PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28628036-4 2017 First, we found that ArcN NPY/AgRP fibers closely appose PVN and DMH presympathetic neurons. 1,2-Dimethylhydrazine 65-68 neuropeptide Y Mus musculus 26-29 24048859-5 2013 Surprisingly, electrophysiological experiments demonstrated that leptin directly depolarized and increased the firing rate of DMH NPY neurons in DIO mice. 1,2-Dimethylhydrazine 126-129 neuropeptide Y Mus musculus 130-133 24048859-8 2013 Importantly, we also demonstrated that DMH NPY neurons coexpress cocaine amphetamine-regulated transcript (CART); however, CART mRNA expression in the DMH peaked earlier in the progression of DIO. 1,2-Dimethylhydrazine 39-42 neuropeptide Y Mus musculus 43-46 24048859-10 2013 First, NPY and CART are coexpressed in the same neurons within the DMH, and second, leptin stimulates DMH NPY neurons. 1,2-Dimethylhydrazine 67-70 neuropeptide Y Mus musculus 7-10 24048859-10 2013 First, NPY and CART are coexpressed in the same neurons within the DMH, and second, leptin stimulates DMH NPY neurons. 1,2-Dimethylhydrazine 102-105 neuropeptide Y Mus musculus 106-109 24048859-11 2013 These studies suggest that during the progression of DIO, there is an unknown signal that drives the expression of the orexigenic NPY signal within the DMH, and that the chronic hyperleptinemia increases the activity of these NPY/CART neurons. 1,2-Dimethylhydrazine 152-155 neuropeptide Y Mus musculus 130-133 9139806-7 1997 However, NPY was expressed at high levels in a new site, the dorsal medial hypothalamic nucleus (DMH). 1,2-Dimethylhydrazine 97-100 neuropeptide Y Mus musculus 9-12 9139806-8 1997 Expression of NPY in the DMH was also seen in obese MC4-RKO homozygous (-/-) mice, but not in lean heterozygous (+/-) or wild type (+/+) control mice. 1,2-Dimethylhydrazine 25-28 neuropeptide Y Mus musculus 14-17 9139806-9 1997 This identifies the DMH as a brain region that is functionally altered by the disruption of melanocortinergic signaling and suggests that this nucleus, possibly via elevated NPY expression, may have an etiological role in the melanocortinergic obesity syndrome. 1,2-Dimethylhydrazine 20-23 neuropeptide Y Mus musculus 174-177 28628036-8 2017 Considering that chronic obesity decreases ArcN NPY content, we propose that the ArcN NPY neuropathway to the PVN and DMH is pivotal in obesity-induced elevations in SNA. 1,2-Dimethylhydrazine 118-121 neuropeptide Y Mus musculus 48-51 28628036-8 2017 Considering that chronic obesity decreases ArcN NPY content, we propose that the ArcN NPY neuropathway to the PVN and DMH is pivotal in obesity-induced elevations in SNA. 1,2-Dimethylhydrazine 118-121 neuropeptide Y Mus musculus 86-89 26073698-5 2015 Neurons expressing both NPW and NPY mRNAs begin to emerge in the DMH at about postnatal day 0 (P-0) through P-3. 1,2-Dimethylhydrazine 65-68 neuropeptide Y Mus musculus 32-35