PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25371203-1 2015 Thyrotropin-releasing hormone is a tripeptide that consists of 5-oxoproline, histidine, and proline. Histidine 77-86 thyrotropin releasing hormone Homo sapiens 0-29 26854379-0 2016 Synthesis and biology of ring-modified l-Histidine containing thyrotropin-releasing hormone (TRH) analogues. Histidine 39-50 thyrotropin releasing hormone Homo sapiens 62-91 26854379-0 2016 Synthesis and biology of ring-modified l-Histidine containing thyrotropin-releasing hormone (TRH) analogues. Histidine 39-50 thyrotropin releasing hormone Homo sapiens 93-96 26854379-1 2016 Thyrotropin-releasing hormone (TRH) analogues bearing halogen groups (Cl, Br and I) at the C-2 and/or C-5 position, and the alkyl group (CH3, C2H5, C3H7, CH2C6H5) at the N-1 position of the imidazole ring of the central histidine residue were synthesized and evaluated for the receptor binding, calcium mobilization (FLIPR), and IP-1 assay at the HEK mTRHR1 and HEK mTRHR2 expressing cell lines. Histidine 220-229 thyrotropin releasing hormone Homo sapiens 0-29 26854379-1 2016 Thyrotropin-releasing hormone (TRH) analogues bearing halogen groups (Cl, Br and I) at the C-2 and/or C-5 position, and the alkyl group (CH3, C2H5, C3H7, CH2C6H5) at the N-1 position of the imidazole ring of the central histidine residue were synthesized and evaluated for the receptor binding, calcium mobilization (FLIPR), and IP-1 assay at the HEK mTRHR1 and HEK mTRHR2 expressing cell lines. Histidine 220-229 thyrotropin releasing hormone Homo sapiens 31-34 16735122-1 2006 Thyrotropin-releasing hormone (TRH) analogues in which the N(1)-position of the imidazole ring of the centrally placed histidine residue is substituted with various alkyl groups were synthesized and studied as agonists for TRH receptor subtype 1 (TRH-R1) and subtype 2 (TRH-R2). Histidine 119-128 thyrotropin releasing hormone Homo sapiens 0-29 17499643-1 2007 A conformationally constrained peptidomimetic derived from the endocrine and neuroactive tripeptide thyrotropin-releasing hormone (pGlu-His-Pro-NH(2)) was synthesized by convenient solid-phase organic chemistry and evaluated as a potential central nervous system agent. Histidine 136-139 thyrotropin releasing hormone Homo sapiens 100-129 17035026-0 2007 Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1. Histidine 43-52 thyrotropin releasing hormone Homo sapiens 65-94 17035026-0 2007 Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1. Histidine 43-52 thyrotropin releasing hormone Homo sapiens 96-99 17035026-0 2007 Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1. Histidine 43-52 thyrotropin releasing hormone Homo sapiens 136-139 17035026-3 2007 For example, the most selective agonist of the series 13, in which pGlu is replaced with the pAad and histidine residue is substituted at the N-1 position with an isopropyl group, was found to activate TRH-R2 with a potency (EC(50)=1.9microM) but did not activate TRH-R1 (potency>100 microM); that is, exhibited >51-fold greater selectivity for TRH-R2 versus TRH-R1. Histidine 102-111 thyrotropin releasing hormone Homo sapiens 202-205 17035026-3 2007 For example, the most selective agonist of the series 13, in which pGlu is replaced with the pAad and histidine residue is substituted at the N-1 position with an isopropyl group, was found to activate TRH-R2 with a potency (EC(50)=1.9microM) but did not activate TRH-R1 (potency>100 microM); that is, exhibited >51-fold greater selectivity for TRH-R2 versus TRH-R1. Histidine 102-111 thyrotropin releasing hormone Homo sapiens 264-267 17035026-3 2007 For example, the most selective agonist of the series 13, in