PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27959508-4 2017 In the current study, a structure-based approach has been applied to a Grp94 nonselective compound, SNX 2112, which led to the development of 8j (ACO1), a Grp94-selective inhibitor that manifests ~440 nM affinity and >200-fold selectivity against cytosolic Hsp90 isoforms. 8j 142-144 heat shock protein 90 beta family member 1 Homo sapiens 71-76 27959508-4 2017 In the current study, a structure-based approach has been applied to a Grp94 nonselective compound, SNX 2112, which led to the development of 8j (ACO1), a Grp94-selective inhibitor that manifests ~440 nM affinity and >200-fold selectivity against cytosolic Hsp90 isoforms. 8j 142-144 heat shock protein 90 beta family member 1 Homo sapiens 155-160