Histidine 54-63 fragile histidine triad diadenosine triphosphatase Homo sapiens 71-75 19486340-1 2009 Though the fragile histidine triad gene product, Fhit, was discovered and characterized as a tumor suppressor 13 years ago, its sequence, structure, and cellular location did not provide clues to aid discovery of its mechanisms of suppression. Histidine 19-28 fragile histidine triad diadenosine triphosphatase Homo sapiens 49-53 19401904-1 2009 PURPOSE: To study whether fragile histidine triad (Fhit) prevents IR-induced hypoxanthineguanine phosphoribosyltransferase (HPRT) mutation and whether Fhit plays any role in preventing HPRT mutation through low dose-induced adaptive response. Histidine 34-43 fragile histidine triad diadenosine triphosphatase Homo sapiens 51-55 19131950-5 2009 In addition, microdeletions at 3p14.2 were detected in 3 (5%) cSCCs, implicating the fragile histidine triad (FHIT) gene as a possible target for inactivation. Histidine 93-102 fragile histidine triad diadenosine triphosphatase Homo sapiens 110-114 19578286-1 2009 The fragile histidine triad (FHIT) gene is a tumor-associated gene, and aberrant FHIT gene and protein expression have been described in many types of human tumors. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 19578286-1 2009 The fragile histidine triad (FHIT) gene is a tumor-associated gene, and aberrant FHIT gene and protein expression have been described in many types of human tumors. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 81-85 20716406-1 2009 BACKGROUND: Fragile histidine triad (FHIT) is a candidate tumor suppressor gene. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 37-41 18717684-2 2008 However, a significant fraction of periocular sebaceous gland carcinomas exhibits microsatellite stability associated with a frequent loss of the candidate tumour suppressor fragile histidine triad (FHIT). Histidine 182-191 fragile histidine triad diadenosine triphosphatase Homo sapiens 199-203 18595145-1 2008 AIM: To evaluate the inhibitory effects of human fragile histidine triad (FHIT) gene on cell proliferation and apoptosis in human hepatocellular carcinoma line Hep3B in vitro. Histidine 57-66 fragile histidine triad diadenosine triphosphatase Homo sapiens 74-78 18596417-7 2008 Here, we summarize these findings with special emphasis on the histidine triad proteins Hint1 and Fhit and their repressive activity on the beta-catenin signaling function. Histidine 63-72 fragile histidine triad diadenosine triphosphatase Homo sapiens 98-102 18221322-1 2008 BACKGROUND: The purpose of this study was to determine fragile histidine triad (FHIT) and p53 protein expression, and to analyze FHIT and p53 gene status in keratocystic odontogenic tumor (KOT), dentigerous cysts (DC) and radicular cysts (RC). Histidine 63-72 fragile histidine triad diadenosine triphosphatase Homo sapiens 80-84 18646716-1 2008 OBJECTIVE: To investigate the expression of nuclear factor-kappa-B (NF-KB)/P65 and fragile histidine triad (FHIT) in colorectal carcinoma and clinical significance thereof. Histidine 91-100 fragile histidine triad diadenosine triphosphatase Homo sapiens 108-112 18038314-1 2008 AIM: To investigate the relationship of fragile histidine triad (FHIT) and Ki-67 expression with clinicopathological variables of patients with malignant pleural mesothelioma (MPM). Histidine 48-57 fragile histidine triad diadenosine triphosphatase Homo sapiens 65-69 18077326-1 2007 The Fra3B locus on chromosome 3p14.2 targeting the fragile histidine triad (Fhit) gene represents one of the most common fragile sites of the human genome and is associated with early preneoplastic and malignant disorders in multiple human tumors. Histidine 59-68 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-9 18077326-1 2007 The Fra3B locus on chromosome 3p14.2 targeting the fragile histidine triad (Fhit) gene represents one of the most common fragile sites of the human genome and is associated with early preneoplastic and malignant disorders in multiple human tumors. Histidine 59-68 fragile histidine triad diadenosine triphosphatase Homo sapiens 76-80 17712558-4 2007 The O6 methylguanine DNA methyltransferase (MGMT) and fragile histidine triad (FHIT) genes are transcriptionally silenced by promoter hypermethylation in DLBCL. Histidine 62-71 fragile histidine triad diadenosine triphosphatase Homo sapiens 79-83 19514467-1 2009 The fragile histidine triad (Fhit) protein is a diadenosine triphosphate hydrolase belonging to the histidine triad family of nucleotide-binding proteins. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 19514467-1 2009 The fragile histidine triad (Fhit) protein is a diadenosine triphosphate hydrolase belonging to the histidine triad family of nucleotide-binding proteins. Histidine 100-109 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 19471558-1 2008 OBJECTIVE: The abnormal expression of fragile histidine triad (FHIT) gene has been frequently reported in a variety of epithelial malignancies including cervical carcinoma. Histidine 46-55 fragile histidine triad diadenosine triphosphatase Homo sapiens 63-67 18357366-1 2008 The fragile histidine triad (FHIT), frequently lost in many cancers, was identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 18243046-5 2008 Furthermore, the status of the fragile histidine triad gene (FHIT) in chromosome band 3p14.2 was studied by fluorescence in situ hybridization (FISH) in epithelial cells that had been cultured after removal of bleomycin. Histidine 39-48 fragile histidine triad diadenosine triphosphatase Homo sapiens 61-65 18618300-0 2008 Inverse correlation of aberrant expression of fragile histidine triad (FHIT) protein with cyclin D1 protein and prognosis in Chinese patients with cholangiocarcinoma. Histidine 54-63 fragile histidine triad diadenosine triphosphatase Homo sapiens 71-75 17694439-1 2007 Abnormality in the fragile histidine triade (FHIT), a candidate tumor suppressor gene located in chromosome region 3 (3p14.2), has been frequently found in multiple tumor types, including lung cancer. Histidine 27-36 fragile histidine triad diadenosine triphosphatase Homo sapiens 45-49 17974981-1 2007 The fragile histidine triad (FHIT) gene has been shown to function as a tumor suppressor gene in vitro and in vivo. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 17539022-3 2007 Consistent with a prior report, we demonstrated by RT-PCR of RNA from lymphoblastoid cells fusion mRNAs derived from the fragile histidine triad (FHIT) at 3p14 and TRC8 at 8q24.1 in both affected siblings. Histidine 129-138 fragile histidine triad diadenosine triphosphatase Homo sapiens 146-150 17359554-6 2007 In nasopharyngeal carcinoma, loss of heterozygosity at the FRA3B/fragile histidine triad locus correlated with the following clinicopathological parameters: tumour T-stage, lymph node status, clinical stage, tumour differentiation and serum antibody titres of immunoglobulin (Ig) A against Epstein-Barr virus capsid antigen. Histidine 73-82 fragile histidine triad diadenosine triphosphatase Homo sapiens 59-64 17596760-1 2007 OBJECTIVE: This cross-sectional study was intended to assess the association between immunohistochemical analysis of p16 and fragile histidine triad (FHIT) and the presence of precancerous cervical lesions. Histidine 133-142 fragile histidine triad diadenosine triphosphatase Homo sapiens 150-154 24557626-1 2007 We detected loss of heterozygosity (LOH) and microsatellite instabilities (MSI), as well as extron expression of the fragile histidine triad (FHIT) gene in gastric carcinoma (GC), in order to evaluate their association with