PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28575002-6 2017 On PND 90, maternal environment during the cross-fostering period had a major effect on DMH Npy expression. 1,2-Dimethylhydrazine 88-91 neuropeptide Y Rattus norvegicus 92-95 31149056-12 2019 Conclusion: These results suggest that DMH NPY knock-down improves hepatic insulin sensitivity in HF diet-fed rats by activating the hepatic PI3K/AKT insulin signalling pathway. 1,2-Dimethylhydrazine 39-42 neuropeptide Y Rattus norvegicus 43-46 29650350-7 2018 Interestingly, DMH Glp1r KD increased neuropeptide Y (NPY) mRNA expression in the DMH. 1,2-Dimethylhydrazine 15-18 neuropeptide Y Rattus norvegicus 38-52 29650350-7 2018 Interestingly, DMH Glp1r KD increased neuropeptide Y (NPY) mRNA expression in the DMH. 1,2-Dimethylhydrazine 15-18 neuropeptide Y Rattus norvegicus 54-57 28575002-8 2017 Reduced expression of Npy in the DMH of LdOp rats was consistent with their reduction of body weight compared to OdOp rats. 1,2-Dimethylhydrazine 33-36 neuropeptide Y Rattus norvegicus 22-25 28575002-11 2017 Together, our results demonstrate effects of both genotype and early postnatal environment on obesity of OLETF rats and further suggest an important role of DMH NPY in the development of obesity of OLETF rats. 1,2-Dimethylhydrazine 157-160 neuropeptide Y Rattus norvegicus 161-164 26561644-11 2016 Together, these results demonstrate a therapeutic action of DMH NPY knockdown against obesity and impaired glucose homeostasis in rats, providing a potential target for the treatment of obesity and diabetes. 1,2-Dimethylhydrazine 60-63 neuropeptide Y Rattus norvegicus 64-67 27534875-4 2016 Since activation of catecholaminergic neurons within the nucleus of solitary tract (NTS) contributes to the feeding effects of CCK, we hypothesized that DMH NPY modulates NTS neural catecholaminergic signaling to affect food intake. 1,2-Dimethylhydrazine 153-156 neuropeptide Y Rattus norvegicus 157-160 27534875-5 2016 We used an adeno-associated virus system to manipulate DMH NPY gene expression in rats to examine this pathway. 1,2-Dimethylhydrazine 55-58 neuropeptide Y Rattus norvegicus 59-62 27534875-6 2016 Viral-mediated hrGFP anterograde tracing revealed that DMH NPY neurons project to the NTS; the projections were in close proximity to catecholaminergic neurons, and some contained NPY. 1,2-Dimethylhydrazine 55-58 neuropeptide Y Rattus norvegicus 59-62 27534875-6 2016 Viral-mediated hrGFP anterograde tracing revealed that DMH NPY neurons project to the NTS; the projections were in close proximity to catecholaminergic neurons, and some contained NPY. 1,2-Dimethylhydrazine 55-58 neuropeptide Y Rattus norvegicus 180-183 27534875-8 2016 Knockdown of DMH NPY produced the opposite effects. 1,2-Dimethylhydrazine 13-16 neuropeptide Y Rattus norvegicus 17-20 27534875-10 2016 Taken together, these results demonstrate that DMH NPY descending signals affect CCK-induced satiety, at least in part, via modulation of NTS catecholaminergic neuronal signaling. 1,2-Dimethylhydrazine 47-50 neuropeptide Y Rattus norvegicus 51-54 27805869-1 2016 Recent evidence has shown that alterations in dorsomedial hypothalamic (DMH) neuropeptide Y (NPY) signaling influence glucose homeostasis, but the mechanism through which DMH NPY acts to affect glucose homeostasis remains unclear. 1,2-Dimethylhydrazine 72-75 neuropeptide Y Rattus norvegicus 77-91 27805869-1 2016 Recent evidence has shown that alterations in dorsomedial hypothalamic (DMH) neuropeptide Y (NPY) signaling influence glucose homeostasis, but the mechanism through which DMH NPY acts to affect glucose homeostasis remains unclear. 