PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17252985-6 2005 Melanocortin peptides, proopiomelanocortin (POMC)-derived peptides which have His-Phe-Arg-Trp sequence, are secreted in large amounts in the sympathoinhibitory phase of cardiovascular regulation in shock. Histidine 78-81 proopiomelanocortin Homo sapiens 23-42 17252985-6 2005 Melanocortin peptides, proopiomelanocortin (POMC)-derived peptides which have His-Phe-Arg-Trp sequence, are secreted in large amounts in the sympathoinhibitory phase of cardiovascular regulation in shock. Histidine 78-81 proopiomelanocortin Homo sapiens 44-48 12904077-1 2003 It has been shown by extensive studies that alpha-MSH bioactivity is critically dependent on the core or central tetrapeptide sequence, His-Phe-Arg-Trp, however with poor selectivity for the human MC3R-MC5R. Histidine 136-139 proopiomelanocortin Homo sapiens 44-53 14584947-3 2003 To probe the receptor active conformation of the pharmacophore His-Phe-Arg-Trp in gamma-MSH, two different series of gamma-MSH analogues have been designed and synthesized and their biological activities determined at hMC3R, hMC4R, and hMC5R. Histidine 63-66 proopiomelanocortin Homo sapiens 82-91 14584947-3 2003 To probe the receptor active conformation of the pharmacophore His-Phe-Arg-Trp in gamma-MSH, two different series of gamma-MSH analogues have been designed and synthesized and their biological activities determined at hMC3R, hMC4R, and hMC5R. Histidine 63-66 proopiomelanocortin Homo sapiens 117-126 11311745-1 2001 The conserved core of melanocyte stimulating hormones (MSH), His-Phe-Arg-Trp, was probed by comparing a cyclic pentapeptide containing His-DPhe-Arg-Trp, with three structurally similar cyclic peptides, that lacked the His residue. Histidine 61-65 proopiomelanocortin Homo sapiens 22-53 11966977-6 2002 For these peptides, the affinity and activity at all three human receptors (MC3R, MC4R and MC5R) decreased significantly, demonstrating that the His-Phe-Arg-Trp sequence in gamma-MSH is important for activity at these three melanocortin receptors. Histidine 145-148 proopiomelanocortin Homo sapiens 173-182 11966977-8 2002 This study highlights the role played by the His-Phe-Arg-Trp sequence in receptor binding and in agonist activity of gamma-MSH. Histidine 45-48 proopiomelanocortin Homo sapiens 117-126 11311745-1 2001 The conserved core of melanocyte stimulating hormones (MSH), His-Phe-Arg-Trp, was probed by comparing a cyclic pentapeptide containing His-DPhe-Arg-Trp, with three structurally similar cyclic peptides, that lacked the His residue. Histidine 61-65 proopiomelanocortin Homo sapiens 55-58 11311745-1 2001 The conserved core of melanocyte stimulating hormones (MSH), His-Phe-Arg-Trp, was probed by comparing a cyclic pentapeptide containing His-DPhe-Arg-Trp, with three structurally similar cyclic peptides, that lacked the His residue. Histidine 135-139 proopiomelanocortin Homo sapiens 22-53 11311745-1 2001 The conserved core of melanocyte stimulating hormones (MSH), His-Phe-Arg-Trp, was probed by comparing a cyclic pentapeptide containing His-DPhe-Arg-Trp, with three structurally similar cyclic peptides, that lacked the His residue. Histidine 135-139 proopiomelanocortin Homo sapiens 55-58 11311745-1 2001 The conserved core of melanocyte stimulating hormones (MSH), His-Phe-Arg-Trp, was probed by comparing a cyclic pentapeptide containing His-DPhe-Arg-Trp, with three structurally similar cyclic peptides, that lacked the His residue. Histidine 61-64 proopiomelanocortin Homo sapiens 22-53 11311745-1 2001 The conserved core of melanocyte stimulating hormones (MSH), His-Phe-Arg-Trp, was probed by comparing a cyclic pentapeptide containing His-DPhe-Arg-Trp, with three structurally similar cyclic peptides, that lacked the His residue. Histidine 61-64 proopiomelanocortin Homo sapiens 55-58 11311745-4 2001 The data indicate that the His residue of the small rigid cyclic MSH core