PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10607427-0	1999	Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels.	correolide	0-10	potassium voltage-gated channel subfamily A member 3	Homo sapiens	80-85	
17261195-0	2007	Monte Carlo-energy minimization of correolide in the Kv1.3 channel: possible role of potassium ion in ligand-receptor interactions.	correolide	35-45	potassium voltage-gated channel subfamily A member 3	Homo sapiens	53-58	
17261195-1	2007	BACKGROUND: Correolide, a nortriterpene isolated from the Costa Rican tree Spachea correa, is a novel immunosuppressant, which blocks Kv1.3 channels in human T lymphocytes.	correolide	12-22	potassium voltage-gated channel subfamily A member 3	Homo sapiens	134-139	
17261195-4	2007	RESULTS: We employed the method of Monte Carlo (MC) with energy minimization to search for optimal complexes of correolide in Kv1.2-based models of the open Kv1.3 with potassium binding sites 2/4 or 1/3/5 loaded with K+ ions.	correolide	112-122	potassium voltage-gated channel subfamily A member 3	Homo sapiens	157-162	
17261195-8	2007	Deficiency of K+ ions in the selectivity filter of C-type inactivated Kv1.3 would stabilize K+-bound correolide in the inner pore.	correolide	101-111	potassium voltage-gated channel subfamily A member 3	Homo sapiens	70-75	
11570869-0	2001	Binding of correolide to the K(v)1.3 potassium channel: characterization of the binding domain by site-directed mutagenesis.	correolide	11-21	potassium voltage-gated channel subfamily A member 3	Homo sapiens	29-36	
11570869-1	2001	Correolide is a novel immunosuppressant that inhibits the voltage-gated potassium channel K(v)1.3 [Felix et al.	correolide	0-10	potassium voltage-gated channel subfamily A member 3	Homo sapiens	90-97	
10961988-9	2000	Selective Kv1.3 inhibitors ShK-Dap(22), margatoxin, and correolide suppressed mitogenesis of resting T-cells but not preactivated T-cells with up-regulated IKCa1 channel expression.	correolide	56-66	potassium voltage-gated channel subfamily A member 3	Homo sapiens	10-15	
15603971-0	2005	Potent Kv1.3 inhibitors from correolide-modification of the C18 position.	correolide	29-39	potassium voltage-gated channel subfamily A member 3	Homo sapiens	7-12	
15603971-2	2005	Correolide (1), a pentacyclic natural product, is a potent and selective Kv1.3 channel blocker.	correolide	0-10	potassium voltage-gated channel subfamily A member 3	Homo sapiens	73-78	
15603971-3	2005	Simplification of correolide via removal of its E-ring generates enone 4, whose modification produced a new series of tetracyclic Kv1.3 blockers.	correolide	18-28	potassium voltage-gated channel subfamily A member 3	Homo sapiens	130-135	
10607427-3	1999	In the present study, a triterpene natural product, correolide, was found to block Kv1.3 channels in human and miniswine T cells by electrophysiological characterization.	correolide	52-62	potassium voltage-gated channel subfamily A member 3	Homo sapiens	83-88	
10213593-1	1999	A novel nortriterpene, termed correolide, purified from the tree Spachea correae, inhibits Kv1.3, a Shaker-type delayed rectifier potassium channel present in human T lymphocytes.	correolide	30-40	potassium voltage-gated channel subfamily A member 3	Homo sapiens	91-96	
10213593-2	1999	Correolide inhibits 86Rb+ efflux through Kv1.3 channels expressed in CHO cells (IC50 86 nM; Hill coefficient 1) and displays a defined structure-activity relationship.	correolide	0-10	potassium voltage-gated channel subfamily A member 3	Homo sapiens	41-46	
10213593-5	1999	Although correolide is most potent as a Kv1.3 inhibitor, it blocks all other members of the Kv1 family with 4-14-fold lower potency.	correolide	9-19	potassium voltage-gated channel subfamily A member 3	Homo sapiens	40-45