PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10051705-2 1999 Histamine is synthesized by L-histidine, catalysed by L-histidine decarboxylase (HDC) and metabolized mainly by histamine N-methyltransferase (HMT). Histidine 28-39 histidine decarboxylase Homo sapiens 54-79 10051705-2 1999 Histamine is synthesized by L-histidine, catalysed by L-histidine decarboxylase (HDC) and metabolized mainly by histamine N-methyltransferase (HMT). Histidine 28-39 histidine decarboxylase Homo sapiens 81-84 9813077-1 1998 L-Histidine decarboxylase (HDC) catalyzes the formation of histamine from L-histidine, and in hematopoietic cell lineages the gene is expressed only in mast cells and basophils. Histidine 74-85 histidine decarboxylase Homo sapiens 0-25 9813077-1 1998 L-Histidine decarboxylase (HDC) catalyzes the formation of histamine from L-histidine, and in hematopoietic cell lineages the gene is expressed only in mast cells and basophils. Histidine 74-85 histidine decarboxylase Homo sapiens 27-30 9546316-2 1998 Basophils and mast cells are the main sources of histamine, which is formed from L-histidine by histidine decarboxylase (HDC). Histidine 81-92 histidine decarboxylase Homo sapiens 96-119 9546316-2 1998 Basophils and mast cells are the main sources of histamine, which is formed from L-histidine by histidine decarboxylase (HDC). Histidine 81-92 histidine decarboxylase Homo sapiens 121-124 2117926-5 1990 The enzyme was inhibited by alpha-fluoromethylhistidine but not by carbidopa, was unable to form dopamine from L-3,4-dihydroxyphenylalanine, and had a Km value for histidine of 0.27 mM, indicating that it was HDC and not aromatic amino acid decarboxylase. Histidine 46-55 histidine decarboxylase Homo sapiens 209-212 8838085-2 1996 L-Histidine decarboxylase (HDC) is a unique enzyme in mammals which catalyzes histamine formation from L-histidine. Histidine 103-114 histidine decarboxylase Homo sapiens 0-25 8838085-2 1996 L-Histidine decarboxylase (HDC) is a unique enzyme in mammals which catalyzes histamine formation from L-histidine. Histidine 103-114 histidine decarboxylase Homo sapiens 27-30 1425659-1 1992 L-Histidine decarboxylase (HisDC) is the enzyme catalyzing the formation of histamine from L-histidine. Histidine 91-102 histidine decarboxylase Homo sapiens 2-25 2238092-1 1990 alpha-Fluoromethyl-[S]-histidine (FMH) is a specific and potent inhibitor of histidine decarboxylase, which forms histamine from histidine. Histidine 23-32 histidine decarboxylase Homo sapiens 77-100 35529437-9 2022 Histidine can be decarboxylated to histamine by histidine decarboxylase. Histidine 0-9 histidine decarboxylase Homo sapiens 48-71 34734351-2 2021 Histidine decarboxylase (HDC), the unique enzyme that converts L-histidine to histamine, is highly expressed in CD11b+ immature myeloid cells. Histidine 63-74 histidine decarboxylase Homo sapiens 0-23 34734351-2 2021 Histidine decarboxylase (HDC), the unique enzyme that converts L-histidine to histamine, is highly expressed in CD11b+ immature myeloid cells. Histidine 63-74 histidine decarboxylase Homo sapiens 25-28 34471328-0 2021 Rapid identification of histamine-producing bacteria isolated from fish using MALDI-TOF MS. Histamine-producing bacteria (HPB) produce histamine from histidine contained in food through the action of histidine decarboxylase. Histidine 150-159 histidine decarboxylase Homo sapiens 200-223 33505099-1 2021 Histamine is a degradation product of the bacterial decarboxylation of the amino acid histidine; such activity is determined by histidine decarboxylase encoded by a gene cluster, carried by some Gram-positive bacteria, that includes the hdcA gene. Histidine 86-95 histidine decarboxylase Homo sapiens 128-151 1220546-0 1975 Proceedings: The kinetics of complex formation between histidine and pyridoxal-5-phosphate in the presence of bacterial histidine decarboxylase. Histidine 55-64 histidine decarboxylase Homo sapiens 120-143 6712729-5 1984 L-Histidine, a substrate, protected HDC against inactivation, but D-histidine did not. Histidine 0-11 histidine decarboxylase Homo sapiens 36-39 117688-1 1979 The hypothesis that N-terminal histidine peptides might act as inhibitors to histidine decarboxylase was investigated. Histidine 31-40 histidine decarboxylase Homo sapiens 77-100 117688-6 1979 Histidine decarboxylase exclusively was inhibited by N-terminal histidine peptides. Histidine 64-73 histidine decarboxylase Homo sapiens 0-23 