peptides does not participate in binding with the melanocortin receptors. Histidine 27-30 proopiomelanocortin Homo sapiens 65-68 8391692-1 1993 The antisense mRNA complementary to the sense strand of Metenkephalin encodes the antisense peptides, His-Glu-Ala-Pro-Ile (compound 88/62). Histidine 102-105 proopiomelanocortin Homo sapiens 56-69 9699465-4 1998 Additional energy calculations for designed cyclic analogues were used for further refinement of the model for the biologically active conformations of the His-Phe-Arg-Trp "message" sequence within the sequences of alpha-MSH and [D-Phe7]alpha-MSH. Histidine 156-159 proopiomelanocortin Homo sapiens 215-224 9699465-4 1998 Additional energy calculations for designed cyclic analogues were used for further refinement of the model for the biologically active conformations of the His-Phe-Arg-Trp "message" sequence within the sequences of alpha-MSH and [D-Phe7]alpha-MSH. Histidine 156-159 proopiomelanocortin Homo sapiens 237-246 9845266-1 1998 The melanocortins form a family of pro-opiomelanocortin-derived peptides that have the melanocyte-stimulating hormone (MSH) core sequence, His-Phe-Arg-Trp, in common. Histidine 139-142 proopiomelanocortin Homo sapiens 87-117 8899819-2 1996 Ac-Ser.Tyr-Ser-Nle4-Glu- His-DPhe7-Arg-Trp-Gly-Lys-Pro-Val-NH2(NDP-MSH), led to the discovery of tripeptide agonists possessing prolonged bioactivity in the frog skin assay. Histidine 25-28 proopiomelanocortin Homo sapiens 67-70 6526885-1 1984 alpha-Melanotropin (alpha-MSH) is a linear tridecapeptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2), that is primarily known for its ability to stimulate melanosome dispersion within integumental melanocytes (F. J. H. Tilders, D. F. Swaab and T. B. van Wimersma Greidanus (Editors), Frontiers of Hormone Research, Vol. Histidine 82-85 proopiomelanocortin Homo sapiens 26-29 1650827-1 1991 The binding and internalization of a novel adrenocorticotropic hormone (ACTH) analog having a potent neuromodulating effect, ebiratide (H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH(CH2)8NH2), by isolated bovine brain capillaries, were examined. Histidine 150-153 proopiomelanocortin Homo sapiens 72-76 1980269-0 1990 Synthesis and 11C-labelling of the ACTH fragment analogue H-Met(O2)-Glu-His-Phe-D-Lys-Phe-OH (Org 2766) via its homocystine-containing precursor. Histidine 72-75 proopiomelanocortin Homo sapiens 35-39 2552247-4 1989 Tryptic mapping of nexly synthetized alpha-MSH generated two fragments with the following amino acid composition: (T1) Trp, Pro, Lys, Gly, Val and (T2) Tyr, Arg, Phe, His, Ser, Glu. Histidine 167-170 proopiomelanocortin Homo sapiens 37-46 2469648-1 1989 Monoclonal antibodies (MAB) were developed which recognize a peptide, His-Glu-Ala-Pro-Ile (HEAPI), encoded by the RNA complementary to the mRNA specifying [Met]-enkephalin. Histidine 70-73 proopiomelanocortin Homo sapiens 156-171 4375978-4 1974 It appears to be related to the beta-MSH species of mammalian species but has only the sequence -His-Phe-Arg-Trp- in common with the heptapeptide core -Met-Glu-His-Phe-Arg-Trp-Gly- which is characteristic not only of the MSH peptides but also of the adrenocorticotrophins and lipotrophins studied so far. Histidine 160-163 proopiomelanocortin Homo sapiens 32-40 6307694-3 1983 In human beta-endorphin, accessibility and mobility of Tyr-27 are strongly reduced in the presence of lipid at physiological pH, whereas in camel beta-endorphin His-27 becomes immobilized only at high pH. Histidine 161-164 proopiomelanocortin Homo sapiens 146-160 223580-4 1978 The ACTH 4--9 analog H-Met(O2)-Glu-His-Phe-D-Lys-Phe-OH (Org 2766) has behavioral activity after oral administration. Histidine 35-38 proopiomelanocortin Homo sapiens 4-8 194605-1 1977 The polypeptides ACTH and ATCH4-10 (OI 63) witha sequence of amino acids H-Met-Glu-His-Phe-Arg-Trp-Gly-OH, have similar stimulating effects on motor units in lower mammals. Histidine 