PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11027216-2 2000 Recent studies reveal that dopamine (DA), norepinephrine (NE), and serotonin (5-HT) transporters (DAT, NET, and SERT, respectively) are rapidly regulated by direct or receptor-mediated activation of cellular kinases, particularly protein kinase C (PKC). Norepinephrine 42-56 solute carrier family 6 member 4 Homo sapiens 112-116 14612149-1 2003 The biogenic amine transporters belong to the class of Na+/Cl--coupled solute carriers and include the transporters for dopamine (DAT), norepinephrine (NET), and serotonin (SERT). Norepinephrine 136-150 solute carrier family 6 member 4 Homo sapiens 173-177 12887693-1 2003 Re-uptake of the neurotransmitters serotonin and noradrenaline out of the synaptic cleft is mediated by selective transporter proteins, the serotonin transporter and the noradrenaline transporter respectively. Norepinephrine 49-62 solute carrier family 6 member 4 Homo sapiens 140-161 12491807-1 2002 Following exocytotic release, the biogenic amine neurotransmitters, norepinephrine, dopamine, and serotonin are removed from the synaptic cleft by the respective transporter, NET, DAT, and SERT, located on the plasma membrane and then re-stored into synaptic vesicles by vesicular monoamine transporter, VMAT. Norepinephrine 68-82 solute carrier family 6 member 4 Homo sapiens 189-193 12196911-1 2002 The norepinephrine, dopamine and serotonin transporters (NET, DAT and SERT, respectively), limit cellular signaling by recapturing released neurotransmitter, and serve as targets for antidepressants and drugs of abuse, emphasizing the integral role these molecules play in neurotransmission and pathology. Norepinephrine 4-18 solute carrier family 6 member 4 Homo sapiens 70-74 30457616-1 2018 Human norepinephrine and serotonin transporters (hNET and hSERT) are closely related monoamine transporters (MATs) that regulate neurotransmitter signaling in neurons and are primary targets for a wide range of therapeutic drugs used in the treatment of mood disorders. Norepinephrine 6-20 solute carrier family 6 member 4 Homo sapiens 58-63 9676821-7 1998 The results suggest that SERT and NET genotypes may participate differentially in the regulation of the norepinephrine turnover rate under presumed steady-state conditions in the central nervous system. Norepinephrine 104-118 solute carrier family 6 member 4 Homo sapiens 25-29 8159777-4 1994 We have used a novel cDNA expression cloning strategy to isolate cDNAs for the antidepressant-sensitive serotonin transporter and for a reserpine-sensitive vesicular monoamine transporter which is critical for packaging serotonin, dopamine, norepinephrine, epinephrine and histamine into synaptic vesicles and secretory granules. Norepinephrine 241-255 solute carrier family 6 member 4 Homo sapiens 104-125 33551812-2 2020 Many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (NET, DAT, and SERT). Norepinephrine 48-61 solute carrier family 6 member 4 Homo sapiens 115-119 33315681-2 2021 We identified 2 cases with remarkably changed pulmonary uptake between 2 metaiodobenzylguanidine scintigraphies; pulmonary uptake was reduced when patients were taking selective serotonin reuptake inhibitor/serotonin noradrenaline reuptake inhibitor and preserved during the medication-naive or withdrawal state, suggesting that pulmonary uptake involves not only the noradrenaline transporter, but also the serotonin transporter. Norepinephrine 217-230 solute carrier family 6 member 4 Homo sapiens 408-429 30055194-4 2019 In contrast to NET, DAT and SERT, OCT3 has higher capacity and lower affinity for substrates, is sodium-independent, and is multi-specific, with the capacity to transport norepinephrine, dopamine, serotonin and histamine. Norepinephrine 171-185 solute carrier family 6 member 4 Homo sapiens 28-32 29300091-3 2018 Pioneer studies provided valuable information on structure, function, and pharmacology of drugs targeting both hSERT and hNET (serotonin-norepinephrine reuptake inhibitors, SNRIs), and the differential binding mechanism between SNRIs and selective inhibitors of 5-HT (SSRIs) or