1,2-Dimethylhydrazine 72-75 neuropeptide Y Rattus norvegicus 93-96 27805869-2 2016 Here we report that DMH NPY descending signals to the dorsal motor nucleus of the vagus (DMV) modulate hepatic insulin sensitivity to control hepatic glucose production in rats. 1,2-Dimethylhydrazine 20-23 neuropeptide Y Rattus norvegicus 24-27 27805869-3 2016 Using the hyperinsulinemic-euglycemic clamp, we revealed that knockdown of NPY in the DMH by adeno-associated virus-mediated NPY-specific RNAi promoted insulin"s action on suppression of hepatic glucose production. 1,2-Dimethylhydrazine 86-89 neuropeptide Y Rattus norvegicus 75-78 27805869-3 2016 Using the hyperinsulinemic-euglycemic clamp, we revealed that knockdown of NPY in the DMH by adeno-associated virus-mediated NPY-specific RNAi promoted insulin"s action on suppression of hepatic glucose production. 1,2-Dimethylhydrazine 86-89 neuropeptide Y Rattus norvegicus 125-128 27805869-4 2016 This knockdown silenced DMH NPY descending signals to the DMV, leading to an elevation of hepatic vagal innervation. 1,2-Dimethylhydrazine 24-27 neuropeptide Y Rattus norvegicus 28-31 27805869-5 2016 Hepatic vagotomy abolished the inhibitory effect of DMH NPY knockdown on hepatic glucose production, but this glycemic effect was not affected by vagal deafferentation. 1,2-Dimethylhydrazine 52-55 neuropeptide Y Rattus norvegicus 56-59 27805869-6 2016 Together, these results demonstrate a distinct role for DMH NPY in the regulation of glucose homeostasis through the hepatic vagal efferents and insulin action on hepatic glucose production. 1,2-Dimethylhydrazine 56-59 neuropeptide Y Rattus norvegicus 60-63 27053000-6 2016 ICV TTR decreased neuropeptide Y (NPY) levels in the DMH and the paraventricular nucleus (P < 0.05). 1,2-Dimethylhydrazine 53-56 neuropeptide Y Rattus norvegicus 18-32 27053000-6 2016 ICV TTR decreased neuropeptide Y (NPY) levels in the DMH and the paraventricular nucleus (P < 0.05). 1,2-Dimethylhydrazine 53-56 neuropeptide Y Rattus norvegicus 34-37 23083763-3 2012 While the actions of ARC NPY in energy balance control have been well studied, a role for DMH NPY is still being unraveled. 1,2-Dimethylhydrazine 90-93 neuropeptide Y Rattus norvegicus 94-97 23172177-2 2013 The DMH contains orexigenic neuropeptide Y (NPY) neurons, but the role of these neurons in the control of energy homeostasis is not well understood. 1,2-Dimethylhydrazine 4-7 neuropeptide Y Rattus norvegicus 28-42 23172177-2 2013 The DMH contains orexigenic neuropeptide Y (NPY) neurons, but the role of these neurons in the control of energy homeostasis is not well understood. 1,2-Dimethylhydrazine 4-7 neuropeptide Y Rattus norvegicus 44-47 23172177-3 2013 NPY expression in the DMH is low under normal conditions in adult rodents but is significantly increased during chronic hyperphagic conditions such as lactation and diet-induced obesity (DIO). 1,2-Dimethylhydrazine 22-25 neuropeptide Y Rattus norvegicus 0-3 23172177-4 2013 To understand better the role of DMH-NPY neurons, we characterized the efferent projections of DMH-NPY neurons using the anterograde tracer biotinylated dextran amine (BDA) in lactating rats and DIO mice. 1,2-Dimethylhydrazine 33-36 neuropeptide Y Rattus norvegicus 37-40 23172177-4 2013 To understand better the role of DMH-NPY neurons, we characterized the efferent projections of DMH-NPY neurons using the anterograde tracer biotinylated dextran amine (BDA) in lactating rats and DIO mice. 1,2-Dimethylhydrazine 95-98 neuropeptide Y Rattus norvegicus 99-102 23172177-9 2013 Furthermore, DMH-NPY projections were not observed within the nucleus of the solitary tract (NTS), another brainstem site critical for the regulation of sympathetic outflow. 