which pGlu is replaced with the pAad and histidine residue is substituted at the N-1 position with an isopropyl group, was found to activate TRH-R2 with a potency (EC(50)=1.9microM) but did not activate TRH-R1 (potency>100 microM); that is, exhibited >51-fold greater selectivity for TRH-R2 versus TRH-R1. Histidine 102-111 thyrotropin releasing hormone Homo sapiens 264-267 17035026-3 2007 For example, the most selective agonist of the series 13, in which pGlu is replaced with the pAad and histidine residue is substituted at the N-1 position with an isopropyl group, was found to activate TRH-R2 with a potency (EC(50)=1.9microM) but did not activate TRH-R1 (potency>100 microM); that is, exhibited >51-fold greater selectivity for TRH-R2 versus TRH-R1. Histidine 102-111 thyrotropin releasing hormone Homo sapiens 264-267 16735122-1 2006 Thyrotropin-releasing hormone (TRH) analogues in which the N(1)-position of the imidazole ring of the centrally placed histidine residue is substituted with various alkyl groups were synthesized and studied as agonists for TRH receptor subtype 1 (TRH-R1) and subtype 2 (TRH-R2). Histidine 119-128 thyrotropin releasing hormone Homo sapiens 31-34 16735122-5 2006 The results of this study indicate that modulation of central histidine residue is important for designing analogues which were selective agonist at TRH receptor subtypes. Histidine 62-71 thyrotropin releasing hormone Homo sapiens 149-152 16611635-2 2006 Pyroglutamyl peptidase II (PPII), a highly specific membrane-bound omegapeptidase, removes N-terminal pyroglutamyl from thyrotropin-releasing hormone (<Glu-His-Pro-NH(2)), inactivating the peptide in the extracellular space. Histidine 159-162 thyrotropin releasing hormone Homo sapiens 120-149 16162016-1 2005 Thyrotropin-releasing hormone (TRH) analogues in which the C-2 position of the imidazole ring of the centrally placed histidine residue is substituted with various alkyl groups were synthesized and studied as agonists for TRH receptor subtype 1 (TRH-R1) and subtype 2 (TRH-R2). Histidine 118-127 thyrotropin releasing hormone Homo sapiens 0-29 16162016-1 2005 Thyrotropin-releasing hormone (TRH) analogues in which the C-2 position of the imidazole ring of the centrally placed histidine residue is substituted with various alkyl groups were synthesized and studied as agonists for TRH receptor subtype 1 (TRH-R1) and subtype 2 (TRH-R2). Histidine 118-127 thyrotropin releasing hormone Homo sapiens 31-34 17160139-12 2005 All the His-containing analogs behave like TRH in terms of the above properties. Histidine 8-11 thyrotropin releasing hormone Homo sapiens 43-46 10985924-7 2000 If DA was not removed, [3-Me-His(2)]-TRH was ineffective. Histidine 29-32 thyrotropin releasing hormone Homo sapiens 37-40 11738621-1 2002 We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives. Histidine 217-226 thyrotropin releasing hormone Homo sapiens 57-86 11738621-1 2002 We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives. Histidine 217-226 thyrotropin releasing hormone Homo sapiens 88-91 10785382-2 2000 Thyrotropin-releasing hormone-degrading ectoenzyme is a member of the M1 family of Zn-dependent aminopeptidases and catalyzes the degradation of thyrotropin-releasing hormone (TRH; Glp-His-Pro-NH2). Histidine 185-188 thyrotropin releasing hormone Homo sapiens 0-29 10785382-2 2000 Thyrotropin-releasing hormone-degrading ectoenzyme is a member of the M1 family of Zn-dependent aminopeptidases and catalyzes the degradation of thyrotropin-releasing hormone (TRH; Glp-His-Pro-NH2). Histidine 185-188 thyrotropin releasing hormone Homo sapiens 145-174 10984068-2 2000 The hypothalamic thyrotropin-releasing