PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30425102-0	2019	Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design.	Fadrozole	91-100	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	38-58	
30425102-4	2019	Here we report the X-ray crystal structure of human CYP11B1 (at 2.1 A resolution) in complex with fadrozole, a racemic compound normally used to treat breast cancer by inhibiting estrogen-producing CYP19A1.	Fadrozole	98-107	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	52-59	
30425102-5	2019	Comparison of fadrozole-bound CYP11B1 with fadrozole-bound CYP11B2 revealed that despite conservation of the active-site residues, the overall structures and active sites had structural rearrangements consistent with distinct protein functions and inhibition.	Fadrozole	14-23	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	30-37	
30425102-6	2019	Whereas fadrozole binds to both CYP11B enzymes by coordinating the heme iron, CYP11B2 binds to the R enantiomer of fadrozole, and CYP11B1 binds to the S enantiomer, each with distinct orientations and interactions.	Fadrozole	8-17	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	32-38	
28759940-6	2017	Higher concentrations of FAD286 did not further reduce aldosterone concentrations, but showed a parallel reduction in corticosterone, cortisol and cortisone levels, reflecting additional inhibition of steroid-11beta-hydroxylase (CYP11B1).	Fadrozole	25-31	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	201-227	
28759940-6	2017	Higher concentrations of FAD286 did not further reduce aldosterone concentrations, but showed a parallel reduction in corticosterone, cortisol and cortisone levels, reflecting additional inhibition of steroid-11beta-hydroxylase (CYP11B1).	Fadrozole	25-31	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	229-236	
19622340-8	2009	FAD286, a reference CYP11B2 inhibitor, inhibited CYP11B2 and CYP11B1 activities with IC(50) values of 1.6+/-0.1 and 9.9+/-0.9 nM (mean+/-SEM, n=3-6), respectively.	Fadrozole	0-6	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	61-68	
24899257-6	2014	Among them, compounds 14 and 23 showed good selectivity over the highly homologous CYP11B1, with selectivity factors (SF = IC50 CYP11B1/IC50 CYP11B2) around 170; thus, they are superior to fadrozole and LCI699 (SFs < 15).	Fadrozole	189-198	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	83-90	
34247511-9	2021	LCI699 binding was compared with that of its analog fadrozole to both CYP11B enzymes.	Fadrozole	52-61	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	70-76	
15985365-5	2005	Fadrozole and compounds 6, 9 and 10 were more potent towards CYP11B2 compared to CYP11B1 with IC(50) values in the nanomolar range.	Fadrozole	0-9	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	81-88