PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27906178-12	2016	The synergistic and potent anti-tumor efficacy observed between DOX and thiosemicarbazones represents a promising treatment combination for advanced cancers, which are heterogeneous and composed of non-Pgp- and Pgp-expressing tumor cells.	Thiosemicarbazones	72-90	ATP binding cassette subfamily B member 1	Homo sapiens	202-205	
29305422-0	2018	Tumor stressors induce two mechanisms of intracellular P-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.	Thiosemicarbazones	130-148	ATP binding cassette subfamily B member 1	Homo sapiens	55-69	
27906178-12	2016	The synergistic and potent anti-tumor efficacy observed between DOX and thiosemicarbazones represents a promising treatment combination for advanced cancers, which are heterogeneous and composed of non-Pgp- and Pgp-expressing tumor cells.	Thiosemicarbazones	72-90	ATP binding cassette subfamily B member 1	Homo sapiens	211-214	
25720491-12	2015	This study highlights a novel Pgp hijacking strategy of the unique dipyridylthiosemicarbazone series of thiosemicarbazones that overcome MDR via utilization of lysosomal Pgp transport activity.	Thiosemicarbazones	104-122	ATP binding cassette subfamily B member 1	Homo sapiens	30-33	
27524608-4	2016	Only thiosemicarbazones with electron-withdrawing substituents at the imine carbon mediated Pgp-dependent potentiated cytotoxicity, which was reversed by Pgp inhibition.	Thiosemicarbazones	5-23	ATP binding cassette subfamily B member 1	Homo sapiens	92-95	
27524608-4	2016	Only thiosemicarbazones with electron-withdrawing substituents at the imine carbon mediated Pgp-dependent potentiated cytotoxicity, which was reversed by Pgp inhibition.	Thiosemicarbazones	5-23	ATP binding cassette subfamily B member 1	Homo sapiens	154-157	
27524608-5	2016	Treatment of resistant cells with these thiosemicarbazones resulted in Pgp-dependent lysosomal membrane permeabilization (LMP) that relied on copper (Cu) chelation, reactive oxygen species generation, and increased relative lipophilicity.	Thiosemicarbazones	40-58	ATP binding cassette subfamily B member 1	Homo sapiens	71-74	
27524608-7	2016	We also demonstrate the mechanism that enables the targeting of resistant tumors, whereby thiosemicarbazones "hijack" lysosomal Pgp and form redox-active Cu complexes that mediate LMP and potentiate cytotoxicity.	Thiosemicarbazones	90-108	ATP binding cassette subfamily B member 1	Homo sapiens	128-131	
25720491-12	2015	This study highlights a novel Pgp hijacking strategy of the unique dipyridylthiosemicarbazone series of thiosemicarbazones that overcome MDR via utilization of lysosomal Pgp transport activity.	Thiosemicarbazones	104-122	ATP binding cassette subfamily B member 1	Homo sapiens	170-173	
19397322-5	2009	The MDR1-selective pharmacophore highlights the importance of aromatic/hydrophobic features at the N4 position of the thiosemicarbazone and the reliance on the isatin moiety as key bioisosteric contributors.	Thiosemicarbazones	118-135	ATP binding cassette subfamily B member 1	Homo sapiens	4-8	
18089722-2	2007	We previously reported that a thiosemicarbazone derivative, NSC73306, is cytotoxic to carcinoma cells that overexpress functional P-glycoprotein, and it resensitizes these cells to chemotherapeutics.	Thiosemicarbazones	30-47	ATP binding cassette subfamily B member 1	Homo sapiens	130-144	
33314614-0	2021	Assessment of thiosemicarbazone-containing compounds as potential anti-leukemia agents against P-gp overexpressing drug resistant K562/A02 cells.	Thiosemicarbazones	14-31	ATP binding cassette subfamily B member 1	Homo sapiens	95-99	
33314614-2	2021	In this study, seventeen thiosemicarbazone-containing compounds were prepared and evaluated as potential anti-leukemia agents against drug resistant K562/A02 cell overexpressing P-gp.	Thiosemicarbazones	25-42	ATP binding cassette subfamily B member 1	Homo sapiens	178-182	
31265310-0	2019	Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells.	Thiosemicarbazones	14-31	ATP binding cassette subfamily B member 1	Homo sapiens	45-59	
31265310-4	2019	We previously identified a series of thiosemicarbazone compounds that inhibit Pgp with an EC50 in the nanomolar range, and herein, we investigate the efficacy of three of them in bypassing Pgp-mediated drug efflux in primary human BBB and GB cells.	Thiosemicarbazones	37-54	ATP binding cassette subfamily B member 1	Homo sapiens	78-81	
31265310-4	2019	We previously identified a series of thiosemicarbazone compounds that inhibit Pgp with an EC50 in the nanomolar range, and herein, we investigate the efficacy of three of them in bypassing Pgp-mediated drug efflux in primary human BBB and GB cells.	Thiosemicarbazones	37-54	ATP binding cassette subfamily B member 1	Homo sapiens	189-192	
31265310-6	2019	Thiosemicarbazone derivatives increased doxorubicin uptake in GB, with greater effects in the Pgp-rich SC clones than in the differentiated clones derived from the same tumor.	Thiosemicarbazones	0-17	ATP binding cassette subfamily B member 1	Homo sapiens	94-97