PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32658257-2 2020 Of these, the highly prevalent FcgammaRIIa (CD32a) histidine (H)-131 variant (CD32aH) is strongly linked to human autoimmune diseases through unclear mechanisms. Histidine 51-60 Fc gamma receptor IIa Homo sapiens 31-42 32658257-2 2020 Of these, the highly prevalent FcgammaRIIa (CD32a) histidine (H)-131 variant (CD32aH) is strongly linked to human autoimmune diseases through unclear mechanisms. Histidine 51-60 Fc gamma receptor IIa Homo sapiens 44-49 23270585-3 2013 The genetic locus of Fc-gamma RIIA consists of two allelic genes: 131-Arg (R131) and 131-His (H131). Histidine 89-92 Fc gamma receptor IIa Homo sapiens 21-34 23994584-5 2013 However, particular alleles at GM 23 and FcgammaRIIa loci interactively contributed to the risk of this malignancy (p = 0.031), the odds ratios ranging from 0.44 in subjects homozygous for the GM 23- allele at the IgG2 locus and for the histidine allele at the FcgammaRIIa locus to 2.86 in subjects homozygous for the GM 23+ allele at the IgG2 locus and the histidine allele at the FcgammaRIIa locus. Histidine 237-246 Fc gamma receptor IIa Homo sapiens 41-52 23994584-5 2013 However, particular alleles at GM 23 and FcgammaRIIa loci interactively contributed to the risk of this malignancy (p = 0.031), the odds ratios ranging from 0.44 in subjects homozygous for the GM 23- allele at the IgG2 locus and for the histidine allele at the FcgammaRIIa locus to 2.86 in subjects homozygous for the GM 23+ allele at the IgG2 locus and the histidine allele at the FcgammaRIIa locus. Histidine 358-367 Fc gamma receptor IIa Homo sapiens 41-52 28988621-4 2017 Although the unfractionated mixture demonstrated weaker interaction/activation of the receptor, differently oxidized isolated subspecies can lead both to stronger as well as weaker binding and activation of the histidine variant of FcgammaRIIa. Histidine 211-220 Fc gamma receptor IIa Homo sapiens 232-243 18179643-2 2008 Two allelic dimorphisms of these receptors, valine/phenylalanine-158 of CD16A and histidine/arginine-131 of CD32A, modulate their affinity for certain human IgG subclasses. Histidine 82-91 Fc gamma receptor IIa Homo sapiens 108-113 19965803-5 2010 The presence of an arginine instead of a histidine residue at amino acid position 131 (H131R) in the extracellular domain of FcgammaRIIa reduces the affinity of the receptor for IgG(2) and IgG(3) isotypes but increases the binding activity for C reactive protein (CRP). Histidine 41-50 Fc gamma receptor IIa Homo sapiens 125-136 22628489-3 2012 Among them, a functional FCGR2A polymorphism leading to amino acid change of histidine (H) to arginine (R) at position 131 appears to be a major candidate in adult invasive pneumococcal diseases (IPDs). Histidine 77-86 Fc gamma receptor IIa Homo sapiens 25-31 21813128-1 2011 OBJECTIVE: A gene polymorphism substituting arginine (R) for histidine (H) at position 131 has been described within the Fcgamma receptor IIa (FcgammaRIIa). Histidine 61-70 Fc gamma receptor IIa Homo sapiens 121-141 21813128-1 2011 OBJECTIVE: A gene polymorphism substituting arginine (R) for histidine (H) at position 131 has been described within the Fcgamma receptor IIa (FcgammaRIIa). Histidine 61-70 Fc gamma receptor IIa Homo sapiens 143-154 21856937-8 2011 Finally, crystal structures of LR (histidine, H134) allele of FcgammaRIIa and FcgammaRIIa-HR reveal two distinct receptor dimers that may represent quaternary states on the cell surface. Histidine 35-44 Fc gamma receptor IIa Homo sapiens 62-73 21856937-8 2011 Finally, crystal structures of LR (histidine, H134) allele of