PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25811420-7 2015 DMH treatment brought about a significant increase in the expression of COX-2. 1,2-Dimethylhydrazine 0-3 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 72-77 29562216-11 2018 Overall, it was concluded that NSAIDs, particularly cyclooxygenase-2 (COX-2) inhibitors, might have a protective effect on CRC development and slow down progression of tumor in a DMH-induced experimental cancer model. 1,2-Dimethylhydrazine 179-182 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 52-68 29562216-11 2018 Overall, it was concluded that NSAIDs, particularly cyclooxygenase-2 (COX-2) inhibitors, might have a protective effect on CRC development and slow down progression of tumor in a DMH-induced experimental cancer model. 1,2-Dimethylhydrazine 179-182 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 70-75 20485182-4 2010 The colonic mucosa showed increased protein expression and the enhanced activity of COX-2 in the DMH group, whereas the constitutively expressed COX-1 remained unaltered. 1,2-Dimethylhydrazine 97-100 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 84-89 23008118-4 2013 In the DMH group treated with green tea, significant reductions in gene overexpressions of colonic nuclear factor kappaB (NF-kappaB), tumour necrosis factor alpha, inducible nitric oxide synthase and cyclooxygenase 2, and NF-kappaB immunostaining indicates the anti-inflammatory effect of green tea in attenuating colon cancer. 1,2-Dimethylhydrazine 7-10 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 200-216 22441428-6 2012 Inflammation remains the dominant molecular mechanism in the development of multiple plaque lesions, the carcinogenic lesions in a DMH-induced process that may be mediated by COX-2. 1,2-Dimethylhydrazine 131-134 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 175-180 22441428-7 2012 Western blot and immunofluorescence analysis revealed a higher expression of COX-2 and nuclear factor-kappaB, the transcription factors responsible for proinflammatory proteins such as TNFalpha, and also the inducible nitric oxide synthase in the DMH group, which was further recovered significantly with the use of Celecoxib and Dolastatin. 1,2-Dimethylhydrazine 247-250 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 77-82 23928829-6 2014 Aloin pretreatment ameliorates the damaging effects induced by DMH through a protective mechanism that involved reduction in increased oxidative stress enzymes (p < 0.001), ACF, MDF, cyclooxygenase-2, inducible nitric oxide synthase, interleukin-6, proliferating cell nuclear antigen protein expression, and tumor necrosis factor-alpha (p < 0.001) release. 1,2-Dimethylhydrazine 63-66 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 186-235 20204254-11 2010 The cytoplasmic expression of COX-2 protein was studied in paraffin sections of the colon by immunohistochemistry with COX-2 specific antibody which showed a very high presence of this inducible enzyme with the DMH group while in all other groups of animals it was not visible or weekly expressed. 1,2-Dimethylhydrazine 211-214 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 30-35 20495296-7 2010 Colonic mucosa of DMH-injected rats had significantly greater COX-2 and iNOS gene expression than those of control rats, while treatment with CoQ10 induced an inhibitory effect on over-expression of COX-2 and iNOS in colon tumors. 1,2-Dimethylhydrazine 18-21 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 62-67 20495296-7 2010 Colonic mucosa of DMH-injected rats had significantly greater COX-2 and iNOS gene expression than those of control rats, while treatment with CoQ10 induced an inhibitory effect on over-expression of COX-2 and iNOS in colon tumors. 1,2-Dimethylhydrazine 18-21 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 199-204 20204254-11 2010 The cytoplasmic expression of COX-2 protein was studied in paraffin sections of the colon by immunohistochemistry with COX-2 specific antibody which showed a very high presence of this inducible enzyme with the DMH group while in all other groups of animals it was not visible or weekly expressed. 1,2-Dimethylhydrazine 211-214 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 119-124 20049376-1 2009 The chemopreventive response was evaluated of nonsteroidal anti-inflammatory drug, Diclofenac, a preferential cyclooxygenase-2 (COX-2) inhibitor in 1,2-dimethyhydrazine (DMH)-induced colon cancer in rat model. 1,2-Dimethylhydrazine 170-173 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 110-126 20049376-1 2009 The chemopreventive response was evaluated of nonsteroidal anti-inflammatory drug, Diclofenac, a preferential cyclooxygenase-2 (COX-2) inhibitor in 1,2-dimethyhydrazine (DMH)-induced colon cancer in rat model. 1,2-Dimethylhydrazine 170-173 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 128-133 20049376-5 2009 A very high expression of COX-2 was seen in the colonic epithelium of DMH-treated rats, as analyzed by immunohistochemistry. 1,2-Dimethylhydrazine 70-73 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 26-31 20192600-13 2009 Studies of a nuclear transcription factor (NF-kB) and COX-2 by Western blot analysis and immunohistochemistry demonstrated expression of both to be elevated in the DMH treated group but reduced in the DMH + Etoricoxib group. 1,2-Dimethylhydrazine 164-167 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 54-59 20192600-13 2009 Studies of a nuclear transcription factor (NF-kB) and COX-2 by Western blot analysis and immunohistochemistry demonstrated expression of both to be elevated in the DMH treated group but reduced in the DMH + Etoricoxib group. 1,2-Dimethylhydrazine 201-204 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 54-59 18361741-8 2008 We conclude that the combination of FOS and soy isoflavones inhibits colonic ACF formation and reduces COX-2 expression in DMH-treated rats. 1,2-Dimethylhydrazine 123-126 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 103-108 14643021-2 2003 The present experiment was designed to assess the potential chemopreventive properties of JTE-522, a new selective cyclooxygenase-2 inhibitor, on the induction of 1,2-dimethylhydrazine (DMH)-induced colonic aberrant crypt foci (ACF), a marker of rat colon carcinogenesis. 1,2-Dimethylhydrazine 163-184 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 115-131 14643021-2 2003 The present experiment was designed to assess the potential chemopreventive properties of JTE-522, a new selective cyclooxygenase-2 inhibitor, on the induction of 1,2-dimethylhydrazine (DMH)-induced colonic aberrant crypt foci (ACF), a marker of rat colon carcinogenesis. 1,2-Dimethylhydrazine 186-189 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 115-131