PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23679128-1 2013 The first asymmetric catalytic biomimetic three-component 1,3-dipolar cycloaddition of alpha-keto esters and benzylamine with electron-deficient olefins, inspired by the transamination of alpha-keto acids involving pyridoxal phosphate (PLP)-dependent enzymes in biological systems, giving several families of structurally diverse pyrrolidine derivatives in high yields and excellent enantioselectivities (up to 99% ee) under mild conditions is described. alpha-keto acids 188-204 pyridoxal phosphatase Homo sapiens 236-239