PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17103145-4 2006 The contractions to 5-HT were competitively antagonized by the 5-HT(2A) receptor antagonist ketanserin, whilst those to noradrenaline were antagonized by alpha(1)-(prazosin), alpha(2)-(rauwolscine and yohimbine) and alpha(2C/2B)-(OPC-28326) adrenoceptor antagonists. Norepinephrine 120-133 adrenoceptor alpha 1D Homo sapiens 154-162 24560685-4 2014 Noradrenaline can modulate both lipolysis (via alpha2- and beta3-ARs) and lipogenesis (via alpha1- and beta3-ARs). Norepinephrine 0-13 adrenoceptor alpha 1D Homo sapiens 91-108 12059116-1 2002 Adrenergic receptors mediate the central and peripheral actions of norepinephrine and epinephrine and are pharmacologically divided into three major types, alpha-1, alpha-2, and beta. Norepinephrine 67-81 adrenoceptor alpha 1D Homo sapiens 156-163 17030082-5 2006 In the spinal cord, norepinephrine released from descending pathways suppresses pain by inhibitory action on alpha-2A-adrenoceptors on central terminals of primary afferent nociceptors (presynaptic inhibition), by direct alpha-2-adrenergic action on pain-relay neurons (postsynaptic inhibition), and by alpha-1-adrenoceptor-mediated activation of inhibitory interneurons. Norepinephrine 20-34 adrenoceptor alpha 1D Homo sapiens 303-310 16505658-1 2006 OBJECTIVES: To evaluate the potential differential effects of norepinephrine, an alpha1-, beta1-, and beta2-receptor agonist, to the alpha1-agonist phenylephrine on jejunal mucosal perfusion, gastric-arterial PCO2 gradient, and the global splanchnic oxygen demand-supply relationship after cardiac surgery. Norepinephrine 62-76 adrenoceptor alpha 1D Homo sapiens 133-139 15615865-7 2005 In functional studies, coexpression with beta2-AR significantly enhanced the coupling of alpha1D-AR to norepinephrine-stimulated Ca2+ mobilization. Norepinephrine 103-117 adrenoceptor alpha 1D Homo sapiens 89-99 11470013-10 2001 At the postsynaptic level, all currently used antihypertensive drugs have been found to attenuate alpha1-adrenergic functions either by interfering directly with intracellular mechanisms underlying alpha1-adrenergic functions or indirectly by decreasing the release of norepinephrine from peripheral sympathetic nerves. Norepinephrine 269-283 adrenoceptor alpha 1D Homo sapiens 98-104 11532892-3 2001 Noradrenaline dose-dependently stimulates phosphoinositide (PI) breakdown in both immature and mature cultures through the activation of alpha1 receptors. Norepinephrine 0-13 adrenoceptor alpha 1D Homo sapiens 137-143 10443582-1 1999 Alpha1-adrenoceptors are one of three subfamilies of receptors (alpha1, alpha2, beta) mediating responses to adrenaline and noradrenaline. Norepinephrine 124-137 adrenoceptor alpha 1D Homo sapiens 0-6 10845761-4 2000 All neurogenic constrictor responses are related to the release of norepinephrine from adrenergic nerves that act on post-junctional alpha-1 and pre-junctional and post-junctional alpha-2 receptor subtypes. Norepinephrine 67-81 adrenoceptor alpha 1D Homo sapiens 133-140 10443582-1 1999 Alpha1-adrenoceptors are one of three subfamilies of receptors (alpha1, alpha2, beta) mediating responses to adrenaline and noradrenaline. Norepinephrine 124-137 adrenoceptor alpha 1D Homo sapiens 64-70 9023284-3 1997 By studying influence of appropriate adrenoceptor blockers, qualitative characteristics of the inotropic response and sensitivity of the inotropic response to cholinergic stimulation, it was revealed that norepinephrine evoked both alpha-1 and beta adrenoceptor-mediated inotropic effects in failing human ventricle myocardium. Norepinephrine 205-219 adrenoceptor alpha 1D Homo sapiens 232-248 9886882-1 1998 OBJECTIVES: Recently, in rat aortae, two putative digitalis-like factors, marinobufagenin and ouabain, were shown to interact with alpha-1 (sarcolemma) and alpha-3 (nerve endings) subunits of the sodium pump, respectively, and elicit vasoconstriction via inhibition of the Na+,K+-pump in vascular smooth muscle or norepinephrine release. Norepinephrine 314-328 adrenoceptor alpha 1D Homo sapiens 