1,2-Dimethylhydrazine 13-16 neuropeptide Y Rattus norvegicus 17-20 23083763-7 2012 In support of this view, adeno-associated virus (AAV)-mediated overexpression of NPY in the DMH causes increases in food intake and body weight and exacerbates high-fat diet-induced hyperphagia and obesity. 1,2-Dimethylhydrazine 92-95 neuropeptide Y Rattus norvegicus 81-84 23083763-8 2012 Knockdown of NPY in the DMH via AAV-mediated RNAi ameliorates hyperphagia, obesity and glucose intolerance of Otsuka Long-Evans Tokushima Fatty rats in which DMH NPY overexpression has been proposed to play a causal role. 1,2-Dimethylhydrazine 24-27 neuropeptide Y Rattus norvegicus 13-16 23083763-8 2012 Knockdown of NPY in the DMH via AAV-mediated RNAi ameliorates hyperphagia, obesity and glucose intolerance of Otsuka Long-Evans Tokushima Fatty rats in which DMH NPY overexpression has been proposed to play a causal role. 1,2-Dimethylhydrazine 158-161 neuropeptide Y Rattus norvegicus 13-16 23083763-8 2012 Knockdown of NPY in the DMH via AAV-mediated RNAi ameliorates hyperphagia, obesity and glucose intolerance of Otsuka Long-Evans Tokushima Fatty rats in which DMH NPY overexpression has been proposed to play a causal role. 1,2-Dimethylhydrazine 158-161 neuropeptide Y Rattus norvegicus 162-165 23083763-9 2012 NPY knockdown in the DMH also prevents high-fat diet-induced hyperphagia, obesity and impaired glucose homeostasis. 1,2-Dimethylhydrazine 21-24 neuropeptide Y Rattus norvegicus 0-3 23083763-10 2012 A detailed examination of actions of DMH NPY reveals that DMH NPY specifically affects nocturnal meal size and produces an inhibitory action on within meal satiety signals. 1,2-Dimethylhydrazine 37-40 neuropeptide Y Rattus norvegicus 62-65 23083763-11 2012 In addition, DMH NPY modulates energy expenditure likely through affecting brown adipocyte formation and thermogenic activity. 1,2-Dimethylhydrazine 13-16 neuropeptide Y Rattus norvegicus 17-20 23083763-12 2012 Overall, the recent findings provide clear evidence demonstrating critical roles for DMH NPY in energy balance control, and also imply a potential role for DMH NPY in maintaining glucose homeostasis. 1,2-Dimethylhydrazine 156-159 neuropeptide Y Rattus norvegicus 160-163 23172177-10 2013 The present data suggest that NPY expression in the DMH during chronic hyperphagic conditions plays important roles in feeding behavior and thermogenesis by modulating neuronal functions within the hypothalamus, but not in the brainstem. 1,2-Dimethylhydrazine 52-55 neuropeptide Y Rattus norvegicus 30-33 23526718-8 2013 While high-fat diet induced hyperphagia, obesity, and hyperinsulinemia, these effects were amplified in rats with DMH NPY overexpression. 1,2-Dimethylhydrazine 114-117 neuropeptide Y Rattus norvegicus 118-121 23313404-2 2013 Previously, we have shown that compared to AAVGFP controls, adeno-associated virus (AAV)-mediated overexpression of NPY in the DMH of lean rats resulted in significantly higher body weight gain that was attributed to increased food intake, and this was further exacerbated by a high-fat diet. 1,2-Dimethylhydrazine 127-130 neuropeptide Y Rattus norvegicus 116-119 23083763-6 2012 The findings of DMH NPY overexpression or induction in animals with increased energy demands and in certain rodent models of obesity implicate a role for DMH NPY in maintaining energy homeostasis. 