hormone (TRH) was the first chemically defined hypophyseotropic hormone with the primary structure pGLU-HIS-PRO.NH2. Histidine 143-146 thyrotropin releasing hormone Homo sapiens 17-46 10984068-2 2000 The hypothalamic thyrotropin-releasing hormone (TRH) was the first chemically defined hypophyseotropic hormone with the primary structure pGLU-HIS-PRO.NH2. Histidine 143-146 thyrotropin releasing hormone Homo sapiens 48-51 9827668-2 1998 The limited proteolysis of thyrotropin-releasing hormone (TRH) by Pyroglutamate aminopeptidase yields cyclo(His-Pro) or CHP, a new biopeptide associated with a variety of pharmacological activities, including regulation of body temperature, inhibition of prolactin secretion, and modulation of motor functions. Histidine 108-111 thyrotropin releasing hormone Homo sapiens 27-56 9827668-2 1998 The limited proteolysis of thyrotropin-releasing hormone (TRH) by Pyroglutamate aminopeptidase yields cyclo(His-Pro) or CHP, a new biopeptide associated with a variety of pharmacological activities, including regulation of body temperature, inhibition of prolactin secretion, and modulation of motor functions. Histidine 108-111 thyrotropin releasing hormone Homo sapiens 58-61 8649348-1 1996 Thyrotropin-releasing hormone (TRH) is a tripeptide (< Glu-His-Pro-NH2) that signals through a G protein-coupled receptor. Histidine 62-65 thyrotropin releasing hormone Homo sapiens 0-29 8672465-8 1996 One interaction is between the aromatic ring of Tyr 282 of TM-6 and His of TRH. Histidine 68-71 thyrotropin releasing hormone Homo sapiens 75-78 8649348-1 1996 Thyrotropin-releasing hormone (TRH) is a tripeptide (< Glu-His-Pro-NH2) that signals through a G protein-coupled receptor. Histidine 62-65 thyrotropin releasing hormone Homo sapiens 31-34 1423781-2 1992 In order to synthesize TRH-labeled beta-D-galactosidase (beta-gal), a newly devised TRH derivative, pGlu-His-Pro-NH-(CH2)6-NH2 (TRH-Hex), was employed. Histidine 105-108 thyrotropin releasing hormone Homo sapiens 23-26 8407917-4 1993 The addition of purified pyroglutamyl aminopeptidase resulted in the transformation of TRH-Gly to His-Pro-Gly and cyclo (His-Pro) but not to TRH. Histidine 98-101 thyrotropin releasing hormone Homo sapiens 87-90 1423781-2 1992 In order to synthesize TRH-labeled beta-D-galactosidase (beta-gal), a newly devised TRH derivative, pGlu-His-Pro-NH-(CH2)6-NH2 (TRH-Hex), was employed. Histidine 105-108 thyrotropin releasing hormone Homo sapiens 84-87 1423781-2 1992 In order to synthesize TRH-labeled beta-D-galactosidase (beta-gal), a newly devised TRH derivative, pGlu-His-Pro-NH-(CH2)6-NH2 (TRH-Hex), was employed. Histidine 105-108 thyrotropin releasing hormone Homo sapiens 84-87 1605801-1 1992 Preferable conformations of thyrotropin-releasing hormone (TRH, Glp-His-Pro-NH2) and its analogues Glp-Glu(R)-Pro-NH2 (R = NHCH(CH3)CH2Ar), Glp-Gln-Abu-NH2, Dho-Gln-Abu-NH2 in DMSO solution are determined using two-dimensional 1H NMR spectroscopy (delta-J-correlated, COSY and NOESY). Histidine 68-71 thyrotropin releasing hormone Homo sapiens 28-57 2122435-3 1990 Bioreversible derivatization of TRH (pGlu-His-Pro-NH2) to protect the tripeptide against rapid enzymatic inactivation in the systemic circulation and to improve the lipophilicity of this highly hydrophilic peptide was performed by N-acylation of the imidazole group of the histidine residue with various chloroformates. Histidine 273-282 thyrotropin releasing hormone Homo sapiens 32-35 1325726-1 1992 Thyrotropin Releasing Hormone (TRH; pyroGlu-His-Pro-NH2) is rapidly hydrolyzed at the pyroGlu-His bond by a heterogeneously distributed ectoenzyme and a TRH-degrading serum enzyme. Histidine 44-47 