131-138 9819240-11 1998 In this same population of dorsal horn neurons, norepinephrine has a direct alpha1-mediated excitatory effect. Norepinephrine 48-62 adrenoceptor alpha 1D Homo sapiens 76-82 9483533-6 1998 The norepinephrine-induced calcium current inhibition was mediated by alpha 2-adrenergic receptors; it was mimicked by UK 14304, an alpha 2-adrenergic receptor agonist and blocked by idazoxan, an alpha 2-adrenergic receptor antagonist, but not affected by prazosin or propanolol (alpha 1 and beta adrenergic antagonists, respectively). Norepinephrine 4-18 adrenoceptor alpha 1D Homo sapiens 280-296 9023284-5 1997 Concomitant stimulation of alpha-1 and beta adrenoceptors by norepinephrine alone revealed a contribution of an alpha-1 adrenoceptor-mediated component to the final and unopposed inotropic response. Norepinephrine 61-75 adrenoceptor alpha 1D Homo sapiens 27-43 9241547-0 1997 Effect of the alpha-1 adrenoceptor blocker on tissue norepinephrine contents in human benign prostatic hyperplasia. Norepinephrine 53-67 adrenoceptor alpha 1D Homo sapiens 14-21 8627569-8 1996 It is concluded that clonidine acts on alpha-1 adrenoceptors as a partial agonist, causing relaxation of the mesenteric artery precontracted with norepinephrine or contraction of preparations precontracted with endothelin. Norepinephrine 146-160 adrenoceptor alpha 1D Homo sapiens 39-46 8755013-2 1996 The selective alpha-1 blockers reduce peripheral vascular resistance by blocking the alpha-1 receptors and preventing norepinephrine from reaching them. Norepinephrine 118-132 adrenoceptor alpha 1D Homo sapiens 14-21 7498294-3 1995 The alpha 1-adrenoceptor antagonist prazosin antagonized the contraction elicited by noradrenaline and phenylephrine. Norepinephrine 85-98 adrenoceptor alpha 1D Homo sapiens 4-11 2566715-7 1989 Noradrenaline excites supraoptic neurons and leads to phasic firing through an alpha-1 mechanism and decreased K+-conductance. Norepinephrine 0-13 adrenoceptor alpha 1D Homo sapiens 79-86 1346639-4 1992 A qualitatively similar difference in maximum responses to alpha-1 vs. alpha-2 adrenoceptor stimulation in calcium-free saline was demonstrated for norepinephrine in the presence of antagonists selective for the two alpha adrenoceptor subtypes. Norepinephrine 148-162 adrenoceptor alpha 1D Homo sapiens 59-66 2156732-3 1990 The response to norepinephrine was fully inhibited by the alpha 1-adrenergic antagonist prazosin, but was unaffected by the beta-adrenergic antagonist propranolol, showing that norepinephrine stimulated the 36Cl- efflux pathway via the alpha 1-adrenoceptor. Norepinephrine 16-30 adrenoceptor alpha 1D Homo sapiens 58-65 2156732-3 1990 The response to norepinephrine was fully inhibited by the alpha 1-adrenergic antagonist prazosin, but was unaffected by the beta-adrenergic antagonist propranolol, showing that norepinephrine stimulated the 36Cl- efflux pathway via the alpha 1-adrenoceptor. Norepinephrine 16-30 adrenoceptor alpha 1D Homo sapiens 236-243 2156732-3 1990 The response to norepinephrine was fully inhibited by the alpha 1-adrenergic antagonist prazosin, but was unaffected by the beta-adrenergic antagonist propranolol, showing that norepinephrine stimulated the 36Cl- efflux pathway via the alpha 1-adrenoceptor. Norepinephrine 177-191 adrenoceptor alpha 1D Homo sapiens 58-65 2156732-3 1990 The response to norepinephrine was fully inhibited by the alpha 1-adrenergic antagonist prazosin, but was unaffected by the beta-adrenergic antagonist propranolol, showing that norepinephrine stimulated the 36Cl- efflux pathway via the alpha 1-adrenoceptor. Norepinephrine 177-191 adrenoceptor alpha 1D Homo sapiens 236-243 2154750-1 1990 The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Norepinephrine 261-275 adrenoceptor alpha 1D Homo sapiens 41-77 1982606-7 1990 From these results we conclude: 1) norepinephrine infusion causes disparate responses in the coronary microvasculature: constriction occurs in vessels greater than 100 microns in diameter, but dilation, via autoregulatory escape, predominates in vessels less than 100 