PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25373728-6 2015 Using the described method for detecting histidine and aspartic acid phosphorylations and our prostate cancer progression cell system, the potential function of NM23-H1 in suppressing metastasis with a two-component regulation system is discussed. Histidine 41-50 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 161-168 32384736-3 2020 Here, we established the Bacillus anthracis protein toxins" transport component PA63 as transporter for the delivery of His-tagged human NDPK-A into the cytosol of cultured cells including human MDA-MB-231 breast cancer cells. Histidine 120-123 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 137-143 29535799-0 2018 The relationship of NM23 (NME) metastasis suppressor histidine phosphorylation to its nucleoside diphosphate kinase, histidine protein kinase and motility suppression activities. Histidine 53-62 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 20-24 29535799-7 2018 Site-directed mutagenesis of NME1 histidine 118 and proline 96 was examined by transfection experiments and partial purification of recombinant proteins. Histidine 34-43 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 29-33 32860079-11 2020 In summary, our studies indicate that NME1 and NME2 are involved in TGF-beta1-induced HSC activation and CCl4-induced liver fibrosis, which may be mediated by histidine phosphorylation. Histidine 159-168 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 38-42 32392889-5 2020 NME1 and NME2 have been shown to possess histidine (His) kinase activity. Histidine 41-50 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 0-4 32392889-8 2020 Our demonstration of NME1 histidine phosphorylation in neuroblastoma and of the potential role of NME1 in neuroblastoma cell migration and differentiation suggest a functional role for NME1 in neuroblastoma pathogenesis and open the possibility of identifying new therapeutic targets and developing novel approaches to neuroblastoma therapy. Histidine 26-35 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 21-25 29863788-10 2018 We also used native and top-down MS to investigate the histidine autophosphorylation activity of purified Nm23 assemblies. Histidine 55-64 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 106-110 29058706-12 2018 It also summarizes why our understanding of phosphorylation is still largely restricted to the acid stable phosphoproteome, and highlights the study of NM23 histidine kinase as an entree into the world of histidine phosphorylation. Histidine 157-166 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 152-156 21121676-0 2011 Mass spectrometry detection of histidine phosphorylation on NM23-H1. Histidine 31-40 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 60-67 22869372-11 2012 AMPK does not appear to phosphorylate NDPK-A directly but rather promotes an NDPK-A autophosphorylation event that involves His-118 and Ser-120. Histidine 124-127 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 77-83 21121676-4 2011 On the basis of a pH titration of LC elution buffers and MS/MS identification, recombinant NM23-H1 subjected to autophosphorylation was shown to contain phosphorylated histidine at residue 118 at pH 5 and 6, with each level giving over 75% peptide coverage for identification. Histidine 168-177 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 91-98 21121676-3 2011 Here, we present a novel buffer system to show histidine phosphorylation of NM23-H1, the product of the first identified putative human metastasis suppressor gene (NME1), which catalyzes the transfer of the gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates. Histidine 47-56 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 76-83 21121676-3 2011 Here, we present a novel buffer system to show histidine phosphorylation of NM23-H1, the product of the first identified putative human metastasis suppressor gene (NME1), which catalyzes the transfer of the gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates. Histidine 47-56 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 164-168 19415463-1 2009 The guest editor (AM) provides his perspective on the most recent advances on nucleoside diphosphate kinase (NDPK, otherwise known as AWD or NM23) showcasing phospho-histidine biochemistry and its impact on diverse pathology when disordered. Histidine 166-175 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 141-145 17197349-9 2006 Other than histidine 118 residue (amino acid sequence 118: histidine) concerned with NDP kinase activity of nm23-H1, serine 120 (amino acid sequence 120: serine) related activity of histidine-dependent protein phosphotransfer was recently reported to be responsible for its biological suppressive effects. Histidine 11-20 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 108-127 20716420-4 2009 Autoradiography was used for detecting the serine and histidine autophosphorylation of wild type (WT) and mutant nm23-H1 (P96S, H118F, S120G and S44A); RP-HPLC was used for detecting the NDPK activity of above proteins. Histidine 54-63 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 113-120 16814409-4 2006 The 190th leucine of rpS3, and the 118th histidine and the 120th serine of nm23-H1 play key roles in the interaction of two proteins, respectively. Histidine 41-50 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 75-82 17197349-9 2006 Other than histidine 118 residue (amino acid sequence 118: histidine) concerned with NDP kinase activity of nm23-H1, serine 120 (amino acid sequence 120: serine) related activity of histidine-dependent protein phosphotransfer was recently reported to be responsible for its biological suppressive effects. Histidine 59-68 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 108-127 15181008-3 2004 Mutation of His-10 in PGM abolishes the Nm23-H1.GAPDH complex-induced phosphorylation. Histidine 12-15 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 40-47 9038158-7 1997 Nm23-H1(S120G), found in advanced human neuroblastomas, exhibited deficient activity in several histidine-dependent protein phosphotransfer reactions, including histidine autophosphorylation, downstream phosphorylation on serines, and slightly decreased histidine protein kinase activity; significant NDPK activity was observed. Histidine 96-105 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 0-4 9256424-3 1997 Here we report that nm23-H1 can transfer a phosphate from its catalytic histidine to aspartate or glutamate residues on 43-kDa membrane proteins. Histidine 72-81 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 20-27 9256424-5 1997 Nm23-H1 also can transfer phosphate from its catalytic histidine to histidines on ATP-citrate lyase and succinic thiokinase. Histidine 55-64 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 0-7 9256424-5 1997 Nm23-H1 also can transfer phosphate from its catalytic histidine to histidines on ATP-citrate lyase and succinic thiokinase. Histidine 68-78 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 0-7 10698688-0 2000 Histidine to aspartate phosphotransferase activity of nm23 proteins: phosphorylation of aldolase C on Asp-319. Histidine 0-9 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 54-58 10698688-2 2000 We have previously described the transfer of phosphate from the catalytic histidine residues of nm23 proteins to an aspartic or a glutamic residue on one or more 43 kDa proteins in detergent extracts of bovine brain membranes. Histidine 74-83 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 96-100 10698688-8 2000 The sequence around Asp-319 of aldolase C has some similarities to those around the histidine residues on ATP-citrate lyase and succinic thiokinase that are phosphorylated by nm23 proteins. Histidine 84-93 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 175-179 9038158-7 1997 Nm23-H1(S120G), found in advanced human neuroblastomas, exhibited deficient activity in several histidine-dependent protein phosphotransfer reactions, including histidine autophosphorylation, downstream phosphorylation on serines, and slightly decreased histidine protein kinase activity; significant NDPK activity was observed. Histidine 161-170 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 0-4 9038158-8 1997 The Nm23-H1(S120A) mutant was deficient in only histidine-dependent serine autophosphorylation. Histidine 48-57 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 4-11 8245015-2 1993 Nm23 was previously demonstrated to exhibit nucleoside diphosphate kinase (NDPK) activity, which transfers a phosphate among nucleoside tri- and diphosphates via an Nm23-phospho-histidine intermediate. Histidine 178-187 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 0-4 8245015-2 1993 Nm23 was previously demonstrated to exhibit nucleoside diphosphate kinase (NDPK) activity, which transfers a phosphate among nucleoside tri- and diphosphates via an Nm23-phospho-histidine intermediate. Histidine 178-187 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 165-169