PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1593712-0 1992 Phospholipase C activation by endothelin-1 and noradrenaline in isolated penile erectile tissue from rabbit. Norepinephrine 47-60 LOC100009319 Oryctolagus cuniculus 0-15 2547494-13 1989 GDP beta S reduced noradrenaline outward current but not caffeine outward current implying the existence of a G-protein step in noradrenaline-evoked Ca-store release, possibly regulating phospholipase C enzyme activity and D-myo inositol 1,4,5 trisphosphate formation. Norepinephrine 128-141 LOC100009319 Oryctolagus cuniculus 187-202 9080371-7 1997 The phospholipase C (PLC) inhibitor U73122 inhibited the amplitude of the noradrenaline-activated Icat in a concentration- and time-dependent manner and the IC50 was about 180 nM. Norepinephrine 74-87 LOC100009319 Oryctolagus cuniculus 4-19 9080371-7 1997 The phospholipase C (PLC) inhibitor U73122 inhibited the amplitude of the noradrenaline-activated Icat in a concentration- and time-dependent manner and the IC50 was about 180 nM. Norepinephrine 74-87 LOC100009319 Oryctolagus cuniculus 21-24 9080371-17 1997 It is concluded that noradrenaline activates Icat via a G-protein coupled to PLC and that the resulting DAG product plays a central role in the activation of cation channels via a protein kinase C-independent mechanism. Norepinephrine 21-34 LOC100009319 Oryctolagus cuniculus 77-80 1593712-1 1992 The effects of endothelin-1 and noradrenaline on phospholipase C activity in the rabbit isolated corpus cavernosum were investigated by measuring the accumulation of inositol phosphates. Norepinephrine 32-45 LOC100009319 Oryctolagus cuniculus 49-64 1593712-9 1992 The results suggest that exogenous endothelin-1 and noradrenaline activate phospholipase C in corpus cavernosum, and that this mechanism is partly independent of extracellular Ca2+. Norepinephrine 52-65 LOC100009319 Oryctolagus cuniculus 75-90 1649301-8 1991 The putative phospholipase C inhibitor neomycin was significantly less effective (IC50 = 13.0 +/- 5.0, 0.44 +/- 0.09 and 0.89 +/- 0.40 mM) at inhibiting F- than norepinephrine and KCl contractile effects. Norepinephrine 161-175 LOC100009319 Oryctolagus cuniculus 13-28