microns in diameter; 2) alpha 1-adrenergic receptors are located in coronary arterioles and arteries; and 3) alpha 2-adrenergic receptors are preferentially located in small coronary arterioles. Norepinephrine 35-49 adrenoceptor alpha 1D Homo sapiens 292-299 1983458-3 1990 The effects of noradrenaline microinjection (30 nmol in 1 microliter) into the LHA on urinary sodium excretion (UNaV) are blocked by previous injection of the alpha-1 antagonist prazosin (4 nmol in 1 microliter) from 3.22 +/- 0.25 to 0.59 +/- 0.04 microEq min-1 100 g body weight-1. Norepinephrine 15-28 adrenoceptor alpha 1D Homo sapiens 159-166 7626916-11 1994 In conclusion, in porcine intrapulmonary arteries, L-NAME inhibited noradrenaline induced endothelium dependent reduction in tone, which was also inhibited by alpha-1 and alpha-2 antagonists. Norepinephrine 68-81 adrenoceptor alpha 1D Homo sapiens 159-166 8094272-7 1993 In addition to this study, the alpha 1-, alpha 2-, beta 1-, beta 2-, and beta 3-agonists norepinephrine and epinephrine were infused with simultaneous infusion of the beta 1- and beta 2-blocker propranolol. Norepinephrine 89-103 adrenoceptor alpha 1D Homo sapiens 31-79 8224066-11 1993 Noradrenaline, the alpha 1-agonist PHE and the beta-agonist ISO exerted a weak depressant action on high-frequency maintained activity, but during low-frequency single spike activity and/or burst activity a facilitatory effect was evident, which prevented the generation of burst discharges and slightly increased single spike firing. Norepinephrine 0-13 adrenoceptor alpha 1D Homo sapiens 19-26 1980236-2 1990 The alpha receptor is divided into two types, alpha 1 and alpha 2, based on response to epinephrine and norepinephrine. Norepinephrine 104-118 adrenoceptor alpha 1D Homo sapiens 46-65 2568732-1 1989 The alpha-adrenoceptor-mediated contractile effects of noradrenaline (alpha 1 + alpha 2), phenylephrine (alpha 1) and clonidine (alpha 2) on human saphenous veins were investigated in vivo and in vitro. Norepinephrine 55-68 adrenoceptor alpha 1D Homo sapiens 70-77 2897878-4 1987 Norepinephrine (NE) released from superior cervical ganglion (SCG) neurons that provide sympathetic innervation to the pineal acts through alpha1- and beta 1- adrenoceptors to stimulate melatonin synthesis and release. Norepinephrine 0-14 adrenoceptor alpha 1D Homo sapiens 139-157 2540318-4 1989 On application of norepinephrine, phenylephrine (alpha-1 adrenergic agonist) or clonidine (alpha-2 adrenergic agonist) the arteries contracted in a dose-dependent manner and, in terms of the mean EC50 values, the order of potencies was clonidine greater than norepinephrine greater than phenylephrine. Norepinephrine 18-32 adrenoceptor alpha 1D Homo sapiens 49-56 2540318-4 1989 On application of norepinephrine, phenylephrine (alpha-1 adrenergic agonist) or clonidine (alpha-2 adrenergic agonist) the arteries contracted in a dose-dependent manner and, in terms of the mean EC50 values, the order of potencies was clonidine greater than norepinephrine greater than phenylephrine. Norepinephrine 259-273 adrenoceptor alpha 1D Homo sapiens 49-56 2540318-7 1989 Prazosin (selective alpha-1 adrenergic antagonist) depressed both the slope and maximal response of the control curve for norepinephrine but the shift was not significant. Norepinephrine 122-136 adrenoceptor alpha 1D Homo sapiens 20-27 2899914-6 1988 Norepinephrine (mixed alpha 1- and alpha 2-agonist) significantly increased intestinal absorption and vascular resistance. Norepinephrine 0-14 adrenoceptor alpha 1D Homo sapiens 22-42 2899848-8 1988 Results of this study support the hypothesis that epinephrine and/or norepinephrine regulate the release of ACTH and vasopressin via alpha-1- and alpha-2-adrenergic receptors associated with CRF- and VP-containing somata within the PVN. Norepinephrine 69-83 adrenoceptor alpha 1D Homo sapiens 133-141 3014117-1 1986 The contractile response of vascular smooth muscle to l-norepinephrine is mediated almost exclusively by alpha-1 adrenoceptors in some blood vessels, and by a mixture of alpha-1 and postsynaptic