1,2-Dimethylhydrazine 16-19 neuropeptide Y Rattus norvegicus 20-23 23083763-6 2012 The findings of DMH NPY overexpression or induction in animals with increased energy demands and in certain rodent models of obesity implicate a role for DMH NPY in maintaining energy homeostasis. 1,2-Dimethylhydrazine 16-19 neuropeptide Y Rattus norvegicus 158-161 23083763-6 2012 The findings of DMH NPY overexpression or induction in animals with increased energy demands and in certain rodent models of obesity implicate a role for DMH NPY in maintaining energy homeostasis. 1,2-Dimethylhydrazine 154-157 neuropeptide Y Rattus norvegicus 20-23 23083763-6 2012 The findings of DMH NPY overexpression or induction in animals with increased energy demands and in certain rodent models of obesity implicate a role for DMH NPY in maintaining energy homeostasis. 1,2-Dimethylhydrazine 154-157 neuropeptide Y Rattus norvegicus 158-161 21531339-2 2011 Here we report that knockdown of NPY expression in the DMH by adeno-associated virus-mediated RNAi reduced fat depots in rats fed regular chow and ameliorated high-fat diet-induced hyperphagia and obesity. 1,2-Dimethylhydrazine 55-58 neuropeptide Y Rattus norvegicus 33-36 21531339-3 2011 DMH NPY knockdown resulted in development of brown adipocytes in inguinal white adipose tissue through the sympathetic nervous system. 1,2-Dimethylhydrazine 0-3 neuropeptide Y Rattus norvegicus 4-7 19129396-2 2009 To elucidate such actions, we used the adenoassociated virus (AAV) system to alter Npy gene expression in the DMH and examined the effects of these alterations on food intake and energy balance as well as explored its downstream signaling pathway. 1,2-Dimethylhydrazine 110-113 neuropeptide Y Rattus norvegicus 83-86 19470705-8 2009 The lactation-induced increase in DMH NPY was unchanged after treatments. 1,2-Dimethylhydrazine 34-37 neuropeptide Y Rattus norvegicus 38-41 19470705-11 2009 The chronic hyperphagia of lactation is most likely sustained by the induction of NPY in the DMH. 1,2-Dimethylhydrazine 93-96 neuropeptide Y Rattus norvegicus 82-85 19129396-3 2009 We found that AAV-mediated overexpression of NPY in the DMH of lean rats increased food intake and body weight, and exacerbated high-fat diet-induced obesity. 1,2-Dimethylhydrazine 56-59 neuropeptide Y Rattus norvegicus 45-48 19129396-4 2009 Knockdown of NPY expression in the DMH via AAV-mediated RNA interference ameliorated the hyperphagia, obesity, and diabetes of Otsuka Long-Evans Tokushima Fatty (OLETF) rats. 1,2-Dimethylhydrazine 35-38 neuropeptide Y Rattus norvegicus 13-16 19129396-5 2009 NPY knockdown in the DMH produced a nocturnal and meal size-specific feeding effect. 1,2-Dimethylhydrazine 21-24 neuropeptide Y Rattus norvegicus 0-3 19129396-7 2009 DMH NPY knockdown increased the feeding inhibitory and NTS c-Fos responses to peripheral administration of cholecystokinin. 1,2-Dimethylhydrazine 0-3 neuropeptide Y Rattus norvegicus 4-7 17196304-4 2007 DMH NPY expression is elevated in pair-fed OLETF rats lacking cholecystokinin (CCK)-1 receptors. 1,2-Dimethylhydrazine 0-3 neuropeptide Y Rattus norvegicus 4-7 18248910-4 2008 We determined the time course of feeding inhibitory effects of exogenous DMH CCK, assessed NPY gene expression in the DMH in response to DMH CCK administration, and characterized c-Fos activation in the entire brain induced by CCK injection into the DMH using c-Fos like immunohistochemistry. 1,2-Dimethylhydrazine 118-121 neuropeptide Y Rattus norvegicus 91-94 18248910-4 2008 We determined the time course of feeding inhibitory effects of exogenous DMH CCK, assessed NPY gene expression in the DMH in response to DMH CCK administration, and characterized c-Fos activation in the entire brain induced by CCK injection into the DMH using c-Fos like immunohistochemistry. 