PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16324277-1	2005	OBJECTIVE: To study the combined effect of isoniazid and rifampicin on the activities of CYP1A2 and 3A4 in primary hepatocytes from healthy human adults.	Isoniazid	43-52	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	89-95	
16324277-7	2005	RESULTS: (1) The activity of CYP1A2 in isoniazid groups with concentrations of 25 micromol/L and 50 micromol/L was (3.33 +/- 0.65), (3.03 +/- 0.38) mAU.min respectively, significantly different compared with that in the negative control group [(5.23 +/- 0.31) mAU.min, P < 0.01].	Isoniazid	39-48	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	29-35	
16324277-10	2005	The activity of CYP1A2 of groups with two kinds of different concentrations of isoniazid and rifampicin combined groups was (3.27 +/- 0.96), (3.97 +/- 0.25) mAU.min respectively, which had significant difference compared with that in the negative control group (P < 0.05).	Isoniazid	79-88	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	16-22	
11868802-0	2002	Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes.	Isoniazid	0-9	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	44-63	
15528841-5	2004	In contrast, in addition to the reported inhibitory effect of isoniazid on CYP1A2, CYP2A6, CYP2C19, and CYP3A activities, our results newly showed its effect on CYP2C9 and CYP2E1 activities.	Isoniazid	62-71	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	75-81	
11868802-5	2002	After a 15-min preincubation with NADPH, isoniazid showed an increased inhibitory potency toward CYP1A2, CYP2A6, CYP2C19 and CYP3A4 activities (Ki = 56, 60, 10 and 36 microM, respectively).	Isoniazid	41-50	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	97-103	
11868802-6	2002	In addition, the inactivation of CYP1A2, CYP2A6, CYP2C19 and CYP3A4 by isoniazid was NADPH-, time- and concentration dependent, and was characterised by Kinact values of 0.11, 0.13, 0.09 and 0.08 min(-1), and K1 values of 285, 173, 112 and 228 microM, respectively.	Isoniazid	71-80	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	33-39	
11868802-7	2002	CONCLUSIONS: As the peak plasma concentrations of isoniazid are around 30-50 microM, isoniazid at clinically relevant concentrations reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 in human liver microsomes.	Isoniazid	85-94	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	216-222