PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23808809-2 2013 The aim of the present investigation was to evaluate the effect of noradrenaline (NA) on the release of IL-1beta, IL-6 and TNFalpha by macrophages from ObZ, as well as the effect of habitual exercise (running, 5days/week for 35 min at 35cm/s for 14week); all of them using lean Zucker rats (Fa/fa) (LZ) as reference values. Norepinephrine 67-80 tumor necrosis factor Rattus norvegicus 123-131 24304472-0 2014 alpha1 adrenoceptor activation by norepinephrine inhibits LPS-induced cardiomyocyte TNF-alpha production via modulating ERK1/2 and NF-kappaB pathway. Norepinephrine 34-48 tumor necrosis factor Rattus norvegicus 84-93 24304472-2 2014 This study was designed to observe the effect of norepinephrine (NE) on lipopolysaccharide (LPS)-induced cardiomyocyte TNF-alpha expression and to further investigate the underlying mechanisms in neonatal rat cardiomyocytes and endotoxaemic mice. Norepinephrine 49-63 tumor necrosis factor Rattus norvegicus 119-128 32451082-1 2020 Noradrenaline (NA) suppresses TNF-alpha production via beta-adrenoceptors (ARs) in brain astrocytes. Norepinephrine 0-13 tumor necrosis factor Rattus norvegicus 30-39 22382522-0 2013 Berberine inhibits norepinephrine-induced apoptosis in neonatal rat cardiomyocytes via inhibiting ROS-TNF-alpha-caspase signaling pathway. Norepinephrine 19-33 tumor necrosis factor Rattus norvegicus 102-111 19212441-1 2009 Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFkappaB in macrophages, causing enhanced release of proinflammatory cytokines (TNFalpha, IL-1beta, IL-6). Norepinephrine 173-187 tumor necrosis factor Rattus norvegicus 286-294 19046481-9 2009 In contrast, in vitro exposure of cultured glial cells to noradrenaline suppressed IL-1beta, TNF-alpha, iNOS and CD40 expression. Norepinephrine 58-71 tumor necrosis factor Rattus norvegicus 93-102 18777604-1 2008 Systemic administration of tumour necrosis factor (TNF)-alpha induces the release of norepinephrine in the paraventricular nucleus (PVN) of hypothalamus and an increase in expression of corticotrophin-releasing factor (CRF) and CRF type 1 receptors. Norepinephrine 85-99 tumor necrosis factor Rattus norvegicus 27-61 18777604-2 2008 We explored the hypothesis that CRF and norepinephrine in PVN mediate the cardiovascular and sympathetic responses to acute systemic administration of TNF-alpha. Norepinephrine 40-54 tumor necrosis factor Rattus norvegicus 151-160 18777604-7 2008 These results are consistent with the hypothesis that norepinephrine and CRF in the PVN mediate the cardiovascular and sympathetic responses to acute systemic administration of TNF-alpha. Norepinephrine 54-68 tumor necrosis factor Rattus norvegicus 177-186 18514187-2 2008 During neuropathic pain development in the chronic constriction injury model, elevated TNF levels in the brain occur in association with enhanced alpha 2-adrenoceptor inhibition of norepinephrine release. Norepinephrine 181-195 tumor necrosis factor Rattus norvegicus 87-90 8170501-5 1994 As an apparent functional consequence of the decrease in IP3 formation following the TNF alpha exposure, the alpha 1-adrenoceptor-mediated induction of arrhythmias by 100 mumol/l noradrenaline + 10 mumol/l timolol was abolished in TNF alpha-pretreated rat cardiomyocytes. Norepinephrine 179-192 tumor necrosis factor Rattus norvegicus 85-94 15672410-0 2005 Effect of tumor necrosis factor-alpha on the reciprocal G-protein-induced regulation of norepinephrine release by the alpha2-adrenergic receptor. Norepinephrine 88-102 tumor necrosis factor Rattus norvegicus 10-37 15721177-2 2005 In brain neurons, tumor necrosis factor-alpha (TNF) levels intensify and TNF-inhibition of norepinephrine (NE) release, dependent upon alpha(2)-adrenergic activation, amplifies during neuropathic pain onset. Norepinephrine 91-105 tumor necrosis factor Rattus norvegicus 73-76 15082752-2 2004 To