clinicopathological processes in gastric carcinogenesis. Histidine 125-134 fragile histidine triad diadenosine triphosphatase Homo sapiens 142-146 17380463-1 2007 OBJECTIVE: To investigate the relationship between the expression of fragile histidine triad (FHIT) protein and the clinicopathological characteristics of rectal carcinoma. Histidine 77-86 fragile histidine triad diadenosine triphosphatase Homo sapiens 94-98 17393360-1 2007 The FHIT gene, a member of the histidine triad gene family, is a tumor suppressor gene exhibiting deletions in the majority of human cancers. Histidine 31-40 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 17143956-1 2006 AIM: To investigate the expression of fragile histidine triad (FHIT) protein in 64 patients with ulcerative colitis (UC) and Crohn"s disease (CD), and its relation with clinicopathological data. Histidine 46-55 fragile histidine triad diadenosine triphosphatase Homo sapiens 63-67 17107382-2 2006 OBJECTIVES: As recent data suggested the fragile histidine triad (FHIT) gene product to participate in DNA damage responses we wished to address whether functional deletion of this tumour suppressor participates in the development of BCC. Histidine 49-58 fragile histidine triad diadenosine triphosphatase Homo sapiens 66-70 21118644-1 2007 BACKGROUND: Fragile histidine triad (FHIT) is a candidate tumor suppressor gene. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 37-41 17310323-0 2007 Expression and simple, one-step purification of fragile histidine triad (Fhit) tumor suppressor mutant forms in Escherichia coli and their interaction with protoporphyrin IX. Histidine 56-65 fragile histidine triad diadenosine triphosphatase Homo sapiens 73-77 17310323-1 2007 The product of human fragile histidine triad (FHIT) gene is a tumor suppressor protein of still largely unknown cellular background. Histidine 29-38 fragile histidine triad diadenosine triphosphatase Homo sapiens 46-50 17310323-3 2007 Fhit, diadenosine triphosphate (Ap3A) hydrolase, possesses the active site with histidine triad His-phi-His-phi-His-phiphi. Histidine 80-89 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 17310323-3 2007 Fhit, diadenosine triphosphate (Ap3A) hydrolase, possesses the active site with histidine triad His-phi-His-phi-His-phiphi. Histidine 96-99 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 17310323-3 2007 Fhit, diadenosine triphosphate (Ap3A) hydrolase, possesses the active site with histidine triad His-phi-His-phi-His-phiphi. Histidine 104-107 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 17310323-3 2007 Fhit, diadenosine triphosphate (Ap3A) hydrolase, possesses the active site with histidine triad His-phi-His-phi-His-phiphi. Histidine 104-107 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 17310323-4 2007 So-called histidine Fhit mutants (His94Asn, His96Asn and His98Asn) exhibit highly reduced activity in vitro, however, their antitumor function has not been fully described yet. Histidine 10-19 fragile histidine triad diadenosine triphosphatase Homo sapiens 20-24 17548701-1 2007 Many studies have established that loss of heterozygosity and/or altered expression of the fragile histidine triad (FHIT) gene is a common event in a number of tumor types including prostate carcinoma. Histidine 99-108 fragile histidine triad diadenosine triphosphatase Homo sapiens 116-120 24557667-1 2007 The fragile histidine triad (FHIT) gene, a candidate tumor suppressor gene located at 3p14.2, has been shown to be involved in the carcinogenesis of many human tissues, including digestive tract tissues. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 17137614-0 2007 Abnormal fragile histidine triad (Fhit) expression in invasive cervical adenocarcinoma: association with tumor aggressiveness. Histidine 17-26 fragile histidine triad diadenosine triphosphatase Homo sapiens 34-38 17137614-1 2007 The fragile histidine triad (FHIT) gene is a candidate tumor suppressor gene. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 17609851-1 2007 The fragile histidine triad (FHIT), which was located on chromosome 3p14.2, was currently considered a promising candidate for a tumor suppressor gene. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 17382535-1 2006 Fragile histidine triad (FHIT) gene, a candidate tumor suppressor gene located at 3p14.2, has been shown to be involved in carcinogenesis of many human tissues, including digestive tract tissues. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 17119051-1 2006 BACKGROUND: In a retrospective analysis of 195 patients with small cell lung cancer (SCLC), we examined the prognostic value of a coexpression of fragile histidine triad (FHIT) protein and c-kit on patient"s survival. Histidine 154-163 fragile histidine triad diadenosine triphosphatase Homo sapiens 171-175 16773697-1 2006 AIM: To detect the loss of heterozygosity (LOH) and microsatellite instabi1ities (MSI) of fragile histidine triad (FHIT) gene in gastric carcinoma and to study their association with the clinical pathological characteristics of gastric carcinoma. Histidine 98-107 fragile histidine triad diadenosine triphosphatase Homo sapiens 115-119 17064501-1 2006 OBJECTIVE: To investigate the expression of the genes fragile histidine triad (FHIT), Bcl-2, and Bax, biological markers of breast infiltrating ductal carcinoma in this carcinoma and clinicopathological significance thereof. Histidine 62-71 fragile histidine triad diadenosine triphosphatase Homo sapiens 79-83 16895604-2 2006 The two most commonly expressed fragile sites FRA3B and FRA16D host the histidine triad (FHIT) and WW domain containing oxidoreductase (WWOX) genes respectively. Histidine 72-81 fragile histidine triad diadenosine triphosphatase Homo sapiens 46-51 16895604-2 2006 The two most commonly expressed fragile sites FRA3B and FRA16D host the histidine triad (FHIT) and WW domain containing oxidoreductase (WWOX) genes respectively. Histidine 72-81 fragile histidine triad diadenosine triphosphatase Homo sapiens 89-93 16863736-2 2006 The fragile histidine triad (FHIT) gene is considered a tumor suppressor gene in different human epithelial cancers. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 16885564-1 2006 Loss of fragile histidine triad (Fhit) expression is often associated with human malignancies, and Fhit functions as a tumor suppressor in controlling cell growth and apoptosis, although specific signal pathways are still undefined. Histidine 16-25 fragile histidine triad diadenosine triphosphatase Homo sapiens 33-37 16698048-2 2006 Human FHIT (fragile histidine triad) gene is highly conserved gene whose loss of function may be important in the development and/or progression of various types of cancer. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 6-10 16821595-2 2006 The purpose of this study was to clarify whether the fragile histidine triad (FHIT) is their target gene in esophageal carcinogenesis as well as in multicentric carcinogenesis. Histidine 61-70 fragile histidine triad diadenosine triphosphatase Homo sapiens 78-82 16985034-1 2006 AIM: The fragile histidine triad (FHIT) gene was discovered and proposed as a tumor suppressor gene for most human cancers. Histidine 17-26 fragile histidine triad diadenosine triphosphatase Homo sapiens 34-38 17009983-2 2006 However, no report existed regarding the methylation status of the fragile histidine triad (FHIT) and E-cadherin genes in plasma samples of cervical cancer patients. Histidine 75-84 fragile histidine triad diadenosine triphosphatase Homo sapiens 92-96 16733051-1 2006 Fragile histidine triad (FHIT) gene is involved in the deletions at the 3p14.2 region in various cancers. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 16407838-1 2006 The Fhit tumor suppressor binds and hydrolyses diadenosine polyphosphates and the Fhit-substrate complex has been proposed as a proapoptotic effector, as determined by infection of susceptible cancer cells with adenoviruses carrying wild-type fragile histidine triad (FHIT) or catalytic site mutants. Histidine 251-260 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 16407838-1 2006 The Fhit tumor suppressor binds and hydrolyses diadenosine polyphosphates and the Fhit-substrate complex has been proposed as a proapoptotic effector, as determined by infection of susceptible cancer cells with adenoviruses carrying wild-type fragile histidine triad (FHIT) or catalytic site mutants. Histidine 251-260 fragile histidine triad diadenosine triphosphatase Homo sapiens 82-86 16800968-1 2006 BACKGROUND: The fragile histidine triad (FHIT) gene is located at 3p14.2, a region frequently lost in various tumor types. Histidine 24-33 fragile histidine triad diadenosine triphosphatase Homo sapiens 41-45 16777001-0 2006 [Expression of fragile histidine triad (FHIT) protein and its significance in diagnosing classical Hodgkin lymphoma]. Histidine 23-32 fragile histidine triad diadenosine triphosphatase Homo sapiens 40-44 15935551-1 2006 The fragile histidine triad (FHIT), located in chromosome region 3p14.2, had been reported to be a frequent allele with loss of heterozygosity (LOH) in smoking lung cancer and HPV-associated cervical cancer. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 16231322-1 2006 The fragile histidine triad (FHIT) gene is a frequent target of deletions in lung cancer. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 16513840-1 2006 The fragile histidine triad (FHIT) gene located at the 3p14.2 locus plays an important role in the pathogenesis of lung cancer. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 16204026-1 2005 Fragile histidine triad (FHIT) gene deletion or promoter methylation and reduced Fhit protein expression occur in approximately 70% of human epithelial tumors and, in some cancers, are clearly associated with tumor progression. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 16378185-2 2006 Two tumor suppressor genes, the fragile histidine triad (FHIT) gene and the WW domain-containing oxidoreductase (WWOX), map to the common fragile sites, FRA3B and FRA16D, respectively. Histidine 40-49 fragile histidine triad diadenosine triphosphatase Homo sapiens 57-61 16378185-2 2006 Two tumor suppressor genes, the fragile histidine triad (FHIT) gene and the WW domain-containing oxidoreductase (WWOX), map to the common fragile sites, FRA3B and FRA16D, respectively. Histidine 40-49 fragile histidine triad diadenosine triphosphatase Homo sapiens 153-158 16115913-2 2005 The fragile histidine triad (FHIT) gene is a tumor suppressor gene that is altered in 80% of tobacco-associated lung cancers. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 16237777-1 2005 AIM: To investigate the expression of fragile histidine triad (FHIT) protein, and the possible relationship between FHIT expression and clinicopathological indices in gastric carcinoma. Histidine 46-55 fragile histidine triad diadenosine triphosphatase Homo sapiens 63-67 15902282-1 2005 To clarify the role of fragile histidine triad (FHIT) in hematological malignancies, we examined the methylation status and the expression level of the FHIT gene in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) cells in comparison with the methylation of the p15(INK4B) gene. Histidine 31-40 fragile histidine triad diadenosine triphosphatase Homo sapiens 48-52 16027075-1 2005 OBJECTIVE: To detect the expressions of fragile histidine triad (FHIT) and cyclin D1/CDK4 in oral squamous cell carcinoma (OSCC) and oral precancerous lesions and investigate the relationship between the expressions and the histopathological changes. Histidine 48-57 fragile histidine triad diadenosine triphosphatase Homo sapiens 65-69 16030101-1 2005 OBJECTIVE: The fragile histidine triad (FHIT) gene is a putative tumor suppressor gene that is thought to be involved in the carcinogenesis of breast cancer. Histidine 23-32 fragile histidine triad diadenosine triphosphatase Homo sapiens 40-44 15929169-1 2005 AIM: To examine the aberrant expression of fragile histidine triad (FHIT) gene and protein in gastric cancer, and to evaluate the role of FHIT gene and the relationship between FHIT gene and EBV infection in gastric carcinogenesis. Histidine 51-60 fragile histidine triad diadenosine triphosphatase Homo sapiens 68-72 16078573-1 2005 OBJECTIVE: To explore the relationship of loss of heterozygosity (LOH) and microsatellite instability (MI) of fragile histidine triad (FHIT) gene to the development of cervical carcinoma. Histidine 118-127 fragile histidine triad diadenosine triphosphatase Homo sapiens 135-139 15674328-1 2005 This study aimed to (a) determine if DNA methylation is a mechanism of WWOX (WW domain containing oxidoreductase) and FHIT (fragile histidine triad) inactivation in lung, breast and bladder cancers; (b) examine distinct methylation patterns in neoplastic and adjacent tissues and (c) seek correlation of methylation patterns with disease status. Histidine 132-141 fragile histidine triad diadenosine triphosphatase Homo sapiens 118-122 15897145-1 2005 OBJECTIVE: To detect the expression of fragile histidine triad (FHIT) in oral cancer and oral precancerous lesions and investigate the relationship between the FHIT expression and the histopathological changes. Histidine 47-56 fragile histidine triad diadenosine triphosphatase Homo sapiens 64-68 15949315-1 2005 OBJECTIVE: To investigate the inhibition effects of fragile histidine triad (FHIT) gene on the malignant growth of A549 cell line. Histidine 60-69 fragile histidine triad diadenosine triphosphatase Homo sapiens 77-81 15835917-1 2005 The human tumor suppressor Fhit is a homodimeric histidine triad (HIT) protein of 147 amino acids which has Ap(3)A hydrolase activity. Histidine 49-58 fragile histidine triad diadenosine triphosphatase Homo sapiens 27-31 15835917-1 2005 The human tumor suppressor Fhit is a homodimeric histidine triad (HIT) protein of 147 amino acids which has Ap(3)A hydrolase activity. Histidine 49-58 fragile histidine triad diadenosine triphosphatase Homo sapiens 108-124 15480422-4 2004 All of the deleted regions were located within the fragile histidine triad (FHIT) gene, and the most frequent region of loss was mapped to 0.4 Mbp of the region encompassing the introns 4 and 5 and exon 5 of the FHIT gene. Histidine 59-68 fragile histidine triad diadenosine triphosphatase Homo sapiens 76-80 15610452-1 2005 BACKGROUND AND AIM: The present study was conducted to address whether homozygous deletion (HZD) or transcriptional alterations of the fragile histidine triad (FHIT) gene play a role in the development and progression of hepatitis C virus-associated hepatocellular carcinoma (HCC). Histidine 143-152 fragile histidine triad diadenosine triphosphatase Homo sapiens 160-164 15906520-1 2005 OBJECTIVE: To investigate the loss of heterozygosity (LOH) and microsatellite instability (MSI) of fragile histidine triad (FHIT) gene in laryngeal squamous cell carcinoma (LSCC). Histidine 107-116 fragile histidine triad diadenosine triphosphatase Homo sapiens 124-128 15489891-1 2004 The expression of the tumour suppressor protein fragile histidine triad (Fhit) is often impaired in many human cancers and its restoration in Fhit-negative cancer cell lines suppresses tumorigenicity