FcgammaRIIa and FcgammaRIIa-HR reveal two distinct receptor dimers that may represent quaternary states on the cell surface. Histidine 35-44 Fc gamma receptor IIa Homo sapiens 78-89 24048792-9 2011 Patients who were heterozygous for the CD32a (Fcgamma receptor IIa) 131 histidine (H) to arginine (R) polymorphism had a significantly decreased PFS (P = .009) after R-bortezomib compared with HH and RR homozygotes. Histidine 72-81 Fc gamma receptor IIa Homo sapiens 39-44 24048792-9 2011 Patients who were heterozygous for the CD32a (Fcgamma receptor IIa) 131 histidine (H) to arginine (R) polymorphism had a significantly decreased PFS (P = .009) after R-bortezomib compared with HH and RR homozygotes. Histidine 72-81 Fc gamma receptor IIa Homo sapiens 46-66 12643213-2 2003 Human Fc gamma RIIa has 2 codominantly expressed alleles, H131 and R131, which differ at amino acid position 131 in the second extracellular domain (histidine or arginine respectively) and differ substantially in their ability to bind human IgG2. Histidine 149-158 Fc gamma receptor IIa Homo sapiens 6-19 16267770-2 2005 METHODS: Fc gamma RIIa mutation at amino acid position 131 (arginine or histidine) was detected by polymerase chain reaction, and in vitro cultures for parasites were used to assess the invasion rate. Histidine 72-81 Fc gamma receptor IIa Homo sapiens 9-22 12975461-9 2003 Conversely, both the Fc gamma RIIIa 158 valine/valine and the Fc gamma RIIa 131 histidine/histidine genotypes were found to be independently associated with the response rate and freedom from progression. Histidine 80-89 Fc gamma receptor IIa Homo sapiens 62-75 12975461-9 2003 Conversely, both the Fc gamma RIIIa 158 valine/valine and the Fc gamma RIIa 131 histidine/histidine genotypes were found to be independently associated with the response rate and freedom from progression. Histidine 90-99 Fc gamma receptor IIa Homo sapiens 62-75 18165525-2 2007 A genetic single nucleotide polymorphism in the Fc gamma RIIa gene, resulting in arginine (R) or histidine (H) at position 131, affects the binding to the different IgG subclasses and may influence the clinical variations seen in onchocerciasis. Histidine 97-106 Fc gamma receptor IIa Homo sapiens 48-61 15604023-1 2004 A guanine to adenine point mutation results in an arginine (R) to histidine (H) substitution in FcgammaRIIa at residue 131 that strongly impacts receptor function. Histidine 66-75 Fc gamma receptor IIa Homo sapiens 96-107 15319871-2 2004 Previous studies have shown that individuals with the IgG1/3-binding Fc gamma RIIa-Arg/Arg131 genotype are relatively protected against high-density malaria, whereas individuals with the IgG2-binding Fc gamma RIIa-His/His131 genotype are at increased risk for developing cerebral malaria. Histidine 214-217 Fc gamma receptor IIa Homo sapiens 200-213 10675363-4 2000 Because the single nucleotide polymorphism in FcgammaRIIA - which encodes histidine or arginine at position 131 - strongly influences IgG2 binding, we determined this polymorphism"s effect on CRP binding. Histidine 74-83 Fc gamma receptor IIa Homo sapiens 46-57 10417619-4 1999 As the human Fc gamma receptor IIa proteins exist in two allotypes (one with a histidine at position 131, which binds immunoglobulin G1, 2, 3 and the other with an arginine at position 131, which binds immunoglobulin G1, and 3, but is unable to bind immunoglobulin G2), we expected an altered prevalence of histidine 131 forms in vasculitis patients. Histidine 79-88 Fc gamma receptor IIa Homo sapiens 13-34 10417619-4 1999 As the human Fc gamma receptor IIa proteins exist in two allotypes (one with a histidine