PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12970348-5	2003	The high resolution crystal structures at 1.75-2.1 A of the N-terminal and adjacent charged domains of GRP94 in complex with N-ethylcarboxamidoadenosine, radicicol, and 2-chlorodideoxyadenosine reveals a structural mechanism for ligand discrimination among hsp90 family members.	Adenosine-5'-(N-ethylcarboxamide)	125-152	heat shock protein 90 beta family member 1	Homo sapiens	103-108	
33738064-4	2021	5"-(N-Ethylcarboxamido)adenosine (NECA) was identified from a high-throughput screen as one of the first molecules to exhibit isoform selectivity toward Grp94, with the ethyl group projecting into a unique pocket within the ATP binding site of Grp94.	Adenosine-5'-(N-ethylcarboxamide)	34-38	heat shock protein 90 beta family member 1	Homo sapiens	153-158	
33738064-4	2021	5"-(N-Ethylcarboxamido)adenosine (NECA) was identified from a high-throughput screen as one of the first molecules to exhibit isoform selectivity toward Grp94, with the ethyl group projecting into a unique pocket within the ATP binding site of Grp94.	Adenosine-5'-(N-ethylcarboxamide)	34-38	heat shock protein 90 beta family member 1	Homo sapiens	244-249	
31501246-0	2019	NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.	Adenosine-5'-(N-ethylcarboxamide)	0-4	heat shock protein 90 beta family member 1	Homo sapiens	86-91	
31501246-9	2019	We found that derivatives that lengthen the 5" moiety of NECA improve selectivity for Grp94 over Hsp90alpha.	Adenosine-5'-(N-ethylcarboxamide)	57-61	heat shock protein 90 beta family member 1	Homo sapiens	86-91	
20667832-7	2010	Experiments using RNA interference or N-ethylcarboxamidoadenosine, a drug that inhibits ER-localized GRP94 but not cytosolic Hsp90, confirmed that the inhibitory effects of GA resulted specifically from the loss of Hsp90 activity.	Adenosine-5'-(N-ethylcarboxamide)	38-65	heat shock protein 90 beta family member 1	Homo sapiens	101-106	
10816561-4	2000	In this report, N-ethylcarboxamidoadenosine (NECA) was used to investigate the nucleotide binding properties of GRP94, the endoplasmic reticulum paralog of Hsp90.	Adenosine-5'-(N-ethylcarboxamide)	16-43	heat shock protein 90 beta family member 1	Homo sapiens	112-117	
10816561-4	2000	In this report, N-ethylcarboxamidoadenosine (NECA) was used to investigate the nucleotide binding properties of GRP94, the endoplasmic reticulum paralog of Hsp90.	Adenosine-5'-(N-ethylcarboxamide)	45-49	heat shock protein 90 beta family member 1	Homo sapiens	112-117	
10816561-6	2000	NECA binding to GRP94 was efficiently blocked by geldanamycin and radicicol.	Adenosine-5'-(N-ethylcarboxamide)	0-4	heat shock protein 90 beta family member 1	Homo sapiens	16-21