PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35101534-6 2022 Four candidate compounds, Fludarabine Phosphate, Fludarabine, 6-Thio-20-Deoxyguanosine (6-Thio-dG), and 5-Iodotubercidin, exhibit remarkable potency in inhibiting SARS-CoV-2 RdRp. 5-iodotubercidin 104-120 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 174-178 35101534-7 2022 Among these four compounds, 5-Iodotubercidin exhibited the strongest inhibition upon SARS-CoV-2 RdRp, and was resistant to viral exoribonuclease activity, thus presenting the best antiviral activity against coronavirus from a different genus. 5-iodotubercidin 28-44 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 96-100 35101534-8 2022 Further study showed that the RdRp inhibitory activity of 5-Iodotubercidin is closely related to its capacity to inhibit adenosine kinase (ADK). 5-iodotubercidin 58-74 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 30-34