at position 131, which binds immunoglobulin G1, 2, 3 and the other with an arginine at position 131, which binds immunoglobulin G1, and 3, but is unable to bind immunoglobulin G2), we expected an altered prevalence of histidine 131 forms in vasculitis patients. Histidine 307-316 Fc gamma receptor IIa Homo sapiens 13-34 8960098-1 1996 A polymorphism of the gene for Fc gamma RIIA, arginine (R) or histidine (H) at position 131, alters the ability of the receptor to bind certain IgG subclasses. Histidine 62-71 Fc gamma receptor IIa Homo sapiens 31-44 10413210-4 1999 The allele FcgammaRIIA-H131 encodes a receptor with a histidine at the 131 amino acid position; the other allele FcgammaRIIA-R131 encodes an arginine. Histidine 54-63 Fc gamma receptor IIa Homo sapiens 11-22 9002937-3 1997 The observation that a common functional polymorphism of Fc gamma RIIA, involving either an arginine (R) or histidine (H) at amino acid 131, may underlie disease susceptibility prompted us to investigate the prevalence of receptor isoforms in patients with HIT and HITT. Histidine 108-117 Fc gamma receptor IIa Homo sapiens 57-70 8772237-2 1995 A polymorphism at amino acid 131 [arginine (Arg) or histidine (His)] of Fc gamma RIIa was first shown to be determinant for MoAb-IgG1 binding on monocytes. Histidine 52-61 Fc gamma receptor IIa Homo sapiens 72-85 8772237-2 1995 A polymorphism at amino acid 131 [arginine (Arg) or histidine (His)] of Fc gamma RIIa was first shown to be determinant for MoAb-IgG1 binding on monocytes. Histidine 63-66 Fc gamma receptor IIa Homo sapiens 72-85 8772237-3 1995 To clarify the role of this polymorphism in platelet activation by MoAb-IgG1 we (i) established the Fc gamma RIIa polymorphism at the gene level by adapting the denaturating gradient gel electrophoresis method, (ii) analyzed the binding affinity of the MoAbs to Fc gamma RIIa on platelets from homozygous Arg, homozygous His, and heterozygous Arg/His donors, and (iii) characterized the different reactivities of platelets according to the Fc gamma RIIA polymorphism. Histidine 321-324 Fc gamma receptor IIa Homo sapiens 100-113 8772237-3 1995 To clarify the role of this polymorphism in platelet activation by MoAb-IgG1 we (i) established the Fc gamma RIIa polymorphism at the gene level by adapting the denaturating gradient gel electrophoresis method, (ii) analyzed the binding affinity of the MoAbs to Fc gamma RIIa on platelets from homozygous Arg, homozygous His, and heterozygous Arg/His donors, and (iii) characterized the different reactivities of platelets according to the Fc gamma RIIA polymorphism. Histidine 347-350 Fc gamma receptor IIa Homo sapiens 100-113 8556514-2 1994 We investigated the His-Arg (CAT/CGT) polymorphism at codon 131 of the Fc gamma receptor IIA gene, which influences ligand binding by the receptor. Histidine 20-23 Fc gamma receptor IIa Homo sapiens 71-92 8046255-2 1994 The method, requiring PCR amplification of genomic DNA and Southern analysis with allele specific oligonucleotide probes, detects a single nucleotide difference (G or A) at base 494 which results in an arginine (R) or histidine (H) at amino acid 131 of the Fc gamma RIIA protein. Histidine 218-227 Fc gamma receptor IIa Homo sapiens 257-270 34255889-3 2021 We identified SNPs in FCGR2A (131 histidine (H) or arginine (R); rs1801274) and reviewed the infectious complication-free survival after ICU discharge. Histidine 34-43 Fc gamma receptor IIa Homo sapiens 22-28 8555090-2 1995 A single base polymorphism at position 131 of Fc gamma RIIA changes the native arginine to histidine. Histidine 91-100 Fc gamma receptor IIa Homo sapiens 46-59