PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20497104-4 2010 D-Lys6-GnRH and [Asn1-Val5]-angiotensin II were modified at their histidine side chain within the peptide, whilst IGF-1 (1-3) was modified at the C-terminal glutamic acid residue. Histidine 66-75 gonadotropin releasing hormone 1 Homo sapiens 7-11 20158486-4 2010 D-Lys6-GnRH and [Asn1-Val5]-angiotensin II were modified at their histidine side chain within the peptide, whilst IGF-1 (1-3) was modified at the C-terminal glutamic acid residue. Histidine 66-75 gonadotropin releasing hormone 1 Homo sapiens 7-11 19655810-0 2009 Histidine residues in the peptide D-Lys(6)-GnRH: potential for copolymerization in polymeric nanoparticles. Histidine 0-9 gonadotropin releasing hormone 1 Homo sapiens 43-47 19655810-4 2009 MALDI TOF/TOF (tandem) analysis revealed that the histidine residue in position 2 of d-Lys(6)-GnRH interacts covalently in the polymerization process. Histidine 50-59 gonadotropin releasing hormone 1 Homo sapiens 94-98 10889019-4 2000 61(98))Glu mutation markedly decreased the affinity for a series of GnRH analogues containing the native His(2) residue. Histidine 105-108 gonadotropin releasing hormone 1 Homo sapiens 68-72 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Histidine 187-190 gonadotropin releasing hormone 1 Homo sapiens 42-46 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Histidine 187-190 gonadotropin releasing hormone 1 Homo sapiens 115-119 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Histidine 187-190 gonadotropin releasing hormone 1 Homo sapiens 115-119 15544487-1 2004 Gonadotropin-releasing hormone (GnRH) or luteinizing hormone-releasing hormone (LHRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) hypothalamic hormone that acts upon 7-trans membrane spanning GnRH receptors in the pituitary. Histidine 109-112 gonadotropin releasing hormone 1 Homo sapiens 0-30 15544487-1 2004 Gonadotropin-releasing hormone (GnRH) or luteinizing hormone-releasing hormone (LHRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) hypothalamic hormone that acts upon 7-trans membrane spanning GnRH receptors in the pituitary. Histidine 109-112 gonadotropin releasing hormone 1 Homo sapiens 32-36 10684817-1 2000 In the brain of all vertebrate classes, chicken (c) GnRH-II ([His(5), Trp(7),Tyr(8)]GnRH, cGnRH-II) is expressed in the mesencephalon. Histidine 62-65 gonadotropin releasing hormone 1 Homo sapiens 52-56 18927217-3 2009 We found that its amino acid sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH(2)) was identical to that of mammalian GnRH. Histidine 44-47 gonadotropin releasing hormone 1 Homo sapiens 122-126 2689597-3 1989 The nuclear magnetic resonance spectroscopy shows that the mode of coordination of Zn(II) to LHRH consists of binding to the imidazole nitrogen and the peptide oxygen of the His-Trp bond. Histidine 174-177 gonadotropin releasing hormone 1 Homo sapiens 93-97 7761629-7 1995 The amino acid sequence of sturgeon GnRH is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. Histidine 49-52 gonadotropin releasing hormone 1 Homo sapiens 36-40 1805795-2 1991 The azotization at histidine and or tyrosine of GnRH was carried out and characterized extensively. Histidine 19-28 gonadotropin releasing hormone 1 Homo sapiens 48-52 11255560-1 2000 Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes. Histidine 61-64 gonadotropin releasing hormone 1 Homo sapiens 0-30 11255560-1 2000 Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes. Histidine 61-64 gonadotropin releasing hormone 1 Homo sapiens 32-36 8816823-5 1996 Tunicate GnRH-I (pGlu-His-Trp-Ser-Asp-Tyr-Phe-Lys-Pro-Gly-NH2) has 60% of its residues conserved, compared with mammalian GnRH, whereas tunicate GnRH-II (pGlu-His-Trp-Ser-Leu-Cys-His-Ala-Pro-Gly-NH2) is unusual in that it was isolated as a disulfide-linked dimer. Histidine 22-25 gonadotropin releasing hormone 1 Homo sapiens 9-13 8816823-5 1996 Tunicate GnRH-I (pGlu-His-Trp-Ser-Asp-Tyr-Phe-Lys-Pro-Gly-NH2) has 60% of its residues conserved, compared with mammalian GnRH, whereas tunicate GnRH-II (pGlu-His-Trp-Ser-Leu-Cys-His-Ala-Pro-Gly-NH2) is unusual in that it was isolated as a disulfide-linked dimer. Histidine 159-162 gonadotropin releasing hormone 1 Homo sapiens 9-13 8816823-5 1996 Tunicate GnRH-I (pGlu-His-Trp-Ser-Asp-Tyr-Phe-Lys-Pro-Gly-NH2) has 60% of its residues conserved, compared with mammalian GnRH, whereas tunicate GnRH-II (pGlu-His-Trp-Ser-Leu-Cys-His-Ala-Pro-Gly-NH2) is unusual in that it was isolated as a disulfide-linked dimer. Histidine 159-162 gonadotropin releasing hormone 1 Homo sapiens 9-13 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Histidine 71-74 gonadotropin releasing hormone 1 Homo sapiens 27-57 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Histidine 71-74 gonadotropin releasing hormone 1 Homo sapiens 59-63 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Histidine 71-74 gonadotropin releasing hormone 1 Homo sapiens 143-147 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Histidine 71-74 gonadotropin releasing hormone 1 Homo sapiens 143-147 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Histidine 71-74 gonadotropin releasing hormone 1 Homo sapiens 143-147 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Histidine 71-74 gonadotropin releasing hormone 1 Homo sapiens 143-147 2681686-1 1989 Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations. Histidine 