PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15528841-5	2004	In contrast, in addition to the reported inhibitory effect of isoniazid on CYP1A2, CYP2A6, CYP2C19, and CYP3A activities, our results newly showed its effect on CYP2C9 and CYP2E1 activities.	Isoniazid	62-71	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	83-89	
24820076-0	2014	Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6.	Isoniazid	0-9	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	155-161	
24820076-7	2014	Importantly, isoniazid demonstrated potent time-dependent inhibition of efavirenz 7-hydroxylation in both HLMs (inhibitor concentration required for half-maximal inactivation [KI] = 30 muM; maximal rate constant of inactivation [kinact] = 0.023 min(-1)) and recombinant CYP2A6 (KI = 15 muM; kinact = 0.024 min(-1)) and also formed a metabolite intermediate complex consistent with mechanism-based inhibition.	Isoniazid	13-22	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	270-276	
24820076-9	2014	In conclusion, the results of this study identify isoniazid as the most likely perpetrator of this clinically important drug-drug interaction through mechanism-based inactivation of CYP2A6.	Isoniazid	50-59	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	182-188	
11868802-5	2002	After a 15-min preincubation with NADPH, isoniazid showed an increased inhibitory potency toward CYP1A2, CYP2A6, CYP2C19 and CYP3A4 activities (Ki = 56, 60, 10 and 36 microM, respectively).	Isoniazid	41-50	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	105-111	
11868802-6	2002	In addition, the inactivation of CYP1A2, CYP2A6, CYP2C19 and CYP3A4 by isoniazid was NADPH-, time- and concentration dependent, and was characterised by Kinact values of 0.11, 0.13, 0.09 and 0.08 min(-1), and K1 values of 285, 173, 112 and 228 microM, respectively.	Isoniazid	71-80	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	41-47	
11868802-7	2002	CONCLUSIONS: As the peak plasma concentrations of isoniazid are around 30-50 microM, isoniazid at clinically relevant concentrations reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 in human liver microsomes.	Isoniazid	85-94	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	224-230