NE (sNRIs) to their corresponding targets was expected to be able to facilitate the discovery of a privileged drug-like scaffold with improved efficacy. Norepinephrine 137-151 solute carrier family 6 member 4 Homo sapiens 111-116 28811134-2 2017 Several neurotransmitters (e.g. serotonin, norepinephrine) are low-affinity substrates for these transporters, but possess higher affinity for other transporters (e.g. the serotonin or norepinephrine transporters; SERT and NET, respectively). Norepinephrine 43-57 solute carrier family 6 member 4 Homo sapiens 214-218 25402186-4 2014 In the present study, using immunodetection methods, we revealed the presence of several proteins important for the dopamine uptake and signalling in mammalian sperm, specifically monoamine transporters as dopamine (DAT), serotonin (SERT) and norepinephrine (NET) transporters in equine sperm. Norepinephrine 243-257 solute carrier family 6 member 4 Homo sapiens 222-231 27596073-1 2016 The human dopamine, norepinephrine, and serotonin transporters (hDAT, hNET, and hSERT) are carriers of neurotransmitters and targets for many drugs. Norepinephrine 20-34 solute carrier family 6 member 4 Homo sapiens 80-85 26674707-0 2016 Polymorphism of rs3813034 in Serotonin Transporter Gene SLC6A4 Is Associated With the Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Response in Depressive Disorder: Sequencing Analysis of SLC6A4. Norepinephrine 120-134 solute carrier family 6 member 4 Homo sapiens 29-50 26674707-0 2016 Polymorphism of rs3813034 in Serotonin Transporter Gene SLC6A4 Is Associated With the Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Response in Depressive Disorder: Sequencing Analysis of SLC6A4. Norepinephrine 120-134 solute carrier family 6 member 4 Homo sapiens 56-62 26674707-0 2016 Polymorphism of rs3813034 in Serotonin Transporter Gene SLC6A4 Is Associated With the Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Response in Depressive Disorder: Sequencing Analysis of SLC6A4. Norepinephrine 120-134 solute carrier family 6 member 4 Homo sapiens 210-216 25402186-4 2014 In the present study, using immunodetection methods, we revealed the presence of several proteins important for the dopamine uptake and signalling in mammalian sperm, specifically monoamine transporters as dopamine (DAT), serotonin (SERT) and norepinephrine (NET) transporters in equine sperm. Norepinephrine 243-257 solute carrier family 6 member 4 Homo sapiens 233-237 19022290-1 2009 Biogenic amine transporters for serotonin, norepinephrine and dopamine (SERT, NET and DAT respectively), are the key players terminating transmission of these amines in the central nervous system by their high-affinity uptake. Norepinephrine 43-57 solute carrier family 6 member 4 Homo sapiens 72-76 24251585-1 2014 BACKGROUND AND PURPOSE: Amphetamines bind to the plasmalemmal transporters for the monoamines dopamine (DAT), noradrenaline (NET) and 5-HT (SERT); influx of amphetamine leads to efflux of substrates. Norepinephrine 110-123 solute carrier family 6 member 4 Homo sapiens 140-144 23421681-4 2013 The 6-position of serotonin and the para-hydroxyl groups of dopamine and norepinephrine were found to face Ala173 in hSERT, Gly153 in hDAT, and Gly149 in hNET. Norepinephrine 73-87 solute carrier family 6 member 4 Homo sapiens 117-122 23421681-7 2013 Uptake experiments support that the 5-hydroxyl group of serotonin and the meta-hydroxyl group norepinephrine and dopamine are placed in the hydrophilic pocket around Ala173, Ser438, and Thr439 in hSERT corresponding to Gly149, Ser419, Ser420 in hNET and Gly153 Ser422 and Ala423 in hDAT. Norepinephrine 94-108 solute carrier family 6 member 4 Homo sapiens 196-201 19632110-2 2009 Synthesis of the two diastereomeric isomers of the molecule followed by chiral resolution of each enantiomer revealed the (2R,3S)-isomer to be a potent norepinephrine reuptake inhibitor (IC(50)=28 nM) with excellent selectivity over the dopamine transporter and 13-fold selectivity over the serotonin transporter. Norepinephrine 152-166 solute carrier family 6 member 4 Homo sapiens 291-312 19430461-8 2009 Conversely, when