117688-10 1979 It is concluded that small peptides with histidine as the N-terminal amino acid might act as specific inhibitors for mammalian histidine decarboxylase. Histidine 41-50 histidine decarboxylase Homo sapiens 127-150 176880-2 1975 The dynamics of the complex formation between pyridoxal 5"-phosphate (PLP) and histidine in the presence of bacterial histidine decarboxylase was examined. Histidine 79-88 histidine decarboxylase Homo sapiens 118-141 33261109-0 2020 Anti-Allergic Potential of Cinnamaldehyde via the Inhibitory Effect of Histidine Decarboxylase (HDC) Producing Klebsiella pneumonia. Histidine 71-80 histidine decarboxylase Homo sapiens 96-99 31730800-1 2020 Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Histidine 142-151 histidine decarboxylase Homo sapiens 167-170 32871134-4 2020 In this study, we demonstrated that a HDC Y334F mutant is capable of catalyzing the decarboxylation-dependent oxidative deamination of histidine to yield imidazole acetaldehyde. Histidine 135-144 histidine decarboxylase Homo sapiens 38-41 33000155-11 2020 Histidine can be decarboxylated to histamine by histidine decarboxylase. Histidine 0-9 histidine decarboxylase Homo sapiens 48-71 31730800-1 2020 Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Histidine 199-202 histidine decarboxylase Homo sapiens 142-165 31730800-1 2020 Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Histidine 199-202 histidine decarboxylase Homo sapiens 167-170 30586560-0 2019 Development of a novel l-histidine assay method using histamine dehydrogenase and a stable mutant of histidine decarboxylase. Histidine 23-34 histidine decarboxylase Homo sapiens 101-124 30586560-3 2019 Here, we describe a novel l-histidine quantitation assay using a combination of histidine decarboxylase (HDC) and histamine dehydrogenase (HDH) enzymes. Histidine 26-37 histidine decarboxylase Homo sapiens 80-103 30586560-3 2019 Here, we describe a novel l-histidine quantitation assay using a combination of histidine decarboxylase (HDC) and histamine dehydrogenase (HDH) enzymes. Histidine 26-37 histidine decarboxylase Homo sapiens 105-108 29973935-2 2018 Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Histidine 57-66 histidine decarboxylase Homo sapiens 110-133 30346159-1 2018 Histidine decarboxylase is a pyridoxal 5"-phosphate enzyme catalyzing the conversion of histidine to histamine, a bioactive molecule exerting its role in many modulatory processes. Histidine 88-97 histidine decarboxylase Homo sapiens 0-23 29884090-1 2018 Histidine decarboxylase (HDC) is the primary enzyme that catalyzes the conversion of histidine to histamine. Histidine 85-94 histidine decarboxylase Homo sapiens 0-23 29884090-1 2018 Histidine decarboxylase (HDC) is the primary enzyme that catalyzes the conversion of histidine to histamine. Histidine 85-94 histidine decarboxylase Homo sapiens 25-28 29973935-2 2018 Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Histidine 57-66 histidine decarboxylase Homo sapiens 135-138 28228363-1 2017 Histidine decarboxylase (HDC) is an enzyme that converts histidine to histamine. Histidine 57-66 histidine decarboxylase Homo sapiens 0-23 28228363-1 2017 Histidine decarboxylase (HDC) is an enzyme that converts histidine to histamine. Histidine 57-66 histidine decarboxylase Homo sapiens 25-28 28228363-2 2017 Inhibition of HDC has several medical applications, and HDC inhibitors are of considerable interest for the study of histidine metabolism. Histidine 117-126 histidine decarboxylase Homo sapiens 56-59 22940786-1 2012 Histamine (HA), a mediator of inflammation, type I allergic responses and neurotransmission, is synthesized from L-histidine, the reaction of which is catalyzed by histidine decarboxylase (HDC). Histidine 125-136 histidine decarboxylase Homo sapiens 188-211 26164497-1 2015 Histidine decarboxylase (HDC) catalyzes the biosynthesis of histamine from L-histidine and is expressed throughout the mammalian nervous system by histaminergic neurons. Histidine 75-86 histidine decarboxylase Homo sapiens 0-23 26164497-1 2015 Histidine decarboxylase (HDC) catalyzes the biosynthesis of histamine from L-histidine and is expressed throughout the mammalian nervous system by histaminergic neurons. Histidine 75-86 histidine decarboxylase Homo sapiens 25-28 25524476-7 2015 Through the colocalized enzymatic activity of Histidine decarboxylase in the histaminergic neurons, the resulting L-histidine may subsequently be