PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25980580-2 2015 To test the hypothesis that IDH1 mutations could generate metabolic vulnerabilities for therapeutic intervention, we utilized an MCF10A cell line engineered with an arginine-to-histidine conversion at position 132 (R132H) in the catalytic site of IDH1, which equips the enzyme with a neomorphic alpha-ketoglutarate to 2HG reducing activity in an otherwise isogenic background. Histidine 177-186 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 28-32 27406240-1 2017 Arginine 132 (R132) mutations to histidine or cysteine frequently occur to cytosolic NADP+ -isocitrate dehydrogenase (IDH1) in secondary glioblastoma multiforme (GBM) patients, in which GBM develops from a lower grade astroctyoma. Histidine 33-42 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 118-122 24590270-3 2014 Mutations of IDH1 have been identified at codon 132, with arginine being replaced with histidine in most cases. Histidine 87-96 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 13-17 25853107-2 2015 In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed to frequently occur in glioma patients. Histidine 112-121 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 37-63 25853107-2 2015 In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed to frequently occur in glioma patients. Histidine 112-121 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 65-69 25853107-2 2015 In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed to frequently occur in glioma patients. Histidine 112-121 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 123-127 24626950-4 2014 The present study, showed that forced expression of an IDH1 mutant, of which the 132th amino acid residue arginine is substituted by histidine (IDH1R132H), promoted cell proliferation in cultured cells, while wild-type IDH1 overexpression had no effect on cell proliferation. Histidine 133-142 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 55-59 24626950-4 2014 The present study, showed that forced expression of an IDH1 mutant, of which the 132th amino acid residue arginine is substituted by histidine (IDH1R132H), promoted cell proliferation in cultured cells, while wild-type IDH1 overexpression had no effect on cell proliferation. Histidine 133-142 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 144-148 23235339-2 2014 The most common IDH1 mutation affects codon 132 and results in the conversion of amino acid residue arginine (R) to histidine (H). Histidine 116-125 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 16-20 21647154-3 2011 The identified IDH1 mutations occurred in codon 132 resulting in replacement of arginine with either cysteine (N=3) or histidine (N=1). Histidine 119-128 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 15-19 23905201-2 2010 The mutated residue in IDH1 is most commonly arginine 132, which is most often replaced with either histidine or cysteine. Histidine 100-109 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 23-27 22904127-5 2012 We detected 31 (41.9%) heterozygous IDH1 mutations resulting in arginine-to-histidine substitution (R132H;CGT-CAT). Histidine 76-85 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 36-40