106-109 gonadotropin releasing hormone 1 Homo sapiens 55-92 2681686-1 1989 Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations. Histidine 106-109 gonadotropin releasing hormone 1 Homo sapiens 94-98 2681686-1 1989 Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations. Histidine 106-109 gonadotropin releasing hormone 1 Homo sapiens 167-171 29232843-1 2017 The decapeptide gonadotropin-releasing hormone, also referred to as luteinizing hormone-releasing hormone with the sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) plays an important role in regulating the reproductive system. Histidine 130-133 gonadotropin releasing hormone 1 Homo sapiens 16-46 3015573-2 1986 We have previously shown that a short preincubation of explants of the median eminence area with copper(II) [Cu(II)] complexed to histidine (CuHis) markedly amplifies PGE2 stimulation of LHRH release. Histidine 130-139 gonadotropin releasing hormone 1 Homo sapiens 187-191 3530729-5 1986 Chicken LHRH-II, where tyrosine is replaced for histidine, has a lower affinity (0.3X) than that of mammalian LHRH. Histidine 48-57 gonadotropin releasing hormone 1 Homo sapiens 8-12 3530729-5 1986 Chicken LHRH-II, where tyrosine is replaced for histidine, has a lower affinity (0.3X) than that of mammalian LHRH. Histidine 48-57 gonadotropin releasing hormone 1 Homo sapiens 110-114 6394691-6 1984 Amino acid composition and sequence analyses confirmed the structure of this form of chicken LHRH as pGlu-His-Trp-Ser-Tyr-Gly-Leu-Gln-Pro-Gly-NH2. Histidine 106-109 gonadotropin releasing hormone 1 Homo sapiens 93-97 6762537-5 1982 Analogs with non-aromatic or hydrophilic amino acids (X: Gly, Leu, Arg, His, Glu) in position 1 generally have much lower activities in this series of LH-RH antagonists. Histidine 72-75 gonadotropin releasing hormone 1 Homo sapiens 151-156 6390443-6 1984 In addition, we found that copper complexed to histidine (Cu-His), but not ionic copper, stimulated LHRH release, the magnitude of which was dependent on the dose of Cu-His. Histidine 47-56 gonadotropin releasing hormone 1 Homo sapiens 100-104 25404067-1 2014 Using the chain-build-up method based on Empirical Conformational Energies of Peptides Program including solvation, we have computed, the low energy conformations of gonadotrpin-releasing hormone, GnRH, whose sequence is Pyro-Glu(PG)-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. Histidine 234-237 gonadotropin releasing hormone 1 Homo sapiens 197-201 25583361-3 2015 We investigated GnRH interactions with the His(7.36(305)) residue of the GnRH receptor, using functional and computational analysis of modified GnRH receptors and peptides. Histidine 43-46 gonadotropin releasing hormone 1 Homo sapiens 16-20 25583361-3 2015 We investigated GnRH interactions with the His(7.36(305)) residue of the GnRH receptor, using functional and computational analysis of modified GnRH receptors and peptides. Histidine 43-46 gonadotropin releasing hormone 1 Homo sapiens 73-77 25583361-3 2015 We investigated GnRH interactions with the His(7.36(305)) residue of the GnRH receptor, using functional and computational analysis of modified GnRH receptors and peptides. Histidine 43-46 gonadotropin releasing hormone 1 Homo sapiens 73-77 25583361-4 2015 Non-polar His(7.36(305)) substitutions decreased receptor affinity for GnRH four- to forty-fold, whereas GnRH signaling potency was more decreased (~150-fold). Histidine 10-13 gonadotropin releasing hormone 1 Homo sapiens 71-75 25583361-5 2015 Uncharged polar His(7.36(305)) substitutions decreased GnRH potency, but not affinity. Histidine 16-19 gonadotropin releasing hormone 1 Homo sapiens 55-59 25583361-6 2015 [2-Nal(3)]-GnRH retained high affinity at receptors with non-polar His(7.36(305)) substitutions, supporting a role for His(7.36(305)) in recognizing Trp(3) of GnRH. Histidine 67-70 gonadotropin releasing hormone 1 Homo sapiens 11-15 25583361-6 2015 [2-Nal(3)]-GnRH retained high affinity at receptors with non-polar His(7.36(305)) substitutions, supporting a role for His(7.36(305)) in recognizing Trp(3) of GnRH. Histidine 119-122 gonadotropin releasing hormone 1 Homo sapiens 11-15 25583361-8 2015 Results suggest that His(7.36(305)) of the GnRH receptor forms two distinct interactions that determine binding to Trp(3) and couple agonist binding to the conserved transmembrane domain network that activates GPCRs. Histidine 21-24 gonadotropin releasing hormone 1 Homo sapiens 43-47 24986677-3 2014 Fluorescein isothiocyanate-labeled luteinizing hormone-releasing hormone (LHRH) peptides were attached to the surface of a Ni block via a histidine-tagged LHRH interaction to specifically bind to a breast cancer cell line, MCF-7. Histidine 138-147 gonadotropin releasing hormone 1 Homo sapiens 35-72 24986677-3 2014 Fluorescein isothiocyanate-labeled luteinizing hormone-releasing hormone (LHRH) peptides were attached to the surface of a Ni block via a histidine-tagged LHRH interaction to specifically bind to a breast cancer cell line, MCF-7. Histidine 138-147 gonadotropin releasing hormone 1 Homo sapiens 74-78 24986677-3 2014 Fluorescein isothiocyanate-labeled luteinizing hormone-releasing hormone (LHRH) peptides were attached to the surface of a Ni block via a histidine-tagged LHRH interaction to specifically bind to a breast cancer cell line, MCF-7. Histidine 138-147 gonadotropin releasing hormone 1 Homo sapiens 155-159