converted into histamine, which could be responsible for the effects of carnosine on neurotransmission and physiological function. Histidine 114-125 histidine decarboxylase Homo sapiens 46-69 24129980-2 2014 In mammals, histamine is formed by decarboxylation of L-histidine, which is catalyzed by pyridoxal-5"-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22). Histidine 54-65 histidine decarboxylase Homo sapiens 128-151 24129980-2 2014 In mammals, histamine is formed by decarboxylation of L-histidine, which is catalyzed by pyridoxal-5"-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22). Histidine 54-65 histidine decarboxylase Homo sapiens 153-156 22940786-1 2012 Histamine (HA), a mediator of inflammation, type I allergic responses and neurotransmission, is synthesized from L-histidine, the reaction of which is catalyzed by histidine decarboxylase (HDC). Histidine 125-136 histidine decarboxylase Homo sapiens 213-216 22767596-2 2012 L-histidine decarboxylase (HDC) is the primary enzyme responsible for histamine synthesis and produces histamine from histidine in a one-step reaction. Histidine 2-11 histidine decarboxylase Homo sapiens 27-30 22767596-6 2012 The S354G mutation at the active site enlarged the size of the hHDC substrate-binding pocket and resulted in a decreased affinity for histidine, but an acquired ability to bind and act on L-DOPA as a substrate. Histidine 134-143 histidine decarboxylase Homo sapiens 63-67 19032907-7 2008 In addition, we found that HCBMCs generate the transcription of histidine decarboxylase (HDC), the enzyme responsible for the generation of histamine from histidine, after SP treatment. Histidine 64-73 histidine decarboxylase Homo sapiens 89-92 20445167-3 2010 Here, we describe an analysis of linkage in a two-generation pedigree leading to the identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis. Histidine 155-166 histidine decarboxylase Homo sapiens 137-140 19266161-1 2009 Histidine decarboxylase (HDC) catalyzes the formation of histamine from histidine. Histidine 72-81 histidine decarboxylase Homo sapiens 0-23 19266161-1 2009 Histidine decarboxylase (HDC) catalyzes the formation of histamine from histidine. Histidine 72-81 histidine decarboxylase Homo sapiens 25-28 18756395-3 2008 In most histamine-containing foods the majority of the histamine is generated by decarboxylation of the histidine through histidine decarboxylase enzymes derived from the bacteria present in food. Histidine 104-113 histidine decarboxylase Homo sapiens 122-145 17965265-1 2008 Histamine, a biogenic amine with important biological functions, is produced from histidine by histidine decarboxylase (HDC), a pyridoxal 5"-phosphate-dependent enzyme. Histidine 82-91 histidine decarboxylase Homo sapiens 95-118 17965265-1 2008 Histamine, a biogenic amine with important biological functions, is produced from histidine by histidine decarboxylase (HDC), a pyridoxal 5"-phosphate-dependent enzyme. Histidine 82-91 histidine decarboxylase Homo sapiens 120-123 17965265-5 2008 The most potent inhibitory compound among nine tested structural variants was the pyridoxyl-histidine methyl ester conjugate (PHME), indicating that the binding site of hHDC does not tolerate groups other than the imidazole side chain of histidine. Histidine 92-101 histidine decarboxylase Homo sapiens 169-173 16328055-2 2006 Histidine decarboxylase (HDC) catalyzes the formation of histamine from histidine. Histidine 72-81 histidine decarboxylase Homo sapiens 0-23 17227057-1 2007 Histidine decarboxylase (HDC) catalyzes histamine formation from histidine. Histidine 65-74 histidine decarboxylase Homo sapiens 0-23 17227057-1 2007 Histidine decarboxylase (HDC) catalyzes histamine formation from histidine. Histidine 65-74 histidine decarboxylase Homo sapiens 25-28 17227057-4 2007 Epicatechin gallate (ECG) was found to be a potent inhibitor as it inhibited HDC activity in a competitive manner with Ki = 10 muM against l-histidine. Histidine 139-150 histidine decarboxylase Homo sapiens 77-80 17713357-6 2007 We also found increased histidine decarboxylase (HDC) expression in activated HUCMC after 6 h of incubation, a rate-limiting enzyme responsible for the generation of histamine from histidine. Histidine 24-33 histidine decarboxylase Homo sapiens 49-52 16919600-1 2006 Histidine decarboxylase gene (HDC) encodes histidine decarboxylase which is the crucial enzyme for the biosynthesis of histidine. Histidine 