the only nonconserved HBP residue in both norepinephrine and dopamine transporters is mutated into that found in SERT, their affinities for all the three SSRIs increase uniformly. Norepinephrine 59-73 solute carrier family 6 member 4 Homo sapiens 130-134 25075188-3 2014 Its combined action on SERT and four subtypes of serotoninergic receptors increases the extracellular concentration of serotonin, dopamine, and noradrenaline. Norepinephrine 144-157 solute carrier family 6 member 4 Homo sapiens 23-27 23086945-1 2012 The serotonin transporter (SERT) and the norepinephrine transporter (NET) are sodium-dependent neurotransmitter transporters responsible for reuptake of released serotonin and norepinephrine, respectively, into nerve terminals in the brain. Norepinephrine 41-55 solute carrier family 6 member 4 Homo sapiens 4-25 23086945-1 2012 The serotonin transporter (SERT) and the norepinephrine transporter (NET) are sodium-dependent neurotransmitter transporters responsible for reuptake of released serotonin and norepinephrine, respectively, into nerve terminals in the brain. Norepinephrine 41-55 solute carrier family 6 member 4 Homo sapiens 27-31 20974189-6 2011 Strikingly, only heterozygous serotonin transporter knockout pups experiencing high maternal care showed increased hippocampal levels of serotonin and norepinephrine and decreased serotonin turnover compared to wild-type littermates. Norepinephrine 151-165 solute carrier family 6 member 4 Homo sapiens 30-51 18815045-1 2008 Norepinephrine transporter (NET) and serotonin transporter (SERT) proteins regulate norepinephrine (NE) and serotonin via their reuptake function and are targets of antidepressants action. Norepinephrine 84-98 solute carrier family 6 member 4 Homo sapiens 37-58 18815045-1 2008 Norepinephrine transporter (NET) and serotonin transporter (SERT) proteins regulate norepinephrine (NE) and serotonin via their reuptake function and are targets of antidepressants action. Norepinephrine 84-98 solute carrier family 6 member 4 Homo sapiens 60-64 16989291-3 2006 For the majority of antidepressants, these changes are the result of their ability to block serotonin and/or norepinephrine activity at their "presynaptic uptake sites" (i.e., at the serotonin transporter [SERT] or the norepinephrine transporter [NET]). Norepinephrine 109-123 solute carrier family 6 member 4 Homo sapiens 183-204 17224717-3 2007 The current study measured SERT occupancy and modulation of DAT by the serotonin/norepinephrine reuptake inhibitor (SNRI) venlafaxine using [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane SPECT. Norepinephrine 81-95 solute carrier family 6 member 4 Homo sapiens 27-31 17728423-0 2007 Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the Heart and Soul Study. Norepinephrine 102-116 solute carrier family 6 member 4 Homo sapiens 17-38 17728423-0 2007 Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the Heart and Soul Study. Norepinephrine 102-116 solute carrier family 6 member 4 Homo sapiens 53-61 17728423-8 2007 CONCLUSIONS: Among patients with chronic illness, carriers of the s allele of 5-HTTLPR are more vulnerable to depression, perceived stress, and high norepinephrine secretion. Norepinephrine 149-163 solute carrier family 6 member 4 Homo sapiens 78-86 16989291-3 2006 For the majority of antidepressants, these changes are the result of their ability to block serotonin and/or norepinephrine activity at their "presynaptic uptake sites" (i.e., at the serotonin transporter [SERT] or the norepinephrine transporter [NET]). Norepinephrine 109-123 solute carrier family 6 member 4 Homo sapiens 206-210 16722229-3 2006 Cotransport in norepinephrine (NET), epinephrine (EpiT), dopamine (DAT), and serotonin (SERT) transporters couples downhill Na+ flux to uphill transmitter flux. Norepinephrine 15-29 solute carrier family 6 member 4 Homo sapiens 77-86 16722229-3 2006 Cotransport in norepinephrine (NET), epinephrine (EpiT), dopamine (DAT), and serotonin (SERT) transporters couples downhill Na+ flux to uphill transmitter flux. Norepinephrine 15-29 solute carrier family 6 member 4 Homo sapiens 88-92