PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21925266-7 2011 Isradipine is a Federal Drug Administration-approved dihydropyridine calcium channel blocker that binds selectively to Ca(v)1.2 in the hippocampus. Isradipine 0-10 immunoglobulin lambda variable 2-8 Homo sapiens 119-127 21925266-8 2011 Our studies have shown that isradipine in vitro attenuates beta amyloid oligomer toxicity by suppressing calcium influx into cytoplasm and by suppressing Ca(v)1.2 expression. Isradipine 28-38 immunoglobulin lambda variable 2-8 Homo sapiens 154-162 21925266-12 2011 This review highlights the importance of Ca(v)1.2 channel overexpression, the accumulation of hyperphosphorylated tau and suppression of autophagy in Alzheimer"s disease and modulation of this pathway by isradipine. Isradipine 204-214 immunoglobulin lambda variable 2-8 Homo sapiens 41-49 21487241-3 2011 What distinguishes snail and mammalian L-type channels is a difference in dihydropyridine sensitivity: 100 nM isradipine exhibits a significant block of mammalian Ca(v) 1.2 currents without effect on snail LCa(v)1 currents. Isradipine 110-120 immunoglobulin lambda variable 2-8 Homo sapiens 163-172