PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11268389-6	2000	The HPA-activating activity of IL-1 is associated with increases in the apparent release of brain noradrenaline (NA) and serotonin (5-HT), but not dopamine, as well as with increased brain tryptophan.	Norepinephrine	98-111	interleukin 1 complex	Mus musculus	31-35	
10601817-1	2000	Endotoxin (lipopolysaccharide, LPS) and interleukin-1 (IL-1) are known to activate the hypothalamo-pituitary- adrenocortical (HPA) axis, as well as brain norepinephrine (NE) and indoleamine metabolism.	Norepinephrine	154-168	interleukin 1 complex	Mus musculus	40-53	
10601817-1	2000	Endotoxin (lipopolysaccharide, LPS) and interleukin-1 (IL-1) are known to activate the hypothalamo-pituitary- adrenocortical (HPA) axis, as well as brain norepinephrine (NE) and indoleamine metabolism.	Norepinephrine	154-168	interleukin 1 complex	Mus musculus	55-59	
2558326-3	1989	Rats chronically cannulated in the right jugular veins showed a time-related increase in plasma corticosterone concentrations in response to intraperitoneal administration of IL-1 that lasted up to 4 h. In the same rats, plasma epinephrine (E) and norepinephrine (NE) concentrations were only slightly elevated (2-fold increase) at 30 min and at 1 h after IL-1 administration.	Norepinephrine	248-262	interleukin 1 complex	Mus musculus	175-179	
7518332-3	1994	IL-1 induced the broadest range of neurochemical changes, affecting central norepinephrine (NE), serotonin (5-HT) and dopamine (DA) activity.	Norepinephrine	76-90	interleukin 1 complex	Mus musculus	0-4	
1473014-1	1992	Both interleukin-1 (IL-1) and endotoxin (lipopolysaccharide, LPS) are potent activators of the hypothalamo-pituitary-adrenal (HPA) axis, and they also increase cerebral norepinephrine metabolism and tryptophan.	Norepinephrine	169-183	interleukin 1 complex	Mus musculus	20-24	
3260987-0	1988	Systemic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism parallelling the increased plasma corticosterone.	Norepinephrine	62-76	interleukin 1 complex	Mus musculus	9-22	
3260987-1	1988	Intraperitoneal injection of purified recombinant interleukin-1 (IL-1) into mice increased the cerebral concentration of the norepinephrine (NE) catabolite, 3-methoxy,4-hydroxyphenylethyleneglycol (MHPG), probably reflecting increased activity of noradrenergic neurons.	Norepinephrine	125-139	interleukin 1 complex	Mus musculus	50-63	
3260987-1	1988	Intraperitoneal injection of purified recombinant interleukin-1 (IL-1) into mice increased the cerebral concentration of the norepinephrine (NE) catabolite, 3-methoxy,4-hydroxyphenylethyleneglycol (MHPG), probably reflecting increased activity of noradrenergic neurons.	Norepinephrine	125-139	interleukin 1 complex	Mus musculus	65-69	
3023761-5	1986	Norepinephrine and epinephrine inhibited the capacity of gamma interferon and lipopolysaccharide to stimulate IL-1 production from mouse peritoneal macrophages.	Norepinephrine	0-14	interleukin 1 complex	Mus musculus	110-114	
3023761-8	1986	This, coupled with the capacity of norepinephrine and epinephrine to enhance intracellular cAMP levels in macrophages, strongly suggested that the catecholamine-induced suppression of IL-1 production may be mediated by elevated intracellular cAMP levels.	Norepinephrine	35-49	interleukin 1 complex	Mus musculus	184-188