establish this role, field stimulation and superfusion of rat hippocampal slices was employed to investigate the regulation of norepinephrine (NE) release by TNF. Norepinephrine 130-144 tumor necrosis factor Rattus norvegicus 161-164 12423672-7 2002 Release of tumor necrosis factor alpha and nitric oxide was suppressed by norepinephrine, phenylephrine, dobutamine and terbutaline. Norepinephrine 74-88 tumor necrosis factor Rattus norvegicus 11-38 11673761-1 2001 OBJECTIVE: To elucidate the effects and molecular mechanism(s) by means of which noradrenaline (NA) protects against the tumor necrosis factor (TNF)-alpha-induced apoptosis of brown adipocytes. Norepinephrine 81-94 tumor necrosis factor Rattus norvegicus 121-154 9663564-5 1998 However, co-stimulation with adrenaline, noradrenaline, or the beta-adrenoceptor agonist isoproterenol (isoprenaline) had an additive (TNF-alpha) or synergistic (LPS) effect on IL-6 release. Norepinephrine 41-54 tumor necrosis factor Rattus norvegicus 135-144 16465289-3 1997 Moreover, noradrenaline, which has been described as having trophic effects on brown fat and accelerating the differentiation of brown adipocytes, is capable of dose-dependently preventing the TNF-alpha-induced apoptosis of brown fat cells. Norepinephrine 10-23 tumor necrosis factor Rattus norvegicus 193-202 8862135-1 1996 Tumor necrosis factor-alpha (TNF alpha) and the imidazoline clonidine modulate norepinephrine (NE) release from noradrenergic nerve terminals in the central nervous system. Norepinephrine 79-93 tumor necrosis factor Rattus norvegicus 0-27 8862135-1 1996 Tumor necrosis factor-alpha (TNF alpha) and the imidazoline clonidine modulate norepinephrine (NE) release from noradrenergic nerve terminals in the central nervous system. Norepinephrine 79-93 tumor necrosis factor Rattus norvegicus 29-38 7895065-5 1994 While no change in sensitivity to TNF was observed in the hippocampus after one day of desipramine administration, TNF enhanced, rather than inhibited [3H]norepinephrine release after 14 days. Norepinephrine 155-169 tumor necrosis factor Rattus norvegicus 115-118 15866053-10 2005 While, however, noradrenaline attenuated the LPS-induced release of TNF-alpha and IL-6, dopamine was ineffective in modulating this response. Norepinephrine 16-29 tumor necrosis factor Rattus norvegicus 68-77 15364025-0 2004 Amitriptyline administration transforms tumor necrosis factor-alpha regulation of norepinephrine release in the brain. Norepinephrine 82-96 tumor necrosis factor Rattus norvegicus 40-67 15364025-1 2004 The present study demonstrates that the mixed action antidepressant drug amitriptyline enhances norepinephrine (NE) release by transforming the nature of the response of neurons to both tumor necrosis factor-alpha (TNF) as well as to an alpha(2)-adrenergic agonist in an area of the central nervous system (CNS) rich in adrenergic neurons. Norepinephrine 96-110 tumor necrosis factor Rattus norvegicus 186-213 15364025-4 2004 Exposure to TNF, as well as activation of the alpha(2)-adrenergic autoreceptor inhibits stimulation-evoked norepinephrine (NE) release from adrenergic neurons of the CNS from naive rats. Norepinephrine 107-121 tumor necrosis factor Rattus norvegicus 12-15 15158148-0 2004 Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a reactive oxygen species-TNF alpha-caspase signaling pathway. Norepinephrine 0-14 tumor necrosis factor Rattus norvegicus 98-101 11476962-0 2001 The role of Kupffer cell alpha(2)-adrenoceptors in norepinephrine-induced TNF-alpha production. Norepinephrine 51-65 tumor necrosis factor Rattus norvegicus 74-83 11303058-1 2001 The pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation regulate norepinephrine (NE) release from neurons in the central nervous system. Norepinephrine 112-126 tumor necrosis factor Rattus norvegicus 25-52 11303058-1 2001 The pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation regulate