PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19418044-8	2009	Intracerebroventricular CP-472555 delivery in conjunction with antecedent NPH dosing prevented transcriptional habituation of GCK and OT genes, but did not modify CRH or VP mRNA profiles.	Insulin, Isophane	74-77	glucokinase	Rattus norvegicus	126-129	
19279382-10	2009	Acute NPH injection had no impact on GK gene profiles in estradiol benzoate (EB)- or oil-implanted ovariectomized (OVX) female rats, but diminished GK-ir cell counts in the OVX + EB caudal ARH.	Insulin, Isophane	6-9	glucokinase	Rattus norvegicus	148-150	
19279382-11	2009	Precedent NPH treatment did not modify baseline GK mRNA levels in either group of females, but resulted in decreased or elevated GK gene and protein expression during recurring injection in the presence or absence of EB, respectively.	Insulin, Isophane	10-13	glucokinase	Rattus norvegicus	129-131	
19279382-12	2009	CONCLUSION: These results provide novel evidence for sex-specific patterns of acclimation of GK mRNA and protein expression within the rat ARH to serial NPH injection, and support the need to elucidate the physiological ramifications of these adaptations regarding behavioral and physiological responses to recurring intermediate insulin administration.	Insulin, Isophane	153-156	glucokinase	Rattus norvegicus	93-95