alpha-2 receptors in others. Norepinephrine 54-70 adrenoceptor alpha 1D Homo sapiens 105-112 2884858-1 1987 Doxazosin is a competitive inhibitor of norepinephrine at alpha 1 adrenoceptors on vascular smooth muscle, where it blocks vasoconstriction. Norepinephrine 40-54 adrenoceptor alpha 1D Homo sapiens 58-65 2883548-2 1987 The theory suggests that final effects on alpha-1 mediated neurotransmission may be produced not only by drugs which have direct effects on the alpha-1 receptor or its second messenger, but also by drugs having effects on neurotransmitter systems such as acetylcholine, GABA, and serotonin, among others, which modulate the activity of central norepinephrine neurons or, via feedback mechanisms, by drugs having effects on adrenergic receptors other than the alpha-1 receptor itself. Norepinephrine 344-358 adrenoceptor alpha 1D Homo sapiens 42-49 2883548-2 1987 The theory suggests that final effects on alpha-1 mediated neurotransmission may be produced not only by drugs which have direct effects on the alpha-1 receptor or its second messenger, but also by drugs having effects on neurotransmitter systems such as acetylcholine, GABA, and serotonin, among others, which modulate the activity of central norepinephrine neurons or, via feedback mechanisms, by drugs having effects on adrenergic receptors other than the alpha-1 receptor itself. Norepinephrine 344-358 adrenoceptor alpha 1D Homo sapiens 144-151 2883548-2 1987 The theory suggests that final effects on alpha-1 mediated neurotransmission may be produced not only by drugs which have direct effects on the alpha-1 receptor or its second messenger, but also by drugs having effects on neurotransmitter systems such as acetylcholine, GABA, and serotonin, among others, which modulate the activity of central norepinephrine neurons or, via feedback mechanisms, by drugs having effects on adrenergic receptors other than the alpha-1 receptor itself. Norepinephrine 344-358 adrenoceptor alpha 1D Homo sapiens 144-151 2824105-4 1987 Under in vitro conditions activation of alpha 1-, alpha 2-, prostaglandin, adenosine, dopamine and serotonin receptors inhibits noradrenaline release from the kidney. Norepinephrine 128-141 adrenoceptor alpha 1D Homo sapiens 40-57 2824105-7 1987 Moreover, neuronally released noradrenaline inhibits its own release through activation of both prejunctional alpha 1- and alpha 2-adrenoceptors. Norepinephrine 30-43 adrenoceptor alpha 1D Homo sapiens 110-117 2824105-9 1987 Locally produced PGE2, which is formed and released via stimulation of postjunctional alpha 1-adrenoceptors, as well as adenosine, released from postjunctional sites by renal nerve stimulation (RNS), seems to inhibit noradrenaline release through their specific prejunctional receptor systems. Norepinephrine 217-230 adrenoceptor alpha 1D Homo sapiens 86-93 2821226-0 1987 Norepinephrine regulation of alpha-1 receptors and alpha-1-stimulated phosphoinositide hydrolysis in primary neuronal cultures. Norepinephrine 0-14 adrenoceptor alpha 1D Homo sapiens 29-36 2821226-1 1987 Alpha-1 receptor density and alpha-1 receptor-stimulated phosphoinositide hydrolysis in neuronal primary cultures are regulated by exposure of the cells to the alpha-1 agonist norepinephrine (NE). Norepinephrine 176-190 adrenoceptor alpha 1D Homo sapiens 0-7 2821226-1 1987 Alpha-1 receptor density and alpha-1 receptor-stimulated phosphoinositide hydrolysis in neuronal primary cultures are regulated by exposure of the cells to the alpha-1 agonist norepinephrine (NE). Norepinephrine 176-190 adrenoceptor alpha 1D Homo sapiens 29-36 2821226-1 1987 Alpha-1 receptor density and alpha-1 receptor-stimulated phosphoinositide hydrolysis in neuronal primary cultures are regulated by exposure of the cells to the alpha-1 agonist norepinephrine (NE). Norepinephrine 176-190 adrenoceptor alpha 1D Homo sapiens 160-167 2887563-5 1987 Studies with selective alpha 1-, alpha 2-, and beta-adrenergic agents indicated that norepinephrine was acting through alpha 1-adrenergic receptors. Norepinephrine 85-99 adrenoceptor alpha 1D Homo sapiens 23-40 