PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28891646-7 2017 The resulting boronate/thiosemicarbazone adduct is a medium-sized ring that forms rapidly and irreversibly without any catalyst at low muM concentrations, in neutral buffer, with a rate constant of 9 M-1 s-1 as measured by NMR spectroscopy. Thiosemicarbazones 23-40 latexin Homo sapiens 135-138 27980346-4 2016 The IC50 ranged from 4.7 - 44.1 muM with the complex having an unsubstituted amino group on the thiosemicarbazone being the most active. Thiosemicarbazones 96-113 latexin Homo sapiens 32-35 25752525-4 2015 Furthermore, one of the thiosemicarbazones was found to be a strong non-competitive inhibitor of alpha-glucosidase (Ki = 9.6 +- 1.6 muM), with an 8-fold increase in activity compared to acarbose (Ki = 77.9 +- 11.4 muM), marketed for the treatment of type-2 diabetes. Thiosemicarbazones 24-42 latexin Homo sapiens 132-135 25752525-4 2015 Furthermore, one of the thiosemicarbazones was found to be a strong non-competitive inhibitor of alpha-glucosidase (Ki = 9.6 +- 1.6 muM), with an 8-fold increase in activity compared to acarbose (Ki = 77.9 +- 11.4 muM), marketed for the treatment of type-2 diabetes. Thiosemicarbazones 24-42 latexin Homo sapiens 214-217 22889304-6 2012 The thiosemicarbazone-proline conjugates L- and D-Pro-STSC show only moderate cytotoxic potency with IC(50) values of 62 and 75 muM, respectively, in CH1 cells and >100 muM in SW480 cells. Thiosemicarbazones 4-21 latexin Homo sapiens 128-131 22889304-6 2012 The thiosemicarbazone-proline conjugates L- and D-Pro-STSC show only moderate cytotoxic potency with IC(50) values of 62 and 75 muM, respectively, in CH1 cells and >100 muM in SW480 cells. Thiosemicarbazones 4-21 latexin Homo sapiens 172-175