norepinephrine (NE) release from neurons in the central nervous system. Norepinephrine 112-126 tumor necrosis factor Rattus norvegicus 54-57 9357451-1 1997 Tumor necrosis factor-alpha (TNF alpha) and the alpha 2-adrenergic agonist clonidine regulate norepinephrine (NE) release from noradrenergic nerve terminals in the central nervous system (CNS). Norepinephrine 94-108 tumor necrosis factor Rattus norvegicus 0-27 9357451-1 1997 Tumor necrosis factor-alpha (TNF alpha) and the alpha 2-adrenergic agonist clonidine regulate norepinephrine (NE) release from noradrenergic nerve terminals in the central nervous system (CNS). Norepinephrine 94-108 tumor necrosis factor Rattus norvegicus 29-38 7475986-10 1995 In addition TNF-alpha infused rats had raised norepinephrine levels. Norepinephrine 46-60 tumor necrosis factor Rattus norvegicus 12-21 8023943-0 1994 Mechanism underlying tumor necrosis factor-alpha suppression of norepinephrine release from rat myenteric plexus. Norepinephrine 64-78 tumor necrosis factor Rattus norvegicus 21-48 8170501-5 1994 As an apparent functional consequence of the decrease in IP3 formation following the TNF alpha exposure, the alpha 1-adrenoceptor-mediated induction of arrhythmias by 100 mumol/l noradrenaline + 10 mumol/l timolol was abolished in TNF alpha-pretreated rat cardiomyocytes. Norepinephrine 179-192 tumor necrosis factor Rattus norvegicus 231-240 8376550-0 1993 Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: synergism with IL-1 beta and TNF alpha. Norepinephrine 0-14 tumor necrosis factor Rattus norvegicus 115-124 8125855-5 1993 The effect of rTNF-alpha on vasoconstriction in response to norepinephrine (NE) was a dramatic reduction after 2 h of exposure to 1 ng/ml rTNF-alpha. Norepinephrine 60-74 tumor necrosis factor Rattus norvegicus 14-24 8125855-5 1993 The effect of rTNF-alpha on vasoconstriction in response to norepinephrine (NE) was a dramatic reduction after 2 h of exposure to 1 ng/ml rTNF-alpha. Norepinephrine 60-74 tumor necrosis factor Rattus norvegicus 138-148 1460089-0 1992 Presynaptic inhibitory effect of TNF-alpha on the release of noradrenaline in isolated median eminence. Norepinephrine 61-74 tumor necrosis factor Rattus norvegicus 33-42 1460089-1 1992 The effect of tumor necrosis factor-alpha (TNF-alpha) on the stimulation-evoked release of noradrenaline (NA) from isolated rat median eminence (ME) was investigated, using a low-volume perfusion system. Norepinephrine 91-104 tumor necrosis factor Rattus norvegicus 14-41 1460089-1 1992 The effect of tumor necrosis factor-alpha (TNF-alpha) on the stimulation-evoked release of noradrenaline (NA) from isolated rat median eminence (ME) was investigated, using a low-volume perfusion system. Norepinephrine 91-104 tumor necrosis factor Rattus norvegicus 43-52 1666552-3 1991 Similar to the noradrenaline exposure, incubation of the cardiomyocytes in the presence of the cytokine TNF alpha (10 U.ml-1) also increases the level of Gi alpha proteins. Norepinephrine 15-28 tumor necrosis factor Rattus norvegicus 104-113 2022725-6 1991 As regards the effect of rTNF on vasoconstriction in response to norepinephrine, vasoconstriction was greatest for the smallest arterioles, and did not change 10 min after rTNF administration for any of the three arteriolar orders. Norepinephrine 65-79 tumor necrosis factor Rattus norvegicus 25-29 1648497-5 1991 The increase in adenylyl cyclase activity induced by TNF alpha was completely suppressed when the cells were cocultured with noradrenaline, a condition leading to an additive increase in Gi alpha level. Norepinephrine 125-138 tumor necrosis factor Rattus norvegicus 53-62 1648497-7 1991 Although TNF alpha, like noradrenaline, exposure of the cells increased the level of membrane Gi alpha proteins, it did not decrease but rather caused an increase in adenylyl cyclase responsiveness. Norepinephrine 25-38 tumor necrosis factor Rattus norvegicus 9-18