PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32038732-0	2019	Possible antioxidant mechanism of coenzyme Q10 in diabetes: impact on Sirt1/Nrf2 signaling pathways.	coenzyme Q10	34-46	sirtuin 1	Rattus norvegicus	70-75	
32038732-2	2019	The aim of this study was to investigate potential antioxidant activity of coenzyme Q10 (Co Q10) against hyperglycemia-induced oxidative stress in diabetic rat and unraveling its mechanism of action by focusing on silent information regulator 1 (Sirt1) and nuclear factor E2-related factor 2 (Nrf2) mRNA expression level.	coenzyme Q10	75-87	sirtuin 1	Rattus norvegicus	246-251	
32038732-2	2019	The aim of this study was to investigate potential antioxidant activity of coenzyme Q10 (Co Q10) against hyperglycemia-induced oxidative stress in diabetic rat and unraveling its mechanism of action by focusing on silent information regulator 1 (Sirt1) and nuclear factor E2-related factor 2 (Nrf2) mRNA expression level.	coenzyme Q10	89-95	sirtuin 1	Rattus norvegicus	246-251	
32038732-8	2019	Co Q10 treatment significantly up-regulated Sirt1 and Nrf2 mRNA levels along with an increase in catalase activity in diabetic group as compared with untreated diabetic rats.	coenzyme Q10	0-6	sirtuin 1	Rattus norvegicus	44-49	
32038732-10	2019	Our data demonstrated that Co Q10 may exert its antioxidant activity in diabetes through the induction of Sirt1/Nrf2 gene expression.	coenzyme Q10	27-33	sirtuin 1	Rattus norvegicus	106-111	
31582012-0	2019	Coenzyme Q10 protects hepatocytes from ischemia reperfusion-induced apoptosis and oxidative stress via regulation of Bax/Bcl-2/PUMA and Nrf-2/FOXO-3/Sirt-1 signaling pathways.	coenzyme Q10	0-12	sirtuin 1	Rattus norvegicus	149-155	
31582012-6	2019	Additionally, CoQ10 restored oxidant/antioxidant balance via marked activated Nrf-2 protein as well as up-regulation of both Sirt-1 and FOXO-3 genes.	coenzyme Q10	14-19	sirtuin 1	Rattus norvegicus	125-131