thyrotropin releasing hormone Homo sapiens 0-29 1325726-1 1992 Thyrotropin Releasing Hormone (TRH; pyroGlu-His-Pro-NH2) is rapidly hydrolyzed at the pyroGlu-His bond by a heterogeneously distributed ectoenzyme and a TRH-degrading serum enzyme. Histidine 44-47 thyrotropin releasing hormone Homo sapiens 31-34 1325726-1 1992 Thyrotropin Releasing Hormone (TRH; pyroGlu-His-Pro-NH2) is rapidly hydrolyzed at the pyroGlu-His bond by a heterogeneously distributed ectoenzyme and a TRH-degrading serum enzyme. Histidine 44-47 thyrotropin releasing hormone Homo sapiens 153-156 2122435-4 1990 Whereas TRH was rapidly hydrolyzed at its pGlu-His bond in human plasma by a TRH-specific pyroglutamyl aminopeptidase serum enzyme, the N-alkoxycarbonyl derivatives were resistant to cleavage by the enzyme. Histidine 47-50 thyrotropin releasing hormone Homo sapiens 8-11 2118634-1 1990 The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics. Histidine 70-73 thyrotropin releasing hormone Homo sapiens 60-63 2118634-1 1990 The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics. Histidine 151-154 thyrotropin releasing hormone Homo sapiens 60-63 2118634-1 1990 The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics. Histidine 151-154 thyrotropin releasing hormone Homo sapiens 60-63 2118634-1 1990 The kinetics and mechanism of degradation of the tripeptide TRH (pGlu-His-Pro-NH2) and its various primary and secondary degradation products (TRH-OH, His-Pro-NH2, and His-Pro) have been determined in human plasma at 37 degrees C. The rates of degradation of both TRH and TRH-OH (pGlu-His-Pro) showed mixed zero-order and first-order kinetics. Histidine 151-154 thyrotropin releasing hormone Homo sapiens 60-63 2118634-3 1990 The initial step in the plasma-catalyzed degradation of TRH is due to hydrolysis of the pGlu-His bond by the TRH-specific pyroglutamyl aminopeptidase serum enzyme, resulting in the exclusive formation of histidyl-proline amide (His-Pro-NH2). Histidine 93-96 thyrotropin releasing hormone Homo sapiens 56-59 2118634-3 1990 The initial step in the plasma-catalyzed degradation of TRH is due to hydrolysis of the pGlu-His bond by the TRH-specific pyroglutamyl aminopeptidase serum enzyme, resulting in the exclusive formation of histidyl-proline amide (His-Pro-NH2). Histidine 93-96 thyrotropin releasing hormone Homo sapiens 109-112 2117583-2 1990 TRH derives from a 242-amino acid precursor protein, prepro-TRH, with six repetitive sequences of -Lys-Arg-Gln-His-Pro-Gly-Lys/Arg)-Arg- connected by hydrophobic linking sequences. Histidine 111-114 thyrotropin releasing hormone Homo sapiens 0-3 2117583-3 1990 Antibodies to TRH-Gly (pGlu-His-Pro-Gly), a final precursor for TRH formation, were used to detect this tetrapeptide as well as other prepro-TRH fragments which cross-react with these antibodies. Histidine 28-31 thyrotropin releasing hormone Homo sapiens 14-17 2117583-3 1990 Antibodies to TRH-Gly (pGlu-His-Pro-Gly), a final precursor for TRH formation, were used to detect this tetrapeptide as well as other prepro-TRH fragments which cross-react with these antibodies. Histidine 28-31 thyrotropin releasing hormone Homo sapiens 64-67 2117583-3 1990 Antibodies to TRH-Gly (pGlu-His-Pro-Gly), a final precursor for TRH formation, were used to detect this tetrapeptide as well as other prepro-TRH fragments which cross-react with these antibodies. Histidine 28-31 thyrotropin releasing hormone Homo sapiens 64-67 2117583-7 1990 A minor, TRH-Gly immunoreactive peak increased 50-fold (P less than 0.001) during 20 h at 60 degrees C. This material co-eluted with Arg-Gln-His-Pro-Gly which is formed by enzymic cleavage of the paired basic residues flanking