PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27453504-3 2016 We identify an association between GMPS and xanthosine using single variant analysis and associations between HAL and histidine, PAH and phenylalanine, and UPB1 and ureidopropionate using gene-based tests (P<5 x 10(-8) in meta-analysis), highlighting novel coding variants that may underlie inborn errors of metabolism. Histidine 118-127 histidine ammonia-lyase Homo sapiens 110-113 2887178-1 1985 Catabolism of histidine was investigated in 24 patients with different speech and language disorders and with significantly low histidase activity in stratum corneum. Histidine 14-23 histidine ammonia-lyase Homo sapiens 128-137 2887178-3 1985 Biochemical investigation of these patients after loading with L-histidine led to the conclusions that low histidase activity in stratum corneum was connected with: disturbances in folic acid metabolism (2 cases); "atypical histidinemia" (1 case); heterozygotes of histidinemia (2 cases); normal liver histidine metabolism but abnormal in other tissues (18 cases); previously unknown error of histidine metabolism (1 case). Histidine 63-74 histidine ammonia-lyase Homo sapiens 107-116 2887178-3 1985 Biochemical investigation of these patients after loading with L-histidine led to the conclusions that low histidase activity in stratum corneum was connected with: disturbances in folic acid metabolism (2 cases); "atypical histidinemia" (1 case); heterozygotes of histidinemia (2 cases); normal liver histidine metabolism but abnormal in other tissues (18 cases); previously unknown error of histidine metabolism (1 case). Histidine 65-74 histidine ammonia-lyase Homo sapiens 107-116 2887178-3 1985 Biochemical investigation of these patients after loading with L-histidine led to the conclusions that low histidase activity in stratum corneum was connected with: disturbances in folic acid metabolism (2 cases); "atypical histidinemia" (1 case); heterozygotes of histidinemia (2 cases); normal liver histidine metabolism but abnormal in other tissues (18 cases); previously unknown error of histidine metabolism (1 case). Histidine 224-233 histidine ammonia-lyase Homo sapiens 107-116 6136484-7 1983 These findings point to the severe impairment of histidase and urocanase, two enzymes regulating the histidine catabolic pathway. Histidine 101-110 histidine ammonia-lyase Homo sapiens 49-58 7334672-0 1981 [Measurement of histidase activity in the oral mucous membrane with radioactivity labelled L-histidine (author"s transl)]. Histidine 91-102 histidine ammonia-lyase Homo sapiens 16-25 6790399-5 1981 In a case of 5 year-old boy with clinical histidinemia, in whom serum histidine level was 12.1 mg/kl, histidase activity of stratum corneum was not detectable, FIGLU and urocanic acid in urine and urocanic acid in sweat were not detected, the half life of histidine at intravenous histidine loading test was too long to measure. Histidine 42-51 histidine ammonia-lyase Homo sapiens 102-111 6164144-1 1980 The histidine metabolism in homogenates of human tissues of nontreated benign prostatic hyperplasia has been examined by means of the determination of L-histidine ammonia lyase activity (EC 4.3.1.3;histidine alpha-deaminase, histidase) and the histidine imidazole metabolites which were separated by means of ion exchange chromatography. Histidine 4-13 histidine ammonia-lyase Homo sapiens 153-176 476954-1 1979 A new sensitive method was developed for assay of histidase in the stratum corneum of human skin with [14C] histidine as substrate. Histidine 108-117 histidine ammonia-lyase Homo sapiens 50-59 430230-0 1979 Effect of induction of histidase on histidine metabolism in vivo. Histidine 36-45 histidine ammonia-lyase Homo sapiens 23-32 886385-0 1977 Effect of histidine intake and hepatic histidase activity on the metabolism of histidine in vivo. Histidine 79-88 histidine ammonia-lyase Homo sapiens 39-48 1150653-2 1975 The alpha,beta eliminations of NH3 from L-histidine and 4-fluoro-L-histidine by histidine ammonia-lyase appear to occur by similar mechanisms, although a large difference in Vmax for the two reactions was observed. Histidine 40-51 histidine ammonia-lyase Homo sapiens 80-103 13863215-1 1962 A deficiency in histidase resulting in the urinary excretion of histidine and of imidazolepyruvic acid. Histidine 64-73 histidine ammonia-lyase Homo sapiens 16-25 33000155-5 2020 Excess histidine may be converted to trans-urocanate by histidine ammonia lyase (histidase) in liver and skin. Histidine 7-16 histidine ammonia-lyase Homo sapiens 56-79 33000155-5 2020 Excess histidine may be converted to trans-urocanate by histidine ammonia lyase (histidase) in liver and skin. Histidine 7-16 histidine ammonia-lyase Homo sapiens 81-90 7211776-1 1981 A highly specific and