2887563-5 1987 Studies with selective alpha 1-, alpha 2-, and beta-adrenergic agents indicated that norepinephrine was acting through alpha 1-adrenergic receptors. Norepinephrine 85-99 adrenoceptor alpha 1D Homo sapiens 23-30 2887563-13 1987 These findings suggest that pineal phospholipase A2 activity is controlled by norepinephrine acting via an alpha 1-adrenergic mechanism which might involve Ca2+ and protein kinase C. Norepinephrine 78-92 adrenoceptor alpha 1D Homo sapiens 107-114 3014117-1 1986 The contractile response of vascular smooth muscle to l-norepinephrine is mediated almost exclusively by alpha-1 adrenoceptors in some blood vessels, and by a mixture of alpha-1 and postsynaptic alpha-2 receptors in others. Norepinephrine 54-70 adrenoceptor alpha 1D Homo sapiens 170-177 3014117-2 1986 To learn the sensitivity of the Schild plot as a test for the presence of more than one receptor type in such tissues, we constructed the plots to be expected from the dissociation constants of l-norepinephrine and prazosin for alpha-1 and alpha-2 adrenoceptors, using values determined by radioligand methods, and examining the effects of varying the proportions of the two types. Norepinephrine 194-210 adrenoceptor alpha 1D Homo sapiens 228-235 3005555-4 1986 Responses to norepinephrine in the presence of rauwolscine were antagonized by prazosin and are therefore mediated predominantly by alpha-1 adrenoceptors. Norepinephrine 13-27 adrenoceptor alpha 1D Homo sapiens 132-139 6476551-7 1984 Norepinephrine and epinephrine demonstrate activity at alpha 1, alpha 2, beta 1, and beta 2 receptor sites. Norepinephrine 0-14 adrenoceptor alpha 1D Homo sapiens 55-91 2579826-2 1985 The contractile response induced by norepinephrine in this tissue could be antagonized by prazosin, a selective alpha 1-antagonist, with a receptor dissociation constant (KB) of 4.0 +/- 0.9 nM. Norepinephrine 36-50 adrenoceptor alpha 1D Homo sapiens 112-119 2579826-4 1985 The irreversible alpha-antagonists benextramine and phenoxybenzamine, both of which preferentially inactivate the alpha 1-subtype, produced marked depression of norepinephrine-induced contraction. Norepinephrine 161-175 adrenoceptor alpha 1D Homo sapiens 114-121 2863008-8 1985 Thus, in these human blood vessels, endogenously released norepinephrine does not preferentially activate postjunctional alpha 1-adrenoceptors, but activates receptors with the properties of both the alpha 1- and alpha 2-adrenoceptor subtypes. Norepinephrine 58-72 adrenoceptor alpha 1D Homo sapiens 200-207 30419287-1 2019 The human alpha1D-adrenergic receptor is a seven transmembrane-domain protein that mediates many of the physiological actions of adrenaline and noradrenaline and participates in the development of hypertension and benign prostatic hyperplasia. Norepinephrine 144-157 adrenoceptor alpha 1D Homo sapiens 10-37 6142395-7 1984 On the other hand, prazosine (alpha 1-type antagonist) blocked the stimulatory effect of epinephrine and norepinephrine on AC system. Norepinephrine 105-119 adrenoceptor alpha 1D Homo sapiens 30-37 6142395-8 1984 Similarly, the alpha 2-agonist, clonidine, did not affect the catecholamines" stimulated AC activity while alpha 1 agonist, phenylephrine, induced an additive enhancement of norepinephrine production of cAMP. Norepinephrine 174-188 adrenoceptor alpha 1D Homo sapiens 107-114 29498170-1 2019 The alpha1 -adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD) presumably by blocking norepinephrine (NE) stimulation and reward from cocaine-induced NE increases. Norepinephrine 109-123 adrenoceptor alpha 1D Homo sapiens 4-10 29962965-10 2018 SBE 13 and cyclapolin 9 inhibited contractions by the alpha1-agonists methoxamine, phenylephrine, and noradrenaline. Norepinephrine 102-115 adrenoceptor alpha 1D Homo sapiens 54-60 28888989-4 2017 alpha1A-Adrenergic receptor interaction with beta-arrestins (colocalization/coimmunoprecipitation) was induced by noradrenaline and oxymetazoline and, to a lesser extent, by phorbol myristate acetate. Norepinephrine 114-127 adrenoceptor alpha 1D Homo sapiens 0-27