PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25980580-2	2015	To test the hypothesis that IDH1 mutations could generate metabolic vulnerabilities for therapeutic intervention, we utilized an MCF10A cell line engineered with an arginine-to-histidine conversion at position 132 (R132H) in the catalytic site of IDH1, which equips the enzyme with a neomorphic alpha-ketoglutarate to 2HG reducing activity in an otherwise isogenic background.	Histidine	177-186	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32	
27406240-1	2017	Arginine 132 (R132) mutations to histidine or cysteine frequently occur to cytosolic NADP+ -isocitrate dehydrogenase (IDH1) in secondary glioblastoma multiforme (GBM) patients, in which GBM develops from a lower grade astroctyoma.	Histidine	33-42	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	118-122	
24590270-3	2014	Mutations of IDH1 have been identified at codon 132, with arginine being replaced with histidine in most cases.	Histidine	87-96	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	13-17	
25853107-2	2015	In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed to frequently occur in glioma patients.	Histidine	112-121	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	37-63	
25853107-2	2015	In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed to frequently occur in glioma patients.	Histidine	112-121	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	65-69	
25853107-2	2015	In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed to frequently occur in glioma patients.	Histidine	112-121	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	123-127	
24626950-4	2014	The present study, showed that forced expression of an IDH1 mutant, of which the 132th amino acid residue arginine is substituted by histidine (IDH1R132H), promoted cell proliferation in cultured cells, while wild-type IDH1 overexpression had no effect on cell proliferation.	Histidine	133-142	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	55-59	
24626950-4	2014	The present study, showed that forced expression of an IDH1 mutant, of which the 132th amino acid residue arginine is substituted by histidine (IDH1R132H), promoted cell proliferation in cultured cells, while wild-type IDH1 overexpression had no effect on cell proliferation.	Histidine	133-142	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	144-148	
23235339-2	2014	The most common IDH1 mutation affects codon 132 and results in the conversion of amino acid residue arginine (R) to histidine (H).	Histidine	116-125	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	16-20	
21647154-3	2011	The identified IDH1 mutations occurred in codon 132 resulting in replacement of arginine with either cysteine (N=3) or histidine (N=1).	Histidine	119-128	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	15-19	
23905201-2	2010	The mutated residue in IDH1 is most commonly arginine 132, which is most often replaced with either histidine or cysteine.	Histidine	100-109	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	23-27	
22904127-5	2012	We detected 31 (41.9%) heterozygous IDH1 mutations resulting in arginine-to-histidine substitution (R132H;CGT-CAT).	Histidine	76-85	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	36-40