PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35636077-4 2022 The influence of CoQ10 on renal injury caused by UUO was evaluated by histopathology and analysis of gene expression, oxidative stress, intracellular organelles, apoptosis, and Wnt3alpha/beta-catenin/GSK-3beta signaling H2O2-exposed human kidney (HK-2) cells were also examined after treatment with CoQ10 or an RIP inhibitor. coenzyme Q10 17-22 glycogen synthase kinase 3 alpha Homo sapiens 200-209 35636077-10 2022 CONCLUSION: These findings suggest that CoQ10 attenuates renal fibrosis by inhibiting RIP1-RIP3-MLKL-mediated necroinflammation via Wnt3alpha/beta-catenin/GSK-3beta signaling in UUO. coenzyme Q10 40-45 glycogen synthase kinase 3 alpha Homo sapiens 155-164