1,2-Dimethylhydrazine 118-121 neuropeptide Y Rattus norvegicus 91-94 18248910-4 2008 We determined the time course of feeding inhibitory effects of exogenous DMH CCK, assessed NPY gene expression in the DMH in response to DMH CCK administration, and characterized c-Fos activation in the entire brain induced by CCK injection into the DMH using c-Fos like immunohistochemistry. 1,2-Dimethylhydrazine 118-121 neuropeptide Y Rattus norvegicus 91-94 18248910-5 2008 We found that parenchymal injection of CCK into the DMH decreased food intake during the entire 22 h observation period, with a primary effect in the first 4 h, and down-regulated NPY gene expression in the DMH. 1,2-Dimethylhydrazine 52-55 neuropeptide Y Rattus norvegicus 180-183 18248910-5 2008 We found that parenchymal injection of CCK into the DMH decreased food intake during the entire 22 h observation period, with a primary effect in the first 4 h, and down-regulated NPY gene expression in the DMH. 1,2-Dimethylhydrazine 207-210 neuropeptide Y Rattus norvegicus 180-183 17409266-6 2007 In situ hybridization determinations revealed that, while HFD reduced neuropeptide Y (NPY) mRNA expression in both the arcuate nucleus (Arc) and the dorsomedial hypothalamus (DMH) of LETO rats, HFD resulted in decreased NPY expression in the Arc but not in the DMH of OLETF rats. 1,2-Dimethylhydrazine 175-178 neuropeptide Y Rattus norvegicus 86-89 17409266-6 2007 In situ hybridization determinations revealed that, while HFD reduced neuropeptide Y (NPY) mRNA expression in both the arcuate nucleus (Arc) and the dorsomedial hypothalamus (DMH) of LETO rats, HFD resulted in decreased NPY expression in the Arc but not in the DMH of OLETF rats. 1,2-Dimethylhydrazine 175-178 neuropeptide Y Rattus norvegicus 220-223 17196304-5 2007 A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats. 1,2-Dimethylhydrazine 30-33 neuropeptide Y Rattus norvegicus 34-37 17196304-5 2007 A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats. 1,2-Dimethylhydrazine 30-33 neuropeptide Y Rattus norvegicus 95-98 17196304-5 2007 A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats. 1,2-Dimethylhydrazine 91-94 neuropeptide Y Rattus norvegicus 34-37 17196304-5 2007 A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats. 1,2-Dimethylhydrazine 91-94 neuropeptide Y Rattus norvegicus 95-98 17196304-5 2007 A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats. 1,2-Dimethylhydrazine 91-94 neuropeptide Y Rattus norvegicus 34-37 17196304-5 2007 A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats. 1,2-Dimethylhydrazine 91-94 neuropeptide Y Rattus norvegicus 95-98 15123537-8 2004 Furthermore, in intact rats, NPY and CCK-AR are colocalized in DMH neurons, and parenchymal injection of CCK into the DMH reduces food intake and down-regulates DMH NPY mRNA expression. 1,2-Dimethylhydrazine 63-66 neuropeptide Y Rattus norvegicus 29-32 16815799-15 2006 Elevated DMH NPY in OLETF rats appears to be a consequence of the absence of CCK-1 receptors. 1,2-Dimethylhydrazine 9-12 neuropeptide Y Rattus norvegicus 13-16 16815799-16 2006 In intact rats NPY and CCK-1 receptors colocalize to neurons within the compact subregion of the DMH and local CCK administration reduces food intake and decreases DMH NPY mRNA expression. 