this sequence in prepro-TRH. Histidine 141-144 thyrotropin releasing hormone Homo sapiens 9-12 2117583-8 1990 When synthetic Arg-Gln-His-Pro-Gly was incubated with fresh semen at 60 degrees C a rapid conversion of most of this peptide to Glu-His-Pro-Gly, Gln-His-Pro-Gly and TRH-Gly occurred within 30 min. Histidine 23-26 thyrotropin releasing hormone Homo sapiens 165-168 2158826-6 1990 The distribution of histidine side-chain conformations in the TRH analogue was deduced from coupling constants and from the short-range interaction between the imidazole ring and one of the prochiral faces of the 2,4-MePro side chain. Histidine 20-29 thyrotropin releasing hormone Homo sapiens 62-65 3118225-0 1987 Is all cyclo(His-Pro) derived from thyrotropin-releasing hormone? Histidine 13-16 thyrotropin releasing hormone Homo sapiens 35-64 3118225-6 1987 It is proposed that 29,247 molecular weight TRH prohormone, prepro TRH, which contains 5 copies of TRH sequence, can be processed to yield cyclo(His-Pro). Histidine 145-148 thyrotropin releasing hormone Homo sapiens 44-47 3118225-6 1987 It is proposed that 29,247 molecular weight TRH prohormone, prepro TRH, which contains 5 copies of TRH sequence, can be processed to yield cyclo(His-Pro). Histidine 145-148 thyrotropin releasing hormone Homo sapiens 67-70 3118225-6 1987 It is proposed that 29,247 molecular weight TRH prohormone, prepro TRH, which contains 5 copies of TRH sequence, can be processed to yield cyclo(His-Pro). Histidine 145-148 thyrotropin releasing hormone Homo sapiens 67-70 3118225-7 1987 Thus, both TRH and cyclo(His-Pro) share a common precursor, prepro[TRH/Cyclo(His-Pro)]. Histidine 25-28 thyrotropin releasing hormone Homo sapiens 67-70 3473473-2 1987 The TRH precursor fragment H-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-OH and the D-glutaminyl stereoisomer of H-Gln-Tyr-Ala-OH did not react under the same conditions. Histidine 41-44 thyrotropin releasing hormone Homo sapiens 4-7 3935636-3 1985 His-Pro diketopiperazine, a biologically active metabolite of TRH consisting of a cyclic dipeptide of histidine and proline, also was measured by specific RIA. Histidine 102-111 thyrotropin releasing hormone Homo sapiens 62-65 2865955-3 1985 The participation of "thyroliberinase", a metalloenzyme which cleaves TRH at the pyroglutamyl-His bond was implied. Histidine 94-97 thyrotropin releasing hormone Homo sapiens 70-73 3935636-5 1985 A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue. Histidine 264-273 thyrotropin releasing hormone Homo sapiens 14-17 3935636-5 1985 A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue. Histidine 264-273 thyrotropin releasing hormone Homo sapiens 196-199 3935636-5 1985 A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue. Histidine 264-273 thyrotropin releasing hormone Homo sapiens 196-199 3935636-5 1985 A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue. Histidine 264-273 thyrotropin releasing hormone Homo sapiens 196-199 3935636-5 1985 A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue. Histidine 319-328 thyrotropin releasing hormone Homo sapiens 14-17 3935636-5 1985 A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue. Histidine 319-328 thyrotropin releasing hormone Homo sapiens 196-199 3935636-5 1985 A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue. Histidine 319-328 thyrotropin releasing hormone Homo sapiens 196-199 3935636-5 1985 A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue. Histidine 319-328 thyrotropin releasing hormone Homo sapiens 196-199 3935636-6 1985 A 3- to 23-fold increase in His-Pro diketopiperazine levels occurred after 4 hours at 37 C. This was not due primarily to