PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35339000-4 2022 The activated caspase-3 and changes of ATPase activity in UMH-treated meat accelerated the postmortem ageing, and L-histidine might competitively inhibit the actin-myosin binding by the imidazole group. Histidine 114-125 caspase 3 Homo sapiens 14-23 29061826-7 2017 A significant reduction in the number of UVA-induced apoptotic cells and caspase-3 activation was observed when histidine was present, which suggested that photodynamically-generated singlet oxygen is an important mediator of apoptosis. Histidine 112-121 caspase 3 Homo sapiens 73-82 28653316-7 2017 Altogether, we found that AFP interacts with caspase-3 through precise amino acids, namely loop-4 residues Glu-248, Asp-253 and His-257. Histidine 128-131 caspase 3 Homo sapiens 45-54 27272775-8 2016 Histidine, a well-known reactive oxygen scavenger, significantly inhibited sonodynamically-induced apoptosis, caspase-3 activation and 4oxoTEMPO formation. Histidine 0-9 caspase 3 Homo sapiens 110-119 25343534-4 2014 Mutation of the central V266 to histidine in the dimer interface of caspase-3 inactivates the enzyme by introducing steric clashes that may ultimately affect positioning of a helix on the protein surface. Histidine 32-41 caspase 3 Homo sapiens 68-77 25345515-8 2014 His-121, Ser-205, Arg-207 which were found to be playing crucial role in the binding of the selected compounds within the active site of caspase-3. Histidine 0-3 caspase 3 Homo sapiens 137-146 23614869-11 2013 Introducing a histidine into the interface of procaspase-3 prevents activation by acting as a negative design element, providing evidence that the interface region is a site of regulation of caspase assembly in general by affecting the rate of dimerization. Histidine 14-23 caspase 3 Homo sapiens 46-58 23082100-7 2012 Sonodynamically induced apoptosis, caspase-3 activation, and nitroxide generation were significantly suppressed by histidine. Histidine 115-124 caspase 3 Homo sapiens 35-44 23082100-9 2012 The significant reduction in sonodynamically induced apoptosis, nitroxide generation, and caspase-3 activation by histidine suggests active species such as singlet oxygen are important in the sonodynamic induction of apoptosis. Histidine 114-123 caspase 3 Homo sapiens 90-99 21696155-6 2011 Phosphorylation of the full-length protein, His-tagged pro-caspase-3, was demonstrated through Fc-phosphoamide transfer to the Ser residues of the surface-bound protein by electrochemical means. Histidine 44-47 caspase 3 Homo sapiens 55-68 20204369-6 2010 Sonodynamically induced apoptosis, caspase-3 activation, and nitroxide generation were significantly suppressed by histidine. Histidine 115-124 caspase 3 Homo sapiens 35-44 20204369-8 2010 The significant reduction in sonodynamically induced apoptosis, nitroxide generation, and caspase-3 activation by histidine suggests that active species such as singlet oxygen are important in the sonodynamic induction of apoptosis. Histidine 114-123 caspase 3 Homo sapiens 90-99 17970784-6 2008 Sonodynamically-induced apoptosis, caspase-3 activation, and nitroxide generation were significantly suppressed by histidine. Histidine 115-124 caspase 3 Homo sapiens 35-44 17893515-7 2007 Both sonodynamically induced apoptosis and caspase-3 activation were significantly suppressed by histidine. Histidine 97-106 caspase 3 Homo sapiens 43-52 17893515-9 2007 Significant reduction by histidine in both sonodynamically induced apoptosis and caspase-3 activation suggests that some ultrasonically generated active species, deactivatable by histidine, are the major mediators to induce the observed apoptosis. Histidine 25-34 caspase 3 Homo sapiens 81-90 17893515-9 2007 Significant reduction by histidine in both sonodynamically induced apoptosis and caspase-3 activation suggests that some ultrasonically generated active species, deactivatable by histidine, are the major mediators to induce the observed apoptosis. Histidine 179-188 caspase 3 Homo sapiens 81-90 16866351-4 2006 Unlike the clan CA cysteine proteases, the catalytic histidine in caspase-3 plays a critical role during protonation and subsequent ring opening of the epoxide moiety and facilitates the nucleophilic attack by the active site cysteine. Histidine 53-62 caspase 3 Homo sapiens 66-75 16866351-6 2006 A favorable network of hydrogen bonds involving the oxyanion hole, catalytic histidine, and the atoms in the prime site of the inhibitor enhance the binding affinity and specificity of the aza-peptide epoxide inhibitors toward caspase-3. Histidine 77-86 caspase 3 Homo sapiens 227-236 16140256-8 2005 Considering that those residues could be protected by caspase-3-specific inhibitor from the inactivation, the modifiers are histidine- and cysteine-specific, respectively, and the involvement of these residues in the characteristic catalytic dyad of caspases, the results indicate that the pKa values of the catalytic histidine and cysteine residues are changed during the activation process. Histidine 124-133 caspase 3 Homo sapiens 54-63 16140256-8 2005 Considering that those residues could be protected by caspase-3-specific inhibitor from the inactivation, the modifiers are histidine- and cysteine-specific, respectively, and the involvement of these residues in the characteristic catalytic dyad of caspases, the results indicate that the pKa values of the catalytic histidine and cysteine residues are changed during the activation process. Histidine 318-327 caspase 3 Homo sapiens 54-63 14567692-3 2003 In contrast, substitution of V266 with histidine abolished the activity of the procaspase-3 as well as that of the mature caspase. Histidine 39-48 caspase 3 Homo sapiens 79-91 10998365-7 2000 Both PDT-induced caspase-3 activation and PAK2 cleavage/activation can be inhibited by the singlet oxygen scavengers, L-histidine and alpha-tocopherol, but not the hydroxyl radical scavenger, mannitol, demonstrating that singlet oxygen is an immediate early-apoptotic signal generated by PDT. Histidine 118-129 caspase 3 Homo sapiens 17-26