PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31614098-8	2020	Protein levels of COX-2 and PCNA and serum levels of IL-6 and TNF-alpha were significantly elevated in the rats receiving DMH and downregulated after performing the exercise program (P < 0.05).	1,2-Dimethylhydrazine	122-125	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	18-23	
17934920-10	2007	It may be concluded that the NSAIDs, particularly the coxib group of the drugs (COX-2 selective), are effective in chemoprevention in the DMH-induced colon carcinogenesis and membrane alterations.	1,2-Dimethylhydrazine	138-141	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	80-85	
29345053-9	2018	Administration of Naringenin ameliorated the development of DMH-induced lipid peroxidation, ROS formation, precancerous lesions (ACF and MDF) and it also reduced the infiltration of mast cells, suppressed the immunostaining of NF-kappaB-p65, COX-2, i-NOS PCNA and Ki 67 Naringenin treatment significantly attenuated the level of TNF-alpha and it also prevented the depletion of the mucous layer.	1,2-Dimethylhydrazine	60-63	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	242-247	
22670549-15	2012	CONCLUSION: COX-2 expression was "induced" by DMH and reverted to a "wild"-type level of expression upon exposure to HBO2.	1,2-Dimethylhydrazine	46-49	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	12-17	
23167349-7	2012	TA treatment prevented deteriorative effects induced by DMH through a protective mechanism that involved reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression levels and TNF-alpha(p&lt;0.001) release.	1,2-Dimethylhydrazine	56-59	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	146-151	
20528746-5	2010	The colonic tissue showed increased COX-2 expression in the DMH group, immunohistochemically and by western blotting.	1,2-Dimethylhydrazine	60-63	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	36-41	
25536541-3	2015	Application of DMH triggered the production of pro-inflammatory cytokines IL-2, IL-6, IL-17, and TNF-alpha, expression of pro-inflammatory mediators NF-kappaB, COX-2 and iNOS and caused depletion of goblet cells.	1,2-Dimethylhydrazine	15-18	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	160-165	
35299250-13	2022	Immunohistochemical analysis revealed significantly lower levels of expression of COX-2 (86%) and PCNA (83%) in the colon of rats treated with DEHE plus DMH, concerning those treated with the carcinogen.	1,2-Dimethylhydrazine	153-156	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	82-87	
33754881-6	2021	Additionally DMH treatment upregulated inflammatory markers expression (NF-kappaB, COX-2 and IL-6) and enhanced mucosal damage in the colon.	1,2-Dimethylhydrazine	13-16	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	83-88