and induces apoptosis. Histidine 56-65 fragile histidine triad diadenosine triphosphatase Homo sapiens 73-77 15489891-1 2004 The expression of the tumour suppressor protein fragile histidine triad (Fhit) is often impaired in many human cancers and its restoration in Fhit-negative cancer cell lines suppresses tumorigenicity and induces apoptosis. Histidine 56-65 fragile histidine triad diadenosine triphosphatase Homo sapiens 142-146 15361849-1 2004 Abnormalities in the expression of the tumour suppressor fragile histidine triad (FHIT) gene have been reported in a variety of human tumours, including lung cancer and restoration of its expression in cancer cell lines resulted in the inhibition of proliferation and apoptosis induction. Histidine 65-74 fragile histidine triad diadenosine triphosphatase Homo sapiens 82-86 15384174-0 2004 Frequent silencing of fragile histidine triad gene (FHIT) in Burkitt"s lymphoma is associated with aberrant hypermethylation. Histidine 30-39 fragile histidine triad diadenosine triphosphatase Homo sapiens 52-56 15384174-1 2004 The fragile histidine triad (FHIT) gene, a potential tumor-suppressor gene, is frequently inactivated in multiple human cancers. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 15569992-1 2004 The fragile histidine triad (FHIT) gene located on chromosome 3p14.2 is frequently deleted in human tumors. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 15219888-1 2004 OBJECTIVE: Loss of the fragile histidine triad (Fhit) protein has been documented in cervical cancer and dysplasia. Histidine 31-40 fragile histidine triad diadenosine triphosphatase Homo sapiens 48-52 15573771-1 2004 OBJECTIVE: To explore the relationship between reduction of FHIT expression of fragile histidine triad (FHIT) and the development of cervical carcinoma. Histidine 87-96 fragile histidine triad diadenosine triphosphatase Homo sapiens 60-64 15573771-1 2004 OBJECTIVE: To explore the relationship between reduction of FHIT expression of fragile histidine triad (FHIT) and the development of cervical carcinoma. Histidine 87-96 fragile histidine triad diadenosine triphosphatase Homo sapiens 104-108 15341994-1 2004 The relative contribution of promoter hypermethylation and aberrant splicing to the inactivation of the fragile histidine triad (FHIT) gene is unclear. Histidine 112-121 fragile histidine triad diadenosine triphosphatase Homo sapiens 129-133 15627891-0 2004 Aberrations in the fragile histidine triad(FHIT) gene may be involved in lung carcinogenesis in patients with chronic pulmonary tuberculosis. Histidine 27-36 fragile histidine triad diadenosine triphosphatase Homo sapiens 43-47 15239028-1 2004 OBJECTIVE: To determine the prognostic significance of p53 and fragile histidine triad (FHIT) expression in advanced oropharyngeal squamous cell carcinoma. Histidine 71-80 fragile histidine triad diadenosine triphosphatase Homo sapiens 88-92 15231689-1 2004 Fragile histidine triad (FHIT) gene plays an important role in the pathogenesis of lung cancer. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 15363189-2 2004 Fragile histidine triad (FHIT) gene is located in 3p14.2, and its deletion or abnormal expression was found in many kinds of cancers. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 15246872-1 2004 Fhit protein is the product of the putative tumor suppressor fragile histidine triad (FHIT) gene. Histidine 69-78 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 15246872-1 2004 Fhit protein is the product of the putative tumor suppressor fragile histidine triad (FHIT) gene. Histidine 69-78 fragile histidine triad diadenosine triphosphatase Homo sapiens 86-90 15182206-0 2004 The mechanism of action of the fragile histidine triad, Fhit: isolation of a covalent adenylyl enzyme and chemical rescue of H96G-Fhit. Histidine 39-48 fragile histidine triad diadenosine triphosphatase Homo sapiens 56-60 15182206-0 2004 The mechanism of action of the fragile histidine triad, Fhit: isolation of a covalent adenylyl enzyme and chemical rescue of H96G-Fhit. Histidine 39-48 fragile histidine triad diadenosine triphosphatase Homo sapiens 130-134 15182206-1 2004 The human fragile histidine triad protein Fhit catalyzes the Mg(2+)-dependent hydrolysis of P(1)-5"-O-adenosine-P(3)-5"-O-adenosine triphosphate, Ap(3)A, to AMP and ADP. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 42-46 15168591-2 2004 In 1996 the fragile histidine triad (FHIT) gene was isolated from the region encompassing the most active fragile FRA3B locus, and recently the WW domain-containing oxidoreductase gene (WWOX) was identified at FRA16D. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 37-41 15168591-2 2004 In 1996 the fragile histidine triad (FHIT) gene was isolated from the region encompassing the most active fragile FRA3B locus, and recently the WW domain-containing oxidoreductase gene (WWOX) was identified at FRA16D. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 114-119 14976524-1 2004 The fragile histidine triad (FHIT) gene, located at chromosome 3p14.2, is deleted in many solid tumors, including lung cancer. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 15025965-0 2004 [Abnormal expression of fragile histidine triad (FHIT) and Mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance]. Histidine 32-41 fragile histidine triad diadenosine triphosphatase Homo sapiens 49-53 15026336-1 2004 The human FHIT (fragile histidine triad) gene is a putative tumor suppressor gene located at chromosome region 3p14.2. Histidine 24-33 fragile histidine triad diadenosine triphosphatase Homo sapiens 10-14 15032614-2 2004 In 1996, the human fragile histidine triad gene, FHIT, was identified by positional cloning of the chromosome region spanning the carcinogen-sensitive, common fragile site, FRA3B at 3p14.2. Histidine 27-36 fragile histidine triad diadenosine triphosphatase Homo sapiens 49-53 15032614-2 2004 In 1996, the human fragile histidine triad gene, FHIT, was identified by positional cloning of the chromosome region spanning the carcinogen-sensitive, common fragile site, FRA3B at 3p14.2. Histidine 27-36 fragile histidine triad diadenosine triphosphatase Homo sapiens 173-178 15025965-1 2004 BACKGROUND & OBJECTIVE: Frequent loss of fragile histidine triad (FHIT) expression in human gastrointestinal tract carcinomas has been reported; however, there were divergent opinions regarding FHIT expression in colorectal carcinoma. Histidine 53-62 fragile histidine triad diadenosine triphosphatase Homo sapiens 70-74 15025965-1 2004 BACKGROUND & OBJECTIVE: Frequent loss of fragile histidine triad (FHIT) expression in human gastrointestinal tract carcinomas has been reported; however, there were divergent opinions regarding FHIT expression in colorectal carcinoma. Histidine 53-62 fragile histidine triad diadenosine triphosphatase Homo sapiens 198-202 15067734-1 2004 OBJECTIVE: To investigate the effect of fragile histidine triad (FHIT) gene on the apoptosis of gastric cancer cells. Histidine 48-57 fragile histidine triad diadenosine triphosphatase Homo sapiens 65-69 15071908-1 2004 OBJECTIVE: To study the expression of fragile histidine triad (FHIT) protein in rhabdomyosarcoma(RMS) and the possible mechanisms of its effect on tumor. Histidine 46-55 fragile histidine triad diadenosine triphosphatase Homo sapiens 63-67 14760383-1 2004 The fragile histidine triad (FHIT) gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumour suppressor gene involved in a variety of tumours, including gastric carcinomas. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 14760383-1 2004 The fragile histidine triad (FHIT) gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumour suppressor gene involved in a variety of tumours, including gastric carcinomas. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 58-63 14678517-2 2003 In 1996, the human fragile histidine triad gene, FHIT, was identified by positional cloning at 3p14.2, a chromosomal region spanning the carcinogen-sensitive, common fragile site FRA3B. Histidine 27-36 fragile histidine triad diadenosine triphosphatase Homo sapiens 49-53 14678517-2 2003 In 1996, the human fragile histidine triad gene, FHIT, was identified by positional cloning at 3p14.2, a chromosomal region spanning the carcinogen-sensitive, common fragile site FRA3B. Histidine 27-36 fragile histidine triad diadenosine triphosphatase Homo sapiens 179-184 14569398-4 2004 The FHIT (fragile histidine triad) tumour suppressor gene, located at 3p14.2, has been proposed to be a target to major human lung carcinogens, such as tobacco smoke and asbestos. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 14695704-1 2003 BACKGROUND/AIMS: The fragile histidine triad (FHIT) gene located at chromosome 3p14.2, is a candidate tumor suppressor gene often involved in various tumors. Histidine 29-38 fragile histidine triad diadenosine triphosphatase Homo sapiens 46-50 12893195-1 2003 OBJECTIVE: The fragile histidine triad (FHIT) gene is located at chromosome 3p14.2 and encompasses the common fragile site, FRA3B, which may contribute to chromosome breakage and rearrangement of cancer cells. Histidine 23-32 fragile histidine triad diadenosine triphosphatase Homo sapiens 40-44 14638866-2 2003 Because the fragile histidine triad (FHIT) gene, a tumor suppressor gene encompassing the most active, common fragile site FRA3B, is frequently deleted in various cancers, we evaluated the expression of WWOX and FHIT in 74 cases of primary hematopoietic neoplasias and 20 leukemia cell lines. Histidine 20-29 fragile histidine triad diadenosine triphosphatase Homo sapiens 37-41 12964015-1 2003 It is unclear how expression of the FHIT (fragile histidine triad) gene by the colorectal neoplasm correlates with histogenesis and progression of the disease. Histidine 50-59 fragile histidine triad diadenosine triphosphatase Homo sapiens 36-40 12969785-2 2003 The Fragile Histidine Triad (FHIT) gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumor suppressor gene in a variety of human malignancies. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 12969785-2 2003 The Fragile Histidine Triad (FHIT) gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumor suppressor gene in a variety of human malignancies. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 58-63 12867802-2 2003 Since little is known about the development of this cancer, we searched for alterations to the fragile histidine triad (FHIT) gene, a putative tumour suppressor gene on chromosome 3p14.2. Histidine 103-112 fragile histidine triad diadenosine triphosphatase Homo sapiens 120-124 12893195-1 2003 OBJECTIVE: The fragile histidine triad (FHIT) gene is located at chromosome 3p14.2 and encompasses the common fragile site, FRA3B, which may contribute to chromosome breakage and rearrangement of cancer cells. Histidine 23-32 fragile histidine triad diadenosine triphosphatase Homo sapiens 124-129 12865924-1 2003 Abnormalities of fragile histidine triad (FHIT) and TP53 have been found frequently in nonsmall cell lung cancers. Histidine 25-34 fragile histidine triad diadenosine triphosphatase Homo sapiens 42-46 12744737-1 2003 FHIT (fragile histidine triad) gene at chromosome 3p14.2 usually expresses at a very low level in human tissue and cells. Histidine 14-23 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 12800227-1 2003 AIM: To investigate the expression of fragile histidine triad (FHIT) gene protein, Fhit, which is recently thought to be a candidate tumor suppressor. Histidine 46-55 fragile histidine triad diadenosine triphosphatase Homo sapiens 63-67 12800227-1 2003 AIM: To investigate the expression of fragile histidine triad (FHIT) gene protein, Fhit, which is recently thought to be a candidate tumor suppressor. Histidine 46-55 fragile histidine triad diadenosine triphosphatase Homo sapiens 83-87 12926121-1 2003 BACKGROUND: The fragile histidine triad (FHIT) gene is a candidate tumor suppressor gene located at 3p14.2, and the absence or reduction of Fhit protein expression has recently been reported in various carcinomas. Histidine 24-33 fragile histidine triad diadenosine triphosphatase Homo sapiens 41-45 12698186-1 2003 We analysed the expression of the fragile histidine triad (FHIT) gene in cervical cancer to evaluate its clinical relevance in relation to human papillomavirus (HPV) infection. Histidine 42-51 fragile histidine triad diadenosine triphosphatase Homo sapiens 59-63 12649173-0 2003 Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines. Histidine 23-32 fragile histidine triad diadenosine triphosphatase Homo sapiens 40-44 12649173-1 2003 The fragile histidine triad (FHIT) gene at chromosome 3p14.2 is a tumor suppressor gene that is altered mainly by deletion in a large fraction of human tumors, including breast cancers. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 12627509-1 2003 BACKGROUND: The fragile histidine triad (FHIT) gene is a tumor suppressor gene that belongs to the histidine triad family of nucleoside binding proteins. Histidine 24-33 fragile histidine triad diadenosine triphosphatase Homo sapiens 41-45 12561436-2 2003 Fragile histidine triad (FHIT) gene is an important tumor suppressor gene at the fragile sites region of 3p14. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 12574506-3 2003 Fhit, a member of branch 2 of the histidine-triad superfamily of nucleoside monophosphate hydrolases and transferases, is a diadenosine polyphosphate hydrolase, the active-site histidine of which is not required for tumor suppression. Histidine 34-43 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 12457722-2 2003 Fragile histidine triad (FHIT) gene is located at 3p14.2 encompassing a common fragile site, and is identified as a tumor suppressor gene. Histidine 8-17 fragile histidine triad diadenosine triphosphatase Homo sapiens 25-29 12483524-2 2002 Previous reports indicate aphidicolin-induced FRA3B instability occurs over approximately 500 kb which is spanned by the 1.5 Mb fragile histidine triad (FHIT) gene. Histidine 136-145 fragile histidine triad diadenosine triphosphatase Homo sapiens 46-51 12483524-2 2002 Previous reports indicate aphidicolin-induced FRA3B instability occurs over approximately 500 kb which is spanned by the 1.5 Mb fragile histidine triad (FHIT) gene. Histidine 136-145 fragile histidine triad diadenosine triphosphatase Homo sapiens 153-157 12355215-1 2002 BACKGROUND AND AIMS: The fragile histidine triad (FHIT) gene, which is frequently lost in many cancers, has been identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2. Histidine 33-42 fragile histidine triad diadenosine triphosphatase Homo sapiens 50-54 12057912-2 2002 Our recent allelotyping analyses have indicated that chromosome 3p loss of heterozygosity (LOH), including the fragile histidine triad (FHIT) candidate tumor-suppressor gene locus at 3p14.2, is frequently detected in this neoplasm. Histidine 119-128 fragile histidine triad diadenosine triphosphatase Homo sapiens 136-140 12177781-1 2002 The Fragile Histidine Triad gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumour suppressor gene involved in multiple tumour types including colorectal carcinomas. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 51-56 12452072-1 2002 BACKGROUND & OBJECTIVE: Fragile histidine triad(FHIT), a tumor suppressor candidate gene, encompasses FRA3B, a common region with the highest fragility in the human genome, and is altered in a large number of human cancers, particularly those of epithelial cell origin and associated with known carcinogenic agents. Histidine 36-45 fragile histidine triad diadenosine triphosphatase Homo sapiens 52-56 12452072-1 2002 BACKGROUND & OBJECTIVE: Fragile histidine triad(FHIT), a tumor suppressor candidate gene, encompasses FRA3B, a common region with the highest fragility in the human genome, and is altered in a large number of human cancers, particularly those of epithelial cell origin and associated with known carcinogenic agents. Histidine 36-45 fragile histidine triad diadenosine triphosphatase Homo sapiens 106-111 11683369-1 2001 BACKGROUND: Human FHIT (fragile histidine triad) gene is highly conserved gene homologous to a group of genes identified in prokaryotes and eukaryotes. Histidine 32-41 fragile histidine triad diadenosine triphosphatase Homo sapiens 18-22 12048684-1 2002 OBJECTIVE: To explore the role of fragile histidine triad(FHIT) gene in the proliferation, apoptosis and tumorigenesis of human lung cancer cells. Histidine 42-51 fragile histidine triad diadenosine triphosphatase Homo sapiens 58-62 11532518-1 2001 The FHIT (fragile histidine triad) gene, which is located on 3p14.2 and believed to be a tumor suppressor gene, has been reported to lose its expression in several solid tumors and hematologic malignancies, including acute lymphoblastic leukemia (ALL). Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 11992403-7 2002 Although in 2 of 3 SCC lines 3p loss was correlated with reduced expression of the FHIT (fragile histidine triad) gene, the potential tumor suppressor mapped to 3p14.2 and 2 MCC lines with normal 3p showed aberrant or no FHIT transcripts. Histidine 97-106 fragile histidine triad diadenosine triphosphatase Homo sapiens 83-87 11920739-1 2002 Clear cell renal cell carcinomas (RCCs) are characterized by a deletion of chromosome 3p, which might result in the inactivation of the FHIT (fragile histidine triad) gene, a putative tumour suppressor gene. Histidine 150-159 fragile histidine triad diadenosine triphosphatase Homo sapiens 136-140 11896678-1 2002 FHIT (Fragile Histidine Triad) is a human tumor suppressor gene. Histidine 14-23 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 11896678-13 2002 Since Cys-39 is not readily accessible in the Fhit molecule, the reaction is most likely facilitated by conformational changes which follow the coordination of Cu(II) by the surface histidines 35, 94, and/or 96. Histidine 182-192 fragile histidine triad diadenosine triphosphatase Homo sapiens 46-50 21315018-1 2002 BACKGROUND: To investigate the role of FHIT (fragile histidine triad) gene in oncogenesis and progression of human lung cancer. Histidine 53-62 fragile histidine triad diadenosine triphosphatase Homo sapiens 39-43 12090476-1 2002 The FHIT gene, a member of the histidine triad family has been identified as a tumor suppressor gene. Histidine 31-40 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 11768238-1 2001 The FHIT (fragile histidine triad) gene located at chromosome 3p14.2 has been proposed as a candidate tumor suppressor gene in human cancers. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 11525944-1 2001 Five years ago the fragile histidine triad (FHIT) gene including the most common fragile site locus of the human genome, FRA3B, was identified. Histidine 27-36 fragile histidine triad diadenosine triphosphatase Homo sapiens 44-48 11525944-1 2001 Five years ago the fragile histidine triad (FHIT) gene including the most common fragile site locus of the human genome, FRA3B, was identified. Histidine 27-36 fragile histidine triad diadenosine triphosphatase Homo sapiens 121-126 11531281-0 2001 FHIT (fragile histidine triad) gene analysis in cervical intraepithelial neoplasia. Histidine 14-23 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 11531281-1 2001 OBJECTIVE: Recently a candidate tumor suppressor gene, FHIT (fragile histidine triad), was identified at chromosome 3p14.2. Histidine 69-78 fragile histidine triad diadenosine triphosphatase Homo sapiens 55-59 11461085-1 2001 The FHIT (fragile histidine triad) gene on chromosome 3p14.2 is a candidate tumour suppressor gene. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 11406559-1 2001 The fragile histidine triad (FHIT) gene is a tumor suppressor gene that is altered by deletion in a large fraction of human tumors, including pancreatic cancer. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 11389064-0 2001 Abnormal fragile histidine triad (FHIT) expression in advanced cervical carcinoma: a poor prognostic factor. Histidine 17-26 fragile histidine triad diadenosine triphosphatase Homo sapiens 34-38 11402444-1 2001 OBJECTIVE: To investigate the role of FHIT(fragile histidine triad) gene in oncogenesis and progression of human lung cancer and explore the relationship of FHIT gene expression with the proliferation and apoptosis of tumor cells. Histidine 51-60 fragile histidine triad diadenosine triphosphatase Homo sapiens 38-42 11337267-5 2001 Recently, the human fragile histidine triad (FHIT) gene was isolated from this region, abnormalities of which have been found at high frequencies in several types of human cancers. Histidine 28-37 fragile histidine triad diadenosine triphosphatase Homo sapiens 45-49 11325823-1 2001 Allele loss and loss of expression of fragile histidine triad (FHIT), a putative tumor suppressor gene located in chromosome region 3p14.2, are frequent in several types of cancers. Histidine 46-55 fragile histidine triad diadenosine triphosphatase Homo sapiens 63-67 10896994-1 2000 BACKGROUND: Recently, fragile histidine triad (FHIT) gene abnormality has been thought to be associated with several malignancies and smoking history. Histidine 30-39 fragile histidine triad diadenosine triphosphatase Homo sapiens 47-51 11115560-2 2001 The majority (4/5) of the patients had LOH at or close to the fragile histidine triad (FHIT) gene (3p14.2; D3S1300), which is a candidate tumor suppressor gene for many cancer types. Histidine 70-79 fragile histidine triad diadenosine triphosphatase Homo sapiens 87-91 11085938-0 2000 Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9. Histidine 29-38 fragile histidine triad diadenosine triphosphatase Homo sapiens 15-19 11085938-1 2000 FHIT (fragile histidine triad), a candidate tumour suppressor gene, has recently been identified at chromosomal region 3p14.2, and deletions of the gene have been reported in many types of human cancer. Histidine 14-23 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 11301476-3 2001 The region of 3p14.2-pter encompasses a region of frequent loss and contains at least three tumor-suppressor genes: fragile histidine triad (FHIT), transforming growth factor-beta receptor II (T beta R-II), and Von Hippel-Lindau. Histidine 124-133 fragile histidine triad diadenosine triphosphatase Homo sapiens 141-145 11007995-9 2000 Interestingly, the human fragile histidine triad (Fhit) tumor suppressor protein appears to be a typical Np(3)N" hydrolase. Histidine 33-42 fragile histidine triad diadenosine triphosphatase Homo sapiens 50-54 11007995-16 2000 In contrast, the Schizosaccharomyces pombe Ap(4)A/Ap(3)A hydrolase, the human Fhit protein, and the yeast Np(n)N" phosphorylases belong to a superfamily GAFH, which includes the histidine triad proteins. Histidine 178-187 fragile histidine triad diadenosine triphosphatase Homo sapiens 78-82 10850413-1 2000 Hemizygous deletions of the fragile histidine triad (FHIT) gene at human chromosome band 3p14.2 and down-regulation of its gene product are found in the majority of renal cell carcinomas (RCCs). Histidine 36-45 fragile histidine triad diadenosine triphosphatase Homo sapiens 53-57 10937063-1 2000 The fragile histidine triad (FHIT) protein is a suspected tumor-suppressor gene frequently expressed in adenocarcinomas of the lung and other organs. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 10873085-1 2000 Abnormalities in structure and expression of the fragile histidine triad transcription (FHIT) gene have been reported in a variety of cancers, including endometrial cancers. Histidine 57-66 fragile histidine triad diadenosine triphosphatase Homo sapiens 88-92 10812172-1 2000 The fragile histidine triad (FHIT) gene is localized on chromosome 3p14 and spans the common fragile site FRA3B. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 10812172-1 2000 The fragile histidine triad (FHIT) gene is localized on chromosome 3p14 and spans the common fragile site FRA3B. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 106-111 10733886-2 2000 We have cloned the human cDNA Fhit in the pPROEX-1 vector and expressed with high yield in Escherichia coli with the sequence Met-Gly-His(6)-Asp-Tyr-Asp-Ile-Pro-Thr-Thr followed by a rTEV protease cleavage site, denoted as "H6TV," fused to the N-terminus of Fhit. Histidine 134-137 fragile histidine triad diadenosine triphosphatase Homo sapiens 30-34 10754525-1 2000 BACKGROUND: The fragile histidine triad (FHIT) is frequently deleted and altered in many human cancers. Histidine 24-33 fragile histidine triad diadenosine triphosphatase Homo sapiens 41-45 10646844-1 2000 Abnormal expression of the fragile histidine triad (FHIT) candidate tumor suppressor gene has been observed in a variety of human tumors, but little is known about its expression during colorectal tumorigenesis. Histidine 35-44 fragile histidine triad diadenosine triphosphatase Homo sapiens 52-56 10745170-1 2000 The FHIT (fragile histidine triad) gene at chromosome 3p14.2 spans the FRA3B fragile site and encodes for a diadenosine triphosphate hydrolase-type protein. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 10745170-1 2000 The FHIT (fragile histidine triad) gene at chromosome 3p14.2 spans the FRA3B fragile site and encodes for a diadenosine triphosphate hydrolase-type protein. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 71-76 10745171-1 2000 Genetic alterations at the FHIT (fragile histidine triad) tumor suppressor gene have been found in various human cancers. Histidine 41-50 fragile histidine triad diadenosine triphosphatase Homo sapiens 27-31 10671479-1 2000 Fhit, a member of the histidine triad superfamily of nucleotide-binding proteins, binds and cleaves diadenosine polyphosphates and functions as a tumor suppressor in human epithelial cancers. Histidine 22-31 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 10675384-2 2000 The fragile histidine triad (FHIT) gene at chromosome region 3p14.2 is a candidate tumor suppressor gene that may play a role in cervical tumorigenesis. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 10652418-1 2000 The fhit (fragile histidine triad) gene on chromosome 3p14.2 is a candidate tumour-suppressor gene; its abnormal transcripts are detected in several human cancers. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 9824201-2 1998 Recently, the FHIT (fragile histidine triad) gene was identified in this part of chromosome 3 as a candidate suppressor gene, and abnormal transcripts of this gene have been observed in various human tumors, including breast tumors. Histidine 28-37 fragile histidine triad diadenosine triphosphatase Homo sapiens 14-18 10440747-1 1999 The FHIT (fragile histidine triad) gene has been recently identified and cloned at chromosome 3p14.2 including FRA3B, the most common fragile site in the human genome. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 10440747-1 1999 The FHIT (fragile histidine triad) gene has been recently identified and cloned at chromosome 3p14.2 including FRA3B, the most common fragile site in the human genome. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 111-116 10411902-1 1999 Alteration of the FHIT (fragile histidine triad) gene occurs as an early and frequent event in lung carcinogenesis. Histidine 32-41 fragile histidine triad diadenosine triphosphatase Homo sapiens 18-22 10416589-0 1999 Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression. Histidine 111-120 fragile histidine triad diadenosine triphosphatase Homo sapiens 128-132 10416589-1 1999 We studied the effects of fragile histidine triad (FHIT) gene overexpression mediated by an adenoviral vector, Ad-FHIT, on cell proliferation, apoptosis, and cell cycle kinetics in human cancer cells and on tumorigenicity and tumor growth in nude mice. Histidine 34-43 fragile histidine triad diadenosine triphosphatase Homo sapiens 51-55 10090754-5 1999 The active site of Fhit contains a histidine motif that is reminiscent of the HPH motif in galactose-1-phosphate uridylyltransferases, in which the first histidine residue serves as the nucleophilic catalyst to which the nucleotidyl group is bonded covalently in the covalent intermediate. Histidine 35-44 fragile histidine triad diadenosine triphosphatase Homo sapiens 19-23 10090754-5 1999 The active site of Fhit contains a histidine motif that is reminiscent of the HPH motif in galactose-1-phosphate uridylyltransferases, in which the first histidine residue serves as the nucleophilic catalyst to which the nucleotidyl group is bonded covalently in the covalent intermediate. Histidine 154-163 fragile histidine triad diadenosine triphosphatase Homo sapiens 19-23 10027335-1 1999 To investigate involvement of an aberrant expression of the FHIT (fragile histidine triad) gene in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by the reverse transcriptase polymerase chain reaction (RT-PCR) and cDNA sequence method in 32 cervical invasive carcinomas (25 squamous cell carcinomas and seven adeno- or adenosquamous carcinomas) and 18 of its precursor lesions [four low-grade and 14 high-grade cervical intraepithelial neoplasias (CINs)]. Histidine 74-83 fragile histidine triad diadenosine triphosphatase Homo sapiens 60-64 10585575-1 2000 We have reported a significant frequency of an alteration of the fragile histidine triad (fhit) gene in squamous-cell carcinoma of the uterine cervix (series 1). Histidine 73-82 fragile histidine triad diadenosine triphosphatase Homo sapiens 90-94 10632340-1 1999 Loss or reduced expression of the fragile histidine triad (FHIT) gene, a tumor suppressor gene localized at chromosome 3p14.2, is common in several solid and hematological cancers and has been associated with tumor progression and worse prognosis. Histidine 42-51 fragile histidine triad diadenosine triphosphatase Homo sapiens 59-63 10589760-1 1999 To determine whether transcriptional alterations of the fragile histidine triad (FHIT) gene play a role in the development and progression of human hepatocellular carcinoma (HCC) we used reverse transcription-PCR to examine mRNA FHIT expression in 28 paired samples of HCC (24 in cirrhotic and 4 in noncirrhotic livers) and matched noncancerous tissue and in 10 normal livers. Histidine 64-73 fragile histidine triad diadenosine triphosphatase Homo sapiens 81-85 10497298-3 1999 Hint-related proteins, found in all forms of life, and fragile histidine triad (Fhit)-related proteins, found in animals and fungi, represent the two main branches of