sensitive procedure for determining histidase activity, with labeled histidine as the substrate, that requires only 1 to 2 mg of stratum corneum epidermidis has been developed. Histidine 91-100 histidine ammonia-lyase Homo sapiens 58-67 7373889-0 1980 [Measurement of histidase activity in the stratum corneum with radioactively labelled L-histidine (author"s transl)]. Histidine 86-97 histidine ammonia-lyase Homo sapiens 16-25 788422-0 1975 [Histidine tolerance in low skin histidase activity]. Histidine 1-10 histidine ammonia-lyase Homo sapiens 33-42 20880231-1 2010 The effect of 8-methoxypsoralen-UVA therapy on the catalysis of histidine to trans-urocanic acid by histidine ammonia lyase (HAL, EC 4.3.1.3) was examined using an enzymatic assay from Sigma-Aldrich where the growth of the trans-urocanic acid peak at 277 nm was monitored. Histidine 64-73 histidine ammonia-lyase Homo sapiens 100-123 20880231-1 2010 The effect of 8-methoxypsoralen-UVA therapy on the catalysis of histidine to trans-urocanic acid by histidine ammonia lyase (HAL, EC 4.3.1.3) was examined using an enzymatic assay from Sigma-Aldrich where the growth of the trans-urocanic acid peak at 277 nm was monitored. Histidine 64-73 histidine ammonia-lyase Homo sapiens 125-128 17191848-1 2004 Although both the structures and the reactions of histidine and phenylalanine ammonia lyases (HAL and PAL) are very similar, the former shows a primary kinetic deuterium (D) isotope effect, while the latter does not. Histidine 50-59 histidine ammonia-lyase Homo sapiens 94-97 18280705-1 2008 BACKGROUND: Histidase (histidine ammonia lyase) converts histidine into urocanic acid, the main ultraviolet (UV) light absorption factor of the stratum corneum. Histidine 23-32 histidine ammonia-lyase Homo sapiens 12-21 15681171-9 2005 The results suggest that previously observed alterations in the activity of histidase, which were correlated to dietary protein intake, are mediated by rapid changes in the mRNA expression of this enzyme, and are not necessarily related to dietary histidine intake. Histidine 248-257 histidine ammonia-lyase Homo sapiens 76-85 11895450-1 2002 Histidine ammonia-lyase (EC 4.3.1.3) catalyzes the nonoxidative elimination of the alpha-amino group of histidine using a 4-methylidene-imidazole-5-one (MIO), which is formed autocatalytically from the internal peptide segment 142Ala-Ser-Gly. Histidine 104-113 histidine ammonia-lyase Homo sapiens 0-23 12686130-3 2003 Histidine and phenylalanine ammonia-lyases (HAL and PAL) possess a catalytically essential electrophilic group which has been believed to be dehydroalanine for 30 years. Histidine 0-9 histidine ammonia-lyase Homo sapiens 44-47 25575548-9 2015 CONCLUSIONS: Three LoF mutations in HAL were associated with increased histidine levels, which in turn were shown to be inversely related to the risk of CHD among both African Americans and European Americans. Histidine 71-80 histidine ammonia-lyase Homo sapiens 36-39 8825190-1 1996 The pharmacokinetics of L-histidine in humans has been investigated to evaluate the in vivo histidine ammonia lyase system for the conversion of L-histidine to urocanic acid. Histidine 145-156 histidine ammonia-lyase Homo sapiens 92-115 8530107-1 1995 Histidase (EC 4.3.1.3) is a cytosolic enzyme that catalyzes the nonoxidative deamination of histidine to urocanic acid. Histidine 92-101 histidine ammonia-lyase Homo sapiens 0-9 2347667-8 1990 These experiments evaluated the effectiveness of encapsulated histidase in depleting histidine. Histidine 85-94 histidine ammonia-lyase Homo sapiens 62-71 25575548-3 2015 METHODS AND RESULTS: By conducting whole exome sequencing on 1152 African Americans in the Atherosclerosis Risk in Communities (ARIC) study and focusing on loss-of-function (LoF) variants, we identified 3 novel rare LoF variants in HAL, a gene that encodes histidine ammonia-lyase in the first step of histidine catabolism. Histidine 257-266 histidine ammonia-lyase Homo sapiens 232-235 1537807-8 1992 The cloned DNA restored the ability of a histidase structural gene mutant to grow on L-histidine as the sole nitrogen source. Histidine 85-96 histidine ammonia-lyase Homo sapiens 41-50 1943682-2 1991 Histidase (histidine ammonia-lyase, EC 4.3.1.3) catalyzes the deamination of L-histidine to trans-urocanic acid in the liver and skin of mammals. Histidine 77-88 histidine ammonia-lyase Homo sapiens 0-9 1943682-2 1991 Histidase (histidine ammonia-lyase, EC 4.3.1.3) catalyzes the deamination of L-histidine to trans-urocanic acid in the liver and skin of mammals. Histidine 77-88 histidine ammonia-lyase Homo sapiens 11-34 1943682-3 1991 Histidase deficiency results in increased histidine and histamine in blood, and decreased urocanic acid in blood and skin. Histidine 42-51 histidine ammonia-lyase Homo sapiens 0-9