enzymatic removal of the pyroglutamyl residue from TRH by pyroglutamate aminopeptidase, since about 1 hour after ejaculation the initial His-Pro diketopiperazine levels were 9.7 +/- 5.1 micrograms/ml, or approximately 1000-fold greater than the corresponding levels of seminal TRH. Histidine 28-31 thyrotropin releasing hormone Homo sapiens 399-402 3922011-4 1985 Several centrally acting TRH analogues showed varying degrees of resistance to degradation by the peptidases in the two fractions, the most stable analogue being RX77368 (pGlu-His-3,3"-dimethyl(ProNH2]. Histidine 176-179 thyrotropin releasing hormone Homo sapiens 25-28 3922011-5 1985 Areas of human postmortem brain appear to contain two of the enzymes capable of degrading TRH, a proline endopeptidase forming TRH-OH and a pyroglutamyl aminopeptidase forming cyclo(His-Pro). Histidine 182-185 thyrotropin releasing hormone Homo sapiens 90-93 107159-2 1979 An extract of porcine brain acetone powder incubated with thyrotropin-releasing hormone (TRH; pGlu-His-ProNH2) produces acid TRH (pGlu-His-Pro), histidine, and prolineamide. Histidine 145-154 thyrotropin releasing hormone Homo sapiens 58-87 6093073-5 1984 In the amygdala, binding was inhibited in the presence of TRH and Me-TRH but not in the presence of up to 1 microM concentrations of cyclo (His-Pro), TRH-OH, pGlu-His or peptides unrelated to TRH. Histidine 163-166 thyrotropin releasing hormone Homo sapiens 58-61 16229164-5 1983 The "stability in vitro" toward enzymes of serum and brain homogenate of a new type of drug based on the combination of peptidic fragment of TRH-(Thyrotropin-Releasing Hormone:pGlu-His-Pro-NH2) with a non peptide moiety (dopamine) is considered and discussed. Histidine 181-184 thyrotropin releasing hormone Homo sapiens 141-175 6788956-2 1981 Practical syntheses for three of these TRH analogues which show the greatest selectivity, less than Aad-His-Tzl-NH2 (5), less than Glu-His-Pip-OMe (2), and less than Aad-His-Pro-NH2 (6), are described. Histidine 104-107 thyrotropin releasing hormone Homo sapiens 39-42 107159-2 1979 An extract of porcine brain acetone powder incubated with thyrotropin-releasing hormone (TRH; pGlu-His-ProNH2) produces acid TRH (pGlu-His-Pro), histidine, and prolineamide. Histidine 145-154 thyrotropin releasing hormone Homo sapiens 89-92 106925-3 1979 Chromatography of TRH-like immunoreactivity obtained from Rana pipiens skin eluted in two solvent systems produced elution profiles identical with that of synthetic Pyroglu-His-Pro-NH2 consistent with reports that frog skin contains large quantities of TRH. Histidine 173-176 thyrotropin releasing hormone Homo sapiens 18-21 821746-4 1975 Of the TRH analogues tested, only two (Ser-His-Pro-NH2, Thr-His-Pro-NH2) had potent reactivity to anti-TRH serum in large dose of 100 ng/tube. Histidine 43-46 thyrotropin releasing hormone Homo sapiens 103-106 4621760-0 1972 On the role of the histidine moiety in the structure of the thyrotropin-releasing hormone. Histidine 19-28 thyrotropin releasing hormone Homo sapiens 60-89 5001098-0 1971 [The significance of histidines in "thyrotropin-releasing" hormone (TRH)]. Histidine 21-31 thyrotropin releasing hormone Homo sapiens 35-66 5001098-0 1971 [The significance of histidines in "thyrotropin-releasing" hormone (TRH)]. Histidine 21-31 thyrotropin releasing hormone Homo sapiens 68-71 33791245-7 2021 The relative abundances of multiple butyrate producing microbes are reduced in patients with high-grade thyroid nodules and the relative abundances of L-histidine metabolism pathways are associated with thyrotropin-releasing hormone. Histidine 151-162 thyrotropin releasing hormone Homo sapiens 203-232