1,2-Dimethylhydrazine 97-100 neuropeptide Y Rattus norvegicus 15-18 16815799-20 2006 Exercise also prevents elevated levels of DMH NPY mRNA expression, suggesting that exercise exerts an alternative, non-CCK mediated, control on DMH NPY. 1,2-Dimethylhydrazine 144-147 neuropeptide Y Rattus norvegicus 148-151 15123537-8 2004 Furthermore, in intact rats, NPY and CCK-AR are colocalized in DMH neurons, and parenchymal injection of CCK into the DMH reduces food intake and down-regulates DMH NPY mRNA expression. 1,2-Dimethylhydrazine 118-121 neuropeptide Y Rattus norvegicus 165-168 15175378-2 2004 Using lactating rats as a model, the present study first showed that in the DMH abundant alpha-MSH and agouti-related protein fibers are in close apposition to NPY-positive cells. 1,2-Dimethylhydrazine 76-79 neuropeptide Y Rattus norvegicus 160-163 15175378-1 2004 In several hyperphagic models, including lactation, in which hypothalamic melanocortin signaling is reduced, a novel expression of NPY mRNA in the dorsomedial hypothalamus (DMH) has been observed, suggesting that melanocortin signaling and the induced NPY in the DMH may constitute unique neurocircuitry in mediating energy balance. 1,2-Dimethylhydrazine 173-176 neuropeptide Y Rattus norvegicus 131-134 15175378-1 2004 In several hyperphagic models, including lactation, in which hypothalamic melanocortin signaling is reduced, a novel expression of NPY mRNA in the dorsomedial hypothalamus (DMH) has been observed, suggesting that melanocortin signaling and the induced NPY in the DMH may constitute unique neurocircuitry in mediating energy balance. 1,2-Dimethylhydrazine 173-176 neuropeptide Y Rattus norvegicus 252-255 15175378-7 2004 Furthermore, MTII treatment greatly attenuated suckling-induced NPY expression in the DMH. 1,2-Dimethylhydrazine 86-89 neuropeptide Y Rattus norvegicus 64-67 15175378-9 2004 In summary, the present study demonstrated that the melanocortin system in the DMH not only plays an important role in inducing NPY expression in the DMH of lactating rats but also in regulating energy homeostasis, at least in part, by modulating appetite and energy expenditure. 1,2-Dimethylhydrazine 79-82 neuropeptide Y Rattus norvegicus 128-131 11404301-5 2001 In contrast, NPY expression was upregulated in the dorsomedial hypothalamus (DMH) in pair-fed OLETF rats. 1,2-Dimethylhydrazine 77-80 neuropeptide Y Rattus norvegicus 13-16 12842868-9 2003 DMH NPY-expressing neurons do not appear to be under the direct control of leptin signaling. 1,2-Dimethylhydrazine 0-3 neuropeptide Y Rattus norvegicus 4-7 11404301-7 2001 These findings suggest a role for DMH NPY upregulation in the etiology of OLETF hyperphagia and obesity. 1,2-Dimethylhydrazine 34-37 neuropeptide Y Rattus norvegicus 38-41 11404301-6 2001 A similar DMH NPY overexpression was evident in 5-wk-old preobese OLETF rats. 1,2-Dimethylhydrazine 10-13 neuropeptide Y Rattus norvegicus 14-17 9886815-5 1999 Resuckling for 24 h induced a significant increase in NPY mRNA levels in the caudal portion of the ARH and in the DMH. 1,2-Dimethylhydrazine 114-117 neuropeptide Y Rattus norvegicus 54-57 9886815-6 1999 Bromocriptine treatment did not alter the increase in NPY mRNA levels in the ARH, whereas the treatment greatly attenuated the increase in NPY mRNA in the DMH. 1,2-Dimethylhydrazine 155-158 neuropeptide Y Rattus norvegicus 139-142 9886815-10 1999 Suckling-induced hyperprolactinemia did not participate in the increase in ARH NPY activity, whereas it played a major stimulatory role in suckling-induced activation of NPY neurons in the DMH and an inhibitory role in suckling-induced suppression of TIDA activity. 1,2-Dimethylhydrazine 189-192 neuropeptide Y Rattus norvegicus 170-173