83-86 proopiomelanocortin Homo sapiens 17-21 212233-6 1976 The following conclusion was drawn: alpha-MSH possesses (in contrast to ACTH) two message sequences (active sites), (i)-Glu-His-Phe-Arg-Trp-, and (ii)-Gly-Lys-Pro-Val-NH2 which are capable of independently triggering the hormone receptor responsible for melanin dispersion. Histidine 124-127 proopiomelanocortin Homo sapiens 36-45 20642005-12 2004 A lactam bridge-cyclized alpha-MSH analog, GlyGlu-c[Lys-Nlc-Glu-His-d-Phe-Arg-Trp-Gly-Arg-Pro-Val-Asp] (GlyGlu-CycMSH), was conjugated with DOTA (11). Histidine 64-67 proopiomelanocortin Homo sapiens 25-34 5476715-3 1970 The sequence of the hormone, Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Met, shows that ten of its 11 residues are the same as ten of the 13 residues of mammalian alpha-MSH. Histidine 41-44 proopiomelanocortin Homo sapiens 160-169 15436813-0 1950 Influence of ACTH on the excretion of histamine and histidine in patients with allergic states or rheumatoid arthritis. Histidine 52-61 proopiomelanocortin Homo sapiens 13-17 15440791-0 1950 Apparent free histidine plasma and urine values in rheumatoid arthritis treated with cortisone and ACTH. Histidine 14-23 proopiomelanocortin Homo sapiens 99-103 32184956-1 2020 The melanocortin receptors are stimulated by agonists (alpha-MSH, beta-MSH, gamma-MSH, and ACTH) processed from the proopiomelanocortin (POMC) gene transcript and possess a common His-Phe-Arg-Trp tetrapeptide sequence critical for receptor activation. Histidine 180-183 proopiomelanocortin Homo sapiens 91-95 32184956-3 2020 Herein, 12 single nucleotide polymorphisms (SNPs) deposited into the Variation Viewer database within the His-Phe-Arg-Trp sequences of ACTH/alpha-MSH, beta-MSH, and gamma-MSH were substituted into tetrapeptide scaffolds to examine the in vitro signaling effects of these polymorphisms at the cloned melanocortin receptors. Histidine 106-109 proopiomelanocortin Homo sapiens 135-139 28579117-2 2017 The core sequence of NDP-alpha-MSH, His-Phe-Arg-Trp, is important for ligand binding and biological activities at the melanocortin receptor subtypes (MCRs). Histidine 36-39 proopiomelanocortin Homo sapiens 25-34 26095376-1 2015 An alpha-MSH peptide analogue, named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]- NH2), is one of the most important ligands of melanotropic receptors but are relatively nonselective. Histidine 56-59 proopiomelanocortin Homo sapiens 3-12 23293326-13 2013 Finally, discovery of this mutation indicates that in humans, the amino acid sequence His(6)Phe(7)Arg(8)Trp(9) is important not only for cAMP activation but also for ACTH binding to MC2R. Histidine 86-89 proopiomelanocortin Homo sapiens 166-170 29659163-2 2018 In this study, the alpha-MSH-derived peptide NAP-NS1 (Nle-Asp-His-d-Phe-Arg-Trp-Gly-NH2 ) with and without linkers was conjugated with 5-(bis(pyridin-2-ylmethyl)amino)pentanoic acid (DPA-COOH) and labeled with [99m Tc]Tc-tricarbonyl by two methods. Histidine 62-65 proopiomelanocortin Homo sapiens 19-28 28714883-2 2017 The central sequence of alpha-MSH (His-Phe-Arg-Trp) has been identified as being essential for receptor binding. Histidine 35-38 proopiomelanocortin Homo sapiens 24-33 17348731-4 2007 The central His-Phe-Arg-Trp tetrapeptide sequence of alpha-MSH is known to form a turn in the bioactive conformation. Histidine 12-15 proopiomelanocortin Homo sapiens 53-62 19558415-3 2009 Here, we report on a panel of tripeptide analogs consisting of a modified alpha-MSH core His(6)-d-Phe(7)-Arg(8), which contained different N-capping groups, C-terminal modifications, or arginine mimics. Histidine 89-92 proopiomelanocortin Homo sapiens 74-83 17545153-7 2007 Further mutagenesis studies indicate that conserved residues Glu(100) in TM2, Asp(122), Asp(126) in TM3 and Trp(258), Phe(261), His(264) in TM6 are involved in alpha-MSH binding and signaling. Histidine 128-131 proopiomelanocortin Homo sapiens 160-169