PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22954227-4	2012	RESULTS: Isobutanol production could be improved by re-locating the valine biosynthesis enzymes Ilv2, Ilv5 and Ilv3 from the mitochondrial matrix into the cytosol.	isobutyl alcohol	9-19	ketol-acid reductoisomerase	Saccharomyces cerevisiae S288C	102-106	
25280745-5	2014	For the production of isobutanol, genes involved in isobutanol production (ILV2, ILV3, ILV5, ARO10, and ADH2) were additionally overexpressed in ald6Deltabat1Delta strain expressing LEU3Delta601, resulting in 376.9 mg/L isobutanol production from 100 g/L glucose.	isobutyl alcohol	22-32	ketol-acid reductoisomerase	Saccharomyces cerevisiae S288C	87-91	
25280745-5	2014	For the production of isobutanol, genes involved in isobutanol production (ILV2, ILV3, ILV5, ARO10, and ADH2) were additionally overexpressed in ald6Deltabat1Delta strain expressing LEU3Delta601, resulting in 376.9 mg/L isobutanol production from 100 g/L glucose.	isobutyl alcohol	52-62	ketol-acid reductoisomerase	Saccharomyces cerevisiae S288C	87-91	
25280745-5	2014	For the production of isobutanol, genes involved in isobutanol production (ILV2, ILV3, ILV5, ARO10, and ADH2) were additionally overexpressed in ald6Deltabat1Delta strain expressing LEU3Delta601, resulting in 376.9 mg/L isobutanol production from 100 g/L glucose.	isobutyl alcohol	52-62	ketol-acid reductoisomerase	Saccharomyces cerevisiae S288C	87-91	
22543927-7	2012	Isobutanol production was further enhanced to 151 mg/L by additional overexpression of acetolactate synthase (Ilv2p), acetohydroxyacid reductoisomerase (Ilv5p), and dihydroxyacid dehydratase (Ilv3p) in the cytosol.	isobutyl alcohol	0-10	ketol-acid reductoisomerase	Saccharomyces cerevisiae S288C	153-158	
21798060-4	2011	RESULTS: The yield of isobutanol was improved from 0.16 to 0.97 mg per g glucose by simultaneous overexpression of biosynthetic genes ILV2, ILV3, and ILV5 in valine metabolism in anaerobic fermentation of glucose in mineral medium in S. cerevisiae.	isobutyl alcohol	22-32	ketol-acid reductoisomerase	Saccharomyces cerevisiae S288C	150-154	
21798060-6	2011	Overexpression of ILV6, encoding the regulatory subunit of Ilv2, in the ILV2 ILV3 ILV5 overexpression strain decreased isobutanol production yield by threefold.	isobutyl alcohol	119-129	ketol-acid reductoisomerase	Saccharomyces cerevisiae S288C	82-86	
21798060-7	2011	In aerobic cultivations in shake flasks in mineral medium, the isobutanol yield of the ILV2 ILV3 ILV5 overexpression strain and the reference strain were 3.86 and 0.28 mg per g glucose, respectively.	isobutyl alcohol	63-73	ketol-acid reductoisomerase	Saccharomyces cerevisiae S288C	97-101	
21798060-9	2011	CONCLUSIONS: Overexpression of genes ILV2, ILV3, ILV5, and BAT2 in valine metabolism led to an increase in isobutanol production in S. cerevisiae.	isobutyl alcohol	107-117	ketol-acid reductoisomerase	Saccharomyces cerevisiae S288C	49-53	
21798060-12	2011	This result implies that other constraints besides the enzyme activities for the supply of 2-ketoisovalerate may become bottlenecks for isobutanol production after ILV2, ILV3, and ILV5 have been overexpressed, which most probably includes the valine inhibition to Ilv2.	isobutyl alcohol	136-146	ketol-acid reductoisomerase	Saccharomyces cerevisiae S288C	180-184