the HIT superfamily. Histidine 63-72 fragile histidine triad diadenosine triphosphatase Homo sapiens 80-84 10551739-1 1999 The expression of Fhit (fragile histidine triad) protein in oral squamous cell carcinoma (OSCC) and adjacent oral epithelium was evaluated by immunohistochemistry on formalin-fixed paraffin-embedded blocks of 32 cases of OSCC. Histidine 32-41 fragile histidine triad diadenosine triphosphatase Homo sapiens 18-22 10223242-3 1999 Recently, the fragile histidine triad (FHIT) gene, which is frequently lost in many cancers, was identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2. Histidine 22-31 fragile histidine triad diadenosine triphosphatase Homo sapiens 39-43 11776848-1 1999 OBJECTIVE: To investigate alterations of fragile histidine triad (FHIT) gene and p16 gene in lung cancer. Histidine 49-58 fragile histidine triad diadenosine triphosphatase Homo sapiens 66-70 9885976-1 1999 Occurrence of abnormal transcripts of the FHIT (fragile histidine triad) gene has been reported in various types of cancer. Histidine 56-65 fragile histidine triad diadenosine triphosphatase Homo sapiens 42-46 9926922-1 1999 Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia Alterations of the recently cloned fragile histidine triad (FHIT) gene at chromosome 3p14.2 are frequent in a variety of solid tumours and cancer cell lines. Histidine 181-190 fragile histidine triad diadenosine triphosphatase Homo sapiens 9-13 9290961-1 1997 The FHIT (fragile histidine triad) gene has been isolated from the chromosome region 3p14.2, which includes the fragile site locus FRA3B and the breakpoint of the t(3;8) of familial renal carcinoma. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 9744812-4 1998 The present report may be related to the recent finding that human Fhit (fragile histidine triad) protein, encoded by the FHIT putative tumor suppressor gene, is a typical dinucleoside 5",5""-P1,P3-triphosphate (Ap3A) hydrolase (EC 3.6.1.29). Histidine 81-90 fragile histidine triad diadenosine triphosphatase Homo sapiens 67-71 9744812-4 1998 The present report may be related to the recent finding that human Fhit (fragile histidine triad) protein, encoded by the FHIT putative tumor suppressor gene, is a typical dinucleoside 5",5""-P1,P3-triphosphate (Ap3A) hydrolase (EC 3.6.1.29). Histidine 81-90 fragile histidine triad diadenosine triphosphatase Homo sapiens 122-126 9744812-4 1998 The present report may be related to the recent finding that human Fhit (fragile histidine triad) protein, encoded by the FHIT putative tumor suppressor gene, is a typical dinucleoside 5",5""-P1,P3-triphosphate (Ap3A) hydrolase (EC 3.6.1.29). Histidine 81-90 fragile histidine triad diadenosine triphosphatase Homo sapiens 212-227 9699676-1 1998 Previous studies suggested that the FHIT (fragile histidine triad) gene on 3p14.2 might be involved in the development of esophageal squamous cell carcinomas, but the mechanisms for inactivating the gene have not been fully revealed. Histidine 50-59 fragile histidine triad diadenosine triphosphatase Homo sapiens 36-40 9621287-5 1998 The fragile histidine triad (FHIT) gene is localized at the most common fragile site at chromosome 3p14.2. Histidine 12-21 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 9576908-3 1998 Fhit protein is a diadenosine P1,P3-triphosphate (ApppA) hydrolase whose fungal and animal homologs form a branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins. Histidine 121-130 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 9576908-7 1998 The form of Fhit bound to two ApppA substrates would present to the cell a dramatically phosphorylated surface, prominently displaying six phosphate groups and two adenosine moieties in place of a deep cavity lined with histidines, arginines, and glutamines. Histidine 220-230 fragile histidine triad diadenosine triphosphatase Homo sapiens 12-16 9537583-2 1998 Recent studies have localized the FHIT (fragile histidine triad) gene in this region and also demonstrated a high frequency of abnormalities of this gene in various cancers. Histidine 48-57 fragile histidine triad diadenosine triphosphatase Homo sapiens 34-38 9713284-0 1998 Expression of abnormal transcripts of the FHIT (fragile histidine triad) gene in ovarian carcinoma. Histidine 56-65 fragile histidine triad diadenosine triphosphatase Homo sapiens 42-46 9713284-1 1998 To elucidate the role of the FHIT (fragile histidine triad) gene in ovarian carcinogenesis, the expression of the gene was analysed by reverse transcription-polymerase chain reaction (RT-PCR) in 51 cases of ovarian carcinoma, 6 cases of borderline tumour and 4 cases of benign ovarian tumour. Histidine 43-52 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 9521166-1 1998 BACKGROUND: The fragile histidine triad (FHIT) gene at chromosome 3p14.2 has been proposed to be a candidate tumor suppressor gene in human cancers. Histidine 24-33 fragile histidine triad diadenosine triphosphatase Homo sapiens 41-45 10063967-1 1998 In early 1996, the Fragile Histidine Triad or FHIT gene (pronounced FIT) was cloned and shown to straddle the most fragile human chromosome site at chromosome band 3p14.2. Histidine 27-36 fragile histidine triad diadenosine triphosphatase Homo sapiens 46-50 9401074-1 1997 Recently the FHIT gene (fragile histidine triad gene) has been identified at chromosome 3p14.2 and a high frequency of abnormalities in this gene has been demonstrated in various cancers. Histidine 32-41 fragile histidine triad diadenosine triphosphatase Homo sapiens 13-17 9261067-1 1997 BACKGROUND: The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins. Histidine 24-33 fragile histidine triad diadenosine triphosphatase Homo sapiens 41-45 9261067-1 1997 BACKGROUND: The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins. Histidine 95-104 fragile histidine triad diadenosine triphosphatase Homo sapiens 41-45 9290961-1 1997 The FHIT (fragile histidine triad) gene has been isolated from the chromosome region 3p14.2, which includes the fragile site locus FRA3B and the breakpoint of the t(3;8) of familial renal carcinoma. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 131-136 9157994-2 1997 Recently, the FHIT (fragile histidine triad) gene was identified at 3p14.2 as a candidate tumor suppressor gene. Histidine 28-37 fragile histidine triad diadenosine triphosphatase Homo sapiens 14-18 9170214-1 1997 The FHIT (fragile histidine triad) gene on chromosome 3p14 is a candidate tumor suppressor gene, and its transcripts are shown to be abnormal in several human cancers. Histidine 18-27 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 8794732-6 1996 Site-directed mutagenesis of FHIT demonstrated that all four conserved histidines are required for full activity, and the central histidine of the triad is absolutely essential for Ap3A hydrolase activity. Histidine 71-81 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 8794732-6 1996 Site-directed mutagenesis of FHIT demonstrated that all four conserved histidines are required for full activity, and the central histidine of the triad is absolutely essential for Ap3A hydrolase activity. Histidine 71-80 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33 8794732-8 1996 Also, Fhit is the first HIT protein in which the histidine residues have been demonstrated by mutagenesis to be critical for function. Histidine 49-58 fragile histidine triad diadenosine triphosphatase Homo sapiens 6-10 8764101-2 1996 Recently, we have cloned the FHIT (fragile histidine triad) gene, located at 3p14.2. Histidine 43-52 fragile histidine triad diadenosine triphosphatase Homo sapiens 29-33