PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17934920-10 2007 It may be concluded that the NSAIDs, particularly the coxib group of the drugs (COX-2 selective), are effective in chemoprevention in the DMH-induced colon carcinogenesis and membrane alterations. 1,2-Dimethylhydrazine 138-141 cytochrome c oxidase II, mitochondrial Rattus norvegicus 80-85 20528746-5 2010 The colonic tissue showed increased COX-2 expression in the DMH group, immunohistochemically and by western blotting. 1,2-Dimethylhydrazine 60-63 cytochrome c oxidase II, mitochondrial Rattus norvegicus 36-41 35299250-13 2022 Immunohistochemical analysis revealed significantly lower levels of expression of COX-2 (86%) and PCNA (83%) in the colon of rats treated with DEHE plus DMH, concerning those treated with the carcinogen. 1,2-Dimethylhydrazine 153-156 cytochrome c oxidase II, mitochondrial Rattus norvegicus 82-87 22670549-15 2012 CONCLUSION: COX-2 expression was "induced" by DMH and reverted to a "wild"-type level of expression upon exposure to HBO2. 1,2-Dimethylhydrazine 46-49 cytochrome c oxidase II, mitochondrial Rattus norvegicus 12-17 33754881-6 2021 Additionally DMH treatment upregulated inflammatory markers expression (NF-kappaB, COX-2 and IL-6) and enhanced mucosal damage in the colon. 1,2-Dimethylhydrazine 13-16 cytochrome c oxidase II, mitochondrial Rattus norvegicus 83-88 31614098-8 2020 Protein levels of COX-2 and PCNA and serum levels of IL-6 and TNF-alpha were significantly elevated in the rats receiving DMH and downregulated after performing the exercise program (P < 0.05). 1,2-Dimethylhydrazine 122-125 cytochrome c oxidase II, mitochondrial Rattus norvegicus 18-23 25536541-3 2015 Application of DMH triggered the production of pro-inflammatory cytokines IL-2, IL-6, IL-17, and TNF-alpha, expression of pro-inflammatory mediators NF-kappaB, COX-2 and iNOS and caused depletion of goblet cells. 1,2-Dimethylhydrazine 15-18 cytochrome c oxidase II, mitochondrial Rattus norvegicus 160-165 29345053-9 2018 Administration of Naringenin ameliorated the development of DMH-induced lipid peroxidation, ROS formation, precancerous lesions (ACF and MDF) and it also reduced the infiltration of mast cells, suppressed the immunostaining of NF-kappaB-p65, COX-2, i-NOS PCNA and Ki 67 Naringenin treatment significantly attenuated the level of TNF-alpha and it also prevented the depletion of the mucous layer. 1,2-Dimethylhydrazine 60-63 cytochrome c oxidase II, mitochondrial Rattus norvegicus 242-247 23167349-7 2012 TA treatment prevented deteriorative effects induced by DMH through a protective mechanism that involved reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression levels and TNF-alpha(p<0.001) release. 1,2-Dimethylhydrazine 56-59 cytochrome c oxidase II, mitochondrial Rattus norvegicus 146-151