PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1647962-5	1991	The activation by lower doses of ET-1, but not the inhibition by higher doses of ET-1, of the BK channel was blocked by 0.1 microM PN 200-110, a Ca2+ channel blocker.	Isradipine	131-141	endothelin 1	Homo sapiens	33-37	
10088199-10	1998	In conclusion, this study has demonstrated that cGMP-enhancing agents, such as the naturally occurring ANP, the calcium channel blocker isradipine, and the synthetic inhibitor of PDE 3, were the most effective relaxants of ET-1 evoked contractions in pLAD in vitro.	Isradipine	136-146	endothelin 1	Homo sapiens	223-227	
9849837-1	1998	BACKGROUND: To examine the effect of endothelin-1 (ET-1) on spontaneous contractile activity and the effects of nimodipine and isradipine on ET-1-induced contractile responses in myometrial strips isolated from normal pregnant and preeclamptic women.	Isradipine	127-137	endothelin 1	Homo sapiens	141-145	
9849837-4	1998	The effect of increasing concentration of ET-1 on spontaneous contractions and effects of increasing concentration of nimodipine and isradipine on ET-1-induced contractions were recorded.	Isradipine	133-143	endothelin 1	Homo sapiens	147-151	
25741585-5	2015	In conclusion, the preventative effect with PTX and CTX, and the absence of an effect with nifedipine, as well as the blockade by isradipine on cytosolic ET-1-induced increase in nuclear calcium, suggest that this nuclear calcium influx in hVSMCs is due to activation of the steady-state R-type calcium channel.	Isradipine	130-140	endothelin 1	Homo sapiens	154-158	
10853442-2	1999	OBJECTIVE: We studied the effect of endothelin (ET)-1 on spontaneous contractions and the effects of nimodipine and isradipine on ET-1-induced contractions in myometrial tissue from normal and diabetic pregnant women.	Isradipine	116-126	endothelin 1	Homo sapiens	130-134	
10853442-15	1999	The contractile effect of ET-1 in normal and diabetic myometrium is mediated partly by dihydropyridine-sensitive calcium channels since it is significantly reduced by nimodipine and isradipine.	Isradipine	182-192	endothelin 1	Homo sapiens	26-30	
8660111-0	1996	Effect of isradipine on endothelin-1 plasma concentrations in patients with Raynaud"s phenomenon.	Isradipine	10-20	endothelin 1	Homo sapiens	24-36	
7946180-2	1994	The aim of this study was to investigate the in vitro influence of isradipine on ET-1-induced contraction of myometrial resistance arteries from pregnant women, as these vessels are partly responsible for the regulation of uteroplacental blood flow in preeclampsia.	Isradipine	67-77	endothelin 1	Homo sapiens	81-85	
7946180-7	1994	Pretreatment with isradipine attenuated ET-1-induced contraction by 26% at 3 x 10(-4) mol/L and by up to 80% at 10(-3) mol/L.	Isradipine	18-28	endothelin 1	Homo sapiens	40-44	
7946180-9	1994	The present study has thus shown that isradipine at high concentrations counteracts ET-1-induced constriction of myometrial arteries in term pregnant women.	Isradipine	38-48	endothelin 1	Homo sapiens	84-88	
7946180-10	1994	Pretreatment with isradipine at high concentrations attenuates the ET-1 contraction.	Isradipine	18-28	endothelin 1	Homo sapiens	67-71	
8156652-5	1994	The results showed that BQ123 and the calcium antagonists nisoldipine, isradipine, nitrendipine and nifedipine fully relaxed IMA precontracted with 3 nmol/L ET-1 with the EC50 values of 7.18 +/- 0.09 (-log mol/L) for BQ123, and 7.68 +/- 0.07, 7.02 +/- 0.12, 6.96 +/- 0.08 and 6.89 +/- 0.09 for the calcium antagonists, respectively.	Isradipine	71-81	endothelin 1	Homo sapiens	157-161