43-52 histidine decarboxylase Homo sapiens 0-23 16919600-1 2006 Histidine decarboxylase gene (HDC) encodes histidine decarboxylase which is the crucial enzyme for the biosynthesis of histidine. Histidine 43-52 histidine decarboxylase Homo sapiens 30-33 16357063-1 2006 Histidine decarboxylase (HDC) is the enzyme that converts histidine to histamine, a bioamine that plays an important role in many physiological aspects including allergic responses, inflammation, neurotransmission, and gastric acid secretion. Histidine 58-67 histidine decarboxylase Homo sapiens 0-23 16357063-1 2006 Histidine decarboxylase (HDC) is the enzyme that converts histidine to histamine, a bioamine that plays an important role in many physiological aspects including allergic responses, inflammation, neurotransmission, and gastric acid secretion. Histidine 58-67 histidine decarboxylase Homo sapiens 25-28 16790022-0 2006 Histamine, histidine, and growth-phase mediated regulation of the histidine decarboxylase gene in lactic acid bacteria isolated from wine. Histidine 11-20 histidine decarboxylase Homo sapiens 66-89 16790022-4 2006 With northern blots and specific activity analysis, we observed that histidine induces the expression of the histidine decarboxylase gene (hdc) and that histamine causes a decrease in the expression of this gene. Histidine 69-78 histidine decarboxylase Homo sapiens 109-132 16790022-4 2006 With northern blots and specific activity analysis, we observed that histidine induces the expression of the histidine decarboxylase gene (hdc) and that histamine causes a decrease in the expression of this gene. Histidine 69-78 histidine decarboxylase Homo sapiens 139-142 16328055-2 2006 Histidine decarboxylase (HDC) catalyzes the formation of histamine from histidine. Histidine 72-81 histidine decarboxylase Homo sapiens 25-28 15144399-1 2004 Histidine decarboxylase (HDC) is an enzyme for decarboxylating l-histidine to histamine and is expressed in various types of cells including neuroendocrine tumors. Histidine 63-74 histidine decarboxylase Homo sapiens 0-23 15189499-1 2004 Previously we demonstrated that histidine decarboxylase (HDC), which produces histamine from l-histidine, was detected in monocytes/macrophages located in human atherosclerotic lesions. Histidine 93-104 histidine decarboxylase Homo sapiens 32-55 15189499-1 2004 Previously we demonstrated that histidine decarboxylase (HDC), which produces histamine from l-histidine, was detected in monocytes/macrophages located in human atherosclerotic lesions. Histidine 93-104 histidine decarboxylase Homo sapiens 57-60 15144399-1 2004 Histidine decarboxylase (HDC) is an enzyme for decarboxylating l-histidine to histamine and is expressed in various types of cells including neuroendocrine tumors. Histidine 63-74 histidine decarboxylase Homo sapiens 25-28 14961766-1 2004 HDC (L-histidine decarboxylase), the enzyme responsible for the catalytic production of histamine from L-histidine, belongs to an evolutionarily conserved family of vitamin B6-dependent enzymes known as the group II decarboxylases. Histidine 5-16 histidine decarboxylase Homo sapiens 0-3 14961766-6 2004 This involves a protease sensitive loop, and incubating recombinant HDC with an L-histidine substrate analogue altered enzyme structure so that the loop was no longer exposed for tryptic proteolysis. Histidine 80-91 histidine decarboxylase Homo sapiens 68-71 11306145-1 2001 Histamine, a principal mediator in various physiological and pathological cell functions is synthesized from L-histidine exclusively by histidine decarboxylase, an enzyme, which is expressed in many tissues of mammalian organism. Histidine 109-120 histidine decarboxylase Homo sapiens 136-159 10951267-2 2000 Histidine decarboxylase, the only enzyme that catalyzes the formation of histamine from L-histidine, is an essential regulator of histamine levels. Histidine 88-99 histidine decarboxylase Homo sapiens 0-23 10888270-1 2000 Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes. Histidine 27-36 histidine decarboxylase Homo sapiens 40-63 10888270-1 2000 Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes. Histidine 27-36 histidine decarboxylase Homo sapiens 65-68 11566179-1 2001 We investigated the localization of histidine decarboxylase (HDC), which is the rate-limiting enzyme that generates histamine from histidine, in human aorta/coronary artery. Histidine 36-45 histidine decarboxylase Homo sapiens 61-64