PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1469101-6 1992 Pretreatment of rats with isonicotinic acid hydrazide and phenobarbital to induce cytochrome P-450 enhanced the production of F2-isoprostanes after CCl4 administration eightfold and fivefold, respectively, whereas inhibition of the cytochrome P-450 system with SKF-525A and 4-methylpyrazole decreased formation of F2-isoprostanes after CCl4 by 55 and 82%, respectively. Isoniazid 26-53 C-C motif chemokine ligand 4 Rattus norvegicus 148-152 1469101-6 1992 Pretreatment of rats with isonicotinic acid hydrazide and phenobarbital to induce cytochrome P-450 enhanced the production of F2-isoprostanes after CCl4 administration eightfold and fivefold, respectively, whereas inhibition of the cytochrome P-450 system with SKF-525A and 4-methylpyrazole decreased formation of F2-isoprostanes after CCl4 by 55 and 82%, respectively. Isoniazid 26-53 C-C motif chemokine ligand 4 Rattus norvegicus 336-340 3377780-1 1988 Oxygen inhibition of CCl4 metabolism by different isoenzymes of cytochrome P-450 was assessed by studying liver microsomes isolated from control rats and rats treated with phenobarbital or isoniazid. Isoniazid 189-198 C-C motif chemokine ligand 4 Rattus norvegicus 21-25 3377780-5 1988 Rats treated with phenobarbital, which increases hepatic cytochrome P-450 content, or isoniazid, which does not increase hepatic cytochrome P-450 content, both metabolized more CCl4 than control rats as indicated by exhalation of greater quantities of CCl4 metabolites and by an increase in CCl4 toxicity. Isoniazid 86-